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Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2009, Volume 284, Issue 21, pp. 14645 - 14656
Anthrolysin O (ALO) is a pore-forming, cholesterol-dependent cytolysin (CDC) secreted by Bacillus anthracis , the etiologic agent for anthrax. Growing evidence... 
LISTERIA-MONOCYTOGENES | TIGHT JUNCTIONS | CELLS | CONFORMATIONAL-CHANGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VITRO MODEL | MEMBRANE INSERTION | THETA-TOXIN | PORE-FORMING TOXINS | PERFRINGOLYSIN-O | BIOLOGICAL WEAPON | Solubility - drug effects | Epithelial Cells - metabolism | Membrane Glycoproteins - metabolism | Calcium - metabolism | Bacteriocins - chemistry | Epithelial Cells - drug effects | Humans | Membrane Glycoproteins - chemistry | Protein Multimerization | Bacterial Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Hemolysin Proteins - chemistry | Occludin | Protein Binding - drug effects | Protein Structure, Quaternary | Membrane Proteins - metabolism | Bacteriocins - metabolism | Epithelial Cells - cytology | Bacillus anthracis - metabolism | Tight Junctions - drug effects | Caco-2 Cells | Protein Structure, Tertiary | Tight Junctions - metabolism | Amino Acid Sequence | Permeability - drug effects | Intracellular Space - drug effects | Protein Structure, Secondary | Perforin - chemistry | Models, Molecular | Bacillus anthracis - cytology | Cholesterol - metabolism | Bacterial Toxins - chemistry | Bacterial Toxins - metabolism | Intracellular Space - metabolism | Ionomycin - pharmacology | Bacterial Proteins - metabolism | Perforin - metabolism | Hemolysin Proteins - metabolism | Intestines - cytology | Life Sciences | Biochemistry, Molecular Biology | HUMAN POPULATIONS | PATHOGENESIS | ELEMENTS | CALCIUM | LIGHT SCATTERING | CRYSTAL STRUCTURE | DIMERIZATION | MATERIALS SCIENCE | BACILLUS | FUNCTIONS | PROTEINS | ULTRACENTRIFUGATION
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 4, p. e19194
The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of metabolism, stress resistance and longevity... 
Biomarkers - metabolism | Sirtuin 1 - metabolism | Protein Carbonylation | Electron Transport | Oxidative Stress | Rats, Wistar | Antioxidants - metabolism | Tumor Suppressor Protein p53 - metabolism | Rats | Mitochondria - metabolism | Aldehydes - metabolism | Organ Specificity | Brain - metabolism | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Intracellular Space - metabolism | Female | Acetylation | DNA Damage | Enzyme Activation | Lipid Peroxidation | NAD - metabolism | Aging - metabolism | Antioxidants | Tyrosine | Niacinamide | Purines | Enzymes | Ionizing radiation | DNA damage | Tumor proteins | Sugars | Monosaccharides | Apoptosis | Dehydrogenases | Syngeneic grafts | Oxidative metabolism | Liver | p53 Protein | Neurobiology | Poly(ADP-ribose) | Lipid peroxidation | Proteins | Electron transport chain | Signal transduction | Mitochondria | Animal tissues | Aging | Physiology | Chronic obstructive pulmonary disease | Deoxyribonucleic acid--DNA | Peroxidation | Liver diseases | Adenosine diphosphate | Longevity | Metabolism | Gene expression | Overexpression | Nicotinamide adenine dinucleotide | Nicotinamide | Oxidative stress | Carbonyl compounds | Neurosciences | Senescence | Biosynthesis | DNA repair | NADH | Ribose | Rodents | Cell cycle | Age | Carbonyls | Kidneys | Organs | Poly(ADP-ribose) polymerase | Adenine | Histology | Pharmacology | Polymerase | NAD | Lungs | Intracellular | Deoxyribonucleic acid | DNA
Journal Article
Molecular biology of the cell, ISSN 1939-4586, 2017, Volume 28, Issue 21, pp. 2773 - 2785
Journal Article
Nature reviews. Immunology, ISSN 1474-1741, 2014, Volume 15, Issue 1, pp. 18 - 29
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e31469
Background: Several activities of the transmembrane form of TNF (memTNF) in immune responses to intracellular bacterial infection have been shown to be... 
