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1. Full Text Propionibacterium acnes biofilm is present in intervertebral discs of patients undergoing microdiscectomy
by Capoor, Manu N and Ruzicka, Filip and Schmitz, Jonathan E and James, Garth A and Machackova, Tana and Jancalek, Radim and Smrcka, Martin and Lipina, Radim and Ahmed, Fahad S and Alamin, Todd F and Anand, Neel and Baird, John C and Bhatia, Nitin and Demir-Deviren, Sibel and Eastlack, Robert K and Fisher, Steve and Garfin, Steven R and Gogia, Jaspaul S and Gokaslan, Ziya L and Kuo, Calvin C and Lee, Yu-Po and Mavrommatis, Konstantinos and Michu, Elleni and Noskova, Hana and Raz, Assaf and Sana, Jiri and Shamie, A. Nick and Stewart, Philip S and Stonemetz, Jerry L and Wang, Jeffrey C and Witham, Timothy F and Coscia, Michael F and Birkenmaier, Christof and Fischetti, Vincent A and Slaby, Ondrej
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 4, pp. e0174518 - e0174518
Background In previous studies, Propionibacterium acnes was cultured from intervertebral disc tissue of similar to 25% of patients undergoing microdiscectomy,... 
DIAGNOSIS | INFECTIONS | PATHOGEN | LOW-BACK-PAIN | SPINE | MULTIDISCIPLINARY SCIENCES | INVOLVEMENT | SCIATICA | ASSOCIATION | SARCOIDOSIS | Intervertebral Disc Degeneration - etiology | Propionibacterium acnes - pathogenicity | Intervertebral Disc - microbiology | Humans | Middle Aged | Propionibacterium acnes - physiology | Biofilms - growth & development | Intervertebral Disc - surgery | Male | Intervertebral Disc Displacement - etiology | Young Adult | Phenotype | Intervertebral Disc Degeneration - microbiology | Intervertebral Disc Displacement - microbiology | Gram-Positive Bacterial Infections - microbiology | Aged, 80 and over | Propionibacterium acnes - isolation & purification | Adult | Female | Aged | Diskectomy | Intervertebral Disc Displacement - surgery | Gram-Positive Bacterial Infections - complications | Complications and side effects | Usage | Discectomy | Acne | Risk factors | Intervertebral disk | Specimen preparation | Parkinson's disease | Pathogenesis | Lung | Chronic infection | Bone surgery | Incidence | Technology | Etiology | Surgery | Bone marrow | Anesthesia | Biocompatibility | Diagnosis | Movement disorders | Antigens | Neurodegenerative diseases | Rheumatic diseases | Wounds | Cultures | Epithelium | Trauma | Studies | Biofilms | Hospitals | Orthopedics | Documents | Disks | Skin | Biotechnology industry | Kidney transplantation | Surgical implants | Microbiology | Laboratories | Oncology | Infections | Neurosurgery | Culture techniques | Joint surgery | Intervertebral discs | Lymph nodes | Engineering | Biomedical materials | Immunology | Clavicle | Shoulder | Bacteria | Bones | Degeneration | Lesions | Elbow | Kidneys | Sarcoidosis | Arthroplasty | Contamination | Medicine | Cancer | Index Medicus
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2. Full Text Obesity as a risk factor for sciatica: A meta-analysis
by Shiri, Rahman and Lallukka, Tea and Karppinen, Jaro and Viikari-Juntura, Eira
American Journal of Epidemiology, ISSN 0002-9262, 04/2014, Volume 179, Issue 8, pp. 929 - 937
The aim of this study was to assess the associations of overweight and obesity with lumbar radicular pain and sciatica using a meta-analysis. We searched the... 
intervertebral disc displacement | sciatica | back pain | hospitalization | overweight | obesity | LOW-BACK-PAIN | FOLLOW-UP | DISORDERS | INTERVERTEBRAL DISC HERNIATION | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | PREDICTORS | DISEASE | BODY-MASS INDEX | YOUNG FINNS | Body Mass Index | Overweight - complications | Obesity - complications | Humans | Risk Factors | Sciatica - etiology | Male | Hospitalization | Intervertebral Disc Displacement - etiology | Models, Statistical | Radiculopathy - etiology | Regression Analysis | Low Back Pain - etiology | Female | Intervertebral Disc Displacement - surgery | Lumbar Vertebrae | Obesity | Back pain | Back surgery | Medical diagnosis | Risk factors | Meta-analysis | Index Medicus
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3. Full Text The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration
by Le Maitre, Christine Lyn and Freemont, Anthony J and Hoyland, Judith Alison
Arthritis research & therapy, ISSN 1478-6354, 2005, Volume 7, Issue 4, pp. R732 - 745
In this study, we investigated the hypotheses that in human intervertebral disc (IVD) degeneration there is local production of the cytokine IL-1, and that... 
