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1. Full Text Nanotoxicity of poly(n-butylcyano-acrylate) nanoparticles at the blood–brain barrier, in human whole blood and in vivo
by Kolter, Marise and Ott, Melanie and Hauer, Christian and Reimold, Isolde and Fricker, Gert
Journal of Controlled Release, ISSN 0168-3659, 01/2015, Volume 197, pp. 165 - 179
Therapy of diseases of the central nervous system is a major challenge since drugs have to overcome the blood–brain barrier (BBB). A powerful strategy to... 
PBCA | Nanoparticle | Toxicity | Cytokine | Blood–brain barrier | Human blood | Blood-brain barrier | FOCUSED ULTRASOUND | RAT | PERMEABILITY | DRUG-DELIVERY | CHEMISTRY, MULTIDISCIPLINARY | INTERLEUKIN-8 | TUMOR-NECROSIS-FACTOR | POLYMERIC NANOPARTICLES | PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | CAPILLARY ENDOTHELIAL-CELLS | POLYSORBATE-80 | L-Lactate Dehydrogenase - metabolism | Cell Survival - drug effects | Brain - cytology | Enbucrilate - pharmacology | Nanoparticles - chemistry | Polysorbates - chemistry | Rats, Wistar | Endothelial Cells - metabolism | Humans | Cells, Cultured | Enbucrilate - toxicity | Male | Blood-Brain Barrier - drug effects | Enbucrilate - chemistry | Nanoparticles - toxicity | Blood-Brain Barrier - metabolism | Oxazines - metabolism | Animals | Adsorption | Xanthenes - metabolism | Swine | Cytokines - blood | Endothelial Cells - drug effects | Nanoparticles | Surface active agents | Analysis | Drugs | Drug delivery systems | Interleukins | Cell death | Vehicles | Index Medicus
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2. Full Text Humoral dysregulation associated with increased systemic inflammation among injection heroin users
by Piepenbrink, Michael S and Samuel, Memorie and Zheng, Bo and Carter, Brittany and Fucile, Christopher and Bunce, Catherine and Kiebala, Michelle and Khan, Atif A and Thakar, Juilee and Maggirwar, Sanjay B and Morse, Diane and Rosenberg, Alexander F and Haughey, Norman J and Valenti, William and Keefer, Michael C and Kobie, James J
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, pp. e0158641 - e0158641
Background Injection drug use is a growing major public health concern. Injection drug users (IDUs) have a higher incidence of co-morbidities including HIV,... 
RHEUMATOID-ARTHRITIS | DRUG-USERS | HIGH-RISK | EFFICACY TRIAL | MULTIDISCIPLINARY SCIENCES | VACCINE | IMMUNE ACTIVATION | BLOOD B-CELLS | OPIOID RECEPTORS | MICROBIAL TRANSLOCATION | HIV-1 INFECTION | HIV Antibodies - blood | Immunoglobulin G - blood | Immunity, Humoral - immunology | CD40 Ligand - blood | HIV Infections - epidemiology | Humans | Tumor Necrosis Factor-alpha - blood | Male | Immunoglobulin M - immunology | Substance Abuse, Intravenous - immunology | CD40 Ligand - immunology | Inflammation - blood | Young Adult | HIV Infections - immunology | Hepatitis C - immunology | HIV Antibodies - immunology | Immunoglobulin G - immunology | Transforming Growth Factor alpha - blood | Hepatitis C - blood | Hepatitis C - epidemiology | Tumor Necrosis Factor-alpha - immunology | Adult | Female | Heroin - administration & dosage | Interleukin-8 - blood | Substance Abuse, Intravenous - blood | HIV Infections - blood | Cross-Sectional Studies | Comorbidity | Narcotics - immunology | Substance Abuse, Intravenous - epidemiology | Inflammation - immunology | Inflammation - epidemiology | Heroin - immunology | Transforming Growth Factor alpha - immunology | Narcotics - administration & dosage | B-Lymphocytes - immunology | Immunoglobulin M - blood | Interleukin-8 - immunology | New York - epidemiology | Inflammation | Immune response | Health aspects | Analysis | Heroin habit | Health care | Immunoglobulin M | Drug abuse | Flow cytometry | Immunoglobulin G | Vaccination | Homeostasis | Infections | Vaccines | Multivariate analysis | Immunity | Hepatitis | Cell activation | Immunology | Metabolites | Human immunodeficiency virus--HIV | Peripheral blood | Ceramide | Aging | Immunity (humoral) | Interleukin 8 | Drug use | Public health | Heroin | Cytokines | Narcotics | Rheumatology | Injection | Tumor necrosis factor-α | Gene expression | Immune response (humoral) | Medicine | Learning algorithms | Cytometry | Infectious diseases | Lymphocytes B | Machine learning | Cocaine | Hepatitis C virus | Hepatitis C | Viral infections | Index Medicus | HIV | Human immunodeficiency virus
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3. Full Text A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors
by Torti, Davide and Sassi, Francesco and Galimi, Francesco and Gastaldi, Stefania and Perera, Timothy and Comoglio, Paolo M and Trusolino, Livio and Bertotti, Andrea
International Journal of Cancer, ISSN 0020-7136, 03/2012, Volume 130, Issue 6, pp. 1357 - 1366
The MET oncogene is amplified in a fraction of human gastric carcinoma cell lines, with consequent overexpression and constitutive activation of the... 
oncogene addiction | surrogate biomarkers | targeted therapies | Met receptor | CARCINOMA CELLS | NECROSIS-FACTOR-ALPHA | PLASMINOGEN-ACTIVATOR RECEPTOR | INTERLEUKIN-8 | IN-VITRO | ONCOLOGY | AUTOCRINE GROWTH-FACTOR | C-MET | PROSTATE-CANCER | UROKINASE RECEPTOR | CELL-LINE | Mannose-Binding Lectins - metabolism | Proto-Oncogene Proteins c-met - metabolism | Interleukin-8 - genetics | Membrane Glycoproteins - metabolism | Humans | Stomach Neoplasms - metabolism | Chemokine CXCL1 - genetics | Gene Expression Profiling | Sulfones - pharmacology | Interleukin-6 - blood | Biomarkers, Tumor - metabolism | Female | Indoles - pharmacology | Interleukin-8 - metabolism | Chemokine CXCL1 - metabolism | Interleukin-8 - blood | Interleukin-6 - metabolism | Stomach Neoplasms - genetics | Interleukin-6 - genetics | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Membrane Glycoproteins - blood | Receptors, Cell Surface - metabolism | Receptors, Cell Surface - blood | Chemokine CXCL1 - blood | Stomach Neoplasms - drug therapy | Membrane Glycoproteins - genetics | Proto-Oncogene Proteins c-met - genetics | Biomarkers, Tumor - blood | Xenograft Model Antitumor Assays | Animals | Mannose-Binding Lectins - genetics | Mannose-Binding Lectins - blood | Stomach Neoplasms - blood | Mice, Nude | Proteomics | Cell Line, Tumor | Biomarkers, Tumor - genetics | Mice | Receptors, Cell Surface - genetics | Biomarkers | Kinases | Gene expression | Tumors | Index Medicus
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4. Full Text Suppressive effect of insulin infusion on chemokines and chemokine receptors
by Ghanim, Husam and Korzeniewski, Kelly and Sia, Chang Ling and Abuaysheh, Sanaa and Lohano, Teekam and Chaudhuri, Ajay and Dandona, Paresh
Diabetes Care, ISSN 0149-5992, 05/2010, Volume 33, Issue 5, pp. 1103 - 1108
OBJECTIVE - In view of the previously described anti-inflammatory effects of insulin, we investigated the potential suppressive effect of insulin on plasma... 
