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The Journal of immunology (1950), ISSN 1550-6606, 2009, Volume 183, Issue 10, pp. 6469 - 6477
Alternatively activated macrophages (AAM) play a crucial role in type 2 immunity. Mice deficient in ST2, a receptor for the latest member of the IL-1 family,... 
IL-1-LIKE CYTOKINE IL-33 | IMMUNE-RESPONSE | ST2 RECEPTOR | EFFECTOR FUNCTION | MAST-CELLS | IN-VIVO | INDUCED ARTHRITIS | ALVEOLAR MACROPHAGES | INTERLEUKIN-1 RECEPTOR | IMMUNOLOGY | T-CELLS | Interleukin-1 Receptor-Like 1 Protein | Asthma - metabolism | Epithelial Cells - metabolism | Ovalbumin - immunology | Humans | Middle Aged | Chemokine CCL24 - metabolism | Interleukin-13 - immunology | Male | Interleukins - metabolism | Receptors, Interleukin - metabolism | Signal Transduction - immunology | Inflammation - metabolism | Interleukins - immunology | Asthma - immunology | Chemokine CCL17 - immunology | Adult | Female | Interleukin-4 - genetics | Macrophages, Alveolar - immunology | Recombinant Proteins - metabolism | Cell Polarity - immunology | Lung - pathology | Receptors, Interleukin - immunology | Interleukin-33 | Macrophage Activation - immunology | Receptors, Interleukin-1 - immunology | Interleukin-4 - metabolism | Receptors, Interleukin-4 - metabolism | Inflammation - immunology | Receptors, Interleukin-4 - immunology | Interleukin-13 - metabolism | Chemokine CCL24 - immunology | Receptors, Interleukin - genetics | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Interleukin-4 - immunology | Animals | Eosinophilia - immunology | Recombinant Proteins - immunology | Epithelial Cells - immunology | Receptors, Interleukin-4 - genetics | Mice | Mice, Inbred BALB C | Macrophages, Alveolar - metabolism | Chemokine CCL17 - metabolism | Lung - immunology
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2009, Volume 106, Issue 32, pp. 13463 - 13468
Journal Article
Journal Article
Molecular cancer, ISSN 1476-4598, 2011, Volume 10, Issue 1, pp. 117 - 117
Journal Article
Autophagy, ISSN 1554-8635, 2018, Volume 15, Issue 4, pp. 652 - 667
EBV has been reported to impair monocyte in vitro differentiation into dendritic cells (DCs) and reduce cell survival. In this study, we added another layer of... 
monocytes | SQSTM1/p62 | autophagy | dendritic cells | ROS | STAT3 | EBV | ATG5 | NFE2L2 | ACTIVATION | PHOSPHORYLATION | TRANSCRIPTION | p62 | CANCER | CELL BIOLOGY | NRF2 | BIOGENESIS | INFECTION | SQSTM1 | EPSTEIN-BARR-VIRUS | Reactive Oxygen Species - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Humans | Cell Survival - genetics | Apoptosis - genetics | Monocytes - metabolism | rab GTP-Binding Proteins - genetics | Autophagy-Related Protein 5 - genetics | Mitochondrial Proteins - genetics | DNA-Binding Proteins - metabolism | Kelch-Like ECH-Associated Protein 1 - genetics | Cell Differentiation - genetics | Mitochondrial Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Autophagy - genetics | Dendritic Cells - virology | Sequestosome-1 Protein - metabolism | Dendritic Cells - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | rab GTP-Binding Proteins - metabolism | Herpesvirus 4, Human - physiology | Interleukin-4 - metabolism | Kelch-Like ECH-Associated Protein 1 - metabolism | Mitochondria - metabolism | Signal Transduction - genetics | Autophagosomes - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Autophagosomes - virology | Transcription Factors - metabolism | Monocytes - virology | Sequestosome-1 Protein - genetics | NF-E2-Related Factor 2 - metabolism | Autophagy-Related Protein 5 - metabolism | RNA, Small Interfering
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 1, pp. 130 - 141.e9
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2006, Volume 116, Issue 10, pp. 2777 - 2790
Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance and immunotherapy. While tumor-recruited CD11b(+) myeloid... 