MATRIX METALLOPROTEINASES | LOW-BACK-PAIN | MESSENGER-RNA | RABBIT ANNULUS FIBROSUS | NUCLEUS-PULPOSUS | PROTEOGLYCAN METABOLISM | GENE-EXPRESSION | ARTICULAR CHONDROCYTES | NECROSIS-FACTOR-ALPHA | EXTRACELLULAR-MATRIX | RHEUMATOLOGY | Lumbar Vertebrae - metabolism | Humans | Middle Aged | Cells, Cultured | Intervertebral Disc Displacement - metabolism | Intervertebral Disc Displacement - pathology | Male | Lumbar Vertebrae - drug effects | Intervertebral Disc Displacement - etiology | Interleukin-1 - pharmacology | Analysis of Variance | Interleukin-1 - physiology | Statistics, Nonparametric | Adult | Female | Aged | Intervertebral Disc - drug effects | Lumbar Vertebrae - pathology | Intervertebral Disc - pathology | Index Medicus
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4. Full Text Posterolateral Disc Prolapse in Flexion Initiated by Lateral Inner Annular Failure: An Investigation of the Herniation Pathway
by van Heeswijk, Vonne M and Thambyah, Ashvin and Robertson, Peter A and Broom, Neil D
SPINE, ISSN 0362-2436, 11/2017, Volume 42, Issue 21, pp. 1604 - 1613
STUDY DESIGN.Structural investigation of mechanically induced herniations in ovine lumbar motion segments. OBJECTIVE.This new study addresses the question of... 
flexion and compression | NUCLEUS PULPOSUS | LUMBAR INTERVERTEBRAL DISCS | LOW-BACK-PAIN | COMPUTED-TOMOGRAPHY DISCOGRAPHY | ANULUS FIBROSUS | anterior shear | herniation pathway | MODEL | progressive transverse sectioning | END-PLATE | CLINICAL NEUROLOGY | structural analysis | DISRUPTION | SPINE | ovine lumbar motion segments | lateral annulus disruption | ORTHOPEDICS | circumferential nuclear tracking | ISSLS PRIZE WINNER | Intervertebral Disc Degeneration - etiology | Animals | Lumbar Vertebrae - diagnostic imaging | Range of Motion, Articular - physiology | Annulus Fibrosus - diagnostic imaging | Stress, Mechanical | Biomechanical Phenomena - physiology | Intervertebral Disc Degeneration - diagnostic imaging | Sheep | Intervertebral Disc - diagnostic imaging | Intervertebral Disc Displacement - etiology | Intervertebral Disc Displacement - diagnostic imaging
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5. Full Text The Effect of Axial Torsion on the Mechanical Properties of the Annulus Fibrosus
by Harvey-Burgess, Maxine and Gregory, Diane E
SPINE, ISSN 0362-2436, 02/2019, Volume 44, Issue 4, pp. E195 - E201
STUDY DESIGN.In-vitro study of the tissue mechanics of annulus fibrosus. OBJECTIVE.To determine the effect of axial torsion on the mechanical properties of the... 
anulus fibrosus | HERNIATION | LUMBAR | DAMAGE | CLINICAL NEUROLOGY | intralamellar matrix | PORCINE | ARCHITECTURE | bovine | INTERVERTEBRAL DISC | injury | ORTHOPEDICS | twist | Intervertebral Disc Degeneration - etiology | Tensile Strength | Biomechanical Phenomena | Animals | Cattle | Annulus Fibrosus - pathology | Stress, Mechanical | Intervertebral Disc Displacement - etiology | Annulus Fibrosus - physiopathology | Pressure | Torsion, Mechanical | Hernia | Physiological aspects | Intervertebral disk displacement | Health aspects | Ligaments | Intervertebral disk | Risk factors
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6. Full Text Instrumentation-related complications of multilevel fusions for adult spinal deformity patients over age 65: Surgical considerations and treatment options in patients with poor bone quality
by DeWald, Christopher J and Stanley, Thomas
Spine, ISSN 0362-2436, 09/2006, Volume 31, Issue 19, pp. S144 - S151
Retrospective follow-up of patients over the age of 65 with a minimum of five-level fusions. To determine the effect on outcomes of long constructs in patients... 
