X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (6109) 6109
humans (5064) 5064
intracellular space - metabolism (3521) 3521
intracellular space - drug effects (2062) 2062
mice (2002) 2002
cell biology (1989) 1989
calcium - metabolism (1969) 1969
rats (1944) 1944
proteins (1758) 1758
biochemistry & molecular biology (1737) 1737
male (1720) 1720
apoptosis (1353) 1353
physiology (1324) 1324
neurosciences (1291) 1291
calcium (1266) 1266
multidisciplinary sciences (1228) 1228
research article (1218) 1218
cells, cultured (1202) 1202
medicine (1149) 1149
cell line, tumor (1111) 1111
female (1107) 1107
intracellular (1028) 1028
biology (1022) 1022
cells (1014) 1014
signal transduction (1000) 1000
science (997) 997
activation (972) 972
cancer (964) 964
expression (959) 959
cell line (913) 913
analysis (908) 908
research (882) 882
pharmacology & pharmacy (871) 871
oxidative stress (863) 863
physiological aspects (840) 840
extracellular space - metabolism (832) 832
gene expression (824) 824
in-vitro (736) 736
kinases (731) 731
apoptosis - drug effects (718) 718
rodents (712) 712
cell survival - drug effects (704) 704
intracellular calcium (692) 692
signal transduction - drug effects (690) 690
reactive oxygen species - metabolism (669) 669
time factors (656) 656
phosphorylation (643) 643
mitochondria (633) 633
hydrogen-ion concentration (629) 629
nanoparticles (627) 627
dose-response relationship, drug (613) 613
biochemistry (612) 612
metabolism (607) 607
models, biological (600) 600
rats, sprague-dawley (593) 593
intracellular membranes - metabolism (587) 587
health aspects (566) 566
inhibition (559) 559
neurons (557) 557
life sciences (540) 540
oncology (519) 519
biophysics (508) 508
in-vivo (507) 507
in vitro techniques (505) 505
rats, wistar (495) 495
immunology (492) 492
protein (472) 472
intracellular fluid - metabolism (471) 471
mitochondria - metabolism (468) 468
fluorescence (464) 464
enzymes (462) 462
chemistry, multidisciplinary (459) 459
kinetics (459) 459
homeostasis (458) 458
cell death (457) 457
cell proliferation - drug effects (453) 453
intracellular ph (450) 450
cell membrane - metabolism (443) 443
inflammation (437) 437
neurons - drug effects (428) 428
microbiology (427) 427
brain (426) 426
mutation (420) 420
cytotoxicity (416) 416
drug delivery systems (415) 415
mechanisms (415) 415
intracellular signaling peptides and proteins - metabolism (411) 411
receptors (399) 399
intracellular signalling (390) 390
medicine, research & experimental (390) 390
mice, inbred c57bl (387) 387
neurons - metabolism (383) 383
toxicity (377) 377
calcium signaling - drug effects (371) 371
drugs (371) 371
enzyme inhibitors - pharmacology (371) 371
peptides (364) 364
biomedicine (359) 359
localization (359) 359
protein transport (356) 356
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (5) 5
Earth Sciences (Noranda) - Circulation Desk (2) 2
Earth Sciences (Noranda) - Oversize (2) 2
Earth Sciences (Noranda) - Stacks (2) 2
Gerstein Science - Circulation Desk (2) 2
Gerstein Science - Reserve desk (2) 2
St. Michael's College (John M. Kelly) - 2nd Floor (2) 2
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (2) 2
Trinity College (John W Graham) - Stacks (2) 2
UofT at Mississauga - Circulation Desk (2) 2
Victoria University E.J. Pratt - Circulation Desk (2) 2
Victoria University E.J. Pratt - Oversize (2) 2
Collection Dvlpm't (Acquisitions) - Closed Orders (1) 1
Collection Dvlpm't (Acquisitions) - Vendor file (1) 1
UofT at Mississauga - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (10757) 10757
Japanese (48) 48
Chinese (24) 24
Russian (16) 16
German (13) 13
Norwegian (4) 4
Portuguese (4) 4
Czech (2) 2
Polish (2) 2
Dutch (1) 1
French (1) 1
Italian (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 2, pp. e88193 - e88193
Intrinsic resistance to cytotoxic drugs has been a main issue in cancer therapy for decades... 