MIGRATION | INFLAMMATION | DISEASE | ENDOCRINOLOGY & METABOLISM | MONONUCLEAR-CELLS | ATHEROSCLEROSIS | SUBSETS | DEFICIENT MICE | KAPPA-B | EXPRESSION | ADIPOSE-TISSUE | Receptors, CCR2 - genetics | Interleukin-8 - genetics | Chemokines - blood | Obesity - immunology | Receptors, Chemokine - blood | Humans | Middle Aged | Chemokine CCL4 - genetics | Receptors, CCR5 - genetics | Insulin - blood | Obesity - blood | Inflammation - blood | Chemokine CCL5 - blood | Hypoglycemic Agents - blood | Chemokine CXCL12 - genetics | Chemokine CX3CL1 - blood | Hypoglycemic Agents - administration & dosage | Inflammation - drug therapy | Diabetes Mellitus, Type 2 - immunology | Gene Expression - immunology | Adult | Receptors, CXCR4 - genetics | Chemokine CCL4 - blood | Interleukin-8 - blood | Receptors, Chemokine - genetics | Immunosuppressive Agents - administration & dosage | Receptors, CCR5 - blood | Chemokine CCL11 - genetics | Chemokine CX3CL1 - genetics | Insulin - administration & dosage | Inflammation - immunology | Chemokines - genetics | Diabetes Mellitus, Type 2 - blood | Chemokine CCL5 - genetics | Chemokine CXCL12 - blood | Receptors, CCR2 - blood | Infusions, Intravenous | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | CX3C Chemokine Receptor 1 | Chemokine CCL11 - blood | Receptors, CXCR4 - blood | Physiological aspects | Dosage and administration | Insulin | Chemokine receptors | Chemokines | Methods | Diabetes therapy | Plasma | Pathogenesis | Rodents | Mortality | Atherosclerosis | Cardiovascular disease | Insulin resistance | Bone density | Diabetes | Blood | Index Medicus | Original Research
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5. Full Text Adipokines and cytokines in non-alcoholic fatty liver disease
by Jarrar, M.H and Baranova, A and Collantes, R and Ranard, B and Stepanova, M and Bennett, C and Fang, Y and Elariny, H and Goodman, Z and Chandhoke, V and Younossi, Z.M
Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, 03/2008, Volume 27, Issue 5, pp. 412 - 421
Background Several adipocytokines have been implicated in the pathogenesis nonalcoholic fatty liver disease (NAFLD). Aim To assess adipocytokines in NAFLD... 
FIBROSIS | POPULATION | OBESE-PATIENTS | ADIPONECTIN | INSULIN-RESISTANCE | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | STEATOHEPATITIS | MICE | TNF-ALPHA | INTERLEUKIN-6 | GASTROENTEROLOGY & HEPATOLOGY | Multivariate Analysis | Humans | Middle Aged | Tumor Necrosis Factor-alpha - blood | Fatty Liver - complications | Male | Insulin - blood | Case-Control Studies | Immunoenzyme Techniques | Adipokines - blood | Interleukin-6 - blood | Adult | Female | Liver - surgery | Interleukin-8 - blood | Nicotinamide Phosphoribosyltransferase - blood | Cytokines - blood | Fasting | Blood Glucose - analysis | Fatty Liver - blood | Obesity - complications | Insulin Resistance | Linear Models | Liver Cirrhosis - blood | Fatty Liver - surgery | Adiponectin - blood | Biopsy | Liver Cirrhosis - pathology | Resistin - blood | Aged | Cohort Studies | Fatty Liver - etiology | Tumor necrosis factor | Analysis | Fatty liver | Index Medicus
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6. Full Text Peripheral blood proteins predict mortality in idiopathic pulmonary fibrosis
by Richards, Thomas J and Kaminski, Naftali and Baribaud, Fred and Flavin, Susan and Brodmerkel, Carrie and Horowitz, Daniel and Li, Katherine and Choi, Jiin and Vuga, Louis J and Lindell, Kathleen O and Klesen, Melinda and Zhang, Yingze and Gibson, Kevin F
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 01/2012, Volume 185, Issue 1, pp. 67 - 76
Rationale: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology with a variable and unpredictable course. Objectives: The aim of... 
