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Journal Article
Journal Article
Journal Article
Cell, ISSN 0092-8674, 2009, Volume 136, Issue 4, pp. 719 - 730
Journal Article
Methods, ISSN 1046-2023, 05/2015, Volume 77-78, pp. 92 - 103
The tumor suppressor PTEN is a key regulator of a plethora of cellular processes that are crucial in cancer development. Through its lipid phosphatase activity... 
Mitochondria | Calcium | Cell death | Endoplasmic reticulum | Cancer | Apoptosis | BINDING MOTIF | PROTEIN | PHOSPHATASE-ACTIVITY | CA2+ RELEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | PLASMA-MEMBRANE | MAMMALIAN-CELLS | MITOCHONDRIA-ASSOCIATED MEMBRANES | NUCLEAR PTEN | TUMOR-SUPPRESSOR FUNCTION | ENDOPLASMIC-RETICULUM | Intracellular Space - chemistry | Tumor Suppressor Proteins - metabolism | Animals | Humans | Intracellular Space - metabolism | PTEN Phosphohydrolase - analysis | PTEN Phosphohydrolase - metabolism | Subcellular Fractions - metabolism | Subcellular Fractions - chemistry | Tumor Suppressor Proteins - analysis | Inositol | Mitochondrial DNA | PM, plasma membrane | IPC, ischemic preconditioning | NES, nuclear export signal | PIP2, phosphatidylinositol-4,5-bisphosphate | YFP, yellow fluorescent protein | STS, staurosporine | ER-RFP, endoplasmic reticulum-targeted red fluorescent protein | PAM, plasma membrane–associated membranes | Ndfip1, NEDD4 family-interacting protein 1 | PTEN, phosphatase and tensin homolog deleted on chromosome 10 | VDAC, voltage-dependent anion channel | RFP, red fluorescent protein | ROS, reactive oxygen species | AKAP, A kinase anchoring protein | Co-IP, co-immunoprecipitation | OMM, outer mitochondrial membrane | PIP3, phosphatidylinositol-3,4,5-trisphosphate | GFP, green fluorescent protein | COX, cytochrome c oxidase | IP3R, inositol 1,4,5-trisphosphate receptor | PK, proteinase K | PML, promyelocytic leukemia | R, ischemia–reperfusion | NLS, nuclear localization signal | CLS, cytoplasmic localization signal | NEDD4, neural precursor cell expressed developmentally downregulated-4 | mtDsRED, mitochondria-targeted red fluorescent protein | Ca2+, calcium | HAUSP, herpesvirus-associated ubiquitin-specific protease | ArA, arachidonic acid | MAMs, mitochondria-associated membranes | IF, immunofluorescence | FRAP, fluorescence recovery after photobleaching | ER, endoplasmic reticulum | HK-I, hexokinase I
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2017, Volume 36, Issue 22, pp. 3356 - 3371
In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β‐secretase to generate a 99‐aa... 
MAM | C99 | mitochondria and sphingolipids | Alzheimer's disease | BETA-SECRETASE ACTIVITY | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYLOID PRECURSOR PROTEIN | SYNAPTIC MITOCHONDRIA | CELL BIOLOGY | C-TERMINAL FRAGMENT | MOUSE MODEL | LIPID RAFTS | A-BETA | ENDOPLASMIC-RETICULUM | TRANSGENIC MICE | Cell Line | Up-Regulation | Humans | Oxygen Consumption | Endoplasmic Reticulum - metabolism | Sphingolipids - metabolism | Mitochondria - metabolism | Mutation - genetics | Mitochondria - ultrastructure | Endoplasmic Reticulum - ultrastructure | Alzheimer Disease - pathology | Intracellular Membranes - ultrastructure | Protein Transport | Amyloid Precursor Protein Secretases - metabolism | Animals | Cell Respiration | Alzheimer Disease - metabolism | Amyloid beta-Protein Precursor - metabolism | Presenilins - genetics | Mice | Intracellular Membranes - metabolism | Amyloidogenesis | Cell culture | Lipid composition | Membranes | Animal models | Pathogenesis | Homeostasis | Lipids | Apposition | Mitochondria | Senile plaques | Ceramide | Fibroblasts | Localization | Neurodegenerative diseases | Abnormalities | Membrane composition | Patients | Amyloid precursor protein | Sphingomyelin | Position (location) | Endoplasmic reticulum | Secretase | Endosomes | Neuroscience | Membrane & Intracellular Transport | Metabolism
Journal Article