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Nature, ISSN 0028-0836, 03/2015, Volume 519, Issue 7541, pp. 92 - 96
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 09/2013, Volume 305, Issue 5, pp. G341 - G347
Colon has been shown to have a two-layered mucus system where the inner layer is devoid of bacteria. However, a complete overview of the mouse gastrointestinal... 
Bacteria | Mucus thickness | Goblet cells | Mucin | Mucus adhesiveness | mucus adhesiveness | PHYSIOLOGY | bacteria | HOST | MICROBIOTA | M-CELLS | mucus thickness | goblet cells | EPITHELIUM | mucin | IN-VIVO | BACTERIAL OVERGROWTH | CYSTIC-FIBROSIS | SECRETION | ACCUMULATION | GASTROENTEROLOGY & HEPATOLOGY | Gastric Mucosa - microbiology | Intestinal Mucosa - metabolism | Peyer's Patches - metabolism | Colon - drug effects | Fluorescent Dyes - metabolism | Male | Microscopy, Video | Peyer's Patches - drug effects | Gastric Mucosa - metabolism | Intestinal Absorption | Intestinal Mucosa - drug effects | Time Factors | Gastric Mucosa - drug effects | Female | Mucus - metabolism | Dinoprostone - pharmacology | Adhesiveness | Intestine, Small - microbiology | Mice, Inbred C57BL | Intestinal Mucosa - microbiology | Permeability | Colon - metabolism | Mucus - microbiology | Carbachol - pharmacology | Microscopy, Confocal | Animals | Intestine, Small - drug effects | Colon - microbiology | Mice | Intestine, Small - metabolism | Physiological aspects | Mucus | Health aspects | Gastrointestinal system | Body fluids | Lipids | Physiology | Digestive system | Mucosal Biology | Dinoprostone | Confocal | Gastric Mucosa | Intestine | pharmacology | Peyer's Patches | Colon | Intestinal Mucosa | Small | Cell and Molecular Biology | microbiology | drug effects | Inbred C57BL | Carbachol | Microscopy | Video | metabolism | Cell- och molekylärbiologi | Fluorescent Dyes
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2015, Volume 112, Issue 32, pp. 10038 - 10043
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits... 
Mucolysis | (Tri)sulfides | Red meat | Mucus barrier | Colorectal cancer | colorectal cancer | MUCIN | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | red meat | mucus barrier | (tri)sulfides | mucolysis | COLORECTAL-CANCER | CALCIUM | FAT | MICE | INHIBITOR | CYTOTOXICITY | EXPRESSION | Immunohistochemistry | Cell Cycle - genetics | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Colon - drug effects | Microbiota - drug effects | Body Weight - drug effects | Ki-67 Antigen - metabolism | Male | Mucus - drug effects | Colony Count, Microbial | Intestinal Mucosa - drug effects | Feces - microbiology | Heme - pharmacology | Mucus - metabolism | Sulfides - metabolism | Cell Death - drug effects | Biomarkers - metabolism | Colon - pathology | Mice, Inbred C57BL | Epithelial Cells - pathology | Up-Regulation - genetics | Antioxidants - pharmacology | Intestinal Mucosa - microbiology | Down-Regulation - drug effects | Down-Regulation - genetics | Up-Regulation - drug effects | Animals | Diet | Models, Biological | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Colon - microbiology | Cell Cycle - drug effects | Intestinal Mucosa - pathology | Cell proliferation | Colon cancer | Epithelial cells | Heme | Physiological aspects | Observations | Health aspects | Bacteria | Microorganisms | Colon | Rodents | Genes | Biological Sciences | susceptibility | expression | bacterial | inhibitor | mucin | fat | colorectal-cancer | mice | cytotoxicity
Journal Article
Nature, ISSN 0028-0836, 01/2018, Volume 553, Issue 7687, pp. 208 - 211
Inflammatory diseases of the gastrointestinal tract are frequently associated with dysbiosis(1-8), characterized by changes in gut microbial communities that... 
