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Immunity, ISSN 1074-7613, 03/2015, Volume 42, Issue 3, pp. 443 - 456
The mechanisms underlying human natural killer (NK) cell phenotypic and functional heterogeneity are unknown. Here, we describe the emergence of diverse... 
NATURAL-KILLER-CELLS | ACTIVATION | CMV REACTIVATION | INNATE | RECEPTOR | FCR-GAMMA | DIFFERENTIATION | IMMUNOLOGY | PLZF CONTROLS | EXPRESSION | T-CELLS | Cell Proliferation | Humans | Transcription Factors - deficiency | NK Cell Lectin-Like Receptor Subfamily C - genetics | Receptors, IgG - deficiency | Intracellular Signaling Peptides and Proteins - immunology | Cytomegalovirus Infections - immunology | Gene Expression Profiling | Killer Cells, Natural - pathology | Cytomegalovirus Infections - genetics | Protein-Tyrosine Kinases - deficiency | Protein-Tyrosine Kinases - immunology | T-Lymphocytes, Cytotoxic - pathology | Intracellular Signaling Peptides and Proteins - deficiency | NK Cell Lectin-Like Receptor Subfamily C - immunology | DNA Methylation | Protein-Tyrosine Kinases - genetics | Receptors, IgG - genetics | Microarray Analysis | Antibodies - immunology | Cytomegalovirus Infections - virology | Killer Cells, Natural - immunology | Cytomegalovirus Infections - pathology | Kruppel-Like Transcription Factors - deficiency | Transcription Factors - immunology | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Adaptive Immunity | T-Lymphocytes, Cytotoxic - immunology | Promoter Regions, Genetic | GPI-Linked Proteins - immunology | Signal Transduction | Killer Cells, Natural - virology | T-Lymphocytes, Cytotoxic - virology | NK Cell Lectin-Like Receptor Subfamily C - deficiency | Immunophenotyping | Receptors, IgG - immunology | Transcription Factors - genetics | Killer Cells, Natural - classification | Promyelocytic Leukemia Zinc Finger Protein | Cytomegalovirus - immunology | Epigenesis, Genetic - immunology | Kruppel-Like Transcription Factors - genetics | Kruppel-Like Transcription Factors - immunology | GPI-Linked Proteins - genetics | Virus diseases | Proteins | Epigenetic inheritance | Killer cells | Immunotherapy | Genomics | Medical genetics | Cytomegalovirus infections | T cells | Methylation | Health aspects | Antigens | Flow cytometry | Cytomegalovirus | Data analysis | Biomedical research | Transplants & implants | Cytokines | Leukemia | Cytotoxicity | Infections | Kinases | Diversification | Gene expression | Experiments | Scholarships & fellowships | Lymphocytes | DNA methylation | Epigenetics | Viral infections | Immune system | Cancer | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 9, pp. 7018 - 7026
The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by phosphorylating them for cytoplasmic sequestration or degradation. In... 
YES-ASSOCIATED PROTEIN | EPITHELIAL-MESENCHYMAL TRANSITION | CELL CONTACT INHIBITION | WW DOMAIN | GROWTH-CONTROL | ORGAN SIZE CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ONCOGENIC TRANSFORMATION | BINDING | CANCER | Adaptor Proteins, Signal Transducing - chemistry | Protein Interaction Domains and Motifs - physiology | Humans | Intercellular Signaling Peptides and Proteins - chemistry | Cytoplasm - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Intercellular Signaling Peptides and Proteins - metabolism | HEK293 Cells | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein Structure, Tertiary | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Phosphoproteins - genetics | Cell Division - physiology | Transcription, Genetic - physiology | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Connective Tissue Growth Factor - genetics | Adaptor Proteins, Signal Transducing - metabolism | Connective Tissue Growth Factor - metabolism | Index Medicus | Gene Transcription | Transcription Coactivators | Signal Transduction | AmotL1 | YAP | Transcription Factors | Serine Threonine Protein Kinase | Hippo Pathway | TAZ | Amot
Journal Article
Science, ISSN 0036-8075, 5/2012, Volume 336, Issue 6081, pp. 579 - 582
Developing animals frequently adjust their growth programs and/or their maturation or metamorphosis to compensate for growth disturbances (such as injury or... 
