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1. Full Text Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: Results of a randomized, placebo-controlled study
by Polidori, David and Sha, Sue and Mudaliar, Sunder and Ciaraldi, Theodore P and Ghosh, Atalanta and Vaccaro, Nicole and Farrell, Kristin and Rothenberg, Paul and Henry, Robert R
Diabetes Care, ISSN 0149-5992, 2013, Volume 36, Issue 8, pp. 2154 - 2161
OBJECTIVECanagliflozin, a sodium glucose cotransporter (SGLT) 2 inhibitor, is also a low-potency SGLT1 inhibitor. This study tested the hypothesis that... 
DIABETES-MELLITUS | GLP-1 | ENDOCRINOLOGY & METABOLISM | COTRANSPORTER | MUSCLE | ORAL GLUCOSE | 2 INHIBITORS | CELL | GIP | Glycosuria - chemically induced | Sodium-Glucose Transporter 1 - antagonists & inhibitors | Thiophenes - therapeutic use | Humans | Intestinal Absorption - drug effects | Depression, Chemical | Male | Insulin - blood | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Blood Glucose - drug effects | Cross-Over Studies | Insulin - metabolism | Canagliflozin | Gastric Emptying - drug effects | Adolescent | Postprandial Period | Glucose - metabolism | Placebos | Adult | Glucosides - therapeutic use | Sodium-Glucose Transporter 1 - metabolism | Acetaminophen - pharmacokinetics | Blood Glucose - metabolism | Type 2 diabetes | Physiological aspects | Glucose metabolism | Research | Drug therapy | Original Research
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2. Toxicology of the gastrointestinal tract
by Gad, Shayne C
2007, ISBN 0849327938, 359
Physiopathologie | Toxicology | Toxicologie | Gastrointestinal system -- Pathophysiology | Tractus gastro-intestinal
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3. Lipid-Based formulations for oral drug delivery: Effects on drug absorption and metabolism
by Zhu, Quanlei and Li, Xiuying and Xia, Dengning and Yu, Hongzhen and Chen, Dan and Fan, Weiwei and Gan, Yong
Current Drug Metabolism, ISSN 1389-2002, 08/2015, Volume 16, Issue 3, pp. 200 - 210
The application of lipid-based drug delivery systems on the industrial scale has successfully demonstrated their therapeutic and manufacturing advantages.... 
Poorly soluble drug | Systemic exposure | Absorption | Metabolism | Lipid formulations | MUCOADHESIVE PROPERTIES | systemic exposure | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPOPHILIC DRUGS | CELLULAR UPTAKE | BIOAVAILABILITY | P-GLYCOPROTEIN | INTESTINAL LYMPHATIC TRANSPORT | lipid formulations | POLYMERIC NANOPARTICLES | IN-VITRO DIGESTION | PHARMACOLOGY & PHARMACY | metabolism | POORLY SOLUBLE DRUGS | poorly soluble drug | COATED LIPOSOMES
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4. Full Text Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo
by Linn, Michael and Collnot, Eva-Maria and Djuric, Dejan and Hempel, Katja and Fabian, Eric and Kolter, Karl and Lehr, Claus-Michael
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 2012, Volume 45, Issue 3, pp. 336 - 343
As many new active pharmaceutical ingredients are poorly water soluble, solubility enhancers are one possibility to overcome the hurdles of drug dissolution... 
