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Molecular pharmaceutics, ISSN 1543-8384, 06/2018, Volume 15, Issue 6, pp. 2069 - 2083
... of chemotherapeutic small molecules, antibodies, and nanoparticles in the tumor interstitial space. This review focuses on the research efforts to deplete extracellular collagen with collagenases to normalize the tumor microenvironment... 
drug diffusion | collagenase | hyaluronidase | drug penetration | extracellular matrix | interstitial fluid pressure | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Index Medicus
Journal Article
The Journal of immunology (1950), ISSN 0022-1767, 08/2017, Volume 199, Issue 3, pp. 982 - 991
In tuberculosis (TB), the innate inflammatory immune response drives tissue destruction, morbidity, and mortality. Monocytes secrete matrix metalloproteinases... 
Up-Regulation | Humans | Mycobacterium tuberculosis - immunology | Extracellular Matrix - metabolism | Matrix Metalloproteinase 7 - immunology | Monocytes - immunology | Integrin alphaVbeta3 - genetics | Matrix Metalloproteinase 7 - metabolism | Matrix Metalloproteinase 10 - metabolism | Monocytes - physiology | Matrix Metalloproteinase 1 - genetics | Integrin alphaVbeta3 - antagonists & inhibitors | Monocytes - microbiology | Collagen Type I - metabolism | Signal Transduction | Extracellular Matrix - drug effects | Gene Expression Regulation | Cell Adhesion | Fibronectins - metabolism | Sputum - chemistry | Matrix Metalloproteinase Inhibitors - pharmacology | Integrin alphaVbeta3 - immunology | Collagenases - metabolism | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 10 - immunology | Cell Movement | Collagen (type I) | Matrix metalloproteinases | Leukocyte migration | Destruction | Matrix metalloproteinase | Tissue inhibitor of metalloproteinase 1 | Fibronectin | Cell adhesion & migration | Recruitment | Cell adhesion | Breakdown | Extracellular matrix | Interstitial collagenase | Immune system | Binding | Immune response | Stromelysin 2 | Inflammation | Collagenase | Gene expression | Cavitation | Adhesion | Morbidity | White blood cells | Signaling | Monocytes | Tuberculosis | Collagen | Sputum | Matrilysin | Index Medicus | Abridged Index Medicus | Infectious Disease and Host Response
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 1, pp. e15956 - e15956
Background: Interstitial flow directly affects cells that reside in tissues and regulates tissue physiology and pathology by modulating important cellular... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Extracellular Fluid - physiology | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Matrix Metalloproteinase 13 - genetics | Rats | Up-Regulation - genetics | Mechanotransduction, Cellular - physiology | Muscle, Smooth, Vascular - cytology | Cell Adhesion | Integrins - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Models, Biological | Collagen | Cytoskeleton - metabolism | Cell Culture Techniques | Cell Movement | Heparan Sulfate Proteoglycans - physiology | Mitogen-Activated Protein Kinase 1 - metabolism | Tissue engineering | Stem cells | Physiological aspects | Sulfates | Cell differentiation | Integrins | Cell proliferation | Transcription factors | Phosphorylation | Motility | Leukocyte migration | Differentiation (biology) | Smooth muscle | Biosynthesis | Shear stresses | Rigidity | Cell surface | Molecular weight | Cell spreading | Cell adhesion & migration | Metastases | Proteins | Morphogenesis | Cell activation | Fibroblasts | Extracellular matrix | Physiology | Trends | Interstitial collagenase | Biomedical engineering | Heparan sulfate | Enzymes | Proteoglycans | Extracellular signal-regulated kinase | c-Jun protein | Collagenase | Collagenase 3 | Flow | Signaling | Three dimensional flow | Heparan sulfate proteoglycans | Cytoskeleton | Focal adhesion kinase | Disruption | Cell migration | Cellular structure | Cancer | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, pp. e42507 - e42507
Remodelling of the extracellular matrix (ECM) and cell surface by matrix metalloproteinases (MMPs) is an important function of monocytes and macrophages.... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Gene Expression Regulation, Enzymologic - drug effects | Matrix Metalloproteinases - genetics | Monocytes - cytology | Humans | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | RNA, Messenger - metabolism | Receptors, IgG - metabolism | Tissue Inhibitor of Metalloproteinases - genetics | Atherosclerosis - enzymology | STAT1 Transcription Factor - metabolism | Janus Kinase 2 - metabolism | Chromones - pharmacology | Janus Kinase 2 - antagonists & inhibitors | Atherosclerosis - pathology | RNA, Messenger - genetics | Morpholines - pharmacology | Thiophenes - pharmacology | Macrophages - cytology | Cell Adhesion - drug effects | Enzyme Activation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Tissue Inhibitor of Metalloproteinases - metabolism | Interleukin-1 - pharmacology | Macrophages - enzymology | Monocytes - drug effects | Up-Regulation - drug effects | Tumor Necrosis Factor-alpha - pharmacology | Phenotype | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mitogen-Activated Protein Kinases - genetics | Matrix Metalloproteinases - metabolism | Macrophage Activation - drug effects | Interferon-gamma - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Heart | Matrix metalloproteinases | Arthritis | Tissue inhibitor of metalloproteinase 3 | mRNA | Matrix metalloproteinase | Kinases | Macrophages | Cell surface | Proteins | Ethics | Signal transduction | Cell activation | Rodents | Atherosclerosis | Interleukin 1 | Janus kinase | Extracellular matrix | Plaques | Interstitial collagenase | Enzymes | Cytokines | Blood & organ donations | Research & development--R&D | Inflammation | Collagenase | Tumor necrosis factor-α | Gene expression | Steady state | Gelatinase A | Signaling | Monocytes | CD16 antigen | Arteriosclerosis | Collagen | Index Medicus | Research & development | R&D
Journal Article
Journal Article