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PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, pp. e108777 - e108777
The pathogenesis of complex diseases, such as type 1 diabetes (T1D), derives from interactions between host genetics and environmental factors. Previous... 
HERPES-SIMPLEX-VIRUS | RHEUMATOID-ARTHRITIS RISK | MULTIDISCIPLINARY SCIENCES | GAMMA-INTERFERON | TOLL-LIKE RECEPTORS | RIG-I | NF-KAPPA-B | I INTERFERON-PRODUCTION | INTERLEUKIN-27 EXPRESSION | SIGNALING PROTEIN | GENOME-WIDE ASSOCIATION | RNA, Small Interfering - genetics | GTPase-Activating Proteins - deficiency | GTPase-Activating Proteins - metabolism | Genetic Loci | Recombinant Proteins - biosynthesis | Interferon Regulatory Factor-3 - genetics | Herpesvirus 1, Human - physiology | Immunity, Cellular - drug effects | Interferon-beta - genetics | Cytokines - genetics | Interleukin-27 - metabolism | Interleukin-27 - pharmacology | Cell Line | Disease Susceptibility | Cytokines - metabolism | Diabetes Mellitus, Type 1 - pathology | Diabetes Mellitus, Type 1 - genetics | Recombinant Proteins - genetics | Macrophages - cytology | Recombinant Proteins - pharmacology | Chemokines - genetics | Interleukin-27 - genetics | Macrophages - metabolism | Animals | High-Throughput Screening Assays | Interferon-beta - metabolism | Virus Replication | Interferon Regulatory Factor-3 - metabolism | Herpesvirus 1, Human - genetics | Macrophages - drug effects | Chemokines - metabolism | Mice | GTPase-Activating Proteins - genetics | Interferon-gamma - pharmacology | Microscopy, Fluorescence | RNA, Small Interfering - metabolism | Virus diseases | Infection | Antiviral agents | Type 1 diabetes | Genes | Genetic research | Genetic aspects | Disease susceptibility | Biological response modifiers | Health aspects | Genetic screening | Pathogenesis | Herpes simplex | Fluorescence | Viruses | Genomes | Biology | Infections | Kinases | Macrophages | Immunity | Interleukin 27 | Medical schools | Proteins | Rodents | Infectivity | Gastroenterology | Genetics | Sensors | Bioinformatics | Recombinant | Pathogens | Cytokines | Diabetes mellitus | Environmental factors | Inflammation | RNA polymerase | Gene expression | Loci | Inflammatory bowel disease | Hospitals | Microscopy | Interferon regulatory factor 3 | γ-Interferon | Interferon | Diabetes | Chemokines | Interferon regulatory factor | Viral infections | Index Medicus | Organic chemistry | Chemical Sciences
Journal Article
Journal Article
Plos Genetics, ISSN 1553-7404, 03/2017, Volume 13, Issue 3, pp. e1006643 - e1006643
Journal Article
BMC Gastroenterology, ISSN 1471-230X, 03/2016, Volume 16, Issue 1, pp. 40 - 40
Background: Breastfeeding is associated with a variety of positive health outcomes in children and is recommended exclusively for the first 6 months of life;... 
Peyer's patches | GALT | Jejunum | Nutrition | Ileum | PIGS | EARLY INFANCY | PERMEABILITY | BARRIER | ENVIRONMENT | COLONIZATION | GUT MICROBIOTA | HUMAN-MILK | IMMUNE-RESPONSES | GASTROENTEROLOGY & HEPATOLOGY | Interleukin-8 - genetics | Up-Regulation | Jejunum - pathology | Cadherins - metabolism | Calcium - metabolism | Humans | Ileum - metabolism | Interleukin-8 - drug effects | Leukemia Inhibitory Factor - genetics | Vascular Endothelial Growth Factor A - metabolism | Peyer's Patches - drug effects | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Antigens, CD - genetics | Antigens, CD - metabolism | Jejunum - metabolism | Leukemia Inhibitory Factor - metabolism | Jejunum - drug effects | Fas Ligand Protein - drug effects | Ileum - drug effects | Swine | Interleukin-8 - metabolism | Cadherins - genetics | Soy Foods | Cytokines - genetics | Interleukin-6 - metabolism | Infant, Newborn | Milk | Animals, Newborn | Interleukin-6 - genetics | Down-Regulation | Interleukin-27 - genetics | Gastrointestinal Microbiome - drug effects | Diet | Interleukin-10 - genetics | Interleukin-15 - metabolism | Intestine, Small - metabolism | Peyer's Patches - immunology | Fas Ligand Protein - genetics | Fas Ligand Protein - metabolism | Ileum - pathology | Interferon-alpha - drug effects | Intestine, Small - pathology | Interferon-alpha - genetics | Interleukin-10 - metabolism | Interleukin-9 - metabolism | Vascular Endothelial Growth Factor A - drug effects | Interleukin-27 - metabolism | RNA, Messenger - drug effects | Interferon-alpha - metabolism | Cytokines - metabolism | Intestine, Small - microbiology | Jejunum - microbiology | Infant Formula - pharmacology | Animals | Interleukin-15 - genetics | Cytokines - drug effects | Interleukin-9 - genetics | Intestine, Small - drug effects | Leukemia Inhibitory Factor - drug effects | Ileum - microbiology | Interleukin-10 | Analysis | Influence | Research | Gene expression | Breast feeding | Health aspects | Index Medicus
Journal Article
The Journal of Immunology, ISSN 0022-1767, 05/2009, Volume 182, Issue 9, pp. 5748 - 5756
IL-27 is secreted by APCs in response to inflammatory stimuli and exerts a proinflammatory Th1-enhancing activity but also has significant anti-inflammatory... 
