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Nature Communications, ISSN 2041-1723, 04/2016, Volume 7, Issue 1, pp. 11215 - 11215
Journal Article
Nature, ISSN 0028-0836, 05/2009, Volume 459, Issue 7245, pp. 433 - 436
Fungal infections represent a serious threat, particularly in immunocompromised patients. Interleukin-1 (IL-1 ) is a key pro-inflammatory factor in innate... 
RHEUMATOID-ARTHRITIS | CELLS | ACTIVATION | CANDIDA-ALBICANS | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | INNATE IMMUNE-RESPONSE | RECEPTOR | MICE | INHIBITOR | NALP3 INFLAMMASOME | Potassium - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Humans | Caspase 1 - metabolism | Monocytes - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Protein-Tyrosine Kinases - deficiency | Intracellular Signaling Peptides and Proteins - deficiency | Protein-Tyrosine Kinases - genetics | Candida albicans - physiology | Interleukin-1beta - biosynthesis | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | Signal Transduction | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Interleukin-1beta - immunology | Inflammation - immunology | Candida albicans - immunology | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Mice | Nigericin - pharmacology | Enzyme Activation | Protein-Tyrosine Kinases - antagonists & inhibitors | Mycoses | Research | Properties | Phosphotransferases | Cellular control mechanisms | Proteins | Studies | Fungi | E coli | Research & development--R&D | Clinical trials | Pattern recognition | Kinases | Cells | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2015, Volume 59, Issue 2, pp. 285 - 297
Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. ULK1/Atg1 is the... 
MAMMALIAN TARGET | COMPLEX | POTENT | PROTEIN | ATG101 | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMPK | CANCER | BINDING | MTOR | DIRECT PHOSPHORYLATION | CELL BIOLOGY | Consensus Sequence | Protein-Serine-Threonine Kinases - deficiency | RNA, Small Interfering - genetics | Phosphorylation | Humans | Molecular Sequence Data | Substrate Specificity | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy - drug effects | Pyrimidines - chemistry | Autophagy-Related Protein-1 Homolog | Protein Kinase Inhibitors - chemistry | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Benzamides - pharmacology | Intracellular Signaling Peptides and Proteins - genetics | Cell Survival - physiology | Protein-Serine-Threonine Kinases - metabolism | Benzamides - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Survival - drug effects | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Catalytic Domain - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Pyrimidines - pharmacology | Gene Knockout Techniques | Animals | Mice | Protein Kinase Inhibitors - pharmacology | Proteins | Medical colleges | Medical research | Cell death | Medicine, Experimental | Cellular signal transduction | Research institutes | Cells | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 2005, Volume 20, Issue 6, pp. 939 - 949
The death-inducing signaling complex (DISC) comprising Fas, Fas-associated death domain (FADD), and caspase-8/10 is assembled via homotypic associations... 
RECEPTOR SIGNALS | APOPTOSIS | INDUCED-PROXIMITY MODEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NMR STRUCTURE | DEATH-EFFECTOR DOMAIN | CASPASE ACTIVATION | CONTAINING PROTEIN | SIGNALING COMPLEX DISC | CELL-DEATH | PYRIN DOMAIN | CELL BIOLOGY | Caspase 8 | Humans | Multiprotein Complexes | Molecular Sequence Data | Crystallography, X-Ray | Intracellular Signaling Peptides and Proteins - metabolism | fas Receptor - metabolism | Viral Proteins - metabolism | Death Domain Receptor Signaling Adaptor Proteins | Caspases - metabolism | Molluscum contagiosum virus - genetics | Caspase 10 | fas Receptor - genetics | Intracellular Signaling Peptides and Proteins - genetics | Amino Acid Sequence | Caspases - genetics | Viral Proteins - chemistry | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Models, Molecular | Viral Proteins - genetics | Fas-Associated Death Domain Protein | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - chemistry | Sequence Alignment | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Molluscum contagiosum virus - chemistry | Protein Conformation | CASP8 and FADD-Like Apoptosis Regulating Protein | Apoptosis - physiology | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Proteins | Oligomers | Structure | Crystals | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2010, Volume 120, Issue 8, pp. 2858 - 2866
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2010, Volume 285, Issue 17, pp. 13107 - 13120
Journal Article
Developmental Biology, ISSN 0012-1606, 10/2014, Volume 394, Issue 1, pp. 142 - 155
Specification of the trophectoderm (TE) and inner cell mass (ICM) lineages in the mouse blastocyst correlates with cell position, as TE derives from outer... 
Trophectoderm | Cell lineage | YAP | Cell polarity | CDX2 | Inner cell mass | LINEAGE DIFFERENTIATION | PREIMPLANTATION EMBRYO | STEM-CELLS | KINASE | EPITHELIAL POLARITY | FATE SPECIFICATION | DEVELOPMENTAL BIOLOGY | BINDING PROTEIN RHO | YAP PATHWAY | rho GTP-Binding Proteins - antagonists & inhibitors | Tumor Suppressor Proteins - antagonists & inhibitors | rho-Associated Kinases - antagonists & inhibitors | Ectoderm - metabolism | RNA Interference | rho-Associated Kinases - metabolism | Gene Expression Regulation, Developmental | Tumor Suppressor Proteins - genetics | Mice, Inbred DBA | Cell Differentiation | Protein-Serine-Threonine Kinases - metabolism | Amides - pharmacology | Homeodomain Proteins - biosynthesis | Nanog Homeobox Protein | Phosphoproteins - biosynthesis | Signal Transduction | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - biosynthesis | Protein Kinase C - antagonists & inhibitors | Cell Lineage | Animals | Blastocyst Inner Cell Mass - metabolism | Homeodomain Proteins - antagonists & inhibitors | rho GTP-Binding Proteins - metabolism | Cell Polarity - physiology | Adaptor Proteins, Signal Transducing - biosynthesis | Mice | Pyridines - pharmacology | RNA, Small Interfering | CDX2 Transcription Factor | G proteins | Index Medicus | trophectoderm | cell polarity | cell lineage
Journal Article
International Journal of Cancer, ISSN 0020-7136, 04/2012, Volume 130, Issue 7, pp. 1695 - 1705
Lung cancer is one of the most commonly occurring malignancies. It has been reported that mammalian target of rapamycin (mTOR) is phosphorylated in lung cancer... 