Biomarkers | Adhesion molecules | MMP-7 | Personalized medicine | Mortality prediction | ACTIVATION | INTERCELLULAR-ADHESION MOLECULE-1 | ICAM-1 EXPRESSION | biomarkers | N-ACETYLCYSTEINE | SERUM | CLINICAL-COURSE | personalized medicine | EPITHELIAL-CELLS | GENE | adhesion molecules | RESPIRATORY SYSTEM | MATRILYSIN | mortality prediction | MICE | CRITICAL CARE MEDICINE | Cell Adhesion Molecules - blood | Enzyme-Linked Immunosorbent Assay - methods | Predictive Value of Tests | Matrix Metalloproteinase 7 - blood | Humans | Proportional Hazards Models | Male | Biomarkers - blood | Idiopathic Pulmonary Fibrosis - blood | S100A12 Protein | Vascular Cell Adhesion Molecule-1 - blood | Matrix Metalloproteinase 1 - blood | Idiopathic Pulmonary Fibrosis - mortality | S100 Proteins - blood | Survival Analysis | Female | Intercellular Adhesion Molecule-1 - blood | Aged | Interleukin-8 - blood | Matrix Metalloproteinases - blood | Cohort Studies | Index Medicus | Abridged Index Medicus
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7. Full Text Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype
by Agusti, A and Edwards, L.D and Rennard, S.I and MacNee, W and Tal Singer, R and Miller, B.E and Vestbo, J and Lomas, D.A and Calverley, P.M and Wouters, E.F.M and Crim, C and Yates, J.C and Silverman, E.K and Coxson, H.O and Bakke, P and Mayer, R.J and Celli, B and ECLIPSE Investigators, the and Evaluation COPD Longitudinally Ide and Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators and for the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators
PLoS One, ISSN 1932-6203, 01/2012, Volume 7, Issue 5, pp. e37483 - e37483
Background: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to... 
GLOBAL BURDEN | BIOMARKERS | OBSTRUCTIVE PULMONARY-DISEASE | ECLIPSE | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | MARKERS | COHORT | FUTURE | PREVALENCE | POINTS | Spirometry | Cross-Sectional Studies | Humans | Tumor Necrosis Factor-alpha - blood | Biomarkers - blood | Pulmonary Disease, Chronic Obstructive - complications | Pulmonary Disease, Chronic Obstructive - pathology | Phenotype | Interleukin-6 - blood | Fibrinogen - analysis | Surveys and Questionnaires | Leukocyte Count | Systemic Inflammatory Response Syndrome - complications | C-Reactive Protein - analysis | Interleukin-8 - blood | Cohort Studies | Smoking | Medical research | Fibrin | Lung diseases, Obstructive | Smokers | Tumor necrosis factor | Patient outcomes | Mortality | Fibrinogen | Medicine, Experimental | Genetic aspects | Inflammation | Blood cell count | Pathogenesis | Erythrocytes | Inflammatory response | Cardiovascular disease | Sleep apnea | Leukocytes | Blood | Clinical outcomes | Interleukin 6 | Proteins | Genotype & phenotype | Peripheral blood | Chronic obstructive pulmonary disease | Bioindicators | Interleukin 8 | Abnormalities | Blood cells | Lung diseases | Thorax | Tumor necrosis factor-α | Patients | White blood cells | Hospitals | Obstructive lung disease | Biomarkers | Index Medicus
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8. Full Text Red blood cell alloimmunization in sickle cell disease: prevalence in 2010
by Miller, Scott T and Kim, Hae‐Young and Weiner, Debra L and Wager, Carrie G and Gallagher, Dianne and Styles, Lori A and Dampier, Carlton D and Roseff, Susan D and Investigators Sickle Cell Dis Clin and Investigators of the Sickle Cell Disease Clinical Research Network (SCDCRN)
Transfusion, ISSN 0041-1132, 04/2013, Volume 53, Issue 4, pp. 704 - 709
BACKGROUND: Transfusion of red blood cells (RBCs) is frequently required for care of individuals with sickle cell disease (SCD). Alloimmunization rates are... 
