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PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0177516
... successful cell-therapy for muscle disorders. Here we expanded mouse muscle stem cells and human myoblasts with Notch ligands, DLL1, DLL4, and JAG1 to activate Notch signaling in vitro and to investigate whether these cells could retain... 
PROGENITOR CELLS | SATELLITE CELL NICHE | MESENCHYMAL PROGENITORS | GENE | MYOD | MULTIDISCIPLINARY SCIENCES | EXPANSION | SELF-RENEWAL | DUCHENNE MUSCULAR-DYSTROPHY | HUMAN SKELETAL-MUSCLE | TRANSPLANTATION | Immunohistochemistry | Jagged-1 Protein - metabolism | MyoD Protein - genetics | Receptors, Notch - metabolism | PAX7 Transcription Factor - genetics | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | PAX7 Transcription Factor - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Cell Differentiation - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Myoblasts - metabolism | Regeneration - genetics | Myoblasts - cytology | Membrane Proteins - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Real-Time Polymerase Chain Reaction | Membrane Proteins - genetics | Muscle Development - physiology | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | MyoD Protein - metabolism | Signal Transduction - genetics | Regeneration - physiology | Jagged-1 Protein - genetics | Muscle Cells - cytology | Animals | Muscle Development - genetics | Signal Transduction - physiology | Mice | Transplantation | Research | Health aspects | Ligands (Biochemistry) | Analysis | Stem cells | Musculoskeletal diseases | Musculoskeletal system | Cell culture | MyoD protein | Allografts | Cell number | Stem cell transplantation | Ligands | Notch protein | Gene expression | Myoblasts | Signal Transduction | Intercellular Signaling Peptides and Proteins | PAX7 Transcription Factor | Intracellular Signaling Peptides and Proteins | Cellular Biology | Stem Cells | Membrane Proteins | Life Sciences | Regeneration | Muscle Development | Receptors, Notch | Cell Differentiation | Muscle Cells | MyoD Protein | Jagged-1 Protein
Journal Article
Developmental cell, ISSN 1534-5807, 2010, Volume 18, Issue 2, pp. 288 - 299
Journal Article
Developmental cell, ISSN 1534-5807, 2010, Volume 18, Issue 2, pp. 300 - 308
...) transcription coactivator. The FERM domain proteins Merlin (Mer) and Expanded (Ex) represent one mode of upstream regulation controlling pathway activity... 
CELLBIO | DEVBIO | SIGNALING | APOPTOSIS | WARTS-HIPPO PATHWAY | GROWTH | GENES | PROTEIN-PROTEIN INTERACTIONS | CELL-PROLIFERATION | HOMOLOG | DEVELOPMENTAL BIOLOGY | PROMOTES | DROSOPHILA | AXIS SPECIFICATION | CELL BIOLOGY | Neurofibromin 2 - genetics | Protein Kinases - genetics | Cell Proliferation | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Drosophila - physiology | Drosophila Proteins - physiology | RNA Interference | Gene Expression Regulation, Developmental | Membrane Proteins - physiology | Base Sequence | Tumor Suppressor Proteins - genetics | Ovarian Follicle - physiology | Cell Cycle Proteins - genetics | Female | Ovarian Follicle - cytology | Drosophila Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - genetics | Drosophila - genetics | Signal Transduction | Animals, Genetically Modified | Membrane Proteins - genetics | Protein-Serine-Threonine Kinases - physiology | Protein-Serine-Threonine Kinases - genetics | Neurofibromin 2 - physiology | Tumor Suppressor Proteins - physiology | Phenotype | Animals | Epistasis, Genetic | Protein Kinases - physiology | Drosophila - growth & development | Drosophila Proteins - genetics | Intracellular Signaling Peptides and Proteins - physiology | Cell Cycle Proteins - physiology | Apoptosis | Proteins | Research | Oncology, Experimental | Cancer | Short
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2011, Volume 286, Issue 9, pp. 7018 - 7026
The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by phosphorylating them for cytoplasmic sequestration or degradation. In... 
