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PloS one, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0177516
... successful cell-therapy for muscle disorders. Here we expanded mouse muscle stem cells and human myoblasts with Notch ligands, DLL1, DLL4, and JAG1 to activate Notch signaling in vitro and to investigate whether these cells could retain... 
PROGENITOR CELLS | SATELLITE CELL NICHE | MESENCHYMAL PROGENITORS | GENE | MYOD | MULTIDISCIPLINARY SCIENCES | EXPANSION | SELF-RENEWAL | DUCHENNE MUSCULAR-DYSTROPHY | HUMAN SKELETAL-MUSCLE | TRANSPLANTATION | Immunohistochemistry | Jagged-1 Protein - metabolism | MyoD Protein - genetics | Receptors, Notch - metabolism | PAX7 Transcription Factor - genetics | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | PAX7 Transcription Factor - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Cell Differentiation - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Myoblasts - metabolism | Regeneration - genetics | Myoblasts - cytology | Membrane Proteins - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Real-Time Polymerase Chain Reaction | Membrane Proteins - genetics | Muscle Development - physiology | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | MyoD Protein - metabolism | Signal Transduction - genetics | Regeneration - physiology | Jagged-1 Protein - genetics | Muscle Cells - cytology | Animals | Muscle Development - genetics | Signal Transduction - physiology | Mice | Transplantation | Research | Health aspects | Ligands (Biochemistry) | Analysis | Stem cells | Musculoskeletal diseases | Musculoskeletal system | Cell culture | MyoD protein | Allografts | Cell number | Stem cell transplantation | Ligands | Notch protein | Gene expression | Myoblasts | Signal Transduction | Intercellular Signaling Peptides and Proteins | PAX7 Transcription Factor | Intracellular Signaling Peptides and Proteins | Cellular Biology | Stem Cells | Membrane Proteins | Life Sciences | Regeneration | Muscle Development | Receptors, Notch | Cell Differentiation | Muscle Cells | MyoD Protein | Jagged-1 Protein
Journal Article
Molecular cell, ISSN 1097-2765, 2005, Volume 20, Issue 6, pp. 939 - 949
The death-inducing signaling complex (DISC) comprising Fas, Fas-associated death domain (FADD... 
RECEPTOR SIGNALS | APOPTOSIS | INDUCED-PROXIMITY MODEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NMR STRUCTURE | DEATH-EFFECTOR DOMAIN | CASPASE ACTIVATION | CONTAINING PROTEIN | SIGNALING COMPLEX DISC | CELL-DEATH | PYRIN DOMAIN | CELL BIOLOGY | Caspase 8 | Humans | Multiprotein Complexes | Molecular Sequence Data | Crystallography, X-Ray | Intracellular Signaling Peptides and Proteins - metabolism | fas Receptor - metabolism | Viral Proteins - metabolism | Death Domain Receptor Signaling Adaptor Proteins | Caspases - metabolism | Molluscum contagiosum virus - genetics | Caspase 10 | fas Receptor - genetics | Intracellular Signaling Peptides and Proteins - genetics | Amino Acid Sequence | Caspases - genetics | Viral Proteins - chemistry | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Models, Molecular | Viral Proteins - genetics | Fas-Associated Death Domain Protein | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - chemistry | Sequence Alignment | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Molluscum contagiosum virus - chemistry | Protein Conformation | CASP8 and FADD-Like Apoptosis Regulating Protein | Apoptosis - physiology | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Proteins | Oligomers | Structure | Crystals
Journal Article
Nature immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
.... Here we found that signaling pathways dependent on the kinases Syk and Jnk were required for the activation of caspase-1 via the ASC-dependent inflammasomes NLRP3 and AIM2... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2011, Volume 140, Issue 4, pp. 1230 - 1240.e7
Background & Aims Ablation of Notch signaling within the intestinal epithelium results in loss of proliferating crypt progenitors due to their conversion into postmitotic secretory cells... 
Gastroenterology and Hepatology | Gene Regulation | GI Development | Knockout Mice | Intestinal Stem Cells | RECOMBINATION | GAMMA-SECRETASE INHIBITORS | SELF-RENEWAL | KLF4 | INHIBITS TUMOR-GROWTH | GENE | PATHWAY | IN-VIVO | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Intestinal Mucosa - metabolism | Receptors, G-Protein-Coupled - metabolism | Cell Count | Intracellular Signaling Peptides and Proteins - metabolism | Intestinal Mucosa - cytology | Intercellular Signaling Peptides and Proteins - metabolism | Kruppel-Like Transcription Factors - metabolism | Serrate-Jagged Proteins | Membrane Proteins - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Adult Stem Cells - cytology | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch1 - metabolism | Goblet Cells - metabolism | Mice, Knockout | Cell Division - physiology | Adult Stem Cells - metabolism | Animals | Homeostasis - physiology | Signal Transduction - physiology | Mice | Receptor, Notch1 - genetics | Kruppel-Like Transcription Factors - genetics | Calcium-Binding Proteins - genetics | Goblet Cells - cytology | GI development | knockout mice | gene regulation | intestinal stem cells
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2011, Volume 286, Issue 9, pp. 7018 - 7026
The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by phosphorylating them for cytoplasmic sequestration or degradation. In... 