MEDICINE, RESEARCH & EXPERIMENTAL | MYELOID SUPPRESSOR-CELLS | RESPONSES | GROWTH-FACTOR-BETA | COLONY-STIMULATING FACTOR | MECHANISM | MACROPHAGES | RECEPTOR EXPRESSION | IMMUNE DYSFUNCTION | IMMUNOSURVEILLANCE | CANCER | Neoplasms - metabolism | Spleen - immunology | Gene Expression - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Receptors, Cell Surface - analysis | Arginase - metabolism | Monocytes - metabolism | Monocytes - immunology | Interferon-gamma - metabolism | Lymphocyte Activation - immunology | CD11b Antigen - analysis | Myeloid Cells - immunology | CD8-Positive T-Lymphocytes - metabolism | Myeloid Cells - drug effects | Interferon-gamma - genetics | Interleukin-4 - genetics | T-Lymphocytes, Cytotoxic - immunology | Interleukin-4 - metabolism | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Mice, Transgenic | Arginase - genetics | Spleen - cytology | Interleukin-13 - metabolism | Interleukin-13 - pharmacology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Mice, Knockout | Monocytes - drug effects | Immunity, Cellular - immunology | Models, Immunological | Animals | Nitric Oxide Synthase Type II - genetics | T-Lymphocytes, Cytotoxic - metabolism | Neoplasms - immunology | Cell Line, Tumor | Myeloid Cells - metabolism | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Interferon-gamma - pharmacology | Nitric Oxide Synthase Type II - metabolism | Receptors, Cell Surface - genetics | Medicine, Experimental | Medical research | Care and treatment | Research | T cells | Tumors
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 10, p. e46082
MicroRNA (miR)-155 is a critical player in both innate and adaptive immune responses. It can influence CD4(+) T cell lineage choice. To clarify the role of... 
PREVENTS DEVELOPMENT | SUPPRESSOR | ACTIVATION | MULTIDISCIPLINARY SCIENCES | STAT3 | T(H)17 | CD4(+) T-CELLS | RECEPTOR | ABSENCE | INDUCTION | EXPRESSION | GATA3 Transcription Factor - genetics | T-Lymphocytes, Regulatory - metabolism | Transforming Growth Factor beta1 - metabolism | STAT Transcription Factors - metabolism | Suppressor of Cytokine Signaling 1 Protein | Janus Kinases - metabolism | Interferon-gamma - metabolism | Cell Differentiation - genetics | Th17 Cells - metabolism | Base Sequence | T-Lymphocytes, Regulatory - cytology | Interleukin-10 - metabolism | Th17 Cells - cytology | Interferon-gamma - genetics | Interleukin-4 - genetics | GATA3 Transcription Factor - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Signal Transduction | Interleukin-4 - metabolism | Gene Expression Regulation | Suppressor of Cytokine Signaling Proteins - genetics | Forkhead Transcription Factors - genetics | T-Box Domain Proteins - genetics | T-Box Domain Proteins - metabolism | Interleukin-17 - metabolism | Animals | Mice | MicroRNAs - genetics | Smad Proteins - metabolism | Physiological aspects | Genetic aspects | MicroRNA | Research | Cell differentiation | T cells | Smad5 protein | Smad protein | Transcription factors | Transcription | Laboratories | Interleukin | Differentiation (biology) | Helper cells | Science | Homology | Lymphocytes T | Inflammatory diseases | Signal transduction | Immunology | Transfection | Lymphocytes | Smad2 protein | Atherosclerosis | CD25 antigen | Janus kinase | miRNA | Cardiology | Growth factors | Immune system | Function analysis | Lupus | Immune response | Cytokines | Cell lineage | T cell receptors | Gene expression | Ribonucleic acid--RNA | Suppressors | CD4 antigen | Signaling | MicroRNAs | Interleukin 10 | RNA | Ribonucleic acid
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 12/2010, Volume 107, Issue 52, pp. 22593 - 22598
We investigated the mechanisms by which T-cell cytokines are able to influence the Toll-like receptor (TLR)-induced, vitamin D-dependent antimicrobial pathway... 
T lymphocytes | Up regulation | Monocytes | Messenger RNA | Cytokines | Vitamin D | Mycobacterium tuberculosis | Antimicrobials | Small interfering RNA | Physiological regulation | Interleukin-4 | Interferon-γ | Innate immune response | interleukin-4 | MYCOBACTERIUM-TUBERCULOSIS | ACTIVATION | CATHELICIDIN | IFN-GAMMA | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | AUTOPHAGY | CUTTING EDGE | TOLL-LIKE RECEPTOR-2 | innate immune response | MICROBIAL LIPOPROTEINS | interferon-gamma | Steroid Hydroxylases - metabolism | Gene Expression - drug effects | Monocytes - cytology | Humans | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics | Monocytes - metabolism | Antimicrobial Cationic Peptides - metabolism | Th1 Cells - metabolism | Interleukin-4 - pharmacology | T-Lymphocytes - metabolism | Calcitriol - metabolism | beta-Defensins - metabolism | Antimicrobial Cationic Peptides - genetics | Steroid Hydroxylases - genetics | beta-Defensins - genetics | Toll-Like Receptor 1 - metabolism | Cells, Cultured | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism | Vitamin D3 24-Hydroxylase | Toll-Like Receptor 2 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Th2 Cells - metabolism | Blotting, Western | Monocytes - drug effects | Signal Transduction - drug effects | Vitamin D - analogs & derivatives | Vitamin D - metabolism | Cytokines - pharmacology | Interferon-gamma - pharmacology | Immune response | Calcifediol | Regulation | Alfacalcidol | Research | T cells | Properties | Health aspects | Biological Sciences | interferon-γ
Journal Article
Clinical immunology (Orlando, Fla.), ISSN 1521-6616, 2010, Volume 137, Issue 1, pp. 89 - 101
Abstract Activated macrophages have been characterized as M1 and M2 according to their inflammatory response pattern. Here we analyzed the M2 marker expression... 
