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Molecular cell, ISSN 1097-2765, 2005, Volume 20, Issue 6, pp. 939 - 949
The death-inducing signaling complex (DISC) comprising Fas, Fas-associated death domain (FADD... 
RECEPTOR SIGNALS | APOPTOSIS | INDUCED-PROXIMITY MODEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NMR STRUCTURE | DEATH-EFFECTOR DOMAIN | CASPASE ACTIVATION | CONTAINING PROTEIN | SIGNALING COMPLEX DISC | CELL-DEATH | PYRIN DOMAIN | CELL BIOLOGY | Caspase 8 | Humans | Multiprotein Complexes | Molecular Sequence Data | Crystallography, X-Ray | Intracellular Signaling Peptides and Proteins - metabolism | fas Receptor - metabolism | Viral Proteins - metabolism | Death Domain Receptor Signaling Adaptor Proteins | Caspases - metabolism | Molluscum contagiosum virus - genetics | Caspase 10 | fas Receptor - genetics | Intracellular Signaling Peptides and Proteins - genetics | Amino Acid Sequence | Caspases - genetics | Viral Proteins - chemistry | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Models, Molecular | Viral Proteins - genetics | Fas-Associated Death Domain Protein | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - chemistry | Sequence Alignment | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Molluscum contagiosum virus - chemistry | Protein Conformation | CASP8 and FADD-Like Apoptosis Regulating Protein | Apoptosis - physiology | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Proteins | Oligomers | Structure | Crystals
Journal Article
Nature (London), ISSN 1476-4687, 2009, Volume 459, Issue 7245, pp. 433 - 436
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2007, Volume 104, Issue 16, pp. 6519 - 6526
Two classes of sterols, cholesterol and oxysterols, block export of sterol regulatory element-binding proteins (SREBPs... 
Transfection | Sterols | Plasmids | Cell lines | Antibodies | Amino acids | Cell membranes | CHO cells | Cholesterols | P branes | COPII vesicles | Cholesterol homeostasis | Oxysterols | SREBP pathway | COAT | cholesterol homeostasis | COENZYME-A REDUCTASE | CHOLESTEROL | oxysterols | MULTIDISCIPLINARY SCIENCES | CLEAVAGE-ACTIVATING PROTEIN | INHIBITION | ER MEMBRANES | HAMSTER OVARY CELLS | SENSING DOMAIN | BINDING | VESICLE | Protein Sorting Signals - physiology | Cricetulus | Vesicular Transport Proteins - metabolism | Humans | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - immunology | Protein Transport - physiology | Antibodies, Blocking - pharmacology | Intracellular Signaling Peptides and Proteins - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Vesicular Transport Proteins - antagonists & inhibitors | Clone Cells | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | CHO Cells | Amino Acid Sequence | Cricetinae | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | COP-Coated Vesicles - metabolism | Membrane Proteins - immunology | Sterol Regulatory Element Binding Proteins - metabolism | Animals | Membrane Proteins - antagonists & inhibitors | Golgi Apparatus - metabolism | Intracellular Signaling Peptides and Proteins - physiology | Homeostasis | Research | Endoplasmic reticulum | Biological Sciences
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2010, Volume 120, Issue 8, pp. 2858 - 2866
Journal Article
Developmental cell, ISSN 1534-5807, 2010, Volume 18, Issue 2, pp. 300 - 308
...) transcription coactivator. The FERM domain proteins Merlin (Mer) and Expanded (Ex) represent one mode of upstream regulation controlling pathway activity... 
CELLBIO | DEVBIO | SIGNALING | APOPTOSIS | WARTS-HIPPO PATHWAY | GROWTH | GENES | PROTEIN-PROTEIN INTERACTIONS | CELL-PROLIFERATION | HOMOLOG | DEVELOPMENTAL BIOLOGY | PROMOTES | DROSOPHILA | AXIS SPECIFICATION | CELL BIOLOGY | Neurofibromin 2 - genetics | Protein Kinases - genetics | Cell Proliferation | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Drosophila - physiology | Drosophila Proteins - physiology | RNA Interference | Gene Expression Regulation, Developmental | Membrane Proteins - physiology | Base Sequence | Tumor Suppressor Proteins - genetics | Ovarian Follicle - physiology | Cell Cycle Proteins - genetics | Female | Ovarian Follicle - cytology | Drosophila Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - genetics | Drosophila - genetics | Signal Transduction | Animals, Genetically Modified | Membrane Proteins - genetics | Protein-Serine-Threonine Kinases - physiology | Protein-Serine-Threonine Kinases - genetics | Neurofibromin 2 - physiology | Tumor Suppressor Proteins - physiology | Phenotype | Animals | Epistasis, Genetic | Protein Kinases - physiology | Drosophila - growth & development | Drosophila Proteins - genetics | Intracellular Signaling Peptides and Proteins - physiology | Cell Cycle Proteins - physiology | Apoptosis | Proteins | Research | Oncology, Experimental | Cancer | Short
Journal Article
Oncogene, ISSN 1476-5594, 2007, Volume 26, Issue 32, pp. 4635 - 4647
...). APBs are PML bodies containing telomeric DNA and telomere-binding proteins, and are observed only in a small fraction of cells within asynchronously dividing ALT-positive cell populations... 