lung cancer | signaling | PI3K | fisetin | mTOR | Akt | flavonoid | dual inhibition | ACTIVATED PROTEIN-KINASE | CYCLE ARREST | KAPPA-B | TUBEROUS-SCLEROSIS | ONCOLOGY | PROSTATE-CANCER | GROWTH | TUMOR-SUPPRESSOR | MTOR INHIBITORS | PI3K/AKT/MTOR PATHWAY | EXPRESSION | Protein Kinases - metabolism | Lung Neoplasms - drug therapy | TOR Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - antagonists & inhibitors | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Lung Neoplasms - metabolism | Eukaryotic Initiation Factor-4E - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Regulatory-Associated Protein of mTOR | Flavonoids - pharmacology | Phosphorylation - drug effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Tumor Suppressor Proteins - metabolism | Lung Neoplasms - enzymology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | MTOR Associated Protein, LST8 Homolog | Carcinoma, Non-Small-Cell Lung - metabolism | Carrier Proteins - antagonists & inhibitors | PTEN Phosphohydrolase - metabolism | Eukaryotic Initiation Factor-4E - antagonists & inhibitors | Carrier Proteins - metabolism | Cell Line, Tumor | Stem Cells - drug effects | Cell Proliferation - drug effects | Carcinoma, Non-Small-Cell Lung - drug therapy | Adaptor Proteins, Signal Transducing - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Kinases | Phosphorylation | Lung cancer | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 04/2013, Volume 32, Issue 14, pp. 1821 - 1830
The Salvador/Warts/Hippo (Hippo) signaling pathway defines a novel signaling cascade regulating cell contact inhibition, organ size control, cell growth,... 
KIBRA | Willin | breast cancer | Hippo pathway | Merlin | claudin-low | APOPTOSIS | PROTEIN | ORGAN SIZE CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | YAP | PROLIFERATION | DROSOPHILA | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER CELLS | ONCOGENE | ONCOLOGY | CYCLE EXIT | GENETICS & HEREDITY | RNA, Small Interfering - genetics | Neurofibromin 2 - genetics | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Cytoskeletal Proteins - genetics | Humans | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Immunoenzyme Techniques | Hepatocyte Growth Factor - antagonists & inhibitors | Biomarkers, Tumor - metabolism | Hepatocyte Growth Factor - genetics | Carcinoma, Ductal, Breast - pathology | Carcinoma, Ductal, Breast - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Real-Time Polymerase Chain Reaction | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Breast - cytology | Membrane Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Blotting, Western | Hepatocyte Growth Factor - metabolism | Breast Neoplasms - genetics | Claudin-1 - genetics | Biomarkers, Tumor - genetics | Cell Movement | Carcinoma, Ductal, Breast - genetics | Phosphorylation | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | Breast - metabolism | Breast Neoplasms - metabolism | Claudin-1 - metabolism | Epithelial-Mesenchymal Transition | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cytoskeletal Proteins - metabolism | Female | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Neurofibromin 2 - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Transcription Factors - antagonists & inhibitors | Phosphoproteins - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Breast Neoplasms - pathology | Nuclear Proteins - antagonists & inhibitors | Apoptosis | Cellular proteins | Prognosis | Physiological aspects | Breast cancer | Genetic aspects | Cellular signal transduction | Research | Health aspects | Mammals | Gene expression | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7381, pp. 329 - 334
Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated by the biallelic loss of RB1. Tumours progress very quickly... 
ANEUPLOIDY | CELLS | GENE | TYROSINE KINASE | MCL-1 | MULTIDISCIPLINARY SCIENCES | GROWTH | TUMOR | SYK INHIBITOR | CANCER | Retinoblastoma - genetics | Protein-Tyrosine Kinases - metabolism | Genomics | Humans | Retinoblastoma - drug therapy | Gene Expression Regulation, Neoplastic | Aneuploidy | Intracellular Signaling Peptides and Proteins - metabolism | Genes, Retinoblastoma - genetics | Molecular Targeted Therapy | Retinoblastoma - pathology | Protein-Tyrosine Kinases - genetics | Cell Death - drug effects | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Cell Line | Cell Survival - drug effects | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Retinoblastoma Protein - deficiency | Mutation - genetics | Sequence Analysis, DNA | Xenograft Model Antitumor Assays | Chromosomal Instability - genetics | Animals | Epigenesis, Genetic - genetics | Protein Kinase Inhibitors - therapeutic use | Retinoblastoma Protein - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | Gene mutations | Development and progression | Genetic aspects | Diagnosis | Research | Retinoblastoma | Gene therapy | Health aspects | Risk factors | Studies | Human subjects | Epigenetics | DNA methylation | Genomes | Mutation | Kinases | Experiments | Chromosomes | Cancer |