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The Journal of Immunology, ISSN 0022-1767, 09/2000, Volume 165, Issue 6, pp. 3506 - 3518
Although interruption of CD40-CD40L interactions via their respective mAbs yields prolonged allograft survival, the relative importance of CD40 or CD40L on... 
B-CELLS | CORONARY ARTERIOSCLEROSIS | TUMOR-NECROSIS-FACTOR | INTERFERON-GAMMA | CELL ACTIVATION | ORTHOTOPIC LIVER-TRANSPLANTATION | ENDOTHELIAL-CELLS | MONOCLONAL-ANTIBODY | TNF-ALPHA | IMMUNOLOGY | T-CELLS | Skin Transplantation - immunology | Isoantibodies - biosynthesis | Spleen - immunology | Membrane Glycoproteins - biosynthesis | Heart Transplantation - pathology | Male | Lymphocyte Culture Test, Mixed | CD4-Positive T-Lymphocytes - immunology | Cell Movement - immunology | B7-2 Antigen | CD40 Antigens - biosynthesis | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Immunoglobulin G - biosynthesis | CD8-Positive T-Lymphocytes - metabolism | B7-1 Antigen - biosynthesis | Graft Rejection - pathology | Heart Transplantation - immunology | Antibodies, Monoclonal - pharmacology | Immune Sera - administration & dosage | CD4-Positive T-Lymphocytes - metabolism | Coronary Artery Disease - prevention & control | Injections, Intraperitoneal | Spleen - cytology | Mice, Knockout | CD3 Complex - immunology | Coronary Artery Disease - genetics | Ligands | Mice | Mice, Inbred BALB C | Coronary Artery Disease - immunology | Graft Rejection - immunology | CD8-Positive T-Lymphocytes - immunology | Graft Rejection - genetics | Haplotypes - immunology | Macrophage-1 Antigen - biosynthesis | CD40 Antigens - immunology | Graft Survival - immunology | Antigens, CD - biosynthesis | Transplantation, Homologous | CD40 Antigens - metabolism | Coronary Artery Disease - pathology | Immunosuppressive Agents - administration & dosage | Immunity, Cellular - genetics | Mice, Inbred C57BL | Cells, Cultured | Transplantation, Heterotopic | Mice, Inbred C3H | Membrane Glycoproteins - genetics | Animals | Graft Survival - genetics | CD28 Antigens - biosynthesis | Immune Tolerance - genetics | CD40 Ligand | Cytokines - biosynthesis | Membrane Glycoproteins - deficiency | Immunoglobulin M - biosynthesis
Journal Article
The Journal of Immunology, ISSN 0022-1767, 05/2002, Volume 168, Issue 10, pp. 5058 - 5069
A 20-day treatment with LF15-0195, a deoxyspergualine analogue, induced allograft tolerance in a fully MHC-mismatched heart allograft model in the rat.... 