ENTERICA SEROTYPE TYPHIMURIUM | SEROVAR TYPHIMURIUM | CROHNS-DISEASE | INFLAMMATORY RESPONSES | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | ULCERATIVE-COLITIS | GROWTH | ELECTRON-ACCEPTOR | CD-HIT | ENTEROBACTERIACEAE | Intestines - drug effects | Inflammation - pathology | Dysbiosis - drug therapy | Molybdenum - metabolism | Tungsten Compounds - therapeutic use | Male | Tungsten Compounds - pharmacology | Dysbiosis - microbiology | Intestinal Mucosa - drug effects | Inflammation - drug therapy | Cell Respiration - drug effects | Female | Colitis - drug therapy | Enterobacteriaceae - growth & development | Inflammation - microbiology | Intestines - pathology | Anaerobiosis - drug effects | Mice, Inbred C57BL | Intestinal Mucosa - microbiology | Enterobacteriaceae - metabolism | Animals | Colitis - microbiology | Gastrointestinal Microbiome - drug effects | Intestines - microbiology | Enterobacteriaceae - drug effects | Mice | Intestinal Mucosa - pathology | Physiological aspects | Colitis | Microbiota (Symbiotic organisms) | Health aspects | Salmonella | Microbial activity | Anaerobic microorganisms | Animal models | Dysbacteriosis | Inflammatory diseases | Microbiota | Microorganisms | E coli | Intestine | Bacteria | Oxidation | Digestive tract | Anaerobic bacteria | Enzymes | Digestive system | Gastrointestinal tract | Inflammation | Metabolism | Gene expression | Molybdenum | Inflammatory bowel disease | Genetic engineering | Binding sites
Journal Article
British Journal of Nutrition, ISSN 0007-1145, 02/2014, Volume 111, Issue 3, pp. 387 - 402
The human intestine is colonised by 10(13) to 10(14) micro-organisms, the vast majority of which belong to the phyla Firmicutes and Bacteroidetes. Although... 
Probiotics | Diet | Health | Intestinal microbiota | RDNA SEQUENCE-ANALYSIS | INDUCED INTERLEUKIN-8 PRODUCTION | NECROTIZING ENTEROCOLITIS | REAL-TIME PCR | LONG-TERM IMPACTS | NUTRITION & DIETETICS | ANTIBIOTIC-ASSOCIATED DIARRHEA | HEAT-KILLED LACTOBACILLUS | DISTAL GUT MICROBIOTA | IRRITABLE-BOWEL-SYNDROME | HUMAN FECAL MICROBIOTA | Intestines - drug effects | Diet - adverse effects | Gram-Positive Bacteria - drug effects | Humans | Inflammatory Bowel Diseases - immunology | Gram-Negative Bacteria - immunology | Intestinal Mucosa - drug effects | Intestines - immunology | Intestinal Mucosa - growth & development | Intestinal Mucosa - immunology | Irritable Bowel Syndrome - immunology | Aging | Anti-Bacterial Agents - adverse effects | Gram-Positive Bacteria - growth & development | Gram-Positive Bacteria - immunology | Irritable Bowel Syndrome - prevention & control | Inflammatory Bowel Diseases - prevention & control | Microbial Viability - drug effects | Irritable Bowel Syndrome - diet therapy | Intestines - growth & development | Intestinal Mucosa - microbiology | Inflammatory Bowel Diseases - diet therapy | Irritable Bowel Syndrome - microbiology | Gram-Negative Bacteria - drug effects | Animals | Intestines - microbiology | Models, Biological | Gram-Negative Bacteria - growth & development | Inflammatory Bowel Diseases - microbiology | Probiotics - therapeutic use | Health Status | Dietary Supplements | Microorganisms | Digestive system
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2016, Volume 113, Issue 1, pp. E7 - E15
A human gut-on-a-chip microdevice was used to coculture multiple commensal microbes in contact with living human intestinal epithelial cells for more than a... 
