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BIOCHEMISTRY, ISSN 0006-2960, 03/2019, Volume 58, Issue 10, pp. 1432 - 1439
Chemokines play important roles in immune defense by directing migration of leukocytes and serve as key promoters of tumorigenesis and metastasis. This study... 
MUTAGENESIS | TERMINUS | DOMAIN | NMR | INTERLEUKIN-8 RECEPTOR | CXCR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | FRAGMENT | SELECTIVITY | IL-8 BINDING
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2018, Volume 61, Issue 6, pp. 2518 - 2532
CXCR2 has emerged as a therapeutic target for not only peripheral inflammatory diseases but also neurological abnormalities in the central nervous system... 
CHEMISTRY, MEDICINAL | INTERLEUKIN-8 RECEPTOR | INFLAMMATORY DISEASES | HEALTHY-SUBJECTS | AIR POUCH MODEL | PHARMACOLOGICAL CHARACTERIZATION | ALZHEIMERS-DISEASE | SMALL-MOLECULE ANTAGONISTS | CHEMOKINE RECEPTORS | PULMONARY-DISEASE | CANCER
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 04/2007, Volume 175, Issue 8, pp. 783 - 790
Journal Article
RSC Advances, ISSN 2046-2069, 2018, Volume 8, Issue 20, pp. 11061 - 11069
CXCR1 and CXCR2 are CXC chemokine receptors (CXCRs), corresponding to cytokines of the CXC chemokine family. CXCR2 was found to be 77% homologous to CXCR1.... 
CELLS | POTENT | ANGIOGENESIS | IMMUNOTHERAPY | PANCREATIC-CANCER | GROWTH | HUMAN INTERLEUKIN-8 RECEPTOR | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Journal of Periodontal Research, ISSN 0022-3484, 08/2008, Volume 43, Issue 4, pp. 400 - 407
Background and Objective:  Periodontitis is a chronic inflammatory disease of bacterial etiology, affecting tooth‐supporting tissues. The host inflammatory... 
cytokine | naringenin | flavanone | Aggregatibacter actinomycetemcomitans | lipopolysaccharide | periodontitis | Lipopolysaccharide | Naringenin | Periodontitis | Flavanone | Cytokine | PERIODONTAL-DISEASES | INFLAMMATORY CYTOKINE PRODUCTION | FLAVONOIDS | ADULT PERIODONTITIS | ACTINOBACILLUS-ACTINOMYCETEMCOMITANS | TISSUE DESTRUCTION | TUMOR-NECROSIS-FACTOR | BONE LOSS | DENTISTRY, ORAL SURGERY & MEDICINE | EXPRESSION | Interleukin-1beta - drug effects | Interleukin-6 - antagonists & inhibitors | Escherichia coli | Humans | Interleukin-8 - drug effects | Periodontitis - blood | Proto-Oncogene Proteins c-jun - antagonists & inhibitors | U937 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Inflammation Mediators - antagonists & inhibitors | Phosphorylation - drug effects | Interleukin-1beta - antagonists & inhibitors | Serine - antagonists & inhibitors | Anti-Inflammatory Agents - pharmacology | Flavanones - pharmacology | Interleukin-8 - antagonists & inhibitors | Macrophages - enzymology | Phosphotransferases - drug effects | Transcription Factor AP-1 - antagonists & inhibitors | Tumor Necrosis Factor-alpha - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Anti-inflammatory drugs | Macrophages | Analysis
Journal Article
The FEBS Journal, ISSN 1742-464X, 07/2017, Volume 284, Issue 14, pp. 2264 - 2283
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 09/2014, Volume 14, Issue 13, pp. 1590 - 1605
Journal Article
RSC Advances, 01/2018, Volume 8, Issue 20, pp. 11061 - 11069
CXCR1 and CXCR2 are CXC chemokine receptors (CXCRs), corresponding to cytokines of the CXC chemokine family. CXCR2 was found to be 77% homologous to CXCR1.... 
Cytokines | Heptanes | Liver | Rats | Homology | Pharmacology | Metastasis | Chemokine receptors | Molecular docking | Anticancer properties | Blood plasma | Receptors | In vivo methods and tests | Chemokines | Cancer
Journal Article
British Journal of Nutrition, ISSN 0007-1145, 02/2014, Volume 111, Issue 3, pp. 415 - 423
Dietary redox-active/antioxidant phytochemicals may help control or mitigate the inflammatory response in chronic inflammatory bowel disease (IBD). In the... 