Allergy and Immunology | M2 phenotype | Th2 cytokines | Pulmonary fibrosis | IL-1RA | CCL22 | Sarcoidosis | JAK/STAT pathway | CCL18 | Alveolar macrophages | CCL17 | INTERLEUKIN-1 RECEPTOR ANTAGONIST | LUNG INJURY | CYTOKINE | IMMUNOLOGY | SYSTEMIC-SCLEROSIS | STAT3 ACTIVATION | IN-VITRO | GENE-EXPRESSION | TNF-ALPHA RELEASE | GROWTH-FACTOR | T-LYMPHOCYTES | Mannose-Binding Lectins - metabolism | Tumor Necrosis Factor-alpha - metabolism | Gene Expression - drug effects | Humans | Middle Aged | STAT Transcription Factors - metabolism | Interleukin 1 Receptor Antagonist Protein - genetics | Male | Monocytes - metabolism | Monocytes - immunology | Sarcoidosis, Pulmonary - diagnosis | Idiopathic Pulmonary Fibrosis - metabolism | Young Adult | Lectins, C-Type - metabolism | Signal Transduction - immunology | Interleukin-4 - pharmacology | Interleukin 1 Receptor Antagonist Protein - metabolism | Scleroderma, Systemic - complications | Aged, 80 and over | Adult | Female | Bronchoalveolar Lavage Fluid - cytology | Pulmonary Fibrosis - metabolism | Interleukin-8 - metabolism | Macrophages, Alveolar - immunology | Pulmonary Fibrosis - etiology | Sarcoidosis, Pulmonary - complications | Cytokines - metabolism | Macrophage Activation - immunology | Scleroderma, Systemic - metabolism | Pulmonary Fibrosis - immunology | Receptors, Cell Surface - metabolism | Idiopathic Pulmonary Fibrosis - immunology | Monocytes - drug effects | Signal Transduction - drug effects | Macrophages, Alveolar - drug effects | Sarcoidosis, Pulmonary - metabolism | Chemokines, CC - genetics | Aged | Macrophages, Alveolar - metabolism | Macrophage Activation - drug effects | Interleukin-10 - pharmacology | Chemokines, CC - metabolism | Respiratory tract diseases | Systemic scleroderma | Transforming growth factors | Macrophages | Scleroderma (Disease) | Alveoli
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 43, pp. 17253 - 17258
Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue microenvironment. Although much is known about how soluble factors... 
Phenotypes | Cell growth | Cytokines | Stem cells | Cell lines | Actins | Physiological regulation | Macrophages | Endothelial cells | Cells | FIBER | MATRIX | ACTIVATION | ACTIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DIFFERENTIATION | SCAFFOLDS | CULTURE | MESENCHYMAL STEM-CELLS | Mannose-Binding Lectins - metabolism | Arginase - metabolism | Lectins, C-Type - immunology | Cell Shape - immunology | Myosin-Light-Chain Kinase - antagonists & inhibitors | Cytochalasin D - pharmacology | Lectins, C-Type - metabolism | Arginase - immunology | Interleukin-4 - pharmacology | Flow Cytometry | Doxorubicin - analogs & derivatives | Inflammation Mediators - metabolism | Female | Immunophenotyping - methods | Cell Polarity - drug effects | Doxorubicin - metabolism | Macrophages - immunology | Cytokines - immunology | Amides - pharmacology | Biomarkers - metabolism | Inflammation Mediators - immunology | Cell Polarity - immunology | Cytokines - metabolism | Myosin-Light-Chain Kinase - metabolism | Mice, Inbred C57BL | Biomarkers - analysis | Cells, Cultured | Receptors, Cell Surface - metabolism | Macrophages - cytology | Interleukin-13 - pharmacology | Receptors, Cell Surface - immunology | Azepines - pharmacology | Cell Shape - drug effects | Macrophages - metabolism | Animals | Mannose-Binding Lectins - immunology | Lipopolysaccharides - pharmacology | Mice | Pyridines - pharmacology | Doxorubicin - immunology | Interferon-gamma - pharmacology | Microscopy, Fluorescence | Physiological aspects | Microbial genetics | Phenotype | Genetic aspects | Research | Biological Sciences | Physical Sciences
Journal Article