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1. Full Text Physiological Level Production of Antigen-Specific Human Immunoglobulin in Cloned Transchromosomic Cattle
by Sano, Akiko and Matsushita, Hiroaki and Wu, Hua and Jiao, Jin-An and Kasinathan, Poothappillai and Sullivan, Eddie J and Wang, Zhongde and Kuroiwa, Yoshimi
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e78119
Therapeutic human polyclonal antibodies (hpAbs) derived from pooled plasma from human donors are Food and Drug Administration approved biologics used in the... 
B-CELL RECEPTOR | ANTIBODIES | PLASMA | INTRAVENOUS IMMUNOGLOBULIN | MULTIDISCIPLINARY SCIENCES | DISEASE | CALVES | BETA | Cell Proliferation | Chromosomes, Artificial, Human - immunology | Immunoglobulin mu-Chains - immunology | Immunoglobulins - immunology | Humans | Immunoglobulin mu-Chains - metabolism | Immunoglobulins - genetics | Immunoglobulin M - immunology | Immunoglobulin M - metabolism | Immunoglobulins - metabolism | Immunoglobulin mu-Chains - genetics | Animals | Immunoglobulin G - genetics | Cattle | Immunoglobulin G - immunology | Chromosomes, Artificial, Human - metabolism | Immunoglobulin Heavy Chains - metabolism | Chromosomes, Artificial, Human - genetics | Immunoglobulin Heavy Chains - immunology | B-Lymphocytes - metabolism | Immunoglobulin Heavy Chains - genetics | Immunoglobulin G - metabolism | Immunoglobulin M - genetics | Antigens | Biological products | Cloning | Immunoglobulin G | Beef cattle | B cells | Health aspects | Drug approval | Immunoglobulin M | Epidemics | Antibodies | Chains | Viruses | B-cell receptor | Proteins | Cell activation | Cell growth | Physiology | Polyclonal antibodies | Immune system | Incompatibility | Immunoglobulins | Immunization | Immune response | Medical treatment | T cell receptors | Artificial chromosomes | Loci | Lymphocytes B
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2. Full Text Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc
by Robert M. Anthony and Falk Nimmerjahn and David J. Ashline and Vernon N. Reinhold and James C. Paulson and Jeffrey V. Ravetch
Science, ISSN 0036-8075, 4/2008, Volume 320, Issue 5874, pp. 373 - 376
It is well established that high doses of monomeric immunoglobulin G (IgG) purified from pooled human plasma [intravenous immunoglobulin (IVIG)] confer... 
Fc receptors | Polysaccharides | Immunoglobulins | Antiinflammatories | Lectins | Antibodies | Cytotoxicity | Recapitulation theory | Idiopathic thrombocytopenic purpura | Reports | Post hoc | OLIGOSACCHARIDES | SPECIFICITY | PROTECTION | MULTIDISCIPLINARY SCIENCES | SIALYLATION | RECEPTOR | GLYCOSYLATION | IMMUNOGLOBULIN-G | AUTOIMMUNE-DISEASE | BINDING | SIALYLTRANSFERASE | Recombinant Proteins - therapeutic use | Arthritis, Experimental - drug therapy | Immunoglobulin Fc Fragments - metabolism | Humans | Receptors, Fc - metabolism | Immunoglobulins, Intravenous - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Immunoglobulin Fc Fragments - administration & dosage | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Polysaccharides - chemistry | Immunoglobulin Fc Fragments - therapeutic use | Autoimmune Diseases - drug therapy | Immunoglobulin G - chemistry | Mice, Inbred C57BL | Immunoglobulin G - therapeutic use | Recombinant Proteins - chemistry | Immunoglobulin Fc Fragments - chemistry | Glycosylation | Immunoglobulin G - administration & dosage | N-Acetylneuraminic Acid - chemistry | Galactose - chemistry | Animals | Immunoglobulins, Intravenous - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Mice, Inbred NOD | Immunoglobulins, Intravenous - chemistry | Mice | Carbohydrate Conformation | Immunoglobulin G - metabolism | Influence | Anti-inflammatory drugs | Properties | Recombinant molecules | Immunoglobulin G | Biochemistry | Immunology | Drug therapy | Autoimmune diseases | Immune system
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3. Full Text Structural Characterization of Anti-Inflammatory Immunoglobulin G Fc Proteins
by Ahmed, Alysia A and Giddens, John and Pincetic, Andrew and Lomino, Joseph V and Ravetch, Jeffrey V and Wang, Lai-Xi and Bjorkman, Pamela J
Journal of Molecular Biology, ISSN 0022-2836, 09/2014, Volume 426, Issue 18, pp. 3166 - 3179
Immunoglobulin G (IgG) is a central mediator of host defense due to its ability to recognize and eliminate pathogens. The recognition and effector responses... 