YES-ASSOCIATED PROTEIN | EPITHELIAL-MESENCHYMAL TRANSITION | CELL CONTACT INHIBITION | WW DOMAIN | GROWTH-CONTROL | ORGAN SIZE CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ONCOGENIC TRANSFORMATION | BINDING | CANCER | Adaptor Proteins, Signal Transducing - chemistry | Protein Interaction Domains and Motifs - physiology | Humans | Intercellular Signaling Peptides and Proteins - chemistry | Cytoplasm - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Intercellular Signaling Peptides and Proteins - metabolism | HEK293 Cells | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein Structure, Tertiary | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Phosphoproteins - genetics | Cell Division - physiology | Transcription, Genetic - physiology | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Connective Tissue Growth Factor - genetics | Adaptor Proteins, Signal Transducing - metabolism | Connective Tissue Growth Factor - metabolism | Gene Transcription | Transcription Coactivators | Signal Transduction | AmotL1 | YAP | Transcription Factors | Serine Threonine Protein Kinase | Hippo Pathway | TAZ | Amot
Journal Article
Nature (London), ISSN 1476-4687, 2009, Volume 459, Issue 7245, pp. 433 - 436
Journal Article
Cancer cell, ISSN 1535-6108, 2012, Volume 22, Issue 5, pp. 668 - 682
Journal Article
The Journal of cell biology, ISSN 1540-8140, 2010, Volume 190, Issue 2, pp. 197 - 207
... (DDR) comprised of early signaling events, including activation of the protein kinases ataxia telangiectasia mutated (ATM... 
Phosphorylation | Chromatin | Mitosis | DNA damage | Ubiquitins | Cell cycle | Cell lines | Histones | Antibodies | Reports | Chromosomes | REPAIR PROTEINS | RECRUITMENT | PHOSPHORYLATION | HUMAN-CELLS | 53BP1 | HISTONE H2AX | ATM | CHECKPOINT | IONIZING-RADIATION | RNF8 UBIQUITIN LIGASE | CELL BIOLOGY | Humans | Intracellular Signaling Peptides and Proteins - metabolism | DNA Breaks, Double-Stranded | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Histones - genetics | Mitosis - physiology | DNA Repair | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Trans-Activators - metabolism | DNA Damage | Histones - metabolism | Tumor Suppressor p53-Binding Protein 1 | Ubiquitin-Protein Ligases - genetics | DNA | Research
Journal Article
Science signaling, ISSN 1937-9145, 2013, Volume 6, Issue 292, pp. ra81 - ra81
Journal Article
Molecular cell, ISSN 1097-2765, 05/2008, Volume 30, Issue 4, pp. 507 - 518
...). The crystal structures of ternary complexes between PHD, HD1, and two different H3K4me peptides reveal a unique mode of histone tail recognition... 
DNA | SIGNALING | ARMADILLO/BETA-CATENIN | TARGET GENES | BINDING MODULES | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COACTIVATOR PYGOPUS | PLANT HOMEODOMAIN | BETA-CATENIN | DNA-REPAIR | PHD-FINGER | CELL BIOLOGY | Histones - chemistry | Humans | Peptides - genetics | Molecular Sequence Data | Crystallography, X-Ray | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Neoplasm Proteins - metabolism | Wnt Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Multiprotein Complexes - metabolism | Peptides - metabolism | Lysine - metabolism | Neoplasm Proteins - genetics | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Amino Acid Sequence | Peptides - chemistry | Models, Molecular | Neoplasm Proteins - chemistry | Drosophila Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Adaptor Proteins, Signal Transducing | Multiprotein Complexes - chemistry | Sequence Alignment | Animals | Histones - genetics | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | Recombinant Fusion Proteins - genetics | Protein Conformation | Signal Transduction - physiology | Drosophila Proteins - genetics | Histones - metabolism | Methylation | Drosophila melanogaster | Histones | Genetic engineering | Genetic transcription | Peptides
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 32, pp. 11212 - 11217
Genetic studies have shown that ubiquitination and endocytosis of the Drosophila ligand Delta in signal-sending cells are required for activation of Notch signaling, but how these events promote Notch... 
T lymphocytes | Molecules | Endocytosis | Receptors | Cell lines | HeLa cells | Antibodies | Ligands | Lipids | Recycling | Ubiquitination | Membrane microdomains | Transendocytosis | Membrane Microdomains - metabolism | Membrane Proteins - genetics | Drosophila | Humans | Intercellular Signaling Peptides and Proteins - genetics | Protein Transport - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Receptor, Notch1 - metabolism | Recombinant Fusion Proteins - metabolism | Endocytosis - physiology | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Membrane Proteins - metabolism | Mice | HeLa Cells | Ubiquitination - physiology | Receptor, Notch1 - genetics | Intracellular Signaling Peptides and Proteins - genetics | Membrane Microdomains - genetics | Physiological aspects | Cellular signal transduction | Genetic aspects | Ligands (Biochemistry) | Membrane Microdomains | Signal Transduction | Intercellular Signaling Peptides and Proteins | Biochemistry, Molecular Biology | Intracellular Signaling Peptides and Proteins | Recombinant Fusion Proteins | Protein Transport | Membrane Proteins | Life Sciences | Receptor, Notch1 | Molecular biology | Hela Cells | Biological Sciences | recycling | transendocytosis | membrane microdomains | ubiquitination
Journal Article