TUMOR-NECROSIS-FACTOR | SECRETED TNF | CALMETTE-GUERIN INFECTION | TRANSMEMBRANE TNF | LIVER-INJURY | CELL-MEDIATED-IMMUNITY | IN-VIVO | BIOLOGY | MICE | MYCOBACTERIAL INFECTION | FACTOR-ALPHA | Tumor Necrosis Factor-alpha - metabolism | Mycobacterium bovis - immunology | Receptors, Tumor Necrosis Factor, Type II - chemistry | Tumor Necrosis Factor-alpha - genetics | NF-kappa B - metabolism | Disease Resistance - immunology | Interferon-gamma - metabolism | Receptors, Tumor Necrosis Factor, Type II - metabolism | Cell Membrane - metabolism | Mycobacterium bovis - pathogenicity | Macrophages - immunology | Macrophages - microbiology | Intracellular Space - immunology | Bone Marrow Cells - cytology | Mice, Inbred C57BL | Solubility | Tuberculosis - veterinary | Gene Knock-In Techniques | Tuberculosis - immunology | Macrophages - metabolism | Animals | Intracellular Space - microbiology | Interferon-gamma - immunology | Intracellular Space - metabolism | Chemokines - metabolism | Mice | Nitric Oxide - metabolism | Nitric Oxide Synthase Type II - metabolism | Infection | Immune response | Bacterial infections | Tumor necrosis factor | Genetic engineering | Comparative analysis | Health aspects | Tumor necrosis factor receptors | Phosphorylation | Liver | Arthritis | Infections | Macrophages | Antiinfectives and antibacterials | Receptors | Microorganisms | Immunology | Transgenic animals | Rodents | Bone marrow | Bacteria | Tumor necrosis factor-TNF | Spleen | NF-κB protein | Cytokines | Dermatology | Immune response (cell-mediated) | BCG | Transgenic mice | Inflammation | Nitric-oxide synthase | Studies | Herbal medicine | Pathology | Tuberculosis | Lungs | γ-Interferon | Regulatory mechanisms (biology) | Ligands | In vivo methods and tests | Interferon | Mutation | Chemokines | Tumors | Apoptosis
Journal Article
Nature (London), ISSN 1476-4687, 2009, Volume 461, Issue 7265, pp. 788 - 792
The innate immune system is critical for the early detection of invading pathogens and for initiating cellular host defence countermeasures, which include the... 
ACTIVATION | HEPATITIS-C VIRUS | RECOGNITION | RNA | MULTIDISCIPLINARY SCIENCES | INFLAMMASOME | RIG-I | CYTOSOLIC DNA | KAPPA-B | ADAPTER PROTEIN | CYTOPLASMIC DNA | DNA, Bacterial - metabolism | Vesicular Transport Proteins - metabolism | Vaccines, DNA - immunology | Endoplasmic Reticulum - metabolism | DNA, Bacterial - immunology | Antigen-Presenting Cells - microbiology | Listeria monocytogenes - immunology | Interferon Type I - immunology | Interferon Type I - biosynthesis | Membrane Proteins - deficiency | Cytoplasmic Vesicles - metabolism | Plasmids - genetics | Herpesvirus 1, Human - immunology | Membrane Proteins - metabolism | Fibroblasts - microbiology | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Fibroblasts - virology | T-Lymphocytes, Cytotoxic - immunology | Antigen-Presenting Cells - metabolism | Intracellular Space - immunology | Membrane Proteins - genetics | Plasmids - immunology | DNA, Viral - metabolism | Antigen-Presenting Cells - immunology | Antigen-Presenting Cells - virology | Mice, Knockout | Protein Transport | DNA, Viral - immunology | Immunity, Innate - immunology | Animals | Intracellular Space - metabolism | Listeria monocytogenes - genetics | Fibroblasts - immunology | Herpesvirus 1, Human - genetics | Mice | Herpesvirus 1, Human - pathogenicity | Physiological aspects | Genetic aspects | Interferon | Immunity | Proteins | Viruses | Immunization | E coli | Research & development--R&D | Cells
Journal Article
Nature Immunology, ISSN 1529-2908, 04/2013, Volume 14, Issue 4, pp. 327 - 336
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 532, Issue 7599, pp. 334 - 339
The serotonin transporter (SERT) terminates serotonergic signalling through the sodium-and chloride-dependent reuptake of neurotransmitter into presynaptic... 
HIGH-AFFINITY RECOGNITION | NEUROTRANSMITTER TRANSPORTERS | NOREPINEPHRINE TRANSPORTERS | N-LINKED GLYCOSYLATION | ALLOSTERIC BINDING | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | SELECTIVE RECOGNITION | MEMBRANE-PROTEINS | DOPAMINE TRANSPORTER | Citalopram - pharmacology | Humans | Protein Conformation - drug effects | Crystallography, X-Ray | Dopamine Plasma Membrane Transport Proteins - chemistry | Structure-Activity Relationship | Antidepressive Agents - metabolism | Citalopram - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Extracellular Space - metabolism | Antidepressive Agents - chemistry | Protein Binding - drug effects | Drug Design | Antidepressive Agents - pharmacology | Protein Stability | Allosteric Regulation - drug effects | Ions - chemistry | Serotonin Plasma Membrane Transport Proteins - immunology | Allosteric Site - drug effects | Models, Molecular | Ions - metabolism | Paroxetine - metabolism | Serotonin Plasma Membrane Transport Proteins - metabolism | Citalopram - chemistry | Intracellular Space - metabolism | Serotonin - metabolism | Ligands | Immunoglobulin Fab Fragments - immunology | Paroxetine - pharmacology | Paroxetine - chemistry | Drug metabolism | Paroxetine | Physiological research | Research | Serotonin | Binding sites (Biochemistry) | X rays | Mutation | Antidepressants | Binding sites | X-ray crystallography | Transporters in the nervous system | BASIC BIOLOGICAL SCIENCES | Membrane proteins
Journal Article