Insect larvae | Pupariation | Animals | DNA damage | Drosophila | REPORTS | Larval development | Genetic mutation | Metamorphosis | Genotypes | Tumors | DROSOPHILA-MELANOGASTER | PUPARIATION | DISKS | MULTIDISCIPLINARY SCIENCES | GENES | SIZE | Intercellular Signaling Peptides and Proteins - chemistry | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Neoplasms, Experimental - pathology | Intercellular Signaling Peptides and Proteins - metabolism | Metamorphosis, Biological - genetics | Gene Expression Regulation, Developmental | Larva - growth & development | Ecdysone - biosynthesis | Imaginal Discs - growth & development | Neoplasms, Experimental - genetics | Pupa - growth & development | Intracellular Signaling Peptides and Proteins - genetics | Genes, Insect | Amino Acid Sequence | Imaginal Discs - physiology | Intercellular Signaling Peptides and Proteins - genetics | Drosophila Proteins - chemistry | Peptide Initiation Factors - metabolism | Peptide Initiation Factors - genetics | Regeneration | Ethyl Methanesulfonate - pharmacology | Drosophila melanogaster - growth & development | Drosophila Proteins - genetics | Neoplasms, Experimental - metabolism | Apoptosis | Physiological aspects | Animal development | Peptides | Health aspects | Insulin | Insulin-like growth factors | Insects | Maturation | Index Medicus | Endocrine systems | Communication systems | Disks | Adults | Damage | Delay
Journal Article
Immunity, ISSN 1074-7613, 05/2012, Volume 36, Issue 5, pp. 742 - 754
In vitro data suggest that a subgroup of NLR proteins, including NLRP12, inhibits the transcription factor NF-κB, although physiologic and disease-relevant... 
MULTIPLE-MYELOMA | CELLS | ACTIVATION | PROTEIN | ANGIOGENESIS | PATHWAY | INNATE | IKK-ALPHA | IMMUNOLOGY | TUMOR-GROWTH | CUTTING EDGE | Colonic Neoplasms - genetics | Colitis - genetics | Colitis - pathology | Male | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Colonic Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - genetics | Chemokine CXCL12 - genetics | Cell Transformation, Neoplastic - genetics | TNF Receptor-Associated Factor 3 - genetics | Proto-Oncogene Proteins c-akt - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Chemokine CXCL13 - genetics | Signal Transduction | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | TNF Receptor-Associated Factor 3 - metabolism | Cell Transformation, Neoplastic - metabolism | Disease Progression | Animals | Chemokine CXCL12 - metabolism | NF-kappa B - genetics | Chemokine CXCL13 - metabolism | Colonic Neoplasms - pathology | Colitis - metabolism | Mice | Cell Transformation, Neoplastic - pathology | Index Medicus | CXCL12 protein | Transcription factors | CXCL13 protein | Extracellular signal-regulated kinase | AKT protein | Data processing | Nlr protein | Inflammation | Signal transduction | NF- Kappa B protein | Colon cancer | Tumorigenesis | Colitis | Polyps
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 499, Issue 7456, pp. 50 - 54
53BP1 (also called TP53BP1) is a chromatin-associated factor that promotes immunoglobulin class switching and DNA double-strand-break (DSB) repair by... 