X-ray crystallography | IVIG | inflammation | sialylated IgG Fc | N-linked glycan | ANTIBODIES | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | IGG | OLIGOSACCHARIDE | GLYCOSYLATION | CARBOHYDRATE INTERACTIONS | FEATURES | GAMMA-RIII | BINDING | REVEALS | Immunoglobulin G - isolation & purification | Immunoglobulin Fc Fragments - metabolism | Humans | Crystallography, X-Ray | Anti-Inflammatory Agents - metabolism | Immunoglobulins, Intravenous - metabolism | Anti-Inflammatory Agents - isolation & purification | Protein Structure, Tertiary | Cell Line | Immunoglobulins, Intravenous - isolation & purification | Immunoglobulin G - chemistry | Sialic Acids - metabolism | Models, Molecular | Immunoglobulin Fc Fragments - chemistry | Glycosylation | Immunoglobulins, Intravenous - genetics | Polysaccharides - metabolism | Immunoglobulin Fc Fragments - isolation & purification | Anti-Inflammatory Agents - chemistry | Immunoglobulin G - genetics | Antigens - immunology | Immunoglobulins, Intravenous - chemistry | Mutation | Immunoglobulin Fc Fragments - genetics | Immunoglobulin G - metabolism | Polysaccharides | Anti-inflammatory drugs | Analysis | Immunoglobulin G | Crystals | Chemical properties | Structure | Antigens | Mass spectrometry
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4. Intravenous immunoglobulin in dermatology
by Jolles, Stephen
2003, ISBN 1841841366, x, 150
This is the first book to bring together the developments in this area. With full colour throughout, each chapter focuses on clinical differentiation and... 
Immunological aspects | Intravenous therapy | Immunoglobulins | Skin | Therapeutic use | Diseases
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5. Full Text Facilitated subcutaneous immunoglobulin (fSCIg) therapy – practical considerations
by Ponsford, M and Carne, E and Kingdon, C and Joyce, C and Price, C and Williams, C and El‐Shanawany, T and Williams, P and Jolles, S
Clinical & Experimental Immunology, ISSN 0009-9104, 12/2015, Volume 182, Issue 3, pp. 302 - 313
There is an increasing range of therapeutic options for primary antibody‐deficient patients who require replacement immunoglobulin. These include intravenous... 
subcutaneous immunoglobulin (SCIg) | facilitated subcutaneous immunoglobulin (fSCIg) | hyaluronidase | intravenous immunoglobulin (IVIg) | primary immunodeficiency (PID) | Hyaluronidase | Subcutaneous immunoglobulin (SCIg) | Intravenous immunoglobulin (IVIg) | Primary immunodeficiency (PID) | Facilitated subcutaneous immunoglobulin (fSCIg) | EFFICACY | SAFETY | IGG | INFUSION | IMMUNOLOGY | PRIMARY IMMUNODEFICIENCY DISEASES | ALLERGIC REACTION | REPLACEMENT THERAPY | PATIENT | Education, Medical, Continuing | Follow-Up Studies | Humans | Injections, Subcutaneous | Immunoglobulins - adverse effects | Female | Male | Immunologic Deficiency Syndromes - drug therapy | Immunoglobulins - administration & dosage | Ultrasound imaging | Immunoglobulins | Immunodeficiency | Patients | Original
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6. Full Text Intravenous immunoglobulin therapy: How does IgG modulate the immune system?
by Schwab, Inessa and Nimmerjahn, Falk
Nature Reviews Immunology, ISSN 1474-1733, 03/2013, Volume 13, Issue 3, pp. 176 - 189
Intravenous immunoglobulin (IVIG) preparations comprise pooled IgG antibodies from the serum of thousands of donors and were initially used as an IgG... 
