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Aging Cell, ISSN 1474-9718, 08/2015, Volume 14, Issue 4, pp. 644 - 658
Summary The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a... 
dasatinib | plasminogen‐activated inhibitor | dependence receptors | quercetin | ephrins | PI3K delta | p21 | Dasatinib | Dependence receptors | Ephrins | Plasminogen-activated inhibitor | Quercetin | P21 | ENDOTHELIAL DYSFUNCTION | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | EXPRESSION PROFILES | plasminogen-activated inhibitor | CELLULAR SENESCENCE | CANCER-THERAPY | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | LUNG-CANCER | SET ENRICHMENT ANALYSIS | GENE-EXPRESSION | IONIZING-RADIATION | TUMOR-GROWTH | Carotid Arteries - drug effects | Endonucleases - genetics | Plasminogen Activator Inhibitor 2 - genetics | Transcriptome | Gene Expression Profiling | Adipocytes - drug effects | Aging - genetics | Osteoporosis - metabolism | Ephrins - metabolism | Plasminogen Activator Inhibitor 2 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Osteoporosis - genetics | Intervertebral Disc - pathology | Fibroblasts - metabolism | Endothelial Cells - metabolism | Intervertebral Disc - chemistry | Fibroblasts - pathology | Mesenchymal Stem Cells - pathology | Mice, Knockout | Dasatinib - pharmacology | Osteoporosis - pathology | Ephrins - genetics | Fibroblasts - drug effects | Mice | Endothelial Cells - pathology | bcl-X Protein - metabolism | Aging - metabolism | Aging - drug effects | bcl-X Protein - genetics | Cellular Senescence - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Endonucleases - metabolism | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Mesenchymal Stem Cells - drug effects | Mesenchymal Stem Cells - metabolism | Heart - physiopathology | Cellular Senescence - genetics | Osteoporosis - prevention & control | DNA-Binding Proteins - genetics | Adipocytes - pathology | Aging - pathology | Phosphatidylinositol 3-Kinases - genetics | Animals | Quercetin - pharmacology | Adipocytes - metabolism | Heart - drug effects | Carotid Arteries - pathology | Intervertebral Disc - drug effects | Drug Combinations | Endothelial Cells - drug effects | Original
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 10/2014, Volume 34, Issue 4, pp. 1175 - 1189
Journal Article
Apoptosis, ISSN 1360-8185, 7/2013, Volume 18, Issue 7, pp. 777 - 785
Degeneration of intervertebral disc (IVD) is mainly a chronic process of excessive destruction of the extracellular matrix (ECM), and also is thought to be the... 
Biochemistry, general | Biomedicine | Cell death | Intervertebral disc | Cancer Research | Oncology | Degeneration | Cell Biology | Virology | REGIONAL-DISTRIBUTION | FAS LIGAND | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN LUMBAR DISC | MEDIATED APOPTOSIS | END-PLATE | CELL BIOLOGY | IN-VITRO | NOTOCHORDAL CELLS | NUCLEUS PULPOSUS CELLS | GENE-EXPRESSION | RNA, Small Interfering - genetics | Transcription Factor CHOP - genetics | Caspase Inhibitors - pharmacology | Low Back Pain - prevention & control | Humans | Extracellular Matrix - metabolism | Stress, Mechanical | Intervertebral Disc Degeneration - metabolism | Intervertebral Disc Degeneration - therapy | Intervertebral Disc Degeneration - pathology | Extracellular Matrix - genetics | Caspases - metabolism | Apoptosis Regulatory Proteins - genetics | Cell Death - drug effects | Intervertebral Disc - pathology | Intervertebral Disc Degeneration - genetics | Signal Transduction | Caspases - genetics | Extracellular Matrix - drug effects | Gene Expression Regulation | Transcription Factor CHOP - antagonists & inhibitors | Intervertebral Disc - metabolism | Apoptosis Regulatory Proteins - metabolism | Animals | Apoptosis Regulatory Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - agonists | Intervertebral Disc - drug effects | Transcription Factor CHOP - metabolism | Extracellular Matrix - pathology | RNA, Small Interfering - metabolism | Biochemistry | Health aspects | Backache | Analysis
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