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Journal Article
Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 622 - 626
A number of human cancers harbor somatic point mutations in the genes encoding isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2). These mutations alter... 
Molecules | Enzymes | Dehydrogenases | Blasts | Myeloid leukemia | REPORTS | Stem cells | Bone marrow cells | Cellular differentiation | Hematopoietic stem cells | Mesenchymal stem cells | ISOCITRATE DEHYDROGENASE | ONCOMETABOLITE 2-HYDROXYGLUTARATE | SUFFICIENT | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC PROGENITORS | MUTATION | Cell Proliferation | Humans | Protein Multimerization | Crystallography, X-Ray | Erythropoiesis - drug effects | Isocitrate Dehydrogenase - antagonists & inhibitors | Molecular Targeted Therapy | Hematopoiesis - drug effects | Antineoplastic Agents - metabolism | Leukemia, Myeloid, Acute - enzymology | Phenylurea Compounds - chemistry | Enzyme Inhibitors - chemistry | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Phenylurea Compounds - metabolism | Mutant Proteins - antagonists & inhibitors | Catalytic Domain | Enzyme Inhibitors - metabolism | Protein Structure, Secondary | Sulfonamides - chemistry | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Isocitrate Dehydrogenase - genetics | Mutant Proteins - metabolism | Gene Expression Regulation, Leukemic | Antineoplastic Agents - chemistry | Sulfonamides - pharmacology | Point Mutation | Isocitrate Dehydrogenase - chemistry | Small Molecule Libraries | Mutant Proteins - chemistry | Allosteric Site | Sulfonamides - metabolism | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Phenylurea Compounds - pharmacology | Leukemia, Erythroblastic, Acute | Leukemia, Myeloid, Acute - genetics | Leukemia | Cancer cells | Physiological aspects | Research | Oxidoreductases | Cell differentiation | Health aspects | Mutation | Cellular biology | Drug therapy | Cells
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2015, Volume 290, Issue 2, pp. 762 - 774
Journal Article
Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 626 - 630
The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy. One... 
Enzymes | Cell growth | Glioma | RNA | Neurons | REPORTS | Methylation | Cellular differentiation | Genetic mutation | Heterologous transplantation | Tumors | TRANSFORMATION | GLIOBLASTOMA | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | PHENOTYPE | ACUTE MYELOID-LEUKEMIA | MUTATIONS | ONCOMETABOLITE 2-HYDROXYGLUTARATE | BRAIN | Benzeneacetamides - toxicity | Protein Multimerization | Imidazoles - administration & dosage | Gene Expression Profiling | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - genetics | RNA Interference | Enzyme Inhibitors - toxicity | Glioma - pathology | Imidazoles - toxicity | Gene Expression Regulation, Neoplastic - drug effects | Benzeneacetamides - pharmacology | Mutant Proteins - antagonists & inhibitors | Glioma - enzymology | Enzyme Inhibitors - pharmacology | Isocitrate Dehydrogenase - genetics | Mutant Proteins - metabolism | Imidazoles - pharmacology | Mice, SCID | Benzeneacetamides - administration & dosage | Xenograft Model Antitumor Assays | Animals | Cell Differentiation - drug effects | Cell Transformation, Neoplastic | Isocitrate Dehydrogenase - chemistry | Mutant Proteins - chemistry | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mice | Histones - metabolism | Glioma - drug therapy | Cell proliferation | Gene mutations | Gliomas | Growth | Cancer cells | Physiological aspects | Genetic aspects | Research | Cancer | Genes | Cells | Mutation | Drugs | Binding | Mutations | Inhibitors | Online | Delay
Journal Article
Science (New York, N.Y.), ISSN 0036-8075, 01/2017, Volume 355, Issue 6323, pp. eaal3655 - eaal3655
Cells synthesize glucose if deprived of it, and destroy gluconeogenic enzymes upon return to glucose-replete conditions. We found that the Gid4 subunit of the... 
PROTEIN-FRAGMENTS | MALATE-DEHYDROGENASE | TERMINAL ACETYLATION | GID COMPLEX | MULTIDISCIPLINARY SCIENCES | SPLIT-UBIQUITIN | YEAST 2-HYBRID | FRUCTOSE-1,6-BISPHOSPHATASE | CATABOLITE DEGRADATION | CELLULAR-PROTEINS | SACCHAROMYCES-CEREVISIAE | Malate Dehydrogenase - metabolism | Isocitrate Lyase - metabolism | Proline - metabolism | Saccharomyces cerevisiae - genetics | Vesicular Transport Proteins - metabolism | Vesicular Transport Proