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animals (209) 209
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intermediate-conductance calcium-activated potassium channels - antagonists & inhibitors (156) 156
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intermediate-conductance calcium-activated potassium channels - drug effects (21) 21
potassium channels, calcium-activated - metabolism (21) 21
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PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 8, p. e12304
Gliomas are morbid brain tumors that are extremely resistant to available chemotherapy and radiology treatments. Some studies have suggested that... 
BREAST-CANCER CELLS | BRAIN-TUMOR | INHIBITION | MULTIDISCIPLINARY SCIENCES | CA2+-ACTIVATED K+ CHANNELS | GROWTH | CLOTRIMAZOLE | INTERMEDIATE-CONDUCTANCE | EPIDEMIOLOGY | MODULATION | CYCLE | Potassium - metabolism | RNA, Small Interfering - genetics | Large-Conductance Calcium-Activated Potassium Channels - metabolism | Small-Conductance Calcium-Activated Potassium Channels - genetics | Intermediate-Conductance Calcium-Activated Potassium Channels - genetics | Humans | Large-Conductance Calcium-Activated Potassium Channels - deficiency | Molecular Sequence Data | Electric Conductivity | Large-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism | RNA, Messenger - metabolism | Gene Knockdown Techniques | Glioblastoma - genetics | Intermediate-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Large-Conductance Calcium-Activated Potassium Channels - genetics | Gene Expression Regulation, Neoplastic - drug effects | Potassium Channel Blockers - pharmacology | Amino Acid Sequence | RNA, Messenger - genetics | Down-Regulation - genetics | Glioblastoma - surgery | Glioblastoma - pathology | Intermediate-Conductance Calcium-Activated Potassium Channels - deficiency | Cell Line, Tumor | Cell Proliferation - drug effects | Chemotherapy | Gliomas | Genes | Brain tumors | Genetic engineering | Potassium channels | Cancer | Cell proliferation | Brain | Biotechnology | Neurosciences | Calcium | Brain cancer | Glioblastoma | Smooth muscle | Potassium conductance | Kinases | Cancer therapies | Channels | Potassium channels (calcium-gated) | Proteins | Cell growth | Surgery | Glioma cells | Cell cycle | Physiology | Calcium channels | Channel gating | Tumor cells | Cultures | siRNA | Pharmacology | Glioblastoma multiforme | Resistance | Studies | Polymerase chain reaction | Gene silencing | Inhibitors | Cell lines | Radiology | Conductance | Glioblastoma cells | Potassium | Prostate cancer | Clotrimazole | Tumors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2013, Volume 288, Issue 22, pp. 15843 - 15853
The intermediate conductance calcium-activated potassium channel KCa3.1 contributes to a variety of cell activation processes in pathologies such as... 
CA2 | PHENOTYPIC MODULATION | IKCA1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CA2+-ACTIVATED K+ CHANNELS | GENE-EXPRESSION | GROWTH-FACTOR | DIFFERENTIATION | BLOCKADE | UP-REGULATION | TRANSCRIPTION FACTOR | Phosphorylation - physiology | Cell Proliferation | Intermediate-Conductance Calcium-Activated Potassium Channels - genetics | Muscle, Smooth, Vascular - metabolism | Atherosclerosis - genetics | Calcium Signaling - physiology | Humans | Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism | Membrane Transport Proteins - genetics | Intermediate-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Membrane Transport Proteins - metabolism | Microfilament Proteins - metabolism | Angiogenesis Inducing Agents - pharmacology | Proto-Oncogene Proteins c-sis - pharmacology | Microfilament Proteins - genetics | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Calcium-Binding Proteins - metabolism | Calmodulin-Binding Proteins - genetics | Atherosclerosis - drug therapy | Cells, Cultured | Proto-Oncogene Proteins c-fos - metabolism | Calmodulin-Binding Proteins - metabolism | Muscle, Smooth, Vascular - cytology | Atherosclerosis - metabolism | Cyclic AMP Response Element-Binding Protein - genetics | Cyclic AMP Response Element-Binding Protein - metabolism | Proto-Oncogene Proteins c-fos - genetics | Calcium-Binding Proteins - genetics | Potassium Channels | Vascular Smooth Muscle Cells | Calcium | Vascular Biology | Atherosclerosis | Calcium Signaling | Cell Biology
Journal Article
Cardiovascular Research, ISSN 0008-6363, 09/2012, Volume 95, Issue 4, pp. 419 - 429
Long QT syndrome (LQTS) is an inheritable and life-threatening disease; however, it is often difficult to determine disease characteristics in sporadic cases... 
Long QT syndrome | Cardiomyocytes | Personalized medicine | Drug examination | iPS cells | CARDIAC & CARDIOVASCULAR SYSTEMS | MODELS | DEATH | LONG-QT SYNDROME | REPOLARIZATION RESERVE | I-KS | KCNQ1 Potassium Channel - genetics | Intermediate-Conductance Calcium-Activated Potassium Channels - genetics | Coculture Techniques | Humans | KCNQ1 Potassium Channel - metabolism | Romano-Ward Syndrome - pathology | Male | Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism | Cellular Reprogramming | Teratoma - metabolism | Action Potentials | Embryoid Bodies - metabolism | Transfection | Potassium Channels, Voltage-Gated - metabolism | Time Factors | Gene Expression Regulation, Developmental | HEK293 Cells | Intermediate-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | KCNQ1 Potassium Channel - antagonists & inhibitors | Cell Differentiation | Romano-Ward Syndrome - genetics | Potassium Channel Blockers - pharmacology | Induced Pluripotent Stem Cells - metabolism | Potassium Channels, Voltage-Gated - genetics | Induced Pluripotent Stem Cells - pathology | Genetic Predisposition to Disease | Induced Pluripotent Stem Cells - drug effects | Romano-Ward Syndrome - diagnosis | Induced Pluripotent Stem Cells - transplantation | Embryoid Bodies - pathology | Potassium Channels, Voltage-Gated - antagonists & inhibitors | Myocytes, Cardiac - pathology | Myocytes, Cardiac - transplantation | Patch-Clamp Techniques | Phenotype | Teratoma - pathology | Animals | Myocytes, Cardiac - drug effects | Adolescent | Fluorescent Antibody Technique | Romano-Ward Syndrome - metabolism | Myocytes, Cardiac - metabolism | Mice
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 10/2015, Volume 132, Issue 15, pp. 1377 - 1386
BACKGROUND—Hypokalemia increases the vulnerability to ventricular fibrillation. We hypothesize that the apamin-sensitive small-conductance calcium-activated... 
arrhythmias | death | sudden | ion channels | cardiac | FIBRILLATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCYTES | arrhythmias, cardiac | T-WAVE | FAILING RABBIT VENTRICLES | REPOLARIZATION | death, sudden, cardiac | CHANNEL | RENIN-ANGIOTENSIN SYSTEM | RECTIFIER K+ CURRENT | EARLY AFTERDEPOLARIZATIONS | CANINE HEART | PERIPHERAL VASCULAR DISEASE | Ventricular Fibrillation - prevention & control | Rabbits | Disease Susceptibility | Heart Conduction System - drug effects | Voltage-Sensitive Dye Imaging | Apamin - pharmacology | Ventricular Fibrillation - etiology | Cardiac Pacing, Artificial - adverse effects | Patch-Clamp Techniques | Potassium - physiology | Animals | Myocytes, Cardiac - drug effects | Heart Conduction System - physiopathology | Heart Ventricles - physiopathology | Myocytes, Cardiac - physiology | Intermediate-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Ventricular Fibrillation - physiopathology | Hypokalemia - complications | Intermediate-Conductance Calcium-Activated Potassium Channels - physiology | Hypokalemia - physiopathology | Action Potentials - drug effects | Potassium Channel Blockers - pharmacology | Hypokalemia | Complications and side effects | Risk factors | Ventricular fibrillation | electrophysiology | pacing | reentry | action potentials | tachyarrhythmias
Journal Article
Pharmacological Research, ISSN 1043-6618, 07/2014, Volume 85, pp. 6 - 14
Journal Article
Journal Article
Cardiovascular Research, ISSN 0008-6363, 09/2012, Volume 95, Issue 4, pp. 439 - 447
Microdomain signalling mechanisms underlie key aspects of artery function and the modulation of intracellular calcium, with transient receptor potential (TRP)... 
Smooth muscle | Calcium channel | Potassium channel | Signalling microdomain | Vasodilation | Endothelium | CARDIAC & CARDIOVASCULAR SYSTEMS | ACTIVATED POTASSIUM CHANNELS | RAT MESENTERIC-ARTERY | INOSITOL 1,4,5-TRISPHOSPHATE | CA2 | SHEAR-STRESS | CALCIUM | TRPC3 CHANNELS | MYOENDOTHELIAL GAP-JUNCTIONS | SMOOTH-MUSCLE-CELLS | K+ CHANNELS | Immunohistochemistry | Myography | TRPC Cation Channels - drug effects | Calcium - metabolism | Humans | Endothelium, Vascular - drug effects | Male | Mesenteric Arteries - drug effects | Mice, 129 Strain | Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism | Microscopy, Immunoelectron | Dose-Response Relationship, Drug | Endothelium, Vascular - ultrastructure | Arterial Pressure | Transfection | Mesenteric Arteries - ultrastructure | HEK293 Cells | Intermediate-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Biological Factors - metabolism | TRPC Cation Channels - genetics | Potassium Channel Blockers - pharmacology | Vasodilator Agents - pharmacology | Signal Transduction | Mice, Inbred C57BL | Rats | Mesenteric Arteries - metabolism | Rats, Sprague-Dawley | Blotting, Western | Small-Conductance Calcium-Activated Potassium Channels - metabolism | Mice, Knockout | Small-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Microscopy, Confocal | Patch-Clamp Techniques | Animals | Membrane Potentials | Endothelium, Vascular - metabolism | TRPC Cation Channels - metabolism | Mice | Vasodilation - drug effects | Original
Journal Article
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 11/2011, Volume 45, Issue 5, pp. 962 - 968
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 08/2009, Volume 106, Issue 34, pp. 14518 - 14523
Journal Article