X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (48542) 48542
Book Chapter (168) 168
Dissertation (39) 39
Book / eBook (31) 31
Publication (16) 16
Conference Proceeding (11) 11
Newspaper Article (11) 11
Magazine Article (7) 7
Web Resource (4) 4
Book Review (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (28765) 28765
animals (27886) 27886
intracellular signaling peptides and proteins - metabolism (14501) 14501
intracellular signaling peptides and proteins (14382) 14382
mice (12962) 12962
intracellular signaling peptides and proteins - genetics (10882) 10882
biochemistry & molecular biology (10869) 10869
cell biology (10380) 10380
male (10053) 10053
signal transduction (8902) 8902
female (8125) 8125
phosphorylation (8115) 8115
proteins (7841) 7841
rats (6742) 6742
expression (6318) 6318
activation (5573) 5573
apoptosis (5233) 5233
cells, cultured (5064) 5064
cell line (4948) 4948
neurosciences (4875) 4875
molecular sequence data (4593) 4593
protein-serine-threonine kinases - metabolism (4490) 4490
gene expression (4399) 4399
research (4365) 4365
mutation (4306) 4306
amino acid sequence (4293) 4293
cell line, tumor (4210) 4210
protein binding (4057) 4057
membrane proteins - metabolism (4014) 4014
oncology (3843) 3843
multidisciplinary sciences (3737) 3737
protein (3648) 3648
research article (3562) 3562
cancer (3468) 3468
immunology (3383) 3383
physiological aspects (3238) 3238
cells (3236) 3236
analysis (3216) 3216
membrane proteins - genetics (3155) 3155
kinases (3081) 3081
adult (2899) 2899
middle aged (2807) 2807
physiology (2782) 2782
genetic aspects (2772) 2772
carrier proteins - metabolism (2748) 2748
biology (2732) 2732
signal transduction - physiology (2725) 2725
transfection (2716) 2716
mice, inbred c57bl (2688) 2688
gene (2623) 2623
medicine (2570) 2570
calcium (2559) 2559
mice, knockout (2538) 2538
genetics & heredity (2522) 2522
intracellular signaling peptides and proteins - physiology (2495) 2495
orexins (2481) 2481
calcium - metabolism (2417) 2417
gene-expression (2416) 2416
science (2271) 2271
neurons (2270) 2270
blotting, western (2262) 2262
protein-serine-threonine kinases - genetics (2203) 2203
cell proliferation (2198) 2198
immunohistochemistry (2198) 2198
rats, sprague-dawley (2178) 2178
signal transduction - drug effects (2141) 2141
carrier proteins - genetics (2114) 2114
identification (2085) 2085
genes (2078) 2078
oxidative stress (2052) 2052
base sequence (2046) 2046
rodents (2044) 2044
rna, messenger - metabolism (2043) 2043
time factors (1975) 1975
aged (1949) 1949
receptor (1943) 1943
intracellular (1937) 1937
gene expression regulation (1935) 1935
binding (1929) 1929
models, biological (1923) 1923
in-vivo (1921) 1921
pharmacology & pharmacy (1894) 1894
syk kinase (1888) 1888
protein-tyrosine kinases - metabolism (1880) 1880
proteins - metabolism (1841) 1841
developmental biology (1840) 1840
protein structure, tertiary (1839) 1839
inhibition (1818) 1818
inflammation (1813) 1813
endocrinology & metabolism (1810) 1810
neurons - metabolism (1810) 1810
enzyme inhibitors - pharmacology (1803) 1803
growth (1772) 1772
binding sites (1771) 1771
phosphoproteins - metabolism (1731) 1731
membrane proteins (1725) 1725
enzyme activation (1714) 1714
health aspects (1702) 1702
biochemistry (1701) 1701
peptides (1691) 1691
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (11) 11
Online Resources - Online (5) 5
Collection Dvlpm't (Acquisitions) - Vendor file (3) 3
UofT at Mississauga - Stacks (3) 3
UofT at Scarborough - Stacks (2) 2
Chemistry (A D Allen) - Stacks (1) 1
Earth Sciences (Noranda) - Circulation Desk (1) 1
Earth Sciences (Noranda) - Oversize (1) 1
Earth Sciences (Noranda) - Stacks (1) 1
Gerstein Science - Circulation Desk (1) 1
Gerstein Science - Reserve desk (1) 1
St Josephs Health Centre - Stacks (1) 1
St. Michael's College (John M. Kelly) - 2nd Floor (1) 1
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (1) 1
Trinity College (John W Graham) - Stacks (1) 1
UofT at Mississauga - Circulation Desk (1) 1
Victoria University E.J. Pratt - Circulation Desk (1) 1
Victoria University E.J. Pratt - Oversize (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (48194) 48194
Japanese (518) 518
Chinese (436) 436
French (85) 85
Russian (73) 73
Spanish (43) 43
Polish (30) 30
German (29) 29
Hungarian (12) 12
Italian (8) 8
Czech (7) 7
Danish (7) 7
Korean (5) 5
Portuguese (4) 4
Ukrainian (3) 3
Dutch (2) 2
Romanian (2) 2
Swedish (2) 2
Finnish (1) 1
Hebrew (1) 1
Norwegian (1) 1
Serbian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0177516
... successful cell-therapy for muscle disorders. Here we expanded mouse muscle stem cells and human myoblasts with Notch ligands, DLL1, DLL4, and JAG1 to activate Notch signaling in vitro and to investigate whether these cells could retain... 
