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Cancer Research, ISSN 0008-5472, 07/2010, Volume 70, Issue 13, pp. 5213 - 5219
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 11/2016, Volume 17, Issue 11, pp. 1844 - 1844
In this study, the anti-melanogenic effects of Heracleum moellendorffii Hance extract (HmHe) and the mechanisms through which it inhibits melanogenesis in... 
MITF | Heracleum moellendorffii | Melanogenesis | Melanin | Tyrosinase | ERK | MELANIN SYNTHESIS | melanin | BIOCHEMISTRY & MOLECULAR BIOLOGY | melanogenesis | tyrosinase | CHEMISTRY, MULTIDISCIPLINARY | INHIBITION | NITRIC-OXIDE | DEGRADATION | EXPRESSION | PIGMENTATION | MODULATION | EXTRACT | MELANOCYTES | Oxidoreductases - antagonists & inhibitors | Membrane Glycoproteins - metabolism | Nitriles - pharmacology | Plant Extracts - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Intramolecular Oxidoreductases - antagonists & inhibitors | Melanocytes - metabolism | Fungal Proteins - antagonists & inhibitors | Monophenol Monooxygenase - antagonists & inhibitors | Melanins - biosynthesis | Monophenol Monooxygenase - metabolism | Indoles - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Melanocytes - cytology | Melanocytes - drug effects | Protective Agents - pharmacology | Mitogen-Activated Protein Kinase 1 - genetics | Phosphorylation - drug effects | Intramolecular Oxidoreductases - metabolism | Cell Line | Butadienes - pharmacology | Melanins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Oxidoreductases - metabolism | Signal Transduction | Oxidoreductases - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Heracleum - chemistry | Plant Extracts - isolation & purification | Protective Agents - isolation & purification | Membrane Glycoproteins - genetics | Animals | Intramolecular Oxidoreductases - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Mice | Indoles - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - genetics | Agaricales - chemistry | Fungal Proteins - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Proteins | Protein expression | Transcription factors | Phosphorylation
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2010, Volume 18, Issue 6, pp. 2337 - 2345
The methanolic extract from the whole plants of Anastatica hierochuntica was found to inhibit melanogenesis in theophylline-stimulated murine B16 melanoma 4A5... 
Anastatica hierochuntica | Silybin | Melanogenesis inhibitor | Isosilybin | Tyrosinase | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TISSUE-CULTURE | CHEMISTRY, ORGANIC | METABOLISM-PROMOTING ACTIVITIES | CULTURED HUMAN MELANOCYTES | CYCLIC-AMP | NITRIC-OXIDE PRODUCTION | DITERPENE ALKALOIDS | EXPRESSION | MEDICINE CYPERUS-LONGUS | CONSTITUENTS | Oxidoreductases - antagonists & inhibitors | Plant Extracts - chemistry | Membrane Glycoproteins - metabolism | Plant Extracts - pharmacology | Melanoma, Experimental - drug therapy | Intramolecular Oxidoreductases - antagonists & inhibitors | Monophenol Monooxygenase - antagonists & inhibitors | Structure-Activity Relationship | RNA, Messenger - metabolism | Monophenol Monooxygenase - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Antineoplastic Agents - isolation & purification | Enzyme Inhibitors - chemistry | RNA, Messenger - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Monophenol Monooxygenase - genetics | Tumor Cells, Cultured | Intramolecular Oxidoreductases - metabolism | Agaricales - enzymology | Cell Survival - drug effects | Oxidoreductases - metabolism | Oxidoreductases - genetics | Brassicaceae - chemistry | RNA, Messenger - genetics | Enzyme Inhibitors - pharmacology | Melanoma, Experimental - pathology | Plant Extracts - isolation & purification | Antineoplastic Agents - chemistry | Enzyme Inhibitors - isolation & purification | Membrane Glycoproteins - genetics | Animals | Melanoma, Experimental - genetics | Intramolecular Oxidoreductases - genetics | Cell Proliferation - drug effects | Mice | Drug Screening Assays, Antitumor
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 09/2013, Volume 59, pp. 521 - 526
•We study the anti-melanogenic effect of Octaphlorethol A (OPA) in α-MSH-stimulated mouse melanoma (B16F10) cells.•OPA inhibited melanin synthesis and... 