Fenofibrate | Extrusion | Bioavailability | Caco-2 | Danazol | Itraconazole | FORMULATION | ORAL ABSORPTION | P-GLYCOPROTEIN | SOLID DISPERSIONS | TRANSPORT | DISSOLUTION | CACO-2 CELL MONOLAYERS | PHARMACOLOGY & PHARMACY | Pharmaceutical Preparations - blood | Area Under Curve | Humans | Intestinal Absorption - drug effects | Biological Availability | Polyethylene Glycols - chemistry | Fenofibrate - chemistry | Excipients - chemistry | Itraconazole - pharmacokinetics | Danazol - pharmacokinetics | Female | Biological Transport - drug effects | Pharmaceutical Preparations - administration & dosage | Danazol - blood | Caco-2 Cells | Itraconazole - blood | Administration, Oral | Solubility | Itraconazole - chemistry | Fenofibrate - blood | Fenofibrate - pharmacokinetics | Animals | Dogs | Pharmaceutical Preparations - chemistry | Polyvinyls - chemistry | Danazol - chemistry | Fibric acids
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5. Full Text Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2
by Oliver J. Mace and Julie Affleck and Nick Patel and George L. Kellett
The Journal of Physiology, ISSN 0022-3751, 07/2007, Volume 582, Issue 1, pp. 379 - 392
Natural sugars and artificial sweeteners are sensed by receptors in taste buds. T2R bitter and T1R sweet taste receptors are coupled through G-proteins,... 
CALCIUM-ABSORPTION | ENTEROENDOCRINE STC-1 CELLS | PROTEIN-KINASE-C | PHYSIOLOGY | FRUCTOSE TRANSPORT | SUGAR ABSORPTION | GASTROINTESTINAL-TRACT | BRUSH-BORDER MEMBRANE | EXPRESSION | CA(V)1.3 | FAMILY | Glucose Transporter Type 2 - agonists | Intestinal Mucosa - metabolism | Rats, Wistar | Receptors, G-Protein-Coupled - metabolism | Calcium - metabolism | Enterocytes - metabolism | Sucrose - analogs & derivatives | Intestinal Absorption - drug effects | Sucrose - pharmacology | Type C Phospholipases - metabolism | Male | Glucose Transporter Type 2 - metabolism | Intestinal Mucosa - drug effects | Jejunum - metabolism | Dose-Response Relationship, Drug | Intestinal Mucosa - cytology | Jejunum - drug effects | Phospholipase C beta | Time Factors | Isoenzymes - metabolism | Thiazines - pharmacology | Transducin - metabolism | Jejunum - cytology | Receptors, G-Protein-Coupled - drug effects | Paneth Cells - metabolism | Sweetening Agents - pharmacology | Rats | Microvilli - drug effects | Animals | Enterocytes - drug effects | Microvilli - metabolism | Signal Transduction - drug effects | Paneth Cells - drug effects | Perfusion | Glucose - metabolism | Saccharin - pharmacology | Alimentary
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6. Full Text Pharmacokinetics and Absorption of Posaconazole Oral Suspension under Various Gastric Conditions in Healthy Volunteers
by Gopal Krishna and Allen Moton and Lei Ma and Matthew M. Medlock and James McLeod
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 03/2009, Volume 53, Issue 3, pp. 958 - 966
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
CELL TRANSPLANT RECIPIENTS | STEADY-STATE PHARMACOKINETICS | BEVERAGE COCA-COLA | SALVAGE THERAPY | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | FOOD INTERACTION | INVASIVE FUNGAL-INFECTION | ITRACONAZOLE | TRIAZOLE ANTIFUNGAL | VERSUS-HOST-DISEASE | FLUCONAZOLE | Triazoles - administration & dosage | Triazoles - adverse effects | Antifungal Agents - adverse effects | Triazoles - blood | Area Under Curve | Humans | Middle Aged | Omeprazole - blood | Intestinal Absorption - drug effects | Male | Anti-Ulcer Agents - blood | Gastric Mucosa - metabolism | Anti-Ulcer Agents - pharmacokinetics | Dose-Response Relationship, Drug | Young Adult | Antifungal Agents - pharmacokinetics | Hydrogen-Ion Concentration - drug effects | Gastric Mucosa - drug effects | Adult | Female | Triazoles - pharmacokinetics | Suspensions | Eating | European Continental Ancestry Group - genetics | Fasting | Drug Administration Schedule | Administration, Oral | Food-Drug Interactions | Omeprazole - administration & dosage | Anti-Ulcer Agents - adverse effects | African Americans - genetics | European Continental Ancestry Group - statistics & numerical data | Omeprazole - adverse effects | Omeprazole - pharmacokinetics | Carbonated Beverages | Anti-Ulcer Agents - administration & dosage | Cross-Over Studies | African Americans - statistics & numerical data | Antifungal Agents - administration & dosage | Antifungal Agents - blood | Index Medicus | Pharmacology
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7. Full Text Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes
by Fujita, Hiroki and Sugimoto, Kotaro and Inatomi, Shuichiro and Maeda, Toshihiro and Osanai, Makoto and Uchiyama, Yasushi and Yamamoto, Yoko and Wada, Takuro and Kojima, Takashi and Yokozaki, Hiroshi and Yamashita, Toshihiko and Kato, Shigeaki and Sawada, Norimasa and Chiba, Hideki
Molecular Biology of the Cell, ISSN 1059-1524, 05/2008, Volume 19, Issue 5, pp. 1912 - 1921
Ca2+ is absorbed across intestinal epithelial monolayers via transcellular and paracellular pathways, and an active form of vitamin D-3, 1... 