APOPTOSIS | PLASMA | VESICLES | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR PH | TRAFFICKING | PROTON PUMP INHIBITORS | MECHANISMS | EXPRESSION | H+-ATPASES | CHEMOTHERAPY | Exosomes - drug effects | Exosomes - metabolism | Proton Pump Inhibitors - pharmacology | Intracellular Space - drug effects | Humans | Extracellular Space - drug effects | Chromatography, High Pressure Liquid | Cisplatin - pharmacology | Melanoma - pathology | Mice, SCID | Spectrophotometry, Atomic | Xenograft Model Antitumor Assays | Extracellular Space - metabolism | Reference Standards | Animals | Solutions | Hydrogen-Ion Concentration - drug effects | Intracellular Space - metabolism | Cell Line, Tumor | Female | Cell Death - drug effects | Buffers | Cellular Microenvironment - drug effects | Drug Resistance, Neoplasm - drug effects | Drugs | Drug delivery systems | Care and treatment | Melanoma | Health aspects | Cisplatin | Vehicles | Cancer | Cell culture | Toxicity | Chemoresistance | Cytotoxicity | Drug delivery | Metastasis | Drug resistance | Exosomes | pH effects | Cancer therapies | Skin cancer | Prevention | Hydrogen ions | Xenografts | Biocompatibility | Inhibition | Pretreatment | Deoxyribonucleic acid--DNA | Antigens | Acidity | Breast cancer | Liquid chromatography | High-performance liquid chromatography | Medicine | Studies | Inductively coupled plasma | Protonation | Scientific imaging | Acidosis | Mass spectrometry | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal of experimental botany, ISSN 1460-2431, 2012, Volume 63, Issue 8, pp. 3207 - 3218
Changes in pH are now widely accepted as a signalling mechanism in cells. In plants, proton pumps in the plasma membrane and tonoplast play a key role in... 
Mesophyll cells | Adhesives | Perfusion | Imaging | Plant roots | Sensors | Plants | Calibration | Cytosol | RESEARCH PAPER | GFP | Auxin | PHusion | Arabidopsis | ATPase | pH homeostasis | Apoplast | Cytoplasm | Sensor | auxin | INTRACELLULAR PH | ROOT-TIPS | pHusion | STOMATAL CLOSURE | PLANT SCIENCES | cytoplasm | GREEN FLUORESCENT PROTEIN | CYTOSOLIC CA2 | ALGAE | H+ BUFFERS | H+-ATPase | sensor | ABSCISIC-ACID | LIVING CELLS | Organ Specificity - drug effects | Gene Expression - drug effects | Cytosol - drug effects | Extracellular Space - drug effects | Imaging, Three-Dimensional - methods | Plant Roots - drug effects | Extracellular Space - metabolism | Hydrogen-Ion Concentration - drug effects | Cell Membrane - metabolism | Mesophyll Cells - drug effects | Mesophyll Cells - metabolism | Homeostasis - drug effects | Cell Membrane - drug effects | Mesophyll Cells - cytology | Alkalies | Cell Survival - drug effects | Arabidopsis - drug effects | Intracellular Space - drug effects | Plant Roots - metabolism | Seedlings - cytology | Arabidopsis - cytology | Adhesives - pharmacology | Genes, Reporter - genetics | Plant Roots - cytology | Seedlings - drug effects | Arabidopsis - metabolism | Indoleacetic Acids - pharmacology | Intracellular Space - metabolism | Biosensing Techniques - methods | Cytosol - metabolism | Research Papers
Journal Article
Journal Article
Biomaterials, ISSN 0142-9612, 2015, Volume 72, pp. 74 - 89
Abstract Dual responsive nanoparticles are developed for co-delivery of multiple anticancer drugs to target the drug resistance mechanisms of cancer stem-like cells (CSCs... 