YES-ASSOCIATED PROTEIN | EPITHELIAL-MESENCHYMAL TRANSITION | CELL CONTACT INHIBITION | WW DOMAIN | GROWTH-CONTROL | ORGAN SIZE CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ONCOGENIC TRANSFORMATION | BINDING | CANCER | Adaptor Proteins, Signal Transducing - chemistry | Protein Interaction Domains and Motifs - physiology | Humans | Intercellular Signaling Peptides and Proteins - chemistry | Cytoplasm - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Intercellular Signaling Peptides and Proteins - metabolism | HEK293 Cells | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein Structure, Tertiary | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Phosphoproteins - genetics | Cell Division - physiology | Transcription, Genetic - physiology | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Connective Tissue Growth Factor - genetics | Adaptor Proteins, Signal Transducing - metabolism | Connective Tissue Growth Factor - metabolism | Gene Transcription | Transcription Coactivators | Signal Transduction | AmotL1 | YAP | Transcription Factors | Serine Threonine Protein Kinase | Hippo Pathway | TAZ | Amot
Journal Article
Oncogene, ISSN 1476-5594, 2008, Volume 27, Issue 38, pp. 5148 - 5167
The Notch signaling pathway regulates a diverse array of cell types and cellular processes and is tightly regulated by ligand binding... 
Endocytosis | Notch ligands | Actin cytoskeleton | Notch signaling | Proteolysis | HUMAN HEMATOPOIETIC STEM | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LUNATIC FRINGE | MIND BOMB | DELTA-ENDOCYTOSIS | CELL BIOLOGY | actin cytoskeleton | ABNORMAL VERTEBRAL SEGMENTATION | ONCOLOGY | SIGNALING PATHWAY | GENETICS & HEREDITY | AXIAL SKELETAL DEFECTS | endocytosis | GROWTH-FACTOR | proteolysis | INTRACELLULAR DOMAIN | Genetic Diseases, Inborn - genetics | Intercellular Signaling Peptides and Proteins - chemistry | Cell Communication - physiology | Receptors, Notch - genetics | Intercellular Signaling Peptides and Proteins - physiology | Ubiquitination | Neoplasms - genetics | Membrane Proteins - physiology | Peptide Hydrolases - physiology | Serrate-Jagged Proteins | Neoplasms - physiopathology | Cell Differentiation - physiology | Calcium-Binding Proteins - chemistry | Protein Structure, Tertiary | Embryonic Development - physiology | Intracellular Signaling Peptides and Proteins | Receptors, Notch - physiology | Glycosylation | Endocytosis - physiology | Protein Interaction Mapping | Membrane Proteins - chemistry | Calcium-Binding Proteins - physiology | Homeostasis - physiology | Ligands | Signal Transduction - physiology | Stem Cells - physiology | Genetic Diseases, Inborn - physiopathology | Protein Processing, Post-Translational | Apoptosis - physiology | Cellular proteins | Care and treatment | Genetic aspects | Cellular signal transduction | Research | Health aspects | Methods | Cancer | Proteins | Signal transduction | Cellular biology | Gene expression
Journal Article
Gastroenterology, ISSN 0016-5085, 2011, Volume 140, Issue 4, pp. 1230 - 1240.e7
Background & Aims Ablation of Notch signaling within the intestinal epithelium results in loss of proliferating crypt progenitors due to their conversion into postmitotic secretory cells... 
Gastroenterology and Hepatology | Gene Regulation | GI Development | Knockout Mice | Intestinal Stem Cells | RECOMBINATION | GAMMA-SECRETASE INHIBITORS | SELF-RENEWAL | KLF4 | INHIBITS TUMOR-GROWTH | GENE | PATHWAY | IN-VIVO | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Intestinal Mucosa - metabolism | Receptors, G-Protein-Coupled - metabolism | Cell Count | Intracellular Signaling Peptides and Proteins - metabolism | Intestinal Mucosa - cytology | Intercellular Signaling Peptides and Proteins - metabolism | Kruppel-Like Transcription Factors - metabolism | Serrate-Jagged Proteins | Membrane Proteins - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Adult Stem Cells - cytology | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch1 - metabolism | Goblet Cells - metabolism | Mice, Knockout | Cell Division - physiology | Adult Stem Cells - metabolism | Animals | Homeostasis - physiology | Signal Transduction - physiology | Mice | Receptor, Notch1 - genetics | Kruppel-Like Transcription Factors - genetics | Calcium-Binding Proteins - genetics | Goblet Cells - cytology | GI development | knockout mice | gene regulation | intestinal stem cells
Journal Article