EXPRESSION PATTERNS | RAT INTESTINE | EPITHELIAL-CELLS | SELECTIVE CHANNELS | EMBRYONAL CARCINOMA-CELLS | SUBCELLULAR-LOCALIZATION | INTESTINAL CALCIUM-ABSORPTION | KNOCKOUT MICE | ACID RECEPTOR HETERODIMERS | CACO-2 CELLS | CELL BIOLOGY | Caco-2 Cells | Tight Junctions - metabolism | Receptors, Calcitriol - deficiency | Calcium - metabolism | Enterocytes - metabolism | Humans | Intestinal Absorption - drug effects | Vitamin D - pharmacology | Intestines - metabolism | Receptors, Calcitriol - metabolism | Sodium - metabolism | Down-Regulation - drug effects | Mice, Knockout | Claudins | Animals | Enterocytes - drug effects | Cell Membrane Permeability - drug effects | Vitamin D - analogs & derivatives | Biological Transport - drug effects | Membrane Proteins - metabolism | Mice | Intestines - cytology | Tight Junctions - drug effects
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8. Full Text Morphine decreases clopidogrel concentrations and effects: A randomized, double-blind, placebo-controlled trial
by Hobl, Eva-Luise and Stimpfl, Thomas and Ebner, Josef and Schoergenhofer, Christian and Derhaschnig, Ulla and Sunder-Plassmann, Raute and Jilma-Stohlawetz, Petra and Mannhalter, Christine and Posch, Martin and Jilma, Bernd
Journal of the American College of Cardiology, ISSN 0735-1097, 02/2014, Volume 63, Issue 7, pp. 630 - 635
Objectives This study sought to examine the possible drug-drug interactions between clopidogrel and morphine. Background Because morphine - the recommended... 
clopidogrel | drug interaction | morphine | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | PLATELET-FUNCTION | GUIDELINES | PERCUTANEOUS CORONARY INTERVENTION | IMPACT | INHIBITION | PRASUGREL | ASSOCIATION | ELEVATION MYOCARDIAL-INFARCTION | Injections, Intravenous | Double-Blind Method | Humans | Intestinal Absorption - drug effects | Male | Treatment Outcome | Morphine - blood | Ticlopidine - analogs & derivatives | Cross-Over Studies | Young Adult | Drug Interactions - physiology | Ticlopidine - administration & dosage | Adult | Female | Drug Therapy, Combination | Morphine - administration & dosage | Intestinal Absorption - physiology | Ticlopidine - blood | Clinical trials | Morphine | Liquid chromatography | Metabolites | Mass spectrometry | Collagen | Myocardial infarction | Phosphorylation | Agglomeration | Variables | Absorption | Pain | Blood platelets | Inhibition | Drug dosages | Aspirin | Adenosine | Adenosine diphosphate | Mass spectroscopy | Pharmacology | Platelet aggregation | Injection | Metabolism | Clopidogrel | Plasma levels | Infarction | Acute coronary syndromes | Pharmacokinetics | Platelets | Prolongation
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9. Full Text Conditions and drugs interfering with thyroxine absorption
by Liwanpo, Llanyee, MD and Hershman, Jerome M., MD
Best Practice & Research: Clinical Endocrinology & Metabolism, ISSN 1521-690X, 2009, Volume 23, Issue 6, pp. 781 - 792
Food, dietary fibre and espresso coffee interfere with the absorption of levothyroxine. Malabsorptive disorders reported to affect the absorption of... 