Osteoporosis | Instrumentation failure | Instrumented spinal fusion | Adult scoliosis | Spinal deformity | Postoperative Complications - etiology | Age Factors | Follow-Up Studies | Humans | Postoperative Complications - prevention & control | Male | Preoperative Care - standards | Spinal Curvatures - physiopathology | Intervertebral Disc Displacement - etiology | Spinal Fusion - adverse effects | Patient Selection | Fractures, Bone - etiology | Internal Fixators - adverse effects | Treatment Failure | Female | Kyphosis - etiology | Retrospective Studies | Spine - pathology | Intervertebral Disc Displacement - physiopathology | Osteoporosis - physiopathology | Spinal Curvatures - surgery | Spinal Fusion - methods | Intervertebral Disc Displacement - prevention & control | Postoperative Complications - physiopathology | Spine - physiopathology | Disease Progression | Spinal Fusion - instrumentation | Kyphosis - prevention & control | Spinal Curvatures - complications | Kyphosis - physiopathology | Osteoporosis - complications | Fractures, Bone - physiopathology | Aged | Spine - surgery | Fractures, Bone - prevention & control | Index Medicus
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7. Full Text Can Prevention of a Reherniation Be Investigated? Establishment of a Herniation Model and Experiments With an Anular Closure Device
by Wilke, Hans-Joachim and Ressel, Lena and Heuer, Frank and Graf, Nicolas and Rath, Stefan
Spine, ISSN 0362-2436, 05/2013, Volume 38, Issue 10, pp. E587 - E593
STUDY DESIGN.Biomechanical in vitro study. OBJECTIVE.To establish a reliable in vitro herniation model with human cadaver spines that enables evaluation of... 
disc herniation provocation | in vitro test | biomechanics | annulus sealing | spinal motion segments | NUCLEUS PULPOSUS | KYPHOPLASTY | INTERVERTEBRAL DISC DEGENERATION | BIOMECHANICAL EVALUATION | COMPRESSION | DEFORMATION | CLINICAL NEUROLOGY | REPLACEMENT | IN-VITRO | LUMBAR SPINE | FINITE-ELEMENT | ORTHOPEDICS | Intervertebral Disc Degeneration - etiology | Intervertebral Disc Displacement - prevention & control | Intervertebral Disc - physiopathology | Humans | Middle Aged | Prostheses and Implants | Stress, Mechanical | Intervertebral Disc Degeneration - physiopathology | Intervertebral Disc Displacement - etiology | Young Adult | Biomechanical Phenomena | Models, Biological | Intervertebral Disc Degeneration - prevention & control | Adult | Intervertebral Disc - pathology | Intervertebral Disc Displacement - physiopathology | Cadaver | Index Medicus | Biomechanics
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8. Full Text Association of modic changes, Schmorl's nodes, spondylolytic defects, high-intensity zone lesions, disc herniations, and radial tears with low back symptom severity among young Finnish adults
by Takatalo, Jani and Karppinen, Jaro and Niinimäki, Jaakko and Taimela, Simo and Mutanen, Pertti and Sequeiros, Roberto Blanco and Näyhä, Simo and Järvelin, Marjo-Riitta and Kyllönen, Eero and Tervonen, Osmo
Spine, ISSN 0362-2436, 2012, Volume 37, Issue 14, pp. 1231 - 1239
Study Design. A cross-sectional magnetic resonance imaging (MRI) study. Objective. We investigated the association among Modic changes, Schmorl's nodes,... 
