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2012, 1st ed., Arsenic in the environment, ISBN 9780415697194, Volume 1876-6218, xxv, 189
"Up to 200 million people in 70 countries are at risk from drinking water contaminated with arsenic, which is a major cause of chronic debilitating illnesses... 
Drinking water | Arsenic | Arsenic in the body | Environmental aspects | Arsenic cycle (Biogeochemistry) | Metabolism | Arsenic content
Book
Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 3, pp. 312 - 318
Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport from ATP production. UCP1 is... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | WHITE | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADULT HUMANS | BROWN ADIPOSE-TISSUE | IDENTIFICATION | CELL BIOLOGY | OBESITY | GENE | INFLAMMATION | EXPRESSION | Enkephalins - metabolism | Humans | Middle Aged | Ion Channels - genetics | Male | RNA, Messenger - metabolism | Enkephalins - genetics | Mitochondrial Proteins - metabolism | Diet, High-Fat | Iodide Peroxidase - metabolism | Adipocytes, Brown - transplantation | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Oxygen Consumption | Apoptosis Regulatory Proteins - metabolism | Protein Precursors - metabolism | Mice | Iodide Peroxidase - genetics | Blood Glucose - metabolism | Integrin beta1 - genetics | Adipocytes, White - metabolism | Glucose Intolerance - metabolism | Proprotein Convertase 1 - genetics | Adipocytes, Brown - metabolism | Homeostasis | Mitochondrial Proteins - genetics | DNA-Binding Proteins - metabolism | Polymerase Chain Reaction | Apoptosis Regulatory Proteins - genetics | Adult | Female | Capillaries | Glucose Tolerance Test | Protein Precursors - genetics | Proprotein Convertase 1 - metabolism | Cell Transplantation | Adipocytes, White - transplantation | DNA-Binding Proteins - genetics | Obesity - metabolism | Integrin beta1 - metabolism | Interleukin-33 - genetics | Animals | Ion Channels - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | Adipocytes - metabolism | Fluorescent Antibody Technique | Interleukin-33 - metabolism | Adipocytes - transplantation | Aged | Glucose Clamp Technique | Uncoupling Protein 1 | Neovascularization, Physiologic | Adipose tissues | Physiological aspects | Genetic aspects | Research | cytokine | human adipocyte | glucose | progenitors | adipokine | capillary | adrenergic | thermogenic adipose tissue | implant
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e25178
Imbalance of the excitatory neurotransmitter glutamate and of the inhibitory neurotransmitter GABA is one of several causes of seizures. ATP has also been... 
HIPPOCAMPAL SLICES | ADENOSINE KINASE | P2X RECEPTOR | HEMICHANNELS | BIOLOGY | ASTROCYTE PROGENITORS | CENTRAL-NERVOUS-SYSTEM | RAT HIPPOCAMPUS | CHANNELS | CELL-CELL COMMUNICATION | ATP RELEASE | Potassium - metabolism | Seizures - prevention & control | Connexins - physiology | Epilepsy - metabolism | Neurons - cytology | Seizures - metabolism | Seizures - chemically induced | Brain - metabolism | Adenosine Triphosphate - metabolism | Behavior, Animal - drug effects | Neurons - metabolism | Astrocytes - cytology | Epilepsy - prevention & control | Brain - cytology | Nerve Tissue Proteins - physiology | Kainic Acid - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Hippocampus - cytology | Blotting, Western | Hippocampus - metabolism | Animals | Epilepsy - chemically induced | Fluorescent Antibody Technique | Mice | Status Epilepticus - metabolism | Astrocytes - metabolism | Brain | Neurons | Epilepsy | GABA | Genetic engineering | Seizures (Medicine) | Glutamate | Neurosciences | Hyperactivity | Nervous system | Membrane channels | Channels | γ-Aminobutyric acid | Membrane conductance | Metabolites | Rodents | Cooperation | Physiology | Seizures | Seizing | Adenosine | Astrocytes | Transgenic mice | Pharmacology | Metabolism | Embryos | Resistance | Medicine | Signaling | Conductance | ATP | Kainic acid | Hippocampus
Journal Article
The Journal of physiology, ISSN 0022-3751, 2013, Volume 591, Issue 2, pp. 571 - 592
Creatine (Cr) plays an important role in muscle energy homeostasis by its participation in the ATP-phosphocreatine phosphoryl exchange reaction mediated by... 
GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY | RESPIRATORY-CHAIN | PHYSIOLOGY | MAGNETIC-RESONANCE-SPECTROSCOPY | ACTIVATED PROTEIN-KINASE | HUMAN BRAIN | IN-VIVO | ACETYL-COA CARBOXYLASE | NEUROSCIENCES | HUMAN SKELETAL-MUSCLE | BETA-GUANIDINOPROPIONIC ACID | ORAL SUPPLEMENTATION | Speech Disorders - diet therapy | Developmental Disabilities - metabolism | Amino Acid Metabolism, Inborn Errors - physiopathology | Amidinotransferases - genetics | Muscle, Skeletal - metabolism | Amino Acid Metabolism, Inborn Errors - diet therapy | Muscle Fibers, Skeletal - metabolism | Mitochondria - ultrastructure | Intellectual Disability - metabolism | Proton-Translocating ATPases - metabolism | Speech Disorders - pathology | Amino Acid Metabolism, Inborn Errors - metabolism | Developmental Disabilities - pathology | Adenosine Triphosphate - metabolism | Creatine - deficiency | Amino Acid Metabolism, Inborn Errors - pathology | Intellectual Disability - diet therapy | Hand Strength | Developmental Disabilities - physiopathology | Speech Disorders - metabolism | Amidinotransferases - deficiency | Magnetic Resonance Spectroscopy | Intellectual Disability - pathology | Ischemia - metabolism | Lipid Metabolism | Muscular Atrophy - genetics | Mitochondria - metabolism | Amidinotransferases - metabolism | Speech Disorders - physiopathology | Mice, Knockout | Intellectual Disability - physiopathology | Phosphates - metabolism | Animals | Energy Metabolism | Muscle, Skeletal - physiopathology | Hindlimb - pathology | Muscle Fibers, Skeletal - pathology | Creatine Kinase - metabolism | Creatine - therapeutic use | Mice | Muscle, Skeletal - pathology | Developmental Disabilities - diet therapy | Hydrogen-Ion Concentration | Physiological aspects | Creatine | Homeostasis | Enzymes | Musculoskeletal system | Biosynthesis | Metabolism | Morphology | Skeletal Muscle and Exercise
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 330, Issue 6008, pp. 1247 - 1251
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism
Journal Article
The New phytologist, ISSN 0028-646X, 2015, Volume 205, Issue 1, pp. 240 - 254
Overexpression of bacterial γ-glutamylcysteine synthetase in the cytosol of × produces higher glutathione (GSH) concentrations in leaves, thereby indicating... 
Full papers | Cadmium | Leaves | Messenger RNA | Genes | Plant roots | Plants | Root tips | Transgenic plants | Genotypes | antioxidant | plasma membrane H+‐ATPase | glutathione | ion flux | phytoremediation | Populus | oxidative stress | cadmium (Cd) | Ion flux | Oxidative stress | Cadmium (Cd) | ATPase | Plasma membrane H | Antioxidant | Glutathione | Phytoremediation | ARABIDOPSIS-THALIANA | PHYTOCHELATIN SYNTHASE | PHYSIOLOGICAL-RESPONSES | GLUTATHIONE SYNTHESIS | TRANSCRIPTIONAL RESPONSES | PLANT SCIENCES | plasma membrane H+-ATPase | POPULUS X CANESCENS | BRASSICA-NAPUS | GENE-EXPRESSION | HEAVY-METAL RESISTANCE | LONG-DISTANCE TRANSPORT | Inactivation, Metabolic | Reactive Oxygen Species - metabolism | Calcium - metabolism | Genes, Plant | Antioxidants - metabolism | Carbohydrate Metabolism - genetics | Populus - genetics | Cadmium - metabolism | RNA, Messenger - metabolism | Sulfhydryl Compounds - metabolism | Biological Transport | Plants, Genetically Modified | Populus - metabolism | Gene Expression Regulation, Plant | Superoxides - metabolism | Dipeptides - metabolism | Principal Component Analysis | Hydrogen - metabolism | Escherichia coli - enzymology | Plant Roots - metabolism | RNA, Messenger - genetics | Wood - metabolism | Plant Leaves - metabolism | Models, Biological | Plant Bark - metabolism | Populus - growth & development
Journal Article
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2008, Volume 205, Issue 10, pp. 2409 - 2417
The current goal of diabetes therapy is to reduce time-averaged mean levels of glycemia, measured as HbA1c, to prevent diabetic complications. However, HbA1c... 