Advanced Basic Science | Dentistry | Topoisomerase | Co-delivery | Drug resistance | Cancer stem-like cell | CD44 | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | TRANSCRIPTION | TOPOISOMERASE-I | DRUG-RESISTANCE | COMBINATION | PACLITAXEL | THERAPY | ANTICANCER | DNA TOPOISOMERASES | ANTITUMOR EFFICACY | XENOGRAFTS | Nanoparticles - chemistry | Neoplastic Stem Cells - drug effects | Humans | Male | Spheroids, Cellular - cytology | Drug Delivery Systems | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Spheroids, Cellular - drug effects | Camptothecin - analogs & derivatives | Poloxamer - chemistry | Tissue Distribution - drug effects | Intracellular Space - drug effects | Lactic Acid - chemistry | Endocytosis - drug effects | Hyaluronic Acid - chemistry | Nanoparticles - ultrastructure | Animals | Chitosan - chemistry | Mice, Nude | Intracellular Space - metabolism | Polyglycolic Acid - chemistry | Cell Line, Tumor | Drug Liberation | Camptothecin - pharmacology | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Hydrogen-Ion Concentration | Nanoparticles | Anthracyclines | Hyaluronic acid | Doxorubicin | Drug approval | Cancer | Biomedical engineering | Drugs | Surgical implants | Biomedical materials | Pluronic F127 | Hydroxyapatite | Chitosan | co-delivery | cancer stem-like cell | topoisomerase | drug resistance
Journal Article
Molecular Endocrinology, ISSN 1944-9917, 2009, Volume 23, Issue 6, pp. 893 - 900
Journal Article
Small (Weinheim an der Bergstrasse, Germany), ISSN 1613-6829, 2010, Volume 6, Issue 7, pp. 832 - 842
Journal Article
Biomaterials, ISSN 0142-9612, 2013, Volume 34, Issue 15, pp. 3912 - 3923
.... On the basis of confirming the antitumor activity of HNP:siRNA, we continued to encapsulate a hydrophobic chemotherapeutic drug-paclitaxel... 
Advanced Basic Science | Dentistry | Nanoparticles | siRNA | Drug delivery | Chitosan | Paclitaxel | SiRNA | CANCER-CELLS | THERAPEUTICS | SYSTEM | TARGET | QUATERNIZED CHITOSAN | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | CO-DELIVERY | THERAPY | TELOMERASE ACTIVITY | IN-VIVO | GROWTH | Gene Silencing - drug effects | Paclitaxel - pharmacology | Nanoparticles - chemistry | Humans | Male | Quaternary Ammonium Compounds - chemistry | Drug Delivery Systems | Carbocyanines | Flow Cytometry | Telomerase - metabolism | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Chitosan - analogs & derivatives | Paclitaxel - administration & dosage | Carcinoma, Lewis Lung | Caco-2 Cells | Gene Transfer Techniques | Permeability - drug effects | Tissue Distribution - drug effects | Intracellular Space - drug effects | Endocytosis - drug effects | Nanoparticles - ultrastructure | Paclitaxel - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Chitosan - chemistry | Intracellular Space - metabolism | Absorption - drug effects | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | RNA, Small Interfering - administration & dosage | RNA, Small Interfering - metabolism | Enzymes | Chemotherapy | Permeability | Telomerase | Cancer | Tumors | Degradation | Drugs | Encapsulation | Surgical implants | Therapy | Biomedical materials
Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 33, Issue 9, pp. 2780 - 2790
...-CD, resulting in bypass of P-glycoprotein (P-gp)-mediated drug efflux. After complex formation of the mdr1 siRNA with Dox-loaded QDs via electrostatic interaction... 
Advanced Basic Science | Dentistry | QDs | β-CD | Co-delivery | siRNA | Doxorubicin | Multidrug resistance | SiRNA | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | MODULATORS | MECHANISMS | DRUG-RESISTANCE | CANCER | P-GLYCOPROTEIN | NANOPARTICLES | MDR1 | THERAPY | beta-CD | INHIBITORS | EXPRESSION | RNA, Small Interfering - genetics | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Adsorption - drug effects | Cell Tracking - methods | Flow Cytometry | Time Factors | Gene Expression Regulation, Neoplastic - drug effects | Gene Transfer Techniques | Microscopy, Electron, Transmission | Drug Resistance, Multiple - genetics | Intracellular Space - drug effects | Spectrometry, Fluorescence | Static Electricity | Cell Shape - drug effects | Particle Size | Microscopy, Confocal | Drug Resistance, Neoplasm - genetics | Quantum Dots | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Intracellular Space - metabolism | ATP Binding Cassette Transporter, Sub-Family B | HeLa Cells | Drug Delivery Systems - methods | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | RNA, Small Interfering - metabolism | Drug resistance in microorganisms | Chemotherapy | Anthracyclines | Biological products | Messenger RNA | Genes | Fluorescence | Cyclodextrins | Cancer
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 4, p. e62087
Silica nanoparticles have become promising carriers for drug delivery or gene therapy... 