IDIOPATHIC THROMBOCYTOPENIC PURPURA | IVIG-MEDIATED AMELIORATION | B-CELLS | RHEUMATOID-ARTHRITIS | FC-GAMMA-RECEPTOR | ANTI-D IMMUNOGLOBULIN | ANTIINFLAMMATORY ACTIVITY | DENDRITIC CELLS | REGULATORY T-CELLS | HIGH-AFFINITY BINDING | IMMUNOLOGY | Immunomodulation - drug effects | Humans | Lectins, C-Type - immunology | Receptors, IgG - chemistry | Cell Adhesion Molecules - immunology | Immunoglobulin Variable Region - immunology | Lymphocyte Subsets - immunology | Immunoglobulin Fc Fragments - immunology | Immunoglobulin G - immunology | Immunoglobulin G - pharmacology | Disease Models, Animal | N-Acetylneuraminic Acid - immunology | Autoimmune Diseases - immunology | Histocompatibility Antigens Class I - immunology | Immunoglobulin G - therapeutic use | Models, Molecular | Clinical Trials as Topic | Glycosylation | Inflammation - immunology | Receptors, IgG - immunology | Immunoglobulins, Intravenous - pharmacology | Receptors, Cell Surface - immunology | Inflammation - therapy | Autoantibodies - immunology | Immunosuppression | Animals | Receptors, Fc - immunology | Immunoglobulins, Intravenous - therapeutic use | Autoimmune Diseases - therapy | Protein Conformation | Mice | Protein Processing, Post-Translational | Immunocompromised Host | Immunomodulation - immunology | Receptors, IgG - classification | Care and treatment | Immunoglobulin G | Immunotherapy | Physiological aspects | Research | Autoimmune diseases | Health aspects | Thrombocytopenia | Immunoglobulins | Intravenous administration | Reviews | Immunocompromised hosts | Inflammatory diseases | Immune system
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7. Full Text Intravenous immunoglobulin for Guillain-Barré syndrome
by Hughes, Richard A. C and Hughes, Richard A.C and Swan, Anthony V and Swan, Anthony V and van Doorn, Pieter A and van Doorn, Pieter A
The Cochrane database of systematic reviews, ISSN 1469-493X, 2014, Volume 9, Issue 9, p. CD002063
Background Guillain-Barr syndrome (GBS) is an acute, paralysing, inflammatory peripheral nerve disease. Intravenous immunoglobulin (IVIg) is beneficial in... 
MULTICENTER | Outcome Assessment (Health Care) | Humans | GAMMA-GLOBULIN | RANDOMIZED-TRIAL | INFLAMMATORY DEMYELINATING POLYNEUROPATHY | Plasma Exchange | Guillain-Barre Syndrome [immunology; therapy] | CHILDHOOD | Recovery of Function | Randomized Controlled Trials as Topic | MEDICINE, GENERAL & INTERNAL | PLASMA-EXCHANGE | THERAPY | DISEASES | POLYRADICULONEUROPATHY | Immunoglobulins, Intravenous [therapeutic use] | Adult | Child | HUMAN IMMUNE GLOBULIN | Guillain-Barre Syndrome - therapy | Guillain-Barre Syndrome - immunology | Immunoglobulins, Intravenous - therapeutic use | Immunoglobulins, Intravenous - adverse effects | Plasma Exchange - adverse effects
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8. Full Text Immunoglobulin G Fc N-glycosylation in Guillain-Barré syndrome treated with intravenous immunoglobulin
by Fokkink, Willem-Jan and Selman, M.H.C and Wuhrer, Manfred and Jacobs, Bart
Clinical and Experimental Immunology, ISSN 0009-9104, 01/2014, Volume 178, Issue S1, pp. 105 - 107
ANTIINFLAMMATORY ACTIVITY | IMMUNOLOGY | ARTHRITIS | SIALYLATION | IGG FC | Immunoglobulin Fc Fragments - metabolism | Humans | Sialic Acids - metabolism | Glycosylation | Randomized Controlled Trials as Topic | Guillain-Barre Syndrome - therapy | Animals | Immunoglobulin Fc Fragments - immunology | Guillain-Barre Syndrome - immunology | Immunoglobulins, Intravenous - therapeutic use | Immunoglobulin G - immunology | Immunoglobulins, Intravenous - immunology | Sialic Acids - immunology | Guillain-Barre Syndrome - metabolism | Immunoglobulin G - metabolism | Mechanisms of Action
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9. Full Text Use of immunoglobulin (Ig) in peripheral neuropathies. Impact of Ig on remission rates: comparison of intravenous immunoglobulin and subcutaneous immunoglobulin