EFFECTOR PHASE | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | TGF-BETA | INTERLEUKIN-27 | INFLAMMATION | HELPER-CELLS | REGULATORY T-CELLS | CENTRAL-NERVOUS-SYSTEM | CYTOKINE | INDUCTION | IMMUNOLOGY | Humans | Receptors, Retinoic Acid - biosynthesis | Encephalomyelitis, Autoimmune, Experimental - immunology | Receptors, Thyroid Hormone - antagonists & inhibitors | Receptors, Retinoic Acid - genetics | Cell Differentiation - genetics | Interleukins - genetics | Receptors, Thyroid Hormone - genetics | Interleukins - physiology | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - pathology | Encephalomyelitis, Autoimmune, Experimental - genetics | Protein Subunits - physiology | Growth Inhibitors - genetics | Cell Lineage - genetics | Protein Subunits - genetics | Nuclear Receptor Subfamily 1, Group F, Member 3 | Genetic Predisposition to Disease | Encephalomyelitis, Autoimmune, Experimental - pathology | T-Lymphocytes, Helper-Inducer - metabolism | Growth Inhibitors - deficiency | Gene Expression Regulation - immunology | Mice, Inbred C57BL | Receptors, Thyroid Hormone - biosynthesis | Cells, Cultured | Receptors, Retinoic Acid - antagonists & inhibitors | Interleukin-17 - biosynthesis | Mice, Knockout | Cell Differentiation - immunology | Animals | Interleukin-17 - antagonists & inhibitors | Protein Subunits - deficiency | Growth Inhibitors - physiology | Interleukins - deficiency | Mice | Cell Lineage - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 04/2015, Volume 42, Issue 4, pp. 613 - 626
Epigenetic regulation of lineage-specific genes is important for the differentiation and function of T cells. Ten-eleven translocation (Tet) proteins catalyze... 
METHYLATION | INTERLEUKIN-27 | TRANSCRIPTION | DISEASE | POPULATIONS | PATTERNS | GENERATION | DIFFERENTIATION | SPECIFICATION | IMMUNOLOGY | PLASTICITY | Cytosine - analogs & derivatives | 5-Methylcytosine - analogs & derivatives | E1A-Associated p300 Protein - immunology | Humans | E1A-Associated p300 Protein - genetics | T-Box Domain Proteins - immunology | Th1 Cells - immunology | DNA Methylation | Cytosine - metabolism | Proto-Oncogene Proteins - immunology | Th17 Cells - cytology | Cell Differentiation | STAT4 Transcription Factor - immunology | Cytokines - immunology | Cytosine - immunology | DNA-Binding Proteins - immunology | Th17 Cells - enzymology | DNA - immunology | Gene Expression Regulation | Mice, Transgenic | Proto-Oncogene Proteins - genetics | DNA - metabolism | DNA-Binding Proteins - genetics | T-Box Domain Proteins - genetics | Animals | Epigenesis, Genetic - immunology | Th17 Cells - immunology | STAT4 Transcription Factor - genetics | Th1 Cells - enzymology | Mice | Th1 Cells - cytology | Genome | Cytokines - biosynthesis | Proteins | Epigenetic inheritance | Cytokines | Genes | Genomics | DNA | Genetic research | Genomes | Ophthalmology | T cells | Gene expression | Cell differentiation | Transcription factors | Lymphocytes | Rodents | DNA methylation | Epigenetics | Genetic testing | Experiments | Binding sites | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 2013, Volume 14, Issue 10, pp. 1054 - 1063
Dendritic cells (DCs) control the balance between effector T cells and regulatory T cells in vivo. Hence, the study of DCs might identify mechanisms of disease... 