Isoantibodies - biosynthesis | Spleen - immunology | Dendritic Cells - immunology | Heart Transplantation - pathology | Interphase - immunology | Male | Spleen - drug effects | Interferon-gamma - metabolism | Transforming Growth Factor beta - biosynthesis | Lymphocyte Culture Test, Mixed | Thymus Gland - transplantation | CD4-Positive T-Lymphocytes - immunology | RNA, Messenger - biosynthesis | T-Lymphocyte Subsets - drug effects | Isoantigens - immunology | Antigen-Presenting Cells - transplantation | Cytokines - genetics | Guanidines - administration & dosage | Spleen - transplantation | Isoantigens - metabolism | Heart Transplantation - immunology | Receptors, Interleukin-2 - biosynthesis | Antigen-Presenting Cells - drug effects | Injections, Intraperitoneal | Rats | T-Lymphocyte Subsets - transplantation | CTLA-4 Antigen | Antigens, Differentiation - biosynthesis | Immunoglobulin Isotypes - biosynthesis | Immunoconjugates | Interleukin-10 - genetics | Antigens, Differentiation - genetics | Graft Rejection - immunology | Interleukin-2 - biosynthesis | Chronic Disease | Antigens, CD | T-Lymphocyte Subsets - immunology | Rats, Inbred Lew | RNA, Messenger - analysis | Adoptive Transfer | Interleukin-2 - antagonists & inhibitors | Th1 Cells - immunology | Abatacept | Immune Tolerance - immunology | Interleukin-10 - metabolism | Dendritic Cells - drug effects | Immunosuppressive Agents - administration & dosage | Immune Tolerance - drug effects | Interleukin-2 - metabolism | Graft Rejection - prevention & control | Thymus Gland - cytology | Antigen-Presenting Cells - immunology | Animals | Transforming Growth Factor beta - genetics | Spleen - metabolism | Lymphocyte Activation - drug effects | T-Lymphocyte Subsets - metabolism | Lymphocyte Count | Thy-1 Antigens - biosynthesis | Interleukin-10 - biosynthesis | Thymus Gland - immunology | Antigen Presentation - drug effects | Dendritic Cells - transplantation | CD4-Positive T-Lymphocytes - drug effects | Cytokines - biosynthesis | Interphase - drug effects
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2009, Volume 183, Issue 9, pp. 5673 - 5684
B-1 and marginal zone (MZ) B cells produce natural Abs, make Ab responses to microbial pathogens, and contribute to autoimmunity. Although the delta isoform of... 
ADHESION | HEART-DISEASE | ACTIVATION | PYK2 TYROSINE PHOSPHORYLATION | ATHEROSCLEROSIS | INJURY | OXIDATION-SPECIFIC EPITOPES | ISOFORM | MOLECULAR MIMICRY | IMMUNOLOGY | DEPENDENT ANTIGEN | Isoantibodies - biosynthesis | Spleen - immunology | Rats, Inbred Lew | Phosphatidylinositol 3-Kinases - metabolism | Spleen - drug effects | Autoantibodies - biosynthesis | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Antibodies, Bacterial - biosynthesis | Spleen - enzymology | Peritoneum - cytology | Peritoneum - immunology | B-Lymphocyte Subsets - immunology | Female | Quinazolines - administration & dosage | Homeostasis - drug effects | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | B-Lymphocyte Subsets - drug effects | Adenine - analogs & derivatives | Administration, Oral | Mice, Inbred C57BL | Cells, Cultured | Homeostasis - immunology | Rats | Spleen - cytology | B-Lymphocyte Subsets - enzymology | Adenine - administration & dosage | Gene Knock-In Techniques | Animals | B-Lymphocyte Subsets - microbiology | Phosphatidylinositol 3-Kinases - physiology | Mice | Peritoneum - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Bacterial | cytology | Phosphorylation | Antibodies | Homeostasis | Oral | Isoantibodies | Quinazolines | B-Lymphocyte Subsets | administration & dosage | biosynthesis | Cultured | immunology | Spleen | Administration | 1-Phosphatidylinositol 3-Kinase | Autoantibodies | physiology | Adenine | microbiology | drug effects | antagonists & inhibitors | enzymology | Cells | Inbred C57BL | Inbred Lew | Patobiologi | Proto-Oncogene Proteins c-akt | Pathobiology | analogs & derivatives | metabolism | Peritoneum
Journal Article
Journal Article
Journal Article
Blood, ISSN 0006-4971, 04/2010, Volume 115, Issue 13, pp. 2682 - 2685
Journal Article
Journal Article
British Journal of Haematology, ISSN 0007-1048, 02/2012, Volume 156, Issue 3, pp. 295 - 302
Summary Monogenic hereditary diseases, such as haemophilia A and B, are ideal targets for gene therapeutic approaches. While these diseases can be treated with... 