PROGENITOR CELLS | SATELLITE CELL NICHE | MESENCHYMAL PROGENITORS | GENE | MYOD | MULTIDISCIPLINARY SCIENCES | EXPANSION | SELF-RENEWAL | DUCHENNE MUSCULAR-DYSTROPHY | HUMAN SKELETAL-MUSCLE | TRANSPLANTATION | Immunohistochemistry | Jagged-1 Protein - metabolism | MyoD Protein - genetics | Receptors, Notch - metabolism | PAX7 Transcription Factor - genetics | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | PAX7 Transcription Factor - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Cell Differentiation - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Myoblasts - metabolism | Regeneration - genetics | Myoblasts - cytology | Membrane Proteins - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Real-Time Polymerase Chain Reaction | Membrane Proteins - genetics | Muscle Development - physiology | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | MyoD Protein - metabolism | Signal Transduction - genetics | Regeneration - physiology | Jagged-1 Protein - genetics | Muscle Cells - cytology | Animals | Muscle Development - genetics | Signal Transduction - physiology | Mice | Transplantation | Research | Health aspects | Ligands (Biochemistry) | Analysis | Stem cells | Musculoskeletal diseases | Musculoskeletal system | Cell culture | MyoD protein | Allografts | Cell number | Stem cell transplantation | Ligands | Notch protein | Gene expression | Myoblasts | Signal Transduction | Intercellular Signaling Peptides and Proteins | PAX7 Transcription Factor | Intracellular Signaling Peptides and Proteins | Cellular Biology | Stem Cells | Membrane Proteins | Life Sciences | Regeneration | Muscle Development | Receptors, Notch | Cell Differentiation | Muscle Cells | MyoD Protein | Jagged-1 Protein
Journal Article
Molecular Cell, ISSN 1097-2765, 2005, Volume 20, Issue 6, pp. 939 - 949
The death-inducing signaling complex (DISC) comprising Fas, Fas-associated death domain (FADD... 
RECEPTOR SIGNALS | APOPTOSIS | INDUCED-PROXIMITY MODEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NMR STRUCTURE | DEATH-EFFECTOR DOMAIN | CASPASE ACTIVATION | CONTAINING PROTEIN | SIGNALING COMPLEX DISC | CELL-DEATH | PYRIN DOMAIN | CELL BIOLOGY | Caspase 8 | Humans | Multiprotein Complexes | Molecular Sequence Data | Crystallography, X-Ray | Intracellular Signaling Peptides and Proteins - metabolism | fas Receptor - metabolism | Viral Proteins - metabolism | Death Domain Receptor Signaling Adaptor Proteins | Caspases - metabolism | Molluscum contagiosum virus - genetics | Caspase 10 | fas Receptor - genetics | Intracellular Signaling Peptides and Proteins - genetics | Amino Acid Sequence | Caspases - genetics | Viral Proteins - chemistry | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Models, Molecular | Viral Proteins - genetics | Fas-Associated Death Domain Protein | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - chemistry | Sequence Alignment | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Molluscum contagiosum virus - chemistry | Protein Conformation | CASP8 and FADD-Like Apoptosis Regulating Protein | Apoptosis - physiology | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Proteins | Oligomers | Structure | Crystals
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 32, pp. 11212 - 11217
Genetic studies have shown that ubiquitination and endocytosis of the Drosophila ligand Delta in signal-sending cells are required for activation of Notch signaling, but how these events promote Notch... 