Inflammatory bowel disease | Gut-on-a-chip | Intestine | Mechanical | Microbiome | intestine | CROHNS-DISEASE | NONPATHOGENIC BACTERIA | MULTIDISCIPLINARY SCIENCES | ULCERATIVE-COLITIS | mechanical | PROBIOTICS | COCULTURE MODEL | microbiome | inflammatory bowel disease | BOWEL-DISEASE | EPITHELIAL-CELLS | GENE-EXPRESSION | LIPOPOLYSACCHARIDE | gut-on-a-chip | CACO-2 CELLS | Intestinal Mucosa - physiopathology | Humans | Inflammatory Bowel Diseases - physiopathology | Intestinal Mucosa - drug effects | Anti-Bacterial Agents - therapeutic use | Bacteria - growth & development | Ileus - microbiology | Tumor Necrosis Factor-alpha - immunology | Peristalsis - drug effects | Caco-2 Cells | Inflammatory Bowel Diseases - drug therapy | Microbiota - physiology | Ileus - physiopathology | Interleukin-1beta - immunology | Lab-On-A-Chip Devices | Intestinal Mucosa - microbiology | Ileus - drug therapy | Animals | Models, Biological | Peristalsis - physiology | Interleukin-6 - immunology | Inflammatory Bowel Diseases - microbiology | Probiotics - therapeutic use | In Vitro Techniques | Interleukin-8 - immunology | Host-bacteria relationships | Physiological aspects | Inflammatory bowel diseases | Observations | Bacteria | Cytokines | Microbiology | Antibiotics | Drug therapy | Cells | Biological Sciences | Physical Sciences | PNAS Plus
Journal Article
Science, ISSN 0036-8075, 11/2010, Volume 330, Issue 6005, pp. 831 - 835
The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is severe diarrhea caused by symbiotic bacterial β-glucuronidases that... 
Enzymes | Anaerobic bacteria | Toxicity | REPORTS | Colorectal cancer | Diarrhea | Anaerobic conditions | Bacteria | Mice | Monomers | Crystal structure | IRINOTECAN CPT-11 | DIARRHEA | METABOLISM | COLITIS | MULTIDISCIPLINARY SCIENCES | BETA-GLUCURONIDASE | CAMPTOTHECINS | TOPOISOMERASE-I | PHARMACOGENETICS | GUT FLORA | CARCINOMA | Camptothecin - toxicity | Humans | Colon - drug effects | Glucuronidase - metabolism | Crystallography, X-Ray | Diarrhea - prevention & control | Intestinal Mucosa - drug effects | Prodrugs - metabolism | Enzyme Inhibitors - chemistry | Female | Glucuronidase - antagonists & inhibitors | Antineoplastic Agents, Phytogenic - metabolism | Escherichia coli Proteins - antagonists & inhibitors | Bacteria, Anaerobic - drug effects | Drug Evaluation, Preclinical | Camptothecin - analogs & derivatives | Camptothecin - metabolism | Escherichia coli - enzymology | Enzyme Inhibitors - metabolism | Colon - pathology | Glucuronidase - isolation & purification | Enzyme Inhibitors - pharmacology | Models, Molecular | Escherichia coli Proteins - metabolism | Glucuronidase - chemistry | Intestinal Mucosa - microbiology | Escherichia coli Proteins - isolation & purification | Antineoplastic Agents, Phytogenic - toxicity | Animals | Prodrugs - toxicity | Cell Line, Tumor | Protein Conformation | Colon - microbiology | Mice, Inbred BALB C | Glucuronidase - pharmacology | Escherichia coli Proteins - chemistry | Intestinal Mucosa - pathology | Antimitotic agents | Drugs | Prevention | Complications and side effects | Care and treatment | Dosage and administration | Antineoplastic agents | Health aspects | Cancer | Chemotherapy | Side effects | Index Medicus | Microorganisms | Inhibitors | LARGE INTESTINE | BACTERIA | NEOPLASMS | BASIC BIOLOGICAL SCIENCES | CRYSTAL STRUCTURE | TOXICITY | 60 APPLIED LIFE SCIENCES | ENZYMES | ORAL ADMINISTRATION | TARGETS | MICE | SIDE EFFECTS
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 07/2017, Volume 102, Issue 1, pp. 52 - 61
Journal Article