ENCEPHALOMYELITIS | DENDRITIC CELLS | MULTIPLE-SCLEROSIS | ARYL-HYDROCARBON RECEPTOR | INTERLEUKIN-27 | INFLAMMATION | GENE-EXPRESSION | CNS | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | ANTIGEN | T-Lymphocyte Subsets - immunology | Transcription, Genetic - drug effects | T-Lymphocyte Subsets - cytology | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | Interleukin-17 - pharmacology | Antigens, CD - genetics | Antigens, CD - metabolism | Cell Differentiation - genetics | Immune Tolerance - immunology | T-Lymphocyte Subsets - drug effects | Antibodies - immunology | Dendritic Cells - drug effects | Encephalomyelitis, Autoimmune, Experimental - genetics | Receptors, Cytokine - metabolism | Receptors, Cytokine - genetics | Dendritic Cells - metabolism | Gene Expression | Myelin Sheath - immunology | Signal Transduction | Apyrase - metabolism | Cells, Cultured | Antigen Presentation - immunology | Mice, Knockout | Gene Expression Regulation - drug effects | Cell Differentiation - immunology | Autoantibodies - immunology | Animals | Carrier Proteins - metabolism | Apyrase - genetics | Antigen Presentation - drug effects | Mice | Autoimmunity - drug effects | Cytokines - biosynthesis | Autoimmunity | Genetic aspects | Research | Interleukins | T cells | Health aspects | Index Medicus
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 07/2016, Volume 194, Issue 1, pp. 48 - 57
Journal Article
Nature, ISSN 0028-0836, 06/2018, Volume 558, Issue 7710, pp. 454 - 459
The expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated... 
PATHWAYS | NETWORK | ACTIVATION | MAF | INTERLEUKIN-27 | LANDSCAPE | MULTIDISCIPLINARY SCIENCES | CENTRAL-NERVOUS-SYSTEM | TIM-3 | EXPRESSION | EXHAUSTION | CD8-Positive T-Lymphocytes - cytology | Male | CD4-Positive T-Lymphocytes - immunology | Immune Tolerance - immunology | Melanoma - genetics | CD8-Positive T-Lymphocytes - metabolism | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Transcription, Genetic | Lymphocytes, Tumor-Infiltrating - cytology | Reproducibility of Results | Gene Regulatory Networks - genetics | Interleukin-27 - immunology | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Receptors, Cell Surface - metabolism | Positive Regulatory Domain I-Binding Factor 1 - metabolism | Mice, Knockout | Animals | Melanoma - immunology | Immune Tolerance - genetics | Proto-Oncogene Proteins c-maf - metabolism | Mice | CD8-Positive T-Lymphocytes - immunology | Lymphocytes, Tumor-Infiltrating - immunology | Receptors, Cell Surface - genetics | Genetic aspects | Genetic transcription | Observations | T cells | Regulators | Transcription factors | PD-1 protein | CD8 antigen | Gene regulation | Homeostasis | Effector cells | Lymphocytes T | Genomes | CD223 antigen | Immunity | Interleukin 27 | Proteins | Receptors | CTLA-4 protein | Lymphocytes | Bioinformatics | Cytokines | Immunoregulation | Melanoma | Protein C | c-Maf protein | Activated protein C | Gene expression | Ribonucleic acid--RNA | Molecular chains | CD4 antigen | Exhaustion | Computer applications | Receptor mechanisms | Bayesian analysis | Tumors | Index Medicus
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 10/2014, Volume 55, pp. 335 - 347
Interleukin-27 (IL-27), a key immunoregulatory cytokine plays an important role in host response to mycobacterial infection as neutralization of IL-27 augments... 
IL-27 | IFN-γ | Autophagy | Mycobacteria | APOPTOSIS | CYTOKINES | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | CELL BIOLOGY | WSX-1 | IFN-gamma | INTERFERON-GAMMA | PATHWAY | INTERLEUKIN-27 | IMMUNE-RESPONSES | GROWTH | Phosphotransferases - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Immunoblotting | Janus Kinases - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Autophagy - drug effects | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - genetics | RNA Interference | Mycobacterium tuberculosis - physiology | Phagosomes - ultrastructure | Autophagy - genetics | Proto-Oncogene Proteins c-akt - metabolism | Phosphotransferases - genetics | Macrophages - microbiology | Phagosomes - drug effects | Interleukin-27 - pharmacology | Microscopy, Electron, Transmission | Janus Kinases - genetics | Phagosomes - metabolism | Signal Transduction - genetics | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Host-Pathogen Interactions | Phosphatidylinositol 3-Kinases - genetics | Microscopy, Confocal | Macrophages - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | Macrophages - drug effects | Interferon-gamma - pharmacology | Index Medicus | Tuberculosis | Pathways | Cytokines | Cascades | Activation | Biology | Macrophages | Survival
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 04/2018, Volume 9, pp. 873 - 873
Journal Article