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Journal of clinical immunology, ISSN 1573-2592, 2011, Volume 31, Issue 3, pp. 472 - 478
Leptin, one of the adipokines, functions as a hormone and a cytokine. In this investigation, we show for the first time that leptin, in a... 
Medical Microbiology | Biomedicine | Immunology | Internal Medicine | Infectious Diseases | activation markers | cytokines | B cells | PROTEIN-KINASE | TRANSDUCER | RECEPTOR | PROLIFERATION | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | DEFICIENCY | PI3K/AKT | IMMUNE-RESPONSES | T-CELLS | Autoimmunity | Interleukin-6 - analysis | Janus Kinase 2 - biosynthesis | Mitogen-Activated Protein Kinase 3 - analysis | Humans | p38 Mitogen-Activated Protein Kinases - biosynthesis | p38 Mitogen-Activated Protein Kinases - analysis | Dose-Response Relationship, Drug | Signal Transduction - immunology | Inflammation - metabolism | Mitogen-Activated Protein Kinases - analysis | Mitogen-Activated Protein Kinase 3 - biosynthesis | Mitogen-Activated Protein Kinase 6 - analysis | Leptin - pharmacology | Phosphorylation - drug effects | Interleukin-10 - analysis | B-Lymphocytes - metabolism | Janus Kinase 2 - analysis | Enzyme-Linked Immunosorbent Assay | Lymphocyte Activation | Cells, Cultured | Mitogen-Activated Protein Kinases - biosynthesis | Receptors, Leptin - immunology | STAT3 Transcription Factor - analysis | Inflammation - immunology | Tumor Necrosis Factor-alpha - analysis | STAT3 Transcription Factor - biosynthesis | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Mitogen-Activated Protein Kinase 6 - biosynthesis | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Receptors, Leptin - metabolism | Tumor Necrosis Factor-alpha - biosynthesis
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2004, Volume 172, Issue 1, pp. 567 - 576
The signaling mechanism by which the anti-inflammatory cytokine IL-10 mediates suppression of proinflammatory cytokine synthesis remains largely unknown.... 
RHEUMATOID-ARTHRITIS | TUMOR-NECROSIS-FACTOR | DNA-BINDING | HUMAN NEUTROPHILS | TYROSINE PHOSPHORYLATION | INTERLEUKIN-10 RECEPTOR | GENE-EXPRESSION | KAPPA-B-ALPHA | IMMUNOLOGY | HUMAN MONOCYTES | MONONUCLEAR PHAGOCYTES | Protein Binding - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Immunoglobulins - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Repressor Proteins - antagonists & inhibitors | Antigens, CD - metabolism | Trans-Activators - physiology | Protein Tyrosine Phosphatases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Protein Tyrosine Phosphatases - genetics | Inflammation Mediators - physiology | Glycoproteins - genetics | DNA-Binding Proteins - physiology | Protein Tyrosine Phosphatases - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | DNA - metabolism | Down-Regulation - genetics | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 | Repressor Proteins - biosynthesis | Up-Regulation - immunology | Interleukin-10 - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Adenoviruses, Human - genetics | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Antigens, CD - biosynthesis | Receptors, Cell Surface | Receptors, IgG - biosynthesis | Receptors, IgG - antagonists & inhibitors | Interleukin-10 - physiology | Signal Transduction - immunology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type II | Trans-Activators - genetics | Inflammation Mediators - antagonists & inhibitors | Trans-Activators - biosynthesis | Immunoglobulins - biosynthesis | Macrophages - immunology | Inflammation Mediators - immunology | Receptors, Tumor Necrosis Factor - metabolism | Immune Sera - pharmacology | Proteins - physiology | Cells, Cultured | Glycoproteins - antagonists & inhibitors | Histocompatibility Antigens Class II - biosynthesis | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Up-Regulation - genetics | DNA-Binding Proteins - genetics | DNA - antagonists & inhibitors | Glycoproteins - biosynthesis | Suppressor of Cytokine Signaling 3 Protein | Down-Regulation - immunology | Interleukin-6 - biosynthesis | Receptors, Tumor Necrosis Factor - biosynthesis | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Genetic Vectors | DNA-Binding Proteins - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Nature communications, ISSN 2041-1723, 2011, Volume 2, Issue 1, p. 240
The immune system can both promote and suppress cancer. Chronic inflammation and proinflammatory cytokines such as interleukin (IL)-1 and IL-6 are considered... 