Octaphlorethol A (OPA) | B16F10 melanoma cells | Anti-melanogenesis | MITF | ERK | APOPTOSIS | ACTIVATED PROTEIN-KINASE | TYROSINASE | FOOD SCIENCE & TECHNOLOGY | P38 MAPK | HUMAN PIGMENTATION | SIGNALING PATHWAY | TOXICOLOGY | LEUKEMIA | EXPRESSION | MELANOCYTES | Oxidoreductases - antagonists & inhibitors | Phenols - isolation & purification | Membrane Glycoproteins - metabolism | Intramolecular Oxidoreductases - antagonists & inhibitors | Melanocytes - metabolism | Neoplasm Proteins - antagonists & inhibitors | Monophenol Monooxygenase - antagonists & inhibitors | Neoplasm Proteins - metabolism | alpha-MSH - metabolism | Melanins - biosynthesis | Monophenol Monooxygenase - metabolism | Skin Lightening Preparations - adverse effects | Membrane Glycoproteins - antagonists & inhibitors | Melanocytes - drug effects | Phenols - antagonists & inhibitors | Intramolecular Oxidoreductases - metabolism | Phenols - pharmacology | Cell Survival - drug effects | Melanocytes - enzymology | Melanins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - metabolism | Pigmentation - drug effects | Oxidoreductases - metabolism | Neoplasm Proteins - biosynthesis | Skin Lightening Preparations - chemistry | Skin Lightening Preparations - pharmacology | Down-Regulation - drug effects | Drug Discovery | Phaeophyta - chemistry | alpha-MSH - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - antagonists & inhibitors | Animals | MAP Kinase Signaling System - drug effects | Phenols - adverse effects | Skin Lightening Preparations - isolation & purification | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 09/2008, Volume 326, Issue 3, pp. 754 - 763
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 13, pp. 3597 - 3602
Journal Article
Circulation, ISSN 0009-7322, 07/2013, Volume 128, Issue 3, pp. 225 - 236
BACKGROUND—Macrophage migration inhibitory factor (MIF) exerts a protective effect on ischemic myocardium by activating AMP-activated protein kinase (AMPK).... 
Glucose transporter | Ischemia | Migration inhibitory factor agonist | migration inhibitory factor agonist | HOMEOSTASIS | CARDIAC & CARDIOVASCULAR SYSTEMS | FACTOR MIF | ELEVATION | DEFICIENCY | DISCOVERY | ischemia | HEART | glucose transporter | INFLAMMATION | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | ANTAGONISTS | BINDING | Myocardial Ischemia - metabolism | AMP-Activated Protein Kinases - metabolism | Macrophage Migration-Inhibitory Factors - antagonists & inhibitors | Intramolecular Oxidoreductases - antagonists & inhibitors | Male | Macrophage Migration-Inhibitory Factors - genetics | Myocardial Infarction - pathology | Histocompatibility Antigens Class II - metabolism | Antigens, Differentiation, B-Lymphocyte - genetics | Intramolecular Oxidoreductases - pharmacology | Myocytes, Cardiac - cytology | Mice, Inbred C57BL | Cells, Cultured | Cardiotonic Agents - pharmacology | Myocardial Infarction - metabolism | Recombinant Proteins - pharmacology | Myocardial Ischemia - drug therapy | Macrophage Migration-Inhibitory Factors - pharmacology | Mice, Knockout | Myocardial Ischemia - pathology | Isoxazoles - pharmacology | Animals | Myocardial Infarction - drug therapy | Myocytes, Cardiac - drug effects | Intramolecular Oxidoreductases - genetics | Signal Transduction - drug effects | Glucose - pharmacokinetics | Myocytes, Cardiac - metabolism | Signal Transduction - physiology | Mice | Antigens, Differentiation, B-Lymphocyte - metabolism | Histocompatibility Antigens Class II - genetics | Macrophage Migration-Inhibitory Factors - agonists | Usage | Physiological aspects | Cellular signal transduction | Research | Drug therapy | Protein kinases | Heart diseases | Health aspects | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2013, Volume 110, Issue 27, pp. 10994 - 10999
Journal Article
Nature, ISSN 0028-0836, 06/2010, Volume 465, Issue 7298, pp. 577 - 583
Journal Article