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Journal Article
Nature, ISSN 0028-0836, 2006, Volume 439, Issue 7075, pp. 484 - 489
While bile acids (BAs) have long been known to be essential in dietary lipid absorption and cholesterol catabolism, in recent years an important role for BAs... 
FXR | HEPATOCYTES | TYPE-2 IODOTHYRONINE DEIODINASE | GENE | ADAPTIVE THERMOGENESIS | INSULIN-RESISTANCE | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | IDENTIFICATION | BROWN FAT | NUCLEAR RECEPTOR | Bile Acids and Salts - pharmacology | Receptors, G-Protein-Coupled - metabolism | Humans | Muscle Cells - drug effects | Body Weight - drug effects | Muscle Cells - enzymology | Muscle, Skeletal - cytology | Cholic Acid - pharmacology | Liver - drug effects | Dietary Fats - pharmacology | Gene Deletion | Dietary Fats - administration & dosage | Iodide Peroxidase - metabolism | Homeostasis - drug effects | Iodide Peroxidase - deficiency | Adiposity - drug effects | Carbon Dioxide - metabolism | Liver - metabolism | Mice, Inbred C57BL | Muscle Cells - metabolism | Adipose Tissue, Brown - enzymology | Animals | Cyclic AMP - biosynthesis | Oxygen Consumption - drug effects | Thyroid Hormones - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Receptors, G-Protein-Coupled - genetics | Iodide Peroxidase - genetics | Energy Metabolism - drug effects | Obesity | Weight control | Thyroid gland | Hormones | Gene expression | Metabolism | Bile | Body Weight | Adipose Tissue, Brown | Liver | Homeostasis | Life Sciences | Adiposity | Thyroid Hormones | Dietary Fats | Muscle Cells | Cholic Acid | Iodide Peroxidase | Biochemistry, Molecular Biology | Oxygen Consumption | Receptors, G-Protein-Coupled | Cyclic AMP | Bile Acids and Salts | Carbon Dioxide | Energy Metabolism | Muscle, Skeletal | Molecular biology
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2016, Volume 22, Issue 3, pp. 312 - 318
Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport from ATP production. UCP1 is... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | WHITE | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADULT HUMANS | BROWN ADIPOSE-TISSUE | IDENTIFICATION | CELL BIOLOGY | OBESITY | GENE | INFLAMMATION | EXPRESSION | Enkephalins - metabolism | Humans | Middle Aged | Ion Channels - genetics | Male | RNA, Messenger - metabolism | Enkephalins - genetics | Mitochondrial Proteins - metabolism | Diet, High-Fat | Iodide Peroxidase - metabolism | Adipocytes, Brown - transplantation | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Oxygen Consumption | Apoptosis Regulatory Proteins - metabolism | Protein Precursors - metabolism | Mice | Iodide Peroxidase - genetics | Blood Glucose - metabolism | Integrin beta1 - genetics | Adipocytes, White - metabolism | Glucose Intolerance - metabolism | Proprotein Convertase 1 - genetics | Adipocytes, Brown - metabolism | Homeostasis | Mitochondrial Proteins - genetics | DNA-Binding Proteins - metabolism | Polymerase Chain Reaction | Apoptosis Regulatory Proteins - genetics | Adult | Female | Capillaries | Glucose Tolerance Test | Protein Precursors - genetics | Proprotein Convertase 1 - metabolism | Cell Transplantation | Adipocytes, White - transplantation | DNA-Binding Proteins - genetics | Obesity - metabolism | Integrin beta1 - metabolism | Interleukin-33 - genetics | Animals | Ion Channels - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | Adipocytes - metabolism | Fluorescent Antibody Technique | Interleukin-33 - metabolism | Adipocytes - transplantation | Aged | Glucose Clamp Technique | Uncoupling Protein 1 | Neovascularization, Physiologic | Adipose tissues | Physiological aspects | Genetic aspects | Research | cytokine | human adipocyte | glucose | progenitors | adipokine | capillary | adrenergic | thermogenic adipose tissue | implant
Journal Article
Cell Metabolism, ISSN 1550-4131, 2007, Volume 6, Issue 1, pp. 38 - 54
Brown fat cells are specialized to dissipate energy and can counteract obesity; however, the transcriptional basis of their determination is largely unknown.... 
HUMDISEASE | DEVBIO | WHITE ADIPOSE-TISSUE | MITOCHONDRIAL BIOGENESIS | IN-VIVO | ENDOCRINOLOGY & METABOLISM | PPAR-GAMMA | UNCOUPLING PROTEIN GENE | DIET-INDUCED OBESITY | COREPRESSOR RIP140 | ENERGY-METABOLISM | OXIDATIVE-METABOLISM | TRANSGENIC MICE | CELL BIOLOGY | Adipocytes, Brown - metabolism | Adipose Tissue, White - metabolism | Cercopithecus aethiops | Ion Channels - genetics | Male | Mitochondrial Proteins - genetics | Adipocytes | Mitochondria | Cell Respiration | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Iodide Peroxidase - metabolism | Trans-Activators - genetics | Fibroblasts | Transcription, Genetic | Cell Differentiation | Electrophoretic Mobility Shift Assay | Genes, Reporter | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Oxygen Consumption | Mice, Transgenic | Transcription Factors - genetics | 3T3-L1 Cells | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Inbred C3H | Mice, Knockout | Phenotype | Animals | Ion Channels - metabolism | Trans-Activators - metabolism | Adipose Tissue, Brown - metabolism | Mice | Iodide Peroxidase - genetics | Uncoupling Protein 1 | COS Cells | Adipocytes, White - metabolism | Physiological aspects | Obesity | Genetic aspects | Ion Channels | Adipose Tissue, Brown | Adipocytes, Brown | Mitochondrial Proteins | DNA-Binding Proteins | Iodide Peroxidase | Trans-Activators | Adipose Tissue, White | Adipocytes, White | Transcription Factors | thermogenesis | brown fat | PRDM16 | UCP1 | PGC-1β | PGC-1α | mitochondrial biogenesis | PPARγ | obesity
Journal Article
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2010, Volume 120, Issue 6, pp. 2206 - 2217
Journal Article