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Nature immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
.... Here we found that signaling pathways dependent on the kinases Syk and Jnk were required for the activation of caspase-1 via the ASC-dependent inflammasomes NLRP3 and AIM2... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases
Journal Article
PloS one, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0177516
... successful cell-therapy for muscle disorders. Here we expanded mouse muscle stem cells and human myoblasts with Notch ligands, DLL1, DLL4, and JAG1 to activate Notch signaling in vitro and to investigate whether these cells could retain... 
PROGENITOR CELLS | SATELLITE CELL NICHE | MESENCHYMAL PROGENITORS | GENE | MYOD | MULTIDISCIPLINARY SCIENCES | EXPANSION | SELF-RENEWAL | DUCHENNE MUSCULAR-DYSTROPHY | HUMAN SKELETAL-MUSCLE | TRANSPLANTATION | Immunohistochemistry | Jagged-1 Protein - metabolism | MyoD Protein - genetics | Receptors, Notch - metabolism | PAX7 Transcription Factor - genetics | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | PAX7 Transcription Factor - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Cell Differentiation - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Myoblasts - metabolism | Regeneration - genetics | Myoblasts - cytology | Membrane Proteins - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Real-Time Polymerase Chain Reaction | Membrane Proteins - genetics | Muscle Development - physiology | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | MyoD Protein - metabolism | Signal Transduction - genetics | Regeneration - physiology | Jagged-1 Protein - genetics | Muscle Cells - cytology | Animals | Muscle Development - genetics | Signal Transduction - physiology | Mice | Transplantation | Research | Health aspects | Ligands (Biochemistry) | Analysis | Stem cells | Musculoskeletal diseases | Musculoskeletal system | Cell culture | MyoD protein | Allografts | Cell number | Stem cell transplantation | Ligands | Notch protein | Gene expression | Myoblasts | Signal Transduction | Intercellular Signaling Peptides and Proteins | PAX7 Transcription Factor | Intracellular Signaling Peptides and Proteins | Cellular Biology | Stem Cells | Membrane Proteins | Life Sciences | Regeneration | Muscle Development | Receptors, Notch | Cell Differentiation | Muscle Cells | MyoD Protein | Jagged-1 Protein
Journal Article
Molecular cell, ISSN 1097-2765, 2005, Volume 20, Issue 6, pp. 939 - 949
The death-inducing signaling complex (DISC) comprising Fas, Fas-associated death domain (FADD... 
RECEPTOR SIGNALS | APOPTOSIS | INDUCED-PROXIMITY MODEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NMR STRUCTURE | DEATH-EFFECTOR DOMAIN | CASPASE ACTIVATION | CONTAINING PROTEIN | SIGNALING COMPLEX DISC | CELL-DEATH | PYRIN DOMAIN | CELL BIOLOGY | Caspase 8 | Humans | Multiprotein Complexes | Molecular Sequence Data | Crystallography, X-Ray | Intracellular Signaling Peptides and Proteins - metabolism | fas Receptor - metabolism | Viral Proteins - metabolism | Death Domain Receptor Signaling Adaptor Proteins | Caspases - metabolism | Molluscum contagiosum virus - genetics | Caspase 10 | fas Receptor - genetics | Intracellular Signaling Peptides and Proteins - genetics | Amino Acid Sequence | Caspases - genetics | Viral Proteins - chemistry | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Models, Molecular | Viral Proteins - genetics | Fas-Associated Death Domain Protein | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - chemistry | Sequence Alignment | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Molluscum contagiosum virus - chemistry | Protein Conformation | CASP8 and FADD-Like Apoptosis Regulating Protein | Apoptosis - physiology | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Proteins | Oligomers | Structure | Crystals
Journal Article
PLoS genetics, ISSN 1553-7404, 2018, Volume 14, Issue 8, p. e1007592
Yeast WHI2 was originally identified in a genetic screen for regulators of cell cycle arrest and later suggested to function in general stress responses... 
YEAST SACCHAROMYCES-CEREVISIAE | COMPLEX | SHUTTLE VECTORS | RAG GTPASES | GENE | SIGNALING PATHWAY | GENETICS & HEREDITY | PROTEIN S6 PHOSPHORYLATION | CELL-PROLIFERATION | MTORC1 PATHWAY | MITOCHONDRIAL FISSION | Chlorocebus aethiops | Membrane Proteins - genetics | Saccharomyces cerevisiae - genetics | Humans | Phosphoprotein Phosphatases - metabolism | Gene Expression Regulation | Intracellular Signaling Peptides and Proteins - metabolism | Monomeric GTP-Binding Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | Saccharomyces cerevisiae - metabolism | Transcription Factors - metabolism | Amino Acids - metabolism | Animals | Phosphoprotein Phosphatases - genetics | Monomeric GTP-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Membrane Proteins - metabolism | COS Cells | Intracellular Signaling Peptides and Proteins - genetics | Amino acids | Usage | Research | Genetic screening | Cell cycle | Protein kinase A | Yeast | Laboratories | Funding | Genes | Kinases | Neurological diseases | Proteins | Cell growth | Immunology | Mutation | Pharmaceutical sciences | Public health | Cancer | Biotechnology | Populations and Evolution | Biochemistry, Molecular Biology | Genomics | Membrane Proteins/genetics | Cercopithecus aethiops | Transcription Factors/genetics | Cellular Biology | Biodiversity | Life Sciences | Transcription Factors/metabolism | Membrane Proteins/metabolism | Intracellular Signaling Peptides and Proteins/genetics | Computer Science | Biomolecules | Genetics | Intracellular Signaling Peptides and Proteins/metabolism | Subcellular Processes | Molecular biology | Bioinformatics
Journal Article
eLife, ISSN 2050-084X, 2015, Volume 4, Issue MAY, p. e06114
...). Here, we report that cytonemes also link flight muscle progenitors (myoblasts) to disc cells and to the ASP, enabling myoblasts to relay signaling between the disc and the ASP. Frizzled (Fz... 
TRANSPORT | PROTEIN | FUSION | PATTERN | EPITHELIUM | BIOLOGY | GENE-EXPRESSION | CELL-PROLIFERATION | MORPHOGEN GRADIENT | DROSOPHILA | RANGE | Wings, Animal - cytology | Wnt1 Protein - genetics | Receptors, Notch - metabolism | Fibroblast Growth Factors - genetics | Receptors, Notch - genetics | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Wnt1 Protein - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Fibroblast Growth Factors - metabolism | Myoblasts - metabolism | Imaginal Discs - cytology | Wings, Animal - growth & development | Gene Expression Regulation, Developmental | Air Sacs - cytology | Larva - growth & development | Imaginal Discs - growth & development | Myoblasts - cytology | Larva - genetics | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Genes, Reporter | Green Fluorescent Proteins - metabolism | Air Sacs - metabolism | Signal Transduction | Membrane Proteins - genetics | Air Sacs - growth & development | Larva - metabolism | Frizzled Receptors - metabolism | Protein Transport | Wings, Animal - metabolism | Animals | Frizzled Receptors - genetics | Embryo, Nonmammalian | Imaginal Discs - metabolism | Drosophila melanogaster - growth & development | Luminescent Proteins - genetics | Drosophila Proteins - genetics | Body Patterning - genetics | Luminescent Proteins - metabolism | Fibroblast growth factor | Flight muscle | Frizzled protein | Flight | Muscles | Thorax | Diversification | Myoblasts | Studies | Signal transduction | Microscopy | Insects | Stem cells | Notch protein
Journal Article
Developmental cell, ISSN 1534-5807, 2010, Volume 18, Issue 2, pp. 300 - 308
...) transcription coactivator. The FERM domain proteins Merlin (Mer) and Expanded (Ex) represent one mode of upstream regulation controlling pathway activity... 
CELLBIO | DEVBIO | SIGNALING | APOPTOSIS | WARTS-HIPPO PATHWAY | GROWTH | GENES | PROTEIN-PROTEIN INTERACTIONS | CELL-PROLIFERATION | HOMOLOG | DEVELOPMENTAL BIOLOGY | PROMOTES | DROSOPHILA | AXIS SPECIFICATION | CELL BIOLOGY | Neurofibromin 2 - genetics | Protein Kinases - genetics | Cell Proliferation | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Drosophila - physiology | Drosophila Proteins - physiology | RNA Interference | Gene Expression Regulation, Developmental | Membrane Proteins - physiology | Base Sequence | Tumor Suppressor Proteins - genetics | Ovarian Follicle - physiology | Cell Cycle Proteins - genetics | Female | Ovarian Follicle - cytology | Drosophila Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - genetics | Drosophila - genetics | Signal Transduction | Animals, Genetically Modified | Membrane Proteins - genetics | Protein-Serine-Threonine Kinases - physiology | Protein-Serine-Threonine Kinases - genetics | Neurofibromin 2 - physiology | Tumor Suppressor Proteins - physiology | Phenotype | Animals | Epistasis, Genetic | Protein Kinases - physiology | Drosophila - growth & development | Drosophila Proteins - genetics | Intracellular Signaling Peptides and Proteins - physiology | Cell Cycle Proteins - physiology | Apoptosis | Proteins | Research | Oncology, Experimental | Cancer | Short
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 130 - 17
.... Multiple signalling pathways can affect the normal function of stromal fibroblasts in tumours, but how these events are coordinated to generate tumour-promoting cancer-associated fibroblasts (CAFs... 