Endocrinology & Metabolism | malabsorption | interfering drugs | levothyroxine | thyroxine absorption | hypothyroidism | ALUMINUM HYDROXIDE | JEJUNOILEAL BYPASS | ORAL THYROXINE | THYROID-HORMONE | CALCIUM-CARBONATE | CELIAC-DISEASE | INTESTINAL-ABSORPTION | HYPOTHYROID PATIENTS | LEVOTHYROXINE ABSORPTION | ENDOCRINOLOGY & METABOLISM | Gastritis, Atrophic - physiopathology | Humans | Intestinal Absorption - drug effects | Celiac Disease - physiopathology | Biological Availability | Calcium Carbonate - adverse effects | Thyroxine - pharmacokinetics | Aluminum Hydroxide - adverse effects | Animals | Drug Interactions | Lactose Intolerance - physiopathology | Antacids - adverse effects | Malabsorption Syndromes - physiopathology | Dietary Fiber - adverse effects | Female | Coffee - adverse effects | Helicobacter Infections - physiopathology | Food | Phosphates | Bile acids | Gastrointestinal diseases | Antacids | Calcium carbonate | Antiulcer drugs
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10. Full Text Soybean β-Conglycinin Induces Inflammation and Oxidation and Causes Dysfunction of Intestinal Digestion and Absorption in Fish
by Zhang, Jin-Xiu and Guo, Lin-Ying and Feng, Lin and Jiang, Wei-Dan and Kuang, Sheng-Yao and Liu, Yang and Hu, Kai and Jiang, Jun and Li, Shu-Hong and Tang, Ling and Zhou, Xiao-Qiu
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e58115
beta-conglycinin has been identified as one of the major feed allergens. However, studies of beta-conglycinin on fish are scarce. This study investigated the... 
FED GRADED-LEVELS | ENZYME-ACTIVITIES | RAINBOW-TROUT | JUVENILE JIAN | MULTIDISCIPLINARY SCIENCES | SALMON SALMO-SALAR | BODY-COMPOSITION | TROUT ONCORHYNCHUS-MYKISS | MORHUA FED STANDARD | ATLANTIC SALMON | GLUTAMINE SUPPLEMENTATION | Inflammation - chemically induced | Inflammation - pathology | Liver - pathology | Liver - enzymology | Intestinal Diseases - chemically induced | Glutathione - metabolism | Soybean Proteins - adverse effects | Seed Storage Proteins - pharmacology | Intestinal Absorption - drug effects | Intestines - metabolism | Antigens, Plant - chemistry | Soybean Proteins - chemistry | Inflammation - metabolism | Oxidation-Reduction - drug effects | Fish Diseases - chemically induced | Seed Storage Proteins - adverse effects | Carps - metabolism | Intestines - pathology | Cytokines - metabolism | Oxidoreductases - metabolism | Globulins - chemistry | Antigens, Plant - pharmacology | Antigens, Plant - adverse effects | Intestinal Diseases - metabolism | Fish Diseases - pathology | Soybean Proteins - pharmacology | Soybeans - chemistry | Inflammation - veterinary | Seed Storage Proteins - chemistry | Animals | Globulins - pharmacology | Globulins - adverse effects | Fish Diseases - metabolism | Intestinal Diseases - pathology | Allergens | Alkaline phosphatase | Soybeans | Growth rate | Creatine kinase | Interleukin | Inflammatory response | Superoxide dismutase | Absorptivity | Creatine | Lipase | Antioxidants | Absorption | Catalase | Glutathione reductase | Glutathione transferase | Intestine | Rodents | Animal tissues | Hepatopancreas | Fish | Oxidation | Peroxidase | Interleukin 8 | Glutathione | Glutathione peroxidase | Carp | Nutrition | Conglycinin | Rapamycin | Inflammation | Digestion | Gene expression | Na+/K+-exchanging ATPase | Chymotrypsin | Enterocytes | Trypsin | Weight reduction | Feeds | Feed efficiency