T lymphocytes | Molecules | Endocytosis | Receptors | Cell lines | HeLa cells | Antibodies | Ligands | Lipids | Recycling | Ubiquitination | Membrane microdomains | Transendocytosis | Membrane Microdomains - metabolism | Membrane Proteins - genetics | Drosophila | Humans | Intercellular Signaling Peptides and Proteins - genetics | Protein Transport - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Receptor, Notch1 - metabolism | Recombinant Fusion Proteins - metabolism | Endocytosis - physiology | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Membrane Proteins - metabolism | Mice | HeLa Cells | Ubiquitination - physiology | Receptor, Notch1 - genetics | Intracellular Signaling Peptides and Proteins - genetics | Membrane Microdomains - genetics | Physiological aspects | Cellular signal transduction | Genetic aspects | Ligands (Biochemistry) | Membrane Microdomains | Signal Transduction | Intercellular Signaling Peptides and Proteins | Biochemistry, Molecular Biology | Intracellular Signaling Peptides and Proteins | Recombinant Fusion Proteins | Protein Transport | Membrane Proteins | Life Sciences | Receptor, Notch1 | Molecular biology | Hela Cells | Biological Sciences | recycling | transendocytosis | membrane microdomains | ubiquitination
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2011, Volume 286, Issue 9, pp. 7018 - 7026
The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by phosphorylating them for cytoplasmic sequestration or degradation. In... 
YES-ASSOCIATED PROTEIN | EPITHELIAL-MESENCHYMAL TRANSITION | CELL CONTACT INHIBITION | WW DOMAIN | GROWTH-CONTROL | ORGAN SIZE CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ONCOGENIC TRANSFORMATION | BINDING | CANCER | Adaptor Proteins, Signal Transducing - chemistry | Protein Interaction Domains and Motifs - physiology | Humans | Intercellular Signaling Peptides and Proteins - chemistry | Cytoplasm - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Intercellular Signaling Peptides and Proteins - metabolism | HEK293 Cells | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein Structure, Tertiary | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Phosphoproteins - genetics | Cell Division - physiology | Transcription, Genetic - physiology | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Connective Tissue Growth Factor - genetics | Adaptor Proteins, Signal Transducing - metabolism | Connective Tissue Growth Factor - metabolism | Gene Transcription | Transcription Coactivators | Signal Transduction | AmotL1 | YAP | Transcription Factors | Serine Threonine Protein Kinase | Hippo Pathway | TAZ | Amot
Journal Article
Journal Article
Gastroenterology, ISSN 0016-5085, 2011, Volume 140, Issue 4, pp. 1230 - 1240.e7
Background & Aims Ablation of Notch signaling within the intestinal epithelium results in loss of proliferating crypt progenitors due to their conversion into postmitotic secretory cells... 
Gastroenterology and Hepatology | Gene Regulation | GI Development | Knockout Mice | Intestinal Stem Cells | RECOMBINATION | GAMMA-SECRETASE INHIBITORS | SELF-RENEWAL | KLF4 | INHIBITS TUMOR-GROWTH | GENE | PATHWAY | IN-VIVO | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Intestinal Mucosa - metabolism | Receptors, G-Protein-Coupled - metabolism | Cell Count | Intracellular Signaling Peptides and Proteins - metabolism | Intestinal Mucosa - cytology | Intercellular Signaling Peptides and Proteins - metabolism | Kruppel-Like Transcription Factors - metabolism | Serrate-Jagged Proteins | Membrane Proteins - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Adult Stem Cells - cytology | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch1 - metabolism | Goblet Cells - metabolism | Mice, Knockout | Cell Division - physiology | Adult Stem Cells - metabolism | Animals | Homeostasis - physiology | Signal Transduction - physiology | Mice | Receptor, Notch1 - genetics | Kruppel-Like Transcription Factors - genetics | Calcium-Binding Proteins - genetics | Goblet Cells - cytology | GI development | knockout mice | gene regulation | intestinal stem cells
Journal Article
Nature (London), ISSN 1476-4687, 2009, Volume 459, Issue 7245, pp. 433 - 436
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 4, pp. 1273 - 1278
The COP9 (Constitutive photomorphogenesis 9) signalosome (CSN), a large multiprotein complex that resembles the 19S lid of the 26S proteasome, plays a central... 
Proteins | Molecules | Enzymes | Active sites | Ubiquitins | Crystals | Dimers | Gene expression regulation | Zinc | Crystal structure | COMPLEX | DOMAIN | JAB1/CSN5 | DROSOPHILA-MELANOGASTER | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | Rpn11 |