BREAST-CANCER | INVASION | METASTASIS | INHIBITION | MICROENVIRONMENT | PATHWAY | MULTIDISCIPLINARY SCIENCES | EXPRESSION | MICROARRAY DATA | PROGRAM | REVEALS | Neoplasms - metabolism | Heat Shock Transcription Factors - metabolism | Cancer-Associated Fibroblasts - metabolism | Humans | Gene Expression Profiling | Phosphoproteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | Neoplasms - genetics | Membrane Proteins - metabolism | Cell Line | Membrane Proteins - genetics | Cells, Cultured | Heat Shock Transcription Factors - genetics | Intercellular Signaling Peptides and Proteins - genetics | Intracellular Signaling Peptides and Proteins | Mice, Transgenic | Phosphoproteins - genetics | Transcription Factors - genetics | beta Catenin - metabolism | beta Catenin - genetics | Transcription Factors - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Wnt Signaling Pathway - genetics | Mice, Nude | Adaptor Proteins, Signal Transducing - genetics | Adaptor Proteins, Signal Transducing - metabolism | Neoplasms - pathology | Chemokines | Phenotypes | Wnt protein | Activation | Cell surface | Yes-associated protein | β-catenin | Signaling | Signal transduction | Fibroblasts | Extracellular matrix | Solid tumors | HSF1 protein | Cancer | Tumors
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2011, Volume 140, Issue 4, pp. 1230 - 1240.e7
Background & Aims Ablation of Notch signaling within the intestinal epithelium results in loss of proliferating crypt progenitors due to their conversion into postmitotic secretory cells... 
Gastroenterology and Hepatology | Gene Regulation | GI Development | Knockout Mice | Intestinal Stem Cells | RECOMBINATION | GAMMA-SECRETASE INHIBITORS | SELF-RENEWAL | KLF4 | INHIBITS TUMOR-GROWTH | GENE | PATHWAY | IN-VIVO | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Intestinal Mucosa - metabolism | Receptors, G-Protein-Coupled - metabolism | Cell Count | Intracellular Signaling Peptides and Proteins - metabolism | Intestinal Mucosa - cytology | Intercellular Signaling Peptides and Proteins - metabolism | Kruppel-Like Transcription Factors - metabolism | Serrate-Jagged Proteins | Membrane Proteins - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Adult Stem Cells - cytology | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch1 - metabolism | Goblet Cells - metabolism | Mice, Knockout | Cell Division - physiology | Adult Stem Cells - metabolism | Animals | Homeostasis - physiology | Signal Transduction - physiology | Mice | Receptor, Notch1 - genetics | Kruppel-Like Transcription Factors - genetics | Calcium-Binding Proteins - genetics | Goblet Cells - cytology | GI development | knockout mice | gene regulation | intestinal stem cells
Journal Article
Science signaling, ISSN 1937-9145, 2013, Volume 6, Issue 292, pp. ra81 - ra81
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2015, Volume 42, Issue 3, pp. 431 - 442
... cells that are often deficient for multiple transcription factors and signaling proteins, including... 
ADAPTIVE IMMUNITY | CD94/NKG2C RECEPTOR | REPERTOIRE | NATURAL-KILLER-CELLS | ACTIVATION | TYROSINE KINASE | FCR-GAMMA | UMBILICAL-CORD BLOOD | DIFFERENTIATION | IMMUNOLOGY | CHILDREN | Cell Proliferation | Humans | NK Cell Lectin-Like Receptor Subfamily C - genetics | Receptors, IgG - deficiency | Intracellular Signaling Peptides and Proteins - immunology | Cytomegalovirus Infections - immunology | Gene Expression Profiling | Killer Cells, Natural - pathology | Cytomegalovirus Infections - genetics | Protein-Tyrosine Kinases - deficiency | Protein-Tyrosine Kinases - immunology | Intracellular Signaling Peptides and Proteins - deficiency | NK Cell Lectin-Like Receptor Subfamily C - immunology | DNA Methylation | Protein-Tyrosine Kinases - genetics | Receptors, IgG - genetics | Microarray Analysis | Antibodies - immunology | Cytomegalovirus Infections - virology | Killer Cells, Natural - immunology | Cytomegalovirus Infections - pathology | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Promoter Regions, Genetic | GPI-Linked Proteins - immunology | Signal Transduction | Killer Cells, Natural - virology | NK Cell Lectin-Like Receptor Subfamily C - deficiency | Immunophenotyping | Receptors, IgG - immunology | Killer Cells, Natural - classification | Cytomegalovirus - immunology | Epigenesis, Genetic - immunology | Immunologic Memory | GPI-Linked Proteins - genetics | Proteins | Viral antibodies | Epigenetic inheritance | Killer cells | Molecular genetics | Antibodies | Gene expression | Antigens | Cytomegalovirus | Cloning | Colleges & universities | Infections | Experiments | Long term | DNA methylation | Epigenetics | Expansion | Viral infections | Deoxyribonucleic acid--DNA | Immune system
Journal Article