Telomeres | siRNA | Alternative lengthening of telomeres | Methionine restriction | PML | ALT-associated PML bodies | CANCER-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | telomeres | DNA-DAMAGE | MAMMALIAN-CELLS | PROTEIN COMPLEX | CELL BIOLOGY | HUMAN RAP1 | METABOLIC DEFECT | LARGE-BODY FORMATION | NUCLEAR-BODIES | ONCOLOGY | alternative lengthening of telomeres | methionine restriction | GENETICS & HEREDITY | PROMYELOCYTIC LEUKEMIA BODIES | TUMOR-CELL-LINES | Humans | Neoplasm Proteins - antagonists & inhibitors | Resting Phase, Cell Cycle | Autoantigens - genetics | RNA Interference | Neoplasm Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Telomeric Repeat Binding Protein 2 - antagonists & inhibitors | DNA Repair Enzymes - physiology | DNA-Binding Proteins - physiology | DNA-Binding Proteins - antagonists & inhibitors | Telomeric Repeat Binding Protein 2 - physiology | Genetic Techniques | Autoantigens - physiology | Tumor Suppressor Proteins - physiology | G1 Phase | Cell Line, Tumor | Intracellular Signaling Peptides and Proteins - physiology | Cell Cycle Proteins - physiology | Telomeric Repeat Binding Protein 1 - physiology | Tumor Suppressor Proteins - antagonists & inhibitors | Neoplasm Proteins - physiology | DNA Repair Enzymes - genetics | Telomeric Repeat Binding Protein 1 - genetics | Cell Cycle Proteins - antagonists & inhibitors | MRE11 Homologue Protein | Telomere-Binding Proteins - genetics | Tumor Suppressor Proteins - genetics | Telomere-Binding Proteins - physiology | Cell Cycle Proteins - genetics | Telomere - metabolism | DNA Repair Enzymes - antagonists & inhibitors | Nuclear Proteins - genetics | Methionine - deficiency | Telomere - genetics | Transcription Factors - physiology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Antigens, Nuclear - physiology | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Telomere-Binding Proteins - antagonists & inhibitors | Antigens, Nuclear - genetics | Nuclear Proteins - antagonists & inhibitors | Telomeric Repeat Binding Protein 1 - antagonists & inhibitors | Cell Proliferation - drug effects | Nuclear Proteins - physiology | Telomeric Repeat Binding Protein 2 - genetics | Tumor Suppressor p53-Binding Protein 1 | Promyelocytic Leukemia Protein | Physiological aspects | Genetic aspects | Research | Cancer cells | Proteins | Ribonucleic acid | Cell cycle | Genetics | Oncology | Ribonucleic acid--RNA | DNA repair | Cancer
Journal Article
Nature communications, ISSN 2041-1723, 2016, Volume 7, Issue 1, p. 11215
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 6, p. e98896
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 10/2015, Volume 75, Issue 19, pp. 4086 - 4096
.... In this study, we report the development of REGN421 (enoticumab), a fully human IgG1 monoclonal antibody that binds human Dll4 with sub-nanomolar affinity and inhibits Notch signaling... 
ANGIOGENESIS | ONCOLOGY | ENDOTHELIAL-CELLS | IN-VIVO | BLOOD-VESSELS | NOTCH | RESISTANCE | ANTI-VEGF THERAPY | UP-REGULATION | LIGAND 4 DLL4 | INHIBITS TUMOR-GROWTH | Species Specificity | Humans | Neoplasm Proteins - physiology | Antibodies, Monoclonal - therapeutic use | Intracellular Signaling Peptides and Proteins - immunology | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Molecular Targeted Therapy | Intercellular Signaling Peptides and Proteins - physiology | Stromal Cells - drug effects | Angiogenesis Inhibitors - therapeutic use | Female | Antineoplastic Agents - pharmacology | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - blood supply | Intracellular Signaling Peptides and Proteins - genetics | Ovarian Neoplasms - drug therapy | Endothelial Cells - metabolism | Membrane Proteins - genetics | Antibodies, Monoclonal - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Stromal Cells - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Angiogenesis Inhibitors - pharmacology | Receptors, Notch - physiology | Membrane Proteins - immunology | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Neovascularization, Pathologic - drug therapy | Mice | Intercellular Signaling Peptides and Proteins - immunology | Endothelial Cells - drug effects
Journal Article
Cancer cell, ISSN 1535-6108, 2012, Volume 22, Issue 5, pp. 668 - 682
Journal Article