PATHWAYS | MAINTENANCE | AIR-POLLUTION | OXIDATIVE STRESS | CHK1 | PARTICLES | MULTIDISCIPLINARY SCIENCES | DISEASE | MITOCHONDRIA | SIZE-DEPENDENT CYTOTOXICITY | CANCER | Protein Kinases - metabolism | Reactive Oxygen Species - metabolism | Nanoparticles - chemistry | Apoptosis - drug effects | Humans | Membrane Potential, Mitochondrial - drug effects | Necrosis | Flow Cytometry | G2 Phase Cell Cycle Checkpoints - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Intracellular Space - drug effects | Subcellular Fractions - drug effects | Endocytosis - drug effects | Nanoparticles - ultrastructure | Hydrodynamics | Static Electricity | Comet Assay | Nanoparticles - toxicity | Subcellular Fractions - metabolism | Particle Size | Human Umbilical Vein Endothelial Cells - enzymology | Silicon Dioxide - toxicity | Intracellular Space - metabolism | Checkpoint Kinase 1 | Human Umbilical Vein Endothelial Cells - pathology | DNA Damage | Oxidative Stress - drug effects | Drugs | Nanoparticles | Drug delivery systems | DNA | DNA damage | Superoxide | Radiation, Background | DNA repair | Silica | Vehicles | Endothelium | Cdc2 protein | Reactive oxygen species | Intravenous administration | Toxicity | Cytology | Cytotoxicity | Superoxide dismutase | Drug delivery | Kinases | Cyclin B1 | Silicon dioxide | Signal transduction | Mitochondria | Peroxidase | Membrane potential | Damage | Heart diseases | Deoxyribonucleic acid--DNA | Glutathione | Glutathione peroxidase | Outdoor air quality | Oxygen | CHK1 protein | Lactate dehydrogenase | Exposure | Hazards | Malondialdehyde | L-Lactate dehydrogenase | Endothelial cells | Signaling | Lactic acid | Mutation | Gene therapy | Cardiovascular diseases | Apoptosis | Deoxyribonucleic acid
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 527, Issue 7578, pp. 323 - 328
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e20786
Photodynamic therapy, unlikely to elicit drug-resistance, deserves attention as a strategy to counter this outstanding problem common to the chemotherapy of all diseases... 
MHC CLASS-I | CUTANEOUS LEISHMANIASIS | IMMUNOGENICITY | THERAPY | UROPORPHYRIA | DENDRITIC CELLS | CLINICAL-TRIAL | EFFICACY | LEISH-F1+MPL-SE VACCINE | MULTIDISCIPLINARY SCIENCES | SINGLET OXYGEN | Endocytosis - radiation effects | Ovalbumin - immunology | Photochemotherapy - methods | Dendritic Cells - immunology | CD8-Positive T-Lymphocytes - parasitology | Phagosomes - radiation effects | Substrate Specificity | Dendritic Cells - radiation effects | Macrophages - parasitology | CD8-Positive T-Lymphocytes - radiation effects | Leishmania - parasitology | Indoles - metabolism | Light | Leishmania - drug effects | Mitochondria - radiation effects | Dendritic Cells - drug effects | Indoles - pharmacology | Host-Parasite Interactions | Macrophages - radiation effects | Intracellular Space - radiation effects | Macrophages - immunology | Phagosomes - drug effects | Cell Line | Dendritic Cells - parasitology | Intracellular Space - drug effects | Antigen Presentation - radiation effects | Endocytosis - drug effects | Phagosomes - metabolism | Solubility | HLA Antigens - immunology | Mitochondria - metabolism | Mitochondria - drug effects | Drug Discovery | Phagosomes - parasitology | Photolysis - radiation effects | Photolysis - drug effects | Animals | CD8-Positive T-Lymphocytes - drug effects | Intracellular Space - metabolism | Indoles - therapeutic use | Macrophages - drug effects | Antigen Presentation - drug effects | Leishmania - physiology | Mice | CD8-Positive T-Lymphocytes - immunology | Indoles - chemistry | Photolysis | Dendritic cells | Vaccination | Genetic engineering | Drug resistance | T cells | Photochemotherapy | Cancer | Porphyrins | Phagolysosomes | CD8 antigen | Transgenic | Biosynthesis | Lymphocytes T | Parasites | Macrophages | Inactivation | Immunity | Accumulation | Immunity (cell-mediated) | Homing | Mitochondria | Immunology | Lymphocytes | Parasitic diseases | Infectivity | Protozoa | Ovalbumin | Antigens | Photodynamic therapy | Deactivation | Host specificity | Mutants | Medicine | Chemistry | Chemotherapy | Major histocompatibility complex | Antigen-presenting cells | Lysis | Intracellular | Cell migration
Journal Article