TRANSFUSION MANAGEMENT | STROKE-PREVENTION TRIAL | RISK-FACTORS | ACUTE CHEST SYNDROME | ANEMIA | HEMATOLOGY | EXPRESSION | INTERLEUKIN-8 | CHILDREN | United States - epidemiology | Acute Chest Syndrome - etiology | Erythrocyte Transfusion - adverse effects | Prevalence | Blood Grouping and Crossmatching - methods | Humans | Middle Aged | Child, Preschool | Male | Blood Group Incompatibility - blood | Erythrocyte Transfusion - methods | Feasibility Studies | Patient Selection | Isoantibodies - blood | Young Adult | Early Termination of Clinical Trials | Blood Group Antigens - immunology | Blood Group Incompatibility - prevention & control | Adult | Female | Anemia, Sickle Cell - immunology | Acute Chest Syndrome - prevention & control | Child | Blood Group Incompatibility - etiology | Erythrocyte Transfusion - statistics & numerical data | Anemia, Sickle Cell - complications | Biomarkers - blood | Anemia, Sickle Cell - therapy | Blood Grouping and Crossmatching - statistics & numerical data | Adolescent | Aged | Anemia, Sickle Cell - blood | Health Care Surveys | Blood Group Incompatibility - epidemiology | Sickle cell anemia | Universities and colleges | Blood transfusion | Prevalence studies (Epidemiology) | Sickle cell disease | Blood | Feasibility studies | Index Medicus | Duffy blood group | PROACTIVE | Transfusion | Cooperative Study of Sickle Cell Disease
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9. Full Text Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy
by Sun, Guilian and Ota, Chiharu and Kitaoka, Setsuko and Chiba, Yoko and Takayanagi, Masaru and Kitamura, Taro and Yamamoto, Katsuya and Fujie, Hiromi and Mikami, Hitoshi and Uematsu, Mitsugu and Hino-Fukuyo, Naomi and Munakata, Mitsutoshi and Kure, Shigeo and Haginoya, Kazuhiro
Journal of the Neurological Sciences, ISSN 0022-510X, 2015, Volume 349, Issue 1, pp. 190 - 195
Abstract We examined serum levels of various cytokines, chemokines, growth factors, and adhesion molecules in patients with uncomplicated influenza (n = 20)... 
Neurology | Neutrophil elastase | Adhesion molecule | Soluble E-selectin | Influenza | Encephalopathy | Cytokine | E-selectin | Soluble | CYTOKINES | ACUTE LUNG INJURY | PREDICTIVE-VALUE | CEREBROSPINAL-FLUID | NEUROSCIENCES | CLINICAL NEUROLOGY | RESPIRATORY-DISTRESS-SYNDROME | CHILDREN | GENE | INHIBITOR SIVELESTAT | SYNDROME ARDS | Humans | Tumor Necrosis Factor-alpha - blood | Granulocyte Colony-Stimulating Factor - blood | Leukocyte Elastase - blood | Child, Preschool | E-Selectin - blood | Interleukin-10 - blood | Infant | Male | Interleukin-1beta - blood | Interleukin-6 - blood | Female | Influenza, Human - virology | Encephalitis, Viral - metabolism | Interleukin-7 - blood | Interleukin-8 - blood | Child | Granulocyte-Macrophage Colony-Stimulating Factor - blood | Interleukin-13 - blood | Cytokines - blood | Tissue Inhibitor of Metalloproteinase-1 - blood | Influenza, Human - metabolism | Influenza, Human - blood | Interleukin-5 - blood | Encephalitis, Viral - blood | Encephalitis, Viral - immunology | Influenza, Human - immunology | Interleukin-2 - blood | Influenza viruses | Care and treatment | Index Medicus
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10. Full Text Systemic inflammation associated with mechanical ventilation among extremely preterm infants
by Bose, Carl L and Laughon, Matthew M and Allred, Elizabeth N and Michael O’Shea, T and Van Marter, Linda J and Ehrenkranz, Richard A and Fichorova, Raina N and Leviton, Alan and ELGAN Study Investigators
Cytokine, ISSN 1043-4666, 01/2013, Volume 61, Issue 1, pp. 315 - 322
► In adults and term infants, ventilation can lead to systemic inflammation. ► Systemic inflammation is associated with short-term ventilation in preterm... 
