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PLoS pathogens, ISSN 1553-7374, 11/2013, Volume 9, Issue 11, pp. e1003773 - e1003773
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to... 
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Index Medicus | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Journal Article
Inflammation research, ISSN 1023-3830, 02/2018, Volume 67, Issue 2, pp. 169 - 177
OBJECTIVE: To investigate the ex vivo pro-inflammatory properties of classical and non-classical monocytes as well as myeloid dendritic cells (mDCs) in... 
Dendrites/metabolism | Humans | Middle Aged | Male | Journal Article | Interleukin-8/metabolism | Immunology | Adult | Female | Classical monocytes | Interferons/metabolism | Pulmonary Fibrosis/metabolism | Myeloid dendritic cells | Inflammation | Sialic Acid Binding Ig-like Lectin 1/metabolism | Pharmacology | Non-classical monocytes | Scleroderma, Systemic/metabolism | Chemokine CCL4/metabolism | Systemic sclerosis | Toll-Like Receptor 4/metabolism | Aged | Myeloid Cells/metabolism | Chemokines | Cytokines/biosynthesis | Chemokine CXCL10/metabolism | Monocytes/metabolism | Dermatology | Rheumatology | Allergology | Neurology | Biomedicine | Pharmacology/Toxicology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Dendrites - metabolism | Scleroderma, Systemic - metabolism | Monocytes - metabolism | Toll-Like Receptor 4 - metabolism | Sialic Acid Binding Ig-like Lectin 1 - metabolism | Interferons - metabolism | Myeloid Cells - metabolism | Chemokine CCL4 - metabolism | Pulmonary Fibrosis - metabolism | Interleukin-8 - metabolism | Chemokine CXCL10 - metabolism | Cytokines - biosynthesis | Interferon | Systemic scleroderma | Dendritic cells | Biological response modifiers | Analysis | Scleroderma (Disease) | Cluster analysis | Flow cytometry | Respiratory function | Carbon tetrachloride | Stimulation | Parameter identification | Interleukin 6 | Proteins | Peripheral blood | Toll-like receptors | Immune system | Cytokines | Lung diseases | Clustering | Patients | Cytometry | Monocytes | Production methods | γ-Interferon | CXCL10 protein | Fibrosis | Pulmonary functions | Index Medicus | Original Research Paper
Journal Article
Journal Article
Gut, ISSN 0017-5749, 02/2018, Volume 67, Issue 2, pp. 320 - 332
ObjectiveLimited efficacy of immune checkpoint inhibitors in pancreatic ductal adenocarcinoma (PDAC) has prompted investigation into combination therapy. We... 
INTERLEUKINS | IMMUNOTHERAPY | PANCREATIC CANCER | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Antineoplastic Agents, Immunological - administration & dosage | Interleukin-6 - antagonists & inhibitors | Pancreatic Neoplasms - metabolism | Humans | Actins - metabolism | Carcinoma, Pancreatic Ductal - metabolism | STAT Transcription Factors - metabolism | Janus Kinases - metabolism | L-Selectin - metabolism | Pancreatic Neoplasms - drug therapy | Th1 Cells - metabolism | Pancreatic Stellate Cells - immunology | Hyaluronan Receptors - metabolism | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Carcinoma, Pancreatic Ductal - immunology | Interleukin-6 - metabolism | Disease Models, Animal | Mice, Inbred C57BL | Survival Rate | B7-H1 Antigen - immunology | Disease Progression | Tumor Microenvironment - immunology | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | B7-H1 Antigen - metabolism | Animals | B7-H1 Antigen - antagonists & inhibitors | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Pancreatic Neoplasms - immunology | Interleukin-6 - immunology | Mice | Pancreatic Stellate Cells - metabolism | Adenocarcinoma | Immunohistochemistry | Flow cytometry | Animal models | Transcription | CD8 antigen | Multiple myeloma | Smooth muscle | Lymphocytes T | Kinases | Metastases | Interleukin 6 | Lymphocytes | Actin | CD44 antigen | Immunotherapy | Fibroblasts | BRCA2 protein | Stellate cells | Cytokines | Stroma | CD62L protein | CD4 antigen | Immune checkpoint | Antibiotics | Pancreatic cancer | Medical prognosis | PD-L1 protein | Ligands | Genetic engineering | Apoptosis | Index Medicus | Abridged Index Medicus | PD-L1 | pancreatic cancer | IL-6
Journal Article
Molecular neurobiology, ISSN 1559-1182, 10/2016, Volume 54, Issue 8, pp. 6507 - 6522
Alzheimer’s disease (AD) is associated with reduced insulin level and impairment of insulin receptor (IR) signaling in the brain, which correlates to amyloid... 
Neurology | post synaptic neurotoxicity | Neurosciences | Glial activation | Biomedicine | Neurobiology | Insulin receptor dysfunction | Amyloidogenic protein expression | Intranasal insulin | Cell Biology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Microglia - metabolism | Streptozocin | Memory Disorders - metabolism | Male | NF-kappa B - metabolism | Hippocampus - drug effects | Insulin Receptor Substrate Proteins - metabolism | Cerebral Cortex - metabolism | Inflammation - metabolism | Hypoglycemic Agents - administration & dosage | Inflammation - drug therapy | Amyloid beta-Peptides - metabolism | Cerebral Cortex - drug effects | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Hypoglycemic Agents - therapeutic use | Astrocytes - drug effects | Peptide Fragments - metabolism | Cytokines - metabolism | Microglia - drug effects | Rats | Insulin - administration & dosage | Down-Regulation - drug effects | Glycogen Synthase Kinase 3 - metabolism | Administration, Intranasal | Glycogen Synthase Kinase 3 beta - metabolism | Hippocampus - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Memory Disorders - drug therapy | Spatial Memory - drug effects | Signal Transduction - drug effects | Aspartic Acid Endopeptidases - metabolism | Receptor, Insulin - metabolism | Insulin - therapeutic use | Astrocytes - metabolism | Proteins | Medical research | Memory | Medicine, Experimental | Amyloidosis | Alzheimer's disease | Insulin | Amyloidogenesis | Neuroprotection | Brain | Cerebral cortex | Mental disorders | Impairment | Neuronal-glial interactions | Inflammatory diseases | Neurotoxicity | Cell activation | Rodents | Amyloid | Drug therapy | Translocation | b-Site APP cleaving enzyme 1 | Neurodegenerative diseases | Neurons | Glial fibrillary acidic protein | Caspase | Inflammation | Hypoglycemia | Pathology | Tumor necrosis factor | Interleukin 10 | Cyclooxygenase-2 | b-Site APP cleaving enzyme | Alzheimers disease | Index Medicus
Journal Article
Journal of pineal research, ISSN 0742-3098, 11/2018, Volume 65, Issue 4, pp. e12520 - n/a
Journal Article
Molecular neurobiology, ISSN 1559-1182, 10/2015, Volume 53, Issue 8, pp. 5782 - 5795
Clinical evidences showing zinc (Zn) accumulation in the post-mortem brain of Parkinson’s disease (PD) patients and experimental studies on rodents chronically... 
Neurology | Oxidative stress | Neurosciences | Biomedicine | Neurodegeneration | Neurobiology | Inflammation | Zinc | Cell Biology | Apoptosis | Neurosciences & Neurology | Life Sciences & Biomedicine |