magnetic resonance imaging | disc herniations | DISCOGRAPHY | DISCOGENIC PAIN | ANULUS FIBROSUS | MR | low back pain | Schmorl's nodes | PREVALENCE | CLINICAL NEUROLOGY | DEGENERATION | intervertebral disc degeneration | radial tears | young adults | ADOLESCENTS | LUMBAR SPINE | MAGNETIC-RESONANCE | INTERVERTEBRAL DISC | ORTHOPEDICS | Geography | Severity of Illness Index | Reproducibility of Results | Cross-Sectional Studies | Spondylolysis - diagnosis | Intervertebral Disc Degeneration - diagnosis | Humans | Magnetic Resonance Imaging - methods | Intervertebral Disc Displacement - etiology | Intervertebral Disc Degeneration - complications | Low Back Pain - diagnosis | Radiography | Young Adult | Spine - diagnostic imaging | Low Back Pain - etiology | Intervertebral Disc Displacement - diagnosis | Sensitivity and Specificity | Adolescent | Finland | Surveys and Questionnaires | Spondylolysis - etiology | Pain Measurement | Cohort Studies | Index Medicus
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9. Full Text Genetic Predisposition to Lumbar Disc Degeneration
by Gologorsky, Yakov and Chi, John
Neurosurgery, ISSN 0148-396X, 02/2014, Volume 74, Issue 2, pp. N10 - N11
SURGERY | CLINICAL NEUROLOGY | Intervertebral Disc Degeneration - etiology | Intervertebral Disc Degeneration - pathology | Sulfotransferases - genetics | Genetic Predisposition to Disease | Humans | Intervertebral Disc Displacement - pathology | Lumbar Vertebrae - pathology | Intervertebral Disc Displacement - etiology | Intervertebral Disc Degeneration - genetics | Intervertebral Disc Displacement - genetics
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10. Full Text From the international space station to the clinic: how prolonged unloading may disrupt lumbar spine stability
by Bailey, Jeannie F and Miller, Stephanie L and Khieu, Kristine and O'Neill, Conor W and Healey, Robert M and Coughlin, Dezba G and Sayson, Jojo V and Chang, Douglas G and Hargens, Alan R and Lotz, Jeffrey C
The Spine Journal, ISSN 1529-9430, 01/2018, Volume 18, Issue 1, pp. 7 - 14
Prolonged microgravity exposure is associated with localized low back pain and an elevated risk of post-flight disc herniation. Although the mechanisms by... 
Unloading | Instability | Lumbar spine | Multifidus | Low back pain | Spaceflight | MICROGRAVITY | PARASPINAL MUSCLE | LOW-BACK-PAIN | VERTEBRAL END-PLATE | CLINICAL NEUROLOGY | DEGENERATION | LONG-DURATION SPACEFLIGHT | INTERVERTEBRAL DISC | ORTHOPEDICS | CROSS-SECTIONAL AREA | BED REST | Intervertebral Disc Degeneration - etiology | Lumbosacral Region - diagnostic imaging | Humans | Middle Aged | Paraspinal Muscles - diagnostic imaging | Intervertebral Disc Displacement - pathology | Intervertebral Disc Degeneration - diagnostic imaging | Lumbosacral Region - pathology | Male | Intervertebral Disc Displacement - etiology | Posture | Intervertebral Disc Degeneration - pathology | Magnetic Resonance Imaging | Paraspinal Muscles - pathology | Weightlessness - adverse effects | Adult | Female | Astronauts | Intervertebral Disc Displacement - diagnostic imaging | Index Medicus
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11. Full Text Lumbar Disk Herniation in Children and Adolescents: The Significance of Configurations of the Lumbar Spine
by Dang, Lei and Chen, Zhongqiang and Liu, Xiaoguang and Guo, Zhaoqing and Qi, Qiang and Li, Weishi and Zeng, Yan and Jiang, Liang and Wei, Feng and Sun, Chuiguo and Liu, Zhongjun
Neurosurgery, ISSN 0148-396X, 12/2015, Volume 77, Issue 6, pp. 954 - 959
BACKGROUND:Lumbar disk herniation in adults is thought to be caused by repetitive overloading and age-rated degenerative changes. However, these causes are... 
Diskectomy | Children | Lumbar vertebrae | Adolescent | SURGERY | LUMBOSACRAL JUNCTION | ILIOLUMBAR LIGAMENT | CLINICAL NEUROLOGY | ANATOMY | SPONDYLOLYSIS | ILIAC CRESTS | SKELETAL | EXCISION | CLINICAL-SIGNIFICANCE | AGE | Age Factors | Intervertebral Disc | Humans | Male | Treatment Outcome | Intervertebral Disc Displacement - etiology | Young Adult | Intervertebral Disc Displacement - diagnosis | Arthrodesis | Female | Intervertebral Disc Displacement - surgery | Retrospective Studies | Lumbar Vertebrae | Child | Index Medicus
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12. Full Text A comparison of the type IX collagen levels of the intervertebral disc materials in diabetic and non-diabetic patients who treated with lumbar microdiscectomy
by Kaplan, Metin and Arici, Lutfu and Ozturk, Sait and Simsek, Bengu Cobanoglu and Hergunsel, Omer Batu and Erol, Fatih Serhat
European Spine Journal, ISSN 0940-6719, 1/2018, Volume 27, Issue 1, pp. 214 - 221
The purpose of this study was to compare type IX collagen levels in the intervertebral disc (IVD) materials of diabetic and non-diabetic patients with lumbar... 