DIABETES-MELLITUS | MEDICINE, RESEARCH & EXPERIMENTAL | HISTONE LYSINE METHYLATION | ACTIVATION | ENDOTHELIAL-CELLS | TRANSCRIPTION | ATHEROSCLEROSIS | CHROMATIN MODIFICATIONS | COMPLICATIONS | IMMUNOLOGY | CORONARY HEART-DISEASE | NF-KAPPA-B | Protein Methyltransferases | Superoxide Dismutase - genetics | Diabetes Complications | Reactive Oxygen Species - metabolism | Epigenesis, Genetic | Glycated Hemoglobin A - metabolism | Humans | Ion Channels - genetics | Male | Mitochondrial Proteins - genetics | Transcription Factor RelA - genetics | Cattle | Mitochondrial Proteins - metabolism | Vascular Cell Adhesion Molecule-1 - genetics | Chemokine CCL2 - metabolism | Endothelial Cells - physiology | Superoxide Dismutase - metabolism | Promoter Regions, Genetic | Histone-Lysine N-Methyltransferase - genetics | Mice, Inbred C57BL | Risk Factors | Cells, Cultured | Gene Expression Regulation | Diabetes Mellitus - metabolism | Chemokine CCL2 - genetics | Mitochondria - metabolism | Mice, Knockout | Hyperglycemia - metabolism | Animals | Histone-Lysine N-Methyltransferase - metabolism | Ion Channels - metabolism | Transcription Factor RelA - metabolism | Endothelial Cells - cytology | Glucose - metabolism | Mice | Uncoupling Protein 1 | Blood Glucose - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Glycated Hemoglobin A - genetics
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, pp. e0145155 - e0145155
The mammalian circadian clock influences most aspects of physiology and behavior through the transcriptional control of a wide variety of genes, mostly in a... 
UBIQUITIN-SPECIFIC PROTEASE | DEUBIQUITINATING ENZYME | DROSOPHILA CLOCK | METABOLISM | SUPRACHIASMATIC NUCLEUS | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | MOUSE | GENE-EXPRESSION | DEUBIQUITYLATION | N-TERMINAL SEQUENCES | Up-Regulation | Intestinal Mucosa - metabolism | Calcium - metabolism | Absorption, Physiological | Humans | Mice, Inbred C57BL | Homeostasis | Male | Phosphoproteins - metabolism | Mice, Knockout | Sodium-Hydrogen Exchangers - metabolism | Drosophila melanogaster - metabolism | Membranes - metabolism | Locomotion | Animals | Clathrin Heavy Chains - metabolism | Hypercalciuria - metabolism | Models, Biological | HEK293 Cells | Circadian Clocks | Protein Binding | Protein Processing, Post-Translational | Ubiquitin-Specific Proteases - metabolism | Cryptochromes - metabolism | Circadian rhythms | Post-translational modification | Physiological aspects | Genetic aspects | Research | Calcium ions | Ubiquitin | Clathrin | Membranes | Ubiquitin-specific proteinase | Transcription | Calcium | Genes | Membrane permeability | Genomes | Small intestine | Calcium influx | Proteins | Toxicology | Rodents | Animal tissues | Post-translation | Evolution | Physiology | Supplementation | Calcium homeostasis | Translation | Calcium (dietary) | Drosophila | Dietary supplements | Pupation | Pharmacology | Cell membranes | Permeability | Rhythms | Circadian rhythm | Gene expression | Mammals | Calcium permeability | Membrane proteins | Calcium absorption | Insects | Diet | Proteomics | Cryptochromes | Index Medicus
Journal Article