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The Journal of immunology (1950), ISSN 1550-6606, 2004, Volume 172, Issue 1, pp. 567 - 576
The signaling mechanism by which the anti-inflammatory cytokine IL-10 mediates suppression of proinflammatory cytokine synthesis remains largely unknown.... 
RHEUMATOID-ARTHRITIS | TUMOR-NECROSIS-FACTOR | DNA-BINDING | HUMAN NEUTROPHILS | TYROSINE PHOSPHORYLATION | INTERLEUKIN-10 RECEPTOR | GENE-EXPRESSION | KAPPA-B-ALPHA | IMMUNOLOGY | HUMAN MONOCYTES | MONONUCLEAR PHAGOCYTES | Protein Binding - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Immunoglobulins - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Repressor Proteins - antagonists & inhibitors | Antigens, CD - metabolism | Trans-Activators - physiology | Protein Tyrosine Phosphatases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Protein Tyrosine Phosphatases - genetics | Inflammation Mediators - physiology | Glycoproteins - genetics | DNA-Binding Proteins - physiology | Protein Tyrosine Phosphatases - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | DNA - metabolism | Down-Regulation - genetics | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 | Repressor Proteins - biosynthesis | Up-Regulation - immunology | Interleukin-10 - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Adenoviruses, Human - genetics | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Antigens, CD - biosynthesis | Receptors, Cell Surface | Receptors, IgG - biosynthesis | Receptors, IgG - antagonists & inhibitors | Interleukin-10 - physiology | Signal Transduction - immunology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type II | Trans-Activators - genetics | Inflammation Mediators - antagonists & inhibitors | Trans-Activators - biosynthesis | Immunoglobulins - biosynthesis | Macrophages - immunology | Inflammation Mediators - immunology | Receptors, Tumor Necrosis Factor - metabolism | Immune Sera - pharmacology | Proteins - physiology | Cells, Cultured | Glycoproteins - antagonists & inhibitors | Histocompatibility Antigens Class II - biosynthesis | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Up-Regulation - genetics | DNA-Binding Proteins - genetics | DNA - antagonists & inhibitors | Glycoproteins - biosynthesis | Suppressor of Cytokine Signaling 3 Protein | Down-Regulation - immunology | Interleukin-6 - biosynthesis | Receptors, Tumor Necrosis Factor - biosynthesis | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Genetic Vectors | DNA-Binding Proteins - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2007, Volume 356, Issue 15, pp. 1517 - 1526
The expression of interleukin-1–receptor antagonist is reduced in pancreatic islets in type 2 diabetes, and high glucose concentrations induce interleukin-1β... 
INSULIN | MEDICINE, GENERAL & INTERNAL | OBESITY | ISLETS | GLUCOSE | BETA-CELL APOPTOSIS | MUSCLE | EXPRESSION | RECEPTOR ANTAGONIST | Recombinant Proteins - therapeutic use | Insulin-Secreting Cells - secretion | Glucose Transporter Type 4 - metabolism | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Male | Diabetes Mellitus, Type 2 - metabolism | RNA, Messenger - metabolism | Heat-Shock Proteins - genetics | Insulin Resistance - physiology | Interleukin-6 - blood | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Female | Interleukin 1 Receptor Antagonist Protein - pharmacology | Body Mass Index | Glucose Tolerance Test | Double-Blind Method | Glucose Transporter Type 4 - genetics | Heat-Shock Proteins - metabolism | C-Reactive Protein - secretion | Recombinant Proteins - pharmacology | Transcription Factors - genetics | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Interleukin 1 Receptor Antagonist Protein - therapeutic use | Insulin-Secreting Cells - drug effects | Interleukin 1 Receptor Antagonist Protein - adverse effects | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Receptors, Interleukin-1 - antagonists & inhibitors | Type 2 diabetes | Interleukin-1 | Research | Drug therapy | Pancreas | Diabetes | Apoptosis | Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
Journal Article
Scientific reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 2410 - 9
...1Scientific REPORtS | (2018) 8:2410 | DOI:10.1038/s41598-018-20000-4 www.nature.com/scientificreports Small-molecule MDM2 antagonists attenuate the senescence... 