LUNG-CANCER | INTERFERON-INDUCIBLE PROTEIN-10 | NECROSIS IN-VIVO | PROGNOSTIC-FACTORS | INTERLEUKIN-1 RECEPTOR ANTAGONIST | IFN-GAMMA | MULTIDISCIPLINARY SCIENCES | CD4(+) T-CELLS | ADJUVANT THERAPY | CARCINOMA | EXPRESSION | Angiostatic Proteins - immunology | Immunohistochemistry | Neoplasms - metabolism | Interleukin-1alpha - immunology | Chemokine CXCL9 - biosynthesis | Tumor Microenvironment | Multiple Myeloma - immunology | Th2 Cells - immunology | Th1 Cells - immunology | CD4-Positive T-Lymphocytes - immunology | Chemokine CXCL10 - biosynthesis | Inflammation - metabolism | Interleukin-2 - immunology | Chemokine CXCL10 - immunology | Lymphoma, B-Cell - immunology | Interleukin-1beta - biosynthesis | Macrophages - immunology | Interleukin-12 - biosynthesis | Lymphoma, B-Cell - metabolism | Signal Transduction | Angiostatic Proteins - biosynthesis | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Interleukin-1beta - immunology | Chemokine CXCL9 - immunology | Inflammation - immunology | Macrophages - cytology | Mice, SCID | Multiple Myeloma - metabolism | Macrophages - metabolism | Multiple Myeloma - pathology | Animals | Neoplasms - immunology | Interferon-gamma - immunology | Interleukin-12 - immunology | Interleukin-6 - immunology | Lymphoma, B-Cell - pathology | Cell Line, Tumor | Interleukin-6 - biosynthesis | Interleukin-1alpha - biosynthesis | Mice | Interleukin-2 - biosynthesis | Neoplasms - pathology | Interferon-gamma - biosynthesis
Journal Article
Hypertension (Dallas, Tex. 1979), ISSN 0194-911X, 09/2004, Volume 44, Issue 3, pp. 264 - 270
Angiotensin II (Ang II) upregulates vascular endothelial growth factor (VEGF) and activates vascular inflammation. However, the decisive role of VEGF in Ang... 
Growth substances | Endothelial growth factors | Angiotensin II | Remodeling | Arteriosclerosis | MACROPHAGE INFILTRATION | remodeling | NITRIC-OXIDE SYNTHESIS | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | NEOINTIMAL HYPERPLASIA | endothelial growth factors | FACTOR-KAPPA-B | TUMOR ANGIOGENESIS | CHRONIC BLOCKADE | TYPE-1 RECEPTOR | arteriosclerosis | growth substances | angiotensin II | PERIPHERAL VASCULAR DISEASE | GENE-THERAPY | TISSUE ANGIOTENSIN | Genetic Therapy | Tetrazoles - pharmacology | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Male | Gene Expression Profiling | Vasculitis - prevention & control | Vascular Endothelial Growth Factor A - genetics | Angiotensin II Type 1 Receptor Blockers - pharmacology | Transforming Growth Factor beta - biosynthesis | Hypoxia-Inducible Factor 1, alpha Subunit | Interleukin-1 - biosynthesis | Vascular Endothelial Growth Factor Receptor-2 - genetics | Imidazoles - therapeutic use | Receptors, Chemokine - genetics | Vasculitis - chemically induced | Coronary Vessels - pathology | Natriuretic Peptide, Brain - genetics | Transforming Growth Factor beta1 | Hypoxia-Inducible Factor 1 | Interleukin-6 - genetics | Extracellular Matrix Proteins - genetics | Imidazoles - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Aorta - pathology | Macrophages - metabolism | Intercellular Adhesion Molecule-1 - genetics | Chemokine CCL2 - biosynthesis | Nonmuscle Myosin Type IIB | Vascular Cell Adhesion Molecule-1 - biosynthesis | Mice | Vascular Endothelial Growth Factor A - physiology | Hypertrophy | Interleukin-1 - genetics | Tunica Media - pathology | Vascular Endothelial Growth Factor A - biosynthesis | Extracellular Matrix Proteins - biosynthesis | Tunica Media - drug effects | Vasculitis - physiopathology | Recombinant Fusion Proteins - physiology | Ventricular Remodeling | Nuclear Proteins - biosynthesis | Cell Division | Intercellular Adhesion Molecule-1 - biosynthesis | Receptors, Chemokine - biosynthesis | Vascular Cell Adhesion Molecule-1 - genetics | Vascular Endothelial Growth Factor Receptor-2 - biosynthesis | Angiotensin II - toxicity | Nuclear Proteins - genetics | Olmesartan Medoxomil | Hypertrophy, Left Ventricular - etiology | Mice, Inbred C57BL | Extracellular Matrix Proteins - physiology | Natriuretic Peptide, Brain - biosynthesis | Chemokine CCL2 - genetics | Renin-Angiotensin System - physiology | Transcription Factors - biosynthesis | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Animals | Transforming Growth Factor beta - genetics | Interleukin-6 - biosynthesis | Myosin Heavy Chains | Tetrazoles - therapeutic use | DNA-Binding Proteins - biosynthesis | Receptors, CCR2
Journal Article
Journal of neuroimmunology, ISSN 0165-5728, 2008, Volume 194, Issue 1-2, pp. 54 - 61
Abstract Interleukin (IL)-17-producing helper T cells may play a pivotal role in the pathogenesis of multiple sclerosis. Here, we examined the effects of IL-17... 
