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European Spine Journal, ISSN 0940-6719, 2/2008, Volume 17, Issue 2, pp. 289 - 299
Journal Article
Journal Article
Journal Article
Spine, ISSN 0362-2436, 10/2012, Volume 37, Issue 21, pp. 1810 - 1818
Study Design. Animal model of intravertebral disc (IVD) degeneration. Objective. To examine production of inflammatory mediators in IVDs and neuropeptides in... 
TRANSCRIPTION FACTORS | LUMBAR INTERVERTEBRAL DISCS | ROOT GANGLION NEURONS | neuropeptide | chronic discogenic low back pain | MODEL | CLINICAL NEUROLOGY | SENSORY INNERVATION | disc dynamic compression | MATRIX METALLOPROTEINASES | inflammatory mediator | DORSAL PORTION | nerve injury | IN-VIVO | NITRIC-OXIDE | ORTHOPEDICS | PROSTAGLANDIN E | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Neurons - pathology | Humans | Male | Ganglia, Spinal - physiopathology | Intervertebral Disc Degeneration - physiopathology | Intervertebral Disc - innervation | Intervertebral Disc Degeneration - metabolism | Low Back Pain - physiopathology | Low Back Pain - etiology | Interleukin-1beta - metabolism | Inflammation Mediators - metabolism | Neurons, Afferent - pathology | Neurons - metabolism | Calcitonin Gene-Related Peptide - metabolism | Intervertebral Disc - pathology | Chronic Pain - etiology | Interleukin-6 - metabolism | Nerve Fibers - pathology | Nerve Fibers - metabolism | Enzyme-Linked Immunosorbent Assay | GAP-43 Protein - metabolism | Awards and Prizes | Rats | Neuropeptides - metabolism | Intervertebral Disc - metabolism | Nerve Regeneration | Activating Transcription Factor 3 - metabolism | Intervertebral Disc Degeneration - complications | Rats, Sprague-Dawley | Chronic Pain - metabolism | Animals | Ganglia, Spinal - pathology | Chronic Pain - physiopathology | Neurons, Afferent - metabolism | Low Back Pain - metabolism | Ganglia, Spinal - metabolism | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2013, Volume 288, Issue 23, pp. 16761 - 16774
The objective of the study was to investigate how inflammatory cytokines, IL-1 beta, and TNF-alpha control NOTCH signaling activity in nucleus pulposus (NP)... 
MATRIX METALLOPROTEINASES | BACK-PAIN | TUMOR-NECROSIS-FACTOR | KAPPA-B ACTIVATION | BASIC SCIENCE | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEGRADATION | TNF-ALPHA | EXPRESSION | FACTOR-ALPHA | Tumor Necrosis Factor-alpha - metabolism | Transcription Factor HES-1 | Homeodomain Proteins - metabolism | Humans | Middle Aged | Tumor Necrosis Factor-alpha - genetics | Male | Receptor, Notch2 - genetics | Interleukin-1beta - genetics | Promoter Regions, Genetic - genetics | Transcription Factor RelA - genetics | Intervertebral Disc Degeneration - metabolism | MAP Kinase Signaling System | Intervertebral Disc Degeneration - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Interleukin-1beta - metabolism | Cell Cycle Proteins - genetics | Adult | Female | Intervertebral Disc - pathology | Repressor Proteins - metabolism | Intervertebral Disc Degeneration - genetics | Cell Line | Basic Helix-Loop-Helix Transcription Factors - genetics | Cell Cycle Proteins - metabolism | Receptor, Notch2 - metabolism | Rats | Repressor Proteins - genetics | Intervertebral Disc - metabolism | Receptor, Notch1 - metabolism | Homeodomain Proteins - genetics | Animals | Transcription Factor RelA - metabolism | Aged | Receptor, Notch1 - genetics | Index Medicus | Intervertebral Disc | Nucleus Pulposus | Chondrocytes | Cytokine | Glycobiology and Extracellular Matrices | NF-kappa B (NF-KB) | Notch Pathway | Osteoarthritis
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2011, Volume 286, Issue 46, pp. 39738 - 39749
Journal Article
Spine, ISSN 0362-2436, 12/2007, Volume 32, Issue 25, pp. 2812 - 2819
Study Design. An in vivo rat model of disc degeneration with emphasis on characterizing acute and chronic cytokine production. Objective. To compare the... 
Animal model | Degeneration | Inflammation | Cytokines | Intervertebral disc | RHEUMATOID-ARTHRITIS | intervertebral disc | LOW-BACK-PAIN | HUMAN INTERVERTEBRAL DISC | NUCLEUS PULPOSUS TISSUE | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | NECROSIS-FACTOR-ALPHA | degeneration | RAT MODEL | CLINICAL NEUROLOGY | MATRIX METALLOPROTEINASES | inflammation | GENE-EXPRESSION | cytokines | animal model | ORTHOPEDICS | NF-KAPPA-B | Phosphorylation | Intervertebral Disc - physiopathology | Spinal Diseases - metabolism | Discitis - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | Lymphotoxin-alpha - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Wound Healing | Wounds, Stab - complications | Wounds, Stab - metabolism | Wounds, Stab - pathology | Low Back Pain - physiopathology | Spinal Diseases - physiopathology | Low Back Pain - etiology | Time Factors | Wounds, Stab - physiopathology | Interleukin-1beta - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-8 - metabolism | Intervertebral Disc - pathology | Low Back Pain - pathology | Interleukin-6 - metabolism | Intervertebral Disc - enzymology | Disease Models, Animal | Discitis - complications | Acute Disease | Cytokines - metabolism | Spinal Diseases - complications | Awards and Prizes | Rats | Intervertebral Disc - metabolism | Spinal Diseases - pathology | Rats, Sprague-Dawley | Discitis - metabolism | Animals | Discitis - physiopathology | Discitis - etiology | Intervertebral Disc - injuries | Low Back Pain - metabolism | Chronic Disease | Index Medicus
Journal Article