CELLS | ACTIVATION | NUTLIN-3A | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GENE-EXPRESSION | P53 PATHWAY | INDUCTION | CELLULAR SENESCENCE | CANCER | Gamma Rays | Proto-Oncogene Proteins c-mdm2 - genetics | Epithelial Cells - metabolism | Interleukin-6 - antagonists & inhibitors | Epithelial Cells - drug effects | Humans | Cellular Senescence - drug effects | Interleukin-1alpha - metabolism | Male | Lung - cytology | Tumor Suppressor Protein p53 - genetics | Tumor Suppressor Protein p53 - agonists | Cellular Senescence - radiation effects | Cell Cycle Checkpoints - genetics | Indoles - pharmacology | Interleukin-1alpha - genetics | Epithelial Cells - cytology | Interleukin-6 - metabolism | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Fibroblasts - metabolism | Cell Line | Cellular Senescence - genetics | Epithelial Cells - radiation effects | Interleukin-6 - genetics | Enzyme Inhibitors - pharmacology | Tumor Suppressor Protein p53 - metabolism | Interleukin-1alpha - antagonists & inhibitors | Imidazoles - pharmacology | Piperazines - pharmacology | Fibroblasts - radiation effects | Foreskin - cytology | Cell Cycle Checkpoints - drug effects | Fibroblasts - drug effects | Fibroblasts - cytology | Spiro Compounds - pharmacology | Biodegradation | MDM2 protein | Phenotypes | Senescence | p53 Protein | Genotoxicity | Breast cancer | Inflammation | Interleukin 6 | Fibroblasts | Aging | Tumor suppressor genes | Growth factors | Cancer
Journal Article
European heart journal, ISSN 1522-9645, 2014, Volume 35, Issue 27, pp. 1782 - 1791
Atherothrombosis is no longer considered solely a disorder of lipoprotein accumulation in the arterial wall. Rather, the initiation and progression of... 
Darapladib | Atherosclerosis | Inflammasome | Inflammation | Colchicine | Salsalate | C reactive protein | Canakinumab | Methotrexate | Interleukin-6 | C-REACTIVE PROTEIN | FUTURE MYOCARDIAL-INFARCTION | CARDIAC & CARDIOVASCULAR SYSTEMS | INTERLEUKIN-1 RECEPTOR ANTAGONIST | RANDOMIZED CLINICAL-TRIAL | SECRETORY PHOSPHOLIPASE A | ACUTE CORONARY SYNDROME | APPARENTLY HEALTHY-MEN | REVERSE CHOLESTEROL TRANSPORT | PLACEBO-CONTROLLED TRIAL | TYPE-2 DIABETES-MELLITUS | Hydroxychloroquine - therapeutic use | Interleukin-6 - antagonists & inhibitors | NLR Family, Pyrin Domain-Containing 3 Protein | Colchicine - therapeutic use | Humans | Cell Adhesion Molecules - antagonists & inhibitors | Methotrexate - therapeutic use | Sirtuins - therapeutic use | Vaccination - methods | Lipoproteins, HDL - drug effects | Interleukin-1 - physiology | Interleukin-6 - physiology | Anti-Inflammatory Agents - therapeutic use | Interleukin-1 - antagonists & inhibitors | Leukotriene Antagonists - therapeutic use | Carrier Proteins - physiology | Adaptive Immunity - physiology | Phospholipase A2 Inhibitors - therapeutic use | Atherosclerosis - drug therapy | Serpins - therapeutic use | C-Reactive Protein - physiology | Antioxidants - therapeutic use | Tumor Necrosis Factor-alpha - drug effects | Signal Transduction - drug effects | Tumor Necrosis Factor-alpha - physiology | Thrombosis - drug therapy | Receptors, Interleukin-1 - antagonists & inhibitors | Review
Journal Article
The Journal of Immunology, ISSN 0022-1767, 06/2002, Volume 168, Issue 12, pp. 6404 - 6411
Previous studies have shown that IL-10 can induce the expression of the suppressor of cytokine signaling 3 (SOCS-3) mRNA in human monocytes and neutrophils,... 
EXPERIMENTAL ENDOTOXEMIA | TUMOR-NECROSIS-FACTOR | CHRONIC ENTEROCOLITIS | HUMAN NEUTROPHILS | MESSENGER-RNA | INTERFERON-GAMMA | NEGATIVE REGULATION | INTERLEUKIN-10 RECEPTOR | TNF-ALPHA | IMMUNOLOGY | HUMAN MONOCYTES | Sialoglycoproteins - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Repressor Proteins | Tumor Necrosis Factor-alpha - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Nitric Oxide Synthase Type II | RNA, Messenger - biosynthesis | Sialoglycoproteins - biosynthesis | Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis | Interleukin-6 - metabolism | Nitric Oxide - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Interleukin-6 - genetics | Macrophage Activation - immunology | Macrophages, Peritoneal - immunology | Signal Transduction - genetics | Mice, Knockout | Macrophages - metabolism | Up-Regulation - immunology | Lipopolysaccharides - pharmacology | Mice | Transcription Factors | Macrophages, Peritoneal - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Macrophage Activation - genetics | Nitric Oxide Synthase - antagonists & inhibitors | Nitric Oxide Synthase - genetics | MAP Kinase Signaling System - immunology | Interleukin-10 - physiology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Transfection | RNA, Messenger - antagonists & inhibitors | Nitric Oxide Synthase - biosynthesis | Macrophages - immunology | Cell Line | Proteins - physiology | Nitric Oxide - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Up-Regulation - genetics | Proteins - genetics | Suppressor of Cytokine Signaling 3 Protein | Animals | Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Interleukin 1 Receptor Antagonist Protein | Trans-Activators - metabolism | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Receptors, Interleukin-1 - antagonists & inhibitors | Interleukin-10 - pharmacology | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
PloS one, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e80873
Numerous studies have reported that inflammatory cytokines are important mediators for osteoclastogenesis, thereby causing excessive bone resorption and... 
REHMANNIA-GLUTINOSA | ACTIVATION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | RECEPTOR | DIFFERENTIATION | MOLECULAR-BASIS | CELL | MICE LACKING | OSTEOPOROSIS | BONE-RESORPTION | Interleukin-6 - antagonists & inhibitors | RANK Ligand - metabolism | Reactive Oxygen Species - metabolism | NF-kappa B - metabolism | Osteoclasts - cytology | Bone Marrow Cells - drug effects | Female | Cell Differentiation | Interleukin-1beta - biosynthesis | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-1beta - antagonists & inhibitors | Phenols - pharmacology | Proto-Oncogene Proteins c-fos - antagonists & inhibitors | Cell Survival - drug effects | Glucosides - pharmacology | NF-kappa B - antagonists & inhibitors | Ovariectomy | Signal Transduction | Bone Marrow Cells - cytology | NFATC Transcription Factors - metabolism | Gene Expression Regulation | Proto-Oncogene Proteins c-fos - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | Antioxidants - pharmacology | Macrophages - cytology | Osteoclasts - metabolism | Mice, Inbred ICR | Bone Resorption - prevention & control | RANK Ligand - genetics | Macrophages - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Animals | NF-kappa B - genetics | RANK Ligand - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Interleukin-6 - biosynthesis | Macrophages - drug effects | Proto-Oncogene Proteins c-fos - genetics | Mice | NFATC Transcription Factors - antagonists & inhibitors | Tumor Necrosis Factor-alpha - biosynthesis | Bone Marrow Cells - metabolism | Osteoclasts - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | NFATC Transcription Factors - genetics | Osteoprogenitor cells | Transcription factors | Phosphorylation | Interleukin | Arthritis | Activation | Kinases | Macrophages | Interleukin 6 | Antioxidants | Bone resorption | Osteoporosis | Bone growth | Bone marrow | Tumor necrosis factor-TNF | Biocompatibility | Inhibition | Pretreatment | Bone loss | TRANCE protein | c-Fos protein | NF-κB protein | Cytokines | c-Jun protein | Pharmacology | Inflammation | Dentistry | Tumor necrosis factor-α | Orthodontics | Medicine | Osteoclastogenesis | Stem cells | Ligands | Osteoclasts | Laboratory animals | Differentiation
Journal Article
British journal of nutrition, ISSN 0007-1145, 02/2014, Volume 111, Issue 3, pp. 415 - 423
Dietary redox-active/antioxidant phytochemicals may help control or mitigate the inflammatory response in chronic inflammatory bowel disease (IBD). In the... 
Full Papers | Molecular Nutrition | Indicaxanthin | Inflammatory bowel disease | Redox-active phytochemicals | Inflammation | In vitro models | NADPH Oxidases - chemistry | Betaxanthins - isolation & purification | Interleukin-6 - antagonists & inhibitors | Reactive Oxygen Species - metabolism | Enterocytes - metabolism | Antioxidants - metabolism | Humans | Inflammatory Bowel Diseases - immunology | NADPH Oxidases - metabolism | Cell Membrane Permeability | NF-kappa B - metabolism | Inflammatory Bowel Diseases - metabolism | Intestinal Absorption | Interleukin-1beta - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Inflammation Mediators - metabolism | Opuntia - chemistry | Inflammation Mediators - antagonists & inhibitors | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Interleukin-1beta - antagonists & inhibitors | NF-kappa B - agonists | Pyridines - isolation & purification | Pyridines - therapeutic use | Caco-2 Cells | NF-kappa B - antagonists & inhibitors | Fruit - chemistry | Cyclooxygenase 2 - chemistry | NADPH Oxidases - antagonists & inhibitors | Betaxanthins - metabolism | Interleukin-8 - antagonists & inhibitors | Inflammatory Bowel Diseases - diet therapy | Betaxanthins - therapeutic use | NADPH Oxidase 1 | Enterocytes - immunology | Antioxidants - therapeutic use | Reactive Oxygen Species - antagonists & inhibitors | Pyridines - metabolism | Antioxidants - isolation & purification | Cyclooxygenase 2 - metabolism | Enzyme Activation | Nitric Oxide Synthase Type II - metabolism
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 12/2010, Volume 207, Issue 3, pp. 343 - 353
Journal Article