Neurology | Allergy and Immunology | EAE | Cytokine | IL-17 | Microglia | MS | cytokine | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MULTIPLE-SCLEROSIS LESIONS | MESSENGER-RNA EXPRESSION | NEUROTROPHIC FACTOR | IMMUNOLOGY | NEUROSCIENCES | NERVE GROWTH-FACTOR | INTERLEUKIN-17 | NEURONAL DEATH | NITRIC-OXIDE | TNF-ALPHA | microglia | T-CELLS | Brain-Derived Neurotrophic Factor - genetics | Microglia - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Interleukin-17 - physiology | Receptors, Interleukin-17 - genetics | Interleukin-17 - pharmacology | Interleukin-1beta - genetics | Interleukin-23 - genetics | RNA, Messenger - biosynthesis | Chemokine CXCL2 - genetics | Brain-Derived Neurotrophic Factor - biosynthesis | Interleukin-1beta - biosynthesis | Multiple Sclerosis - metabolism | Autocrine Communication | Nitric Oxide - biosynthesis | Cells, Cultured - drug effects | Interleukin-6 - genetics | Microglia - drug effects | Receptors, Interleukin-17 - biosynthesis | Glial Cell Line-Derived Neurotrophic Factor - biosynthesis | Glial Cell Line-Derived Neurotrophic Factor - genetics | Interleukin-17 - biosynthesis | Recombinant Proteins - pharmacology | Gene Expression Regulation - drug effects | Up-Regulation - drug effects | Animals | Interleukin-23 - biosynthesis | Interleukin-6 - biosynthesis | Cells, Cultured - metabolism | Chemokine CXCL2 - biosynthesis | Mice | Tumor Necrosis Factor-alpha - biosynthesis | Multiple sclerosis | Interleukins | T cells | Nitric oxide
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 04/2011, Volume 300, Issue 4, pp. 1418 - 1426
Post-myocardial infarction (MI), chemokine homing of inflammatory cells into the injured left ventricle (LV) regulates ventricular remodeling, in part by... 
CC chemokines | Inflammation | Matrix metalloproteinases | RECRUITMENT | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | ANGIOGENESIS | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | INCREASES | ISLET XENOGRAFTS | HEART | inflammation | PERIPHERAL VASCULAR DISEASE | MICE | matrix metalloproteinases | EXPRESSION | LEFT-VENTRICULAR FUNCTION | Myocardial Infarction - genetics | Macrophage Activation - genetics | Antigens, CD - biosynthesis | Mannose-Binding Lectins - biosynthesis | Receptors, CCR5 - genetics | Arginase - biosynthesis | Male | Lectins, C-Type - biosynthesis | Gene Deletion | Myocardial Infarction - pathology | Ventricular Remodeling - genetics | Female | Interleukin-1beta - biosynthesis | Receptors, Cell Surface - biosynthesis | Receptors, CCR5 - physiology | Procollagen - biosynthesis | Transforming Growth Factor beta1 - biosynthesis | HSP47 Heat-Shock Proteins - biosynthesis | Antigens, Differentiation, Myelomonocytic - biosynthesis | Macrophages - pathology | Ventricular Remodeling - physiology | Collagen Type I - biosynthesis | Macrophages - metabolism | Animals | Interleukin-6 - biosynthesis | Mice | Tumor Necrosis Factor-alpha - biosynthesis | Gene mutations | Physiological aspects | Genetic aspects | Research | Macrophages | Health aspects | Chemokine receptors | Heart attack | Risk factors | Integrative Cardiovascular Physiology and Pathophysiology
Journal Article
Journal Article
Blood, ISSN 1528-0020, 2005, Volume 106, Issue 7, pp. 2366 - 2374
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2010, Volume 70, Issue 6, pp. 2235 - 2244
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 08/2012, Volume 32, Issue 15, pp. 3121 - 3131
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
