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Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7693, pp. 538 - 543
Most patients with colorectal cancer die as a result of the disease spreading to other organs. However, no prevalent mutations have been associated with... 
STEM-CELLS | GENE | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | MOUSE | LEADS | RECEPTOR | MICE | GROWTH-FACTOR | TUMORIGENESIS | EXPRESSION | Intestines - drug effects | Colonic Neoplasms - genetics | Intestinal Mucosa - metabolism | Colonic Neoplasms - drug therapy | Humans | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Stem Cells - metabolism | Th1 Cells - immunology | T-Lymphocytes, Cytotoxic - drug effects | Neoplasm Metastasis - drug therapy | Neoplasm Metastasis - immunology | Colonic Neoplasms - immunology | Immunotherapy | Transforming Growth Factor beta - antagonists & inhibitors | Female | Liver Neoplasms - secondary | Disease Models, Animal | T-Lymphocytes, Cytotoxic - immunology | Transforming Growth Factor beta - immunology | Tumor Microenvironment - drug effects | Th1 Cells - drug effects | Intestines - pathology | Liver Neoplasms - drug therapy | Liver Neoplasms - immunology | Drug Synergism | Tumor Microenvironment - immunology | Neoplasm Metastasis - genetics | Animals | Cell Differentiation - drug effects | Neoplasm Metastasis - pathology | Colonic Neoplasms - pathology | Alleles | Immune Evasion - drug effects | Stem Cells - drug effects | Stem Cells - pathology | Mice | Mutation | T-Lymphocytes, Cytotoxic - cytology | PD-1 protein | Liver | Colorectal carcinoma | Colorectal cancer | Stem cell transplantation | Cytotoxicity | Lymphocytes T | Metastasis | Metastases | Colon cancer | Intestine | Lymphocytes | Genetic analysis | Fibroblasts | Colon | Inhibition | Growth factors | Phenotypes | Data analysis | Liver diseases | Microsatellites | Organs | Gene expression | Patients | Signaling | Immune checkpoint | PD-L1 protein | Stem cells | Tumors | Cancer
Journal Article
Journal Article
Gastroenterology, ISSN 0016-5085, 2010, Volume 138, Issue 6, pp. 2101 - 2114.e5
The connection between inflammation and tumorigenesis is well-established and in the last decade has received a great deal of supporting evidence from genetic,... 
Gastroenterology and Hepatology | Inflammation | Cytokines | Immunity | Colon Cancer | CHRONIC INTESTINAL INFLAMMATION | COLITIS-ASSOCIATED CANCER | SEVERE CROHNS-DISEASE | EPITHELIAL-MESENCHYMAL TRANSITION | TUMOR-NECROSIS-FACTOR | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | KINASE-I-EPSILON | TOLL-LIKE RECEPTORS | GASTROENTEROLOGY & HEPATOLOGY | NF-KAPPA-B | GENOME-WIDE ASSOCIATION | Colonic Neoplasms - genetics | Colonic Neoplasms - prevention & control | Colonic Neoplasms - drug therapy | Colorectal Neoplasms - genetics | Humans | Inflammatory Bowel Diseases - immunology | Gene Expression Regulation, Neoplastic | Colon - immunology | Cell Transformation, Neoplastic - genetics | Colonic Neoplasms - immunology | Colorectal Neoplasms - drug therapy | Inflammation Mediators - metabolism | Inflammatory Bowel Diseases - genetics | Anti-Inflammatory Agents - therapeutic use | Inflammatory Bowel Diseases - complications | Anticarcinogenic Agents - therapeutic use | Inflammatory Bowel Diseases - drug therapy | Genetic Predisposition to Disease | Cytokines - metabolism | Risk Assessment | Signal Transduction | Neoplasm Invasiveness | Risk Factors | Colorectal Neoplasms - prevention & control | Colonic Neoplasms - secondary | Cell Transformation, Neoplastic - immunology | Animals | Colorectal Neoplasms - immunology | Colorectal Neoplasms - secondary | Colon - microbiology | Dendritic cells | Measles-mumps-rubella vaccine | Biological response modifiers | Sulfates | Risk factors | Dextran | Prostaglandins | Colon cancer | Gastrointestinal diseases | Vascular endothelial growth factor | Growth factors | Tumors
Journal Article
Endocrine-Related Cancer, ISSN 1351-0088, 10/2013, Volume 20, Issue 5, pp. 649 - 657
Journal Article
Cell Reports, ISSN 2211-1247, 05/2016, Volume 15, Issue 6, pp. 1144 - 1160
Journal Article
Cancer Treatment Reviews, ISSN 0305-7372, 2016, Volume 50, pp. 61 - 67
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2012, Volume 109, Issue 21, pp. 8253 - 8258
Autophagy is a lysosome-dependent degradative process that protects cancer cells from multiple stresses. In preclinical models, autophagy inhibition with... 
Cell death | Medical treatment | Cell lines | Lysosomes | Immunoblotting | Cytotoxicity | Dosage | Heterologous transplantation | Tumors | Cancer | Antimalarials | Cancer cell survival | Stress responses | Drug resistance | BISQUINOLINES | cancer cell survival | PROTEIN | cell death | MULTIDISCIPLINARY SCIENCES | TARGETING AUTOPHAGY | MOUSE | antimalarials | TUMOR | CELL-SURVIVAL | stress responses | NECROSIS | drug resistance | CYTOTOXICITY | Autophagy-Related Proteins | Colonic Neoplasms - genetics | Adenocarcinoma - pathology | Aminoquinolines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Colonic Neoplasms - drug therapy | Humans | Brain Neoplasms - pathology | Aminoquinolines - toxicity | Drug Resistance, Neoplasm | Polyamines - toxicity | Intestinal Obstruction - chemically induced | Autophagy - drug effects | Antineoplastic Agents - toxicity | Glioblastoma - genetics | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Autophagy - genetics | Cell Death - drug effects | Aminoquinolines - pharmacology | Lysosomes - drug effects | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Adenocarcinoma - drug therapy | Antimalarials - pharmacology | HT29 Cells | Xenograft Model Antitumor Assays | Carrier Proteins - genetics | Polyamines - pharmacology | Animals | Mice, Nude | Colonic Neoplasms - pathology | Glioblastoma - pathology | Hydroxychloroquine - pharmacology | Mice | Glioblastoma - drug therapy | Intestinal Obstruction - genetics | Polyamines - chemical synthesis | Autophagy (Cytology) | Phenotype | Genetic aspects | Dosage and administration | Enzyme inhibitors | Identification and classification | Index Medicus | Biological Sciences
Journal Article
Blood, ISSN 0006-4971, 04/2016, Volume 127, Issue 17, pp. 2082 - 2092
Journal Article
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7647, pp. 676 - 680
Journal Article