by Yoon, M.‐S
Clinical & Experimental Immunology, ISSN 0009-9104, 12/2014, Volume 178, Issue 1, pp. 25 - 26
MULTIFOCAL MOTOR NEUROPATHY | INFLAMMATORY DEMYELINATING POLYNEUROPATHY | THERAPY | IMMUNOLOGY | POLYRADICULONEUROPATHY | Cost-Benefit Analysis - methods | Clinical Trials, Phase III as Topic | Immunoglobulins, Intravenous - economics | Humans | Immunoglobulins, Intravenous - administration & dosage | Peripheral Nervous System Diseases - therapy | Peripheral Nervous System Diseases - economics | Retrospective Studies | Immunoglobulins, Intravenous - immunology | Peripheral Nervous System Diseases - immunology | Randomized Controlled Trials as Topic | Comparative analysis | Immunoglobulins | Usage | Neurology
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10. Full Text Intravenous immunoglobulin for myasthenia gravis
by Gajdos, Philippe and Chevret, Sylvie and Toyka, Klaus V
Cochrane database of systematic reviews (Online), ISSN 1469-493X, 2012, Volume 12, Issue 12, p. CD002277
Background Myasthenia gravis is an autoimmune disease in which autoantibodies interfere with neuromuscular transmission. As with other autoimmune diseases,... 
CONTROLLED-TRIAL | DRUG-THERAPY | Myasthenia Gravis [therapy] | Humans | BLOCKING ANTIBODIES | GAMMA-GLOBULIN | Plasma Exchange | Randomized Controlled Trials as Topic | PLASMAPHERESIS | MEDICINE, GENERAL & INTERNAL | PLASMA-EXCHANGE | Immunoglobulins, Intravenous [therapeutic use] | DOUBLE-BLIND | THROMBOCYTOPENIC PURPURA | EXPERIENCE | Neuroprotective Agents - therapeutic use | Immunoglobulins, Intravenous - therapeutic use | Methylprednisolone - therapeutic use | Myasthenia Gravis - therapy | Chronic Disease | Disease Progression
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11. Full Text Intravenous immunoglobulins understanding properties and mechanisms
by Durandy, A and Kaveri, S. V and Kuijpers, T. W and Basta, M and Miescher, S and Ravetch, J. V and Rieben, R
Clinical & Experimental Immunology, ISSN 0009-9104, 12/2009, Volume 158, Issue s1, pp. 2 - 13
Summary High-dose intravenous immunoglobulin (IVIg) preparations are used currently for the treatment of autoimmune or inflammatory diseases. Despite numerous... 
sialylation | Fc receptor | immunoglobulin | complement | dendritic cell | Dendritic cell | Complement | Immunoglobulin | Sialylation | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ANTIINFLAMMATORY ACTIVITY | DENDRITIC CELLS | IMMUNE GLOBULIN | COMMON VARIABLE IMMUNODEFICIENCY | IMMUNOLOGY | IDIOPATHIC THROMBOCYTOPENIC PURPURA | FC-RECEPTOR | GENE-EXPRESSION | COPY NUMBER VARIATION | AUTOIMMUNE-DISEASE | Dendritic Cells - immunology | Humans | Immunoglobulin G - therapeutic use | Receptors, IgG - immunology | Inflammation - therapy | Receptors, IgG - genetics | Animals | Immunoglobulins, Intravenous - therapeutic use | Immunoglobulin G - immunology | Mice | Polymorphism, Single Nucleotide | Immunoglobulins, Intravenous - immunology | Disease Models, Animal | Immunomodulation - immunology | Fc receptors | Universities and colleges | Dendritic cells | Immunoglobulin G | Review
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12. Full Text Japanese multicenter clinical trial of intravenous polyethylene glycol‐treated immunoglobulin and comparison with previous clinical trial of sulfonated immunoglobulin in Guillain–Barré syndrome
by Nomura, Kyoichi and Kusunoki, Susumu and the Research Group of IVIG for GBS in Japan
Clinical and Experimental Neuroimmunology, ISSN 1759-1961, 08/2017, Volume 8, Issue 3, pp. 258 - 266
We conducted a multicenter, open‐label, and single‐arm Japanese clinical trial to verify the efficacy and safety of treatment with PEG‐Ig in patients with GBS.... 
sulfonated immunoglobulin | Guillain–Bar