Chemokine | Ventilation | Inflammation | Preterm infant | Cytokine | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | BIRTH-WEIGHT | DEVELOPMENTAL DELAY | IMMUNOLOGY | RESPIRATORY-DISTRESS-SYNDROME | CHRONIC LUNG-DISEASE | CELL BIOLOGY | BRONCHOPULMONARY DYSPLASIA | GESTATION | BORN | T-CELLS | AGE | Chemokines - blood | Chorioamnionitis - blood | Infant, Premature, Diseases | Systemic Inflammatory Response Syndrome | Humans | Tumor Necrosis Factor-alpha - blood | Vascular Endothelial Growth Factor A - blood | Male | Chemokine CCL2 - blood | Inflammation - blood | Interleukin-1beta - blood | Chemokine CCL5 - blood | Pregnancy | Respiration, Artificial - adverse effects | Infant, Premature | Female | Infant, Extremely Premature | Intercellular Adhesion Molecule-1 - blood | Chemokine CCL4 - blood | Interleukin-8 - blood | Infant, Newborn | Cytokines - blood | Matrix Metalloproteinase 9 - blood | Infants (Premature) | Corticoids | Neonates | Chorioamnionitis | Cytokines | RANTES | Infants | Gestation | Matrix metalloproteinase | intercellular adhesion molecule 1 | Bacteremia | Blood | Gelatinase B | Models | Growth factors | Vascular endothelial growth factor | Chemokines | Injuries | Interleukin 8 | Interstitial collagenase | Monocyte chemoattractant protein 1 | Index Medicus | cytokine | chemokine | preterm infant | inflammation | ventilation
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11. Full Text Serum levels of vascular dysfunction markers reflect disease severity and stage in systemic sclerosis patients
by Cossu, Marta and Anacco, Romina and Santaniello, Alessano and Marchini, Maurizio and Severino, Aiana and Caronni, Monica and Radstake, Timothy and Beretta, Lorenzo
Rheumatology (Oxford, England), ISSN 1462-0324, 06/2016, Volume 55, Issue 6, pp. 1112 - 1116
Objective. To improve knowledge of vasculopathy in SSc through the assessment of serum levels of circulating angiogenetic and endothelial dysfunction markers... 
Angiogenesis | Adhesion molecules | Systemic sclerosis | Early disease | LUNG | systemic sclerosis | adhesion molecules | angiogenesis | RHEUMATOLOGY | early disease | CLASSIFICATION CRITERIA | CXCL16 | Cell Adhesion Molecules - blood | Severity of Illness Index | Scleroderma, Systemic - blood | Chemokine CXCL16 | Chemokines, CXC - blood | Humans | Middle Aged | Endothelium, Vascular - physiopathology | Inflammation Mediators - blood | Vascular Endothelial Growth Factor A - blood | E-Selectin - blood | Male | Receptors, Scavenger - blood | Biomarkers - blood | Angiogenesis Inhibitors - blood | Case-Control Studies | Amine Oxidase (Copper-Containing) - blood | Scleroderma, Systemic - physiopathology | Adult | Female | Intercellular Adhesion Molecule-1 - blood | Aged | Interleukin-8 - blood | Angiopoietin-2 - blood | Index Medicus | Abridged Index Medicus
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