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11. Full Text Improved Transport and Absorption through Gastrointestinal Tract by PEGylated Solid Lipid Nanoparticles
by Yuan, Hong and Chen, Chun-Yan and Chai, Gui-hong and Du, Yong-Zhong and Hu, Fu-Qiang
Molecular Pharmaceutics, ISSN 1543-8384, 05/2013, Volume 10, Issue 5, pp. 1865 - 1873
The aim of the present study was to evaluate the potential of PEGylated solid lipid nanoparticle (pSLN) as mucus penetrating particles (MPP) for oral delivery... 
polyethylene glycol | Caco-2 cells | HT29 cells | oral drug delivery | solid lipid nanoparticles | CELLS | HUMAN MUCUS BARRIER | BIOAVAILABILITY | PACLITAXEL | IN-VITRO | POLYMERIC NANOPARTICLES | ORAL-DRUG DELIVERY | NANOSPHERES | PHARMACOLOGY & PHARMACY | NANOSCALE | COCULTURES | Caco-2 Cells | Intestinal Mucosa - metabolism | Nanoparticles - chemistry | Administration, Oral | Coculture Techniques | Endocytosis - drug effects | Humans | Intestinal Absorption - drug effects | Nanoparticles - ultrastructure | Drug Carriers - administration & dosage | Rats | Biological Availability | Male | Polyethylene Glycols - chemistry | Rats, Sprague-Dawley | Doxorubicin - pharmacokinetics | Drug Carriers - chemistry | Drug Delivery Systems | HT29 Cells | Lipids - chemistry | Animals | Nanoparticles - administration & dosage | Doxorubicin - administration & dosage
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12. Full Text Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic
by Maher, Sam and Leonard, Thomas W and Jacobsen, Jette and Brayden, David J
Advanced Drug Delivery Reviews, ISSN 0169-409X, 2009, Volume 61, Issue 15, pp. 1427 - 1449
A major challenge in oral drug delivery is the development of novel dosage forms to promote absorption of poorly permeable drugs across the intestinal... 
Drug delivery systems | Absorption promoter | Drug delivery platforms | Sodium caprate (C 10) | Clinical trials | Oral formulation | Oral drug delivery | Sodium caprate (C | INTESTINAL MUCOSAL TOXICITY | BETA-D-MALTOPYRANOSIDE | Sodium caprate (C-10) | ENHANCING MECHANISM | EPITHELIAL GENE-TRANSFER | CHAIN FATTY-ACIDS | EPIDERMAL-GROWTH-FACTOR | WATER-SOLUBLE DRUGS | CACO-2 CELL MONOLAYERS | RECTAL ABSORPTION | PHARMACOLOGY & PHARMACY | TIGHT JUNCTION PERMEABILITY | Animals | Administration, Oral | Models, Biological | Humans | Intestinal Absorption - drug effects | Decanoic Acids - administration & dosage | Decanoic Acids - pharmacokinetics | Drug Evaluation, Preclinical | In Vitro Techniques | Decanoic Acids - adverse effects | Drug Delivery Systems - methods | Drugs | Ampicillin | Phosphonates | Universities and colleges | Permeability | Fatty acids | Vehicles | Monoglycerides
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