CRB2 | RECRUITMENT | FISSION YEAST | METHYLATION | CHROMATIN | DEPENDENT RESPONSE | RESECTION | MULTIDISCIPLINARY SCIENCES | SITES | DOUBLE-STRAND BREAKS | CLASS-SWITCH RECOMBINATION | Schizosaccharomyces pombe Proteins - chemistry | Histones - chemistry | Nucleosomes - chemistry | Humans | Ubiquitin - metabolism | Molecular Sequence Data | Male | Intracellular Signaling Peptides and Proteins - metabolism | DNA Breaks, Double-Stranded | DNA-Binding Proteins - deficiency | Cell Cycle Proteins - chemistry | Intracellular Signaling Peptides and Proteins - deficiency | Ubiquitination | Schizosaccharomyces pombe Proteins - metabolism | Female | Lysine - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Schizosaccharomyces | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Signal Transduction | Cell Cycle Proteins - metabolism | Nucleosomes - metabolism | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Chromosomal Proteins, Non-Histone - deficiency | Amino Acid Motifs | Chromosomal Proteins, Non-Histone - genetics | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Mutant Proteins - chemistry | Protein Binding | Mice | DNA Damage | Histones - metabolism | Tumor Suppressor p53-Binding Protein 1 | Chromosomal Proteins, Non-Histone - chemistry | Ubiquitin | Research | Properties | DNA repair | DNA damage | Proteins | DNA methylation | Mutation | Experiments | Recruitment | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 2005, Volume 20, Issue 6, pp. 939 - 949
The death-inducing signaling complex (DISC) comprising Fas, Fas-associated death domain (FADD), and caspase-8/10 is assembled via homotypic associations... 
RECEPTOR SIGNALS | APOPTOSIS | INDUCED-PROXIMITY MODEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NMR STRUCTURE | DEATH-EFFECTOR DOMAIN | CASPASE ACTIVATION | CONTAINING PROTEIN | SIGNALING COMPLEX DISC | CELL-DEATH | PYRIN DOMAIN | CELL BIOLOGY | Caspase 8 | Humans | Multiprotein Complexes | Molecular Sequence Data | Crystallography, X-Ray | Intracellular Signaling Peptides and Proteins - metabolism | fas Receptor - metabolism | Viral Proteins - metabolism | Death Domain Receptor Signaling Adaptor Proteins | Caspases - metabolism | Molluscum contagiosum virus - genetics | Caspase 10 | fas Receptor - genetics | Intracellular Signaling Peptides and Proteins - genetics | Amino Acid Sequence | Caspases - genetics | Viral Proteins - chemistry | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Models, Molecular | Viral Proteins - genetics | Fas-Associated Death Domain Protein | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - chemistry | Sequence Alignment | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Molluscum contagiosum virus - chemistry | Protein Conformation | CASP8 and FADD-Like Apoptosis Regulating Protein | Apoptosis - physiology | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Proteins | Oligomers | Structure | Crystals | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 04/2016, Volume 7, Issue 1, pp. 11215 - 11215
Journal Article
Journal Article
Book Chapter
Developmental Cell, ISSN 1534-5807, 02/2010, Volume 18, Issue 2, pp. 288 - 299
Journal Article
Genes and Development, ISSN 0890-9369, 11/2010, Volume 24, Issue 21, pp. 2383 - 2388
Although a developmental role for Hippo signaling in organ size control is well appreciated, how this pathway functions in tissue regeneration is largely... 
Regeneration | Hippo signaling | Mouse | Growth control | Cancer | regeneration | ORGAN SIZE CONTROL | STAT3 | YAP | CELL-PROLIFERATION | DEVELOPMENTAL BIOLOGY | DROSOPHILA | CELL BIOLOGY | mouse | EPITHELIAL-CELLS | COLITIS | LIVER | GENETICS & HEREDITY | growth control | cancer | TUMORIGENESIS | Immunohistochemistry | Dextran Sulfate | Humans | Male | Intestines - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Colonic Polyps - physiopathology | Colonic Polyps - genetics | Regeneration - genetics | Cell Cycle Proteins - genetics | Female | Phosphoproteins - physiology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Gene Expression | Intestines - pathology | Mice, Inbred C57BL | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | Phosphoproteins - genetics | Regeneration - physiology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Colonic Polyps - chemically induced | Mice, Knockout | Adaptor Proteins, Signal Transducing - physiology | Animals | Adaptor Proteins, Signal Transducing - deficiency | Phosphoproteins - deficiency | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Mice | Drosophila Proteins - genetics | Intestines - physiopathology | Dextran | Usage | Analysis | Genetic aspects | Chemical properties | Research | Gene expression | Index Medicus | Research Communication
Journal Article