Microdiscectomy | Surgical Orthopedics | Medicine & Public Health | Diabetes mellitus | Collagen | Disc herniation | Neurosurgery | Type IX | CELLS | TISSUE | CLINICAL NEUROLOGY | DEGENERATION | CARTILAGE | TWIN | EXTRACELLULAR-MATRIX | ORTHOPEDICS | SPINAL LEVEL | AGE | Glycated Hemoglobin A - analysis | Immunohistochemistry | Intervertebral Disc Degeneration - etiology | Collagen Type IX - metabolism | Humans | Middle Aged | Intervertebral Disc - surgery | Intervertebral Disc Displacement - metabolism | Diskectomy - methods | Male | Intervertebral Disc - metabolism | Diabetes Mellitus, Type 2 - metabolism | Intervertebral Disc Displacement - etiology | Intervertebral Disc Degeneration - metabolism | Lumbar Vertebrae - surgery | Adult | Female | Intervertebral Disc Displacement - surgery | Diabetes Mellitus, Type 2 - complications | Diabetics | Medical research | Care and treatment | Medicine, Experimental | Diabetes | Comparative analysis | Surgery | Back | Immunoreactivity | Intervertebral discs | Index Medicus
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13. Full Text "Surprise" Loading in Flexion Increases the Risk of Disc Herniation Due to Annulus-Endplate Junction Failure A Mechanical and Microstructural Investigation
by Wade, KR and Robertson, PA and Thambyah, A and Broom, ND
SPINE, ISSN 0362-2436, 06/2015, Volume 40, Issue 12, pp. 891 - 901
Study Design. Microstructural investigation of compression-induced herniation of the flexed lumbar disc. Objective. To provide a microstructural analysis of... 
flexion | INJURIES | mechanism of herniation | annular-endplate rupture | MODEL | SCIATICA | ANTERIOR CRUCIATE LIGAMENT | CLINICAL NEUROLOGY | DEGENERATION | TEARS | high rate of compression | sudden loading | annular disruption | DISRUPTION | microstructural analysis | LUMBAR SPINE | ovine lumbar motion segments | PROLAPSED INTERVERTEBRAL-DISK | "surprise" loading | ORTHOPEDICS | ISSLS PRIZE WINNER | Back Muscles - pathology | Back Muscles - physiopathology | Intervertebral Disc - physiopathology | Risk Assessment | Risk Factors | Intervertebral Disc Displacement - pathology | Stress, Mechanical | Intervertebral Disc Displacement - etiology | Biomechanical Phenomena | Animals | Time Factors | Female | Sheep | Weight-Bearing | Lumbar Vertebrae - pathology | Intervertebral Disc - pathology | Intervertebral Disc Displacement - physiopathology | Lumbar Vertebrae - physiopathology | Index Medicus
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14. Full Text Higher risk for cervical herniated intervertebral disc in physicians: A retrospective nationwide population-based cohort study with claims analysis
by Liu, Cheng and Huang, Chien-Cheng and Hsu, Chien-Chin and Lin, Hung-Jung and Guo, How-Ran and Su, Shih-Bin and Wang, Jhi-Joung and Weng, Shih-Feng
Medicine, ISSN 0025-7974, 10/2016, Volume 95, Issue 41, pp. e5055 - e5055
There is no study about cervical herniated intervertebral disc (cervical HIVD) in physicians in the literature; therefore, we conceived a retrospective... 
MEDICINE, GENERAL & INTERNAL | cervical | herniated intervertebral disc | physician | SYMPTOMS | Risk Assessment - methods | Cervical Vertebrae | Humans | Insurance Claim Review | Middle Aged | Risk Factors | Male | Intervertebral Disc Displacement - etiology | Intervertebral Disc Displacement - epidemiology | Incidence | Occupational Health - statistics & numerical data | Taiwan - epidemiology | Adult | Female | Retrospective Studies | Odds Ratio | Physicians - statistics & numerical data | Hernia | Practice | Intervertebral disk displacement | Physicians | Risk factors | Intervertebral disk | Index Medicus | Abridged Index Medicus
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