Indicaxanthin | Inflammatory bowel disease | Redox-active phytochemicals | Inflammation | In vitro models | NADPH Oxidases - chemistry | Betaxanthins - isolation & purification | Interleukin-6 - antagonists & inhibitors | Reactive Oxygen Species - metabolism | Enterocytes - metabolism | Antioxidants - metabolism | Humans | Inflammatory Bowel Diseases - immunology | NADPH Oxidases - metabolism | Cell Membrane Permeability | NF-kappa B - metabolism | Inflammatory Bowel Diseases - metabolism | Intestinal Absorption | Interleukin-1beta - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Inflammation Mediators - metabolism | Opuntia - chemistry | Inflammation Mediators - antagonists & inhibitors | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Interleukin-1beta - antagonists & inhibitors | NF-kappa B - agonists | Pyridines - isolation & purification | Pyridines - therapeutic use | Caco-2 Cells | NF-kappa B - antagonists & inhibitors | Fruit - chemistry | Cyclooxygenase 2 - chemistry | NADPH Oxidases - antagonists & inhibitors | Betaxanthins - metabolism | Interleukin-8 - antagonists & inhibitors | Inflammatory Bowel Diseases - diet therapy | Betaxanthins - therapeutic use | NADPH Oxidase 1 | Enterocytes - immunology | Antioxidants - therapeutic use | Reactive Oxygen Species - antagonists & inhibitors | Pyridines - metabolism | Antioxidants - isolation & purification | Cyclooxygenase 2 - metabolism | Enzyme Activation | Nitric Oxide Synthase Type II - metabolism
Journal Article
Molecular Vision, ISSN 1090-0535, 07/2018, Volume 24, pp. 459 - 470
Purpose: Preservative-free cationic emulsion-based artificial tears (ATs) or drug vehicles are innovative eye drop formulations with tear film stabilization... 
ARTIFICIAL TEARS | PROTEIN-KINASE-C | IN-VITRO | SEVERE DRY EYE | CYCLOSPORINE-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | CORNEAL EPITHELIAL-CELLS | OPHTHALMOLOGY | CYTOKINE RELEASE | NF-KAPPA-B | RECEPTOR 4 | Interleukin-8 - genetics | Emulsions | Interleukin-6 - antagonists & inhibitors | Thrombospondin 1 - antagonists & inhibitors | Chemokine CCL2 - immunology | Epithelial Cells - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Cornea - immunology | Interleukin-17 - immunology | Lipopolysaccharides - antagonists & inhibitors | CD4-Positive T-Lymphocytes - immunology | Fatty Alcohols - pharmacology | Cornea - drug effects | Leukocytes, Mononuclear - immunology | Thrombospondin 1 - genetics | Interferon-gamma - antagonists & inhibitors | Tumor Necrosis Factor-alpha - immunology | Cornea - cytology | Interferon-gamma - genetics | Epithelial Cells - cytology | Lubricant Eye Drops - pharmacology | Cell Line | Leukocytes, Mononuclear - drug effects | Interleukin-6 - genetics | Signal Transduction | Anti-Inflammatory Agents - pharmacology | CD4-Positive T-Lymphocytes - cytology | Chemokine CXCL9 - antagonists & inhibitors | Interleukin-17 - genetics | Chemokine CCL2 - genetics | Thrombospondin 1 - immunology | Chemokine CXCL9 - immunology | Interleukin-8 - antagonists & inhibitors | Chemokine CXCL9 - genetics | Gene Expression Regulation - drug effects | Interleukin-17 - antagonists & inhibitors | Epithelial Cells - immunology | Interferon-gamma - immunology | Interleukin-6 - immunology | Lipopolysaccharides - pharmacology | Leukocytes, Mononuclear - cytology | Chemokine CCL2 - antagonists & inhibitors | Interleukin-8 - immunology | CD4-Positive T-Lymphocytes - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Quaternary Ammonium Compounds - pharmacology
Journal Article
Journal Article
Journal Article
Life Sciences, ISSN 0024-3205, 07/2017, Volume 180, pp. 137 - 142
The P2Y nucleotide receptor is widely involved in inflammatory responses, and is a promising molecular target for the treatment of inflammatory diseases.... 
High-throughput screening | Interleukin-8 | P2Y6 receptor antagonist | receptor antagonist | P2Y | Index Medicus
Journal Article
LIFE SCIENCES, ISSN 0024-3205, 07/2017, Volume 180, pp. 137 - 142
Aims: The P2Y(6) nucleotide receptor is widely involved in inflammatory responses, and is a promising molecular target for the treatment of inflammatory... 
UDP | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | CLONING | High-throughput screening | PHARMACOLOGY & PHARMACY | P2Y receptor antagonist | Interleukin-8 | CONTRIBUTES | EXPRESSION
Journal Article