haemophilia | factor VIII (FVIII) | factor IX (FIX) | gene therapy | immune tolerance | Haemophilia | Factor IX (FIX) | Factor VIII (FVIII) | Gene therapy | Immune tolerance | ANTIGEN-SPECIFIC EFFECTOR | A MICE | IMMUNOLOGICAL-TOLERANCE | HUMAN-FACTOR-VIII | HEMATOPOIETIC STEM-CELLS | FACTOR-IX | REGULATORY T-CELLS | TRANSGENE PRODUCT | NEPHROTIC SYNDROME | HEMATOLOGY | IMMUNE TOLERANCE INDUCTION | Hemophilia B - therapy | Recombinant Fusion Proteins - immunology | Dependovirus - genetics | Factor IX - antagonists & inhibitors | Factor VIII - immunology | Isoantibodies - biosynthesis | Factor IX - therapeutic use | Humans | Recombinant Fusion Proteins - therapeutic use | Genetic Vectors - adverse effects | Male | Genetic Vectors - therapeutic use | T-Lymphocytes, Regulatory - immunology | Recombinant Fusion Proteins - antagonists & inhibitors | Retroviridae - genetics | Factor VIII - antagonists & inhibitors | Female | Factor VIII - therapeutic use | Recombinant Fusion Proteins - biosynthesis | Gene Transfer Techniques | Factor IX - immunology | Genetic Vectors - immunology | Gene Expression Regulation | Genes, Synthetic | Factor VIII - genetics | Immune Tolerance | Cell Transplantation | Dependovirus - immunology | Factor IX - genetics | Hemophilia B - genetics | Hemophilia A - therapy | Forecasting | Genetic Vectors - genetics | Recombinant Fusion Proteins - genetics | Hemophilia A - genetics | Factor VIII - biosynthesis | Clinical Trials, Phase I as Topic | Factor IX - biosynthesis | Genetic Therapy - methods | Prevention | Anopheles | Care and treatment | Blood coagulation factor VIII | Genes | Hemophilia | Health aspects | Prothrombin complex concentrate | inhibitors | vectors | factor VIII (F8) | factor IX (F9)
Journal Article
American Journal of Transplantation, ISSN 1600-6135, 10/2005, Volume 5, Issue 10, pp. 2339 - 2348
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 11/2015, Volume 13, Issue 11, pp. 1989 - 1998
Summary Background Vatreptacog alfa, a recombinant human factor VIIa (rFVIIa) analog developed to improve the treatment of bleeds in hemophilia patients with... 
hemophilia | vatreptacog alfa | antibody formation | antibodies | recombinant factor VIIa | immunoglobulin isotypes | Antibodies | Immunoglobulin isotypes | Recombinant factor VIIa | Vatreptacog alfa | Antibody formation | Hemophilia | SEVERE HEMOPHILIA-A | MULTICENTER | COAGULATION-FACTOR VIIA | EFFICACY | SAFETY | RFVIIA | RESPONSES | INHIBITOR RISK | HOME TREATMENT | DOUBLE-BLIND | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Antibody Specificity | Isoantibodies - biosynthesis | Humans | Neutralization Tests | Recombinant Proteins - pharmacokinetics | Structure-Activity Relationship | Antigen-Antibody Reactions | Epitopes - immunology | Immunoglobulin G - biosynthesis | Immunoglobulin G - immunology | Hemorrhage - etiology | Factor VIIa - chemistry | Amino Acid Sequence | Factor VIIa - immunology | HLA-D Antigens - genetics | Recombinant Proteins - chemistry | Protein Structure, Tertiary - genetics | Recombinant Proteins - genetics | Hemophilia A - blood | Cross Reactions | Hemorrhage - drug therapy | Recombinant Proteins - immunology | Isoantibodies - immunology | Factor VIIa - genetics | Epitopes - chemistry | Factor VIIa - pharmacokinetics | HLA-D Antigens - analysis | Amino Acid Substitution | Amino acids | Biological products | Blood coagulation factor VIII | Immunoglobulin G | Antigenic determinants | Immunoglobulins
Journal Article