RNA-POLYMERASE-II | INDEPENDENT GROWTH | ANDROGEN RECEPTOR EXPRESSION | ACTIVATION | COACTIVATOR | LYSINE METHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROSTATE-CANCER | GENE-EXPRESSION | PROGRESSION | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | Chromatin - metabolism | Neoplasm Transplantation | Prostatic Neoplasms - metabolism | Vascular Endothelial Growth Factor A - biosynthesis | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Histones - biosynthesis | Male | NF-kappa B - metabolism | Transplantation, Heterologous | Vascular Endothelial Growth Factor A - metabolism | Histone-Lysine N-Methyltransferase - biosynthesis | Proto-Oncogene Proteins c-bcl-2 - metabolism | RNA Interference | Inhibitor of Apoptosis Proteins - metabolism | Acetylation | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Repressor Proteins - metabolism | Autocrine Communication | Promoter Regions, Genetic | Prostatic Neoplasms - pathology | Inhibitor of Apoptosis Proteins - biosynthesis | Signal Transduction | Cell Survival | Interleukin-8 - biosynthesis | Survivin | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | p300-CBP Transcription Factors - metabolism | Animals | Repressor Proteins - biosynthesis | Histone-Lysine N-Methyltransferase - metabolism | Cell Line, Tumor | Cyclin D - biosynthesis | Interleukin-6 - biosynthesis | Mice | Mice, Inbred BALB C | RNA, Small Interfering | Histones - metabolism | Cyclin D - metabolism
Journal Article
Molecular neurobiology, ISSN 1559-1182, 2014, Volume 52, Issue 3, pp. 1547 - 1560
In this study, we tried to explore the molecular mechanism that Corilagin protected against herpes simplex virus-1 encephalitis through inhibiting the TLR2... 
Signaling pathways | Neurology | Neurosciences | Biomedicine | Toll-like receptor 2 | Neurobiology | Corilagin | Inflammation | Herpes simplex virus-1 | Cell Biology | ACTIVATION | INNATE IMMUNE-SYSTEM | MICROGLIAL CELLS | NEUROSCIENCES | ETHANOL EXTRACT | RESPONSES | HERPES-SIMPLEX-VIRUS | TOLL-LIKE RECEPTORS | INFECTION | TNF-ALPHA | PATTERN-RECOGNITION RECEPTORS | Microglia - metabolism | RNA, Small Interfering - genetics | TNF Receptor-Associated Factor 6 - biosynthesis | Toll-Like Receptor 2 - antagonists & inhibitors | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - biosynthesis | Receptors, Interleukin-1 - genetics | Tumor Necrosis Factor-alpha - genetics | Male | Brain - metabolism | RNA, Messenger - biosynthesis | Protein Processing, Post-Translational - drug effects | RNA Interference | Nerve Tissue Proteins - biosynthesis | Hydrolyzable Tannins - pharmacology | Encephalitis, Herpes Simplex - prevention & control | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | TNF Receptor-Associated Factor 6 - genetics | Intracellular Signaling Peptides and Proteins - genetics | Lipopeptides - toxicity | Antiviral Agents - pharmacology | Glucosides - pharmacology | Interleukin-6 - genetics | Microglia - drug effects | RNA, Messenger - genetics | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Receptors, Interleukin-1 - biosynthesis | Down-Regulation - drug effects | Intracellular Signaling Peptides and Proteins - biosynthesis | Nerve Tissue Proteins - genetics | Toll-Like Receptor 2 - biosynthesis | Herpesvirus 1, Human | Membrane Glycoproteins - genetics | Animals | NF-kappa B - genetics | Signal Transduction - drug effects | NF-kappa B - biosynthesis | Brain - pathology | Interleukin-6 - biosynthesis | Mice | Mice, Inbred BALB C | Myeloid Differentiation Factor 88 - biosynthesis | Tumor Necrosis Factor-alpha - biosynthesis | RNA | Yuan (China) | Encephalitis | Signaling | Tumor necrosis factor-TNF | Molecular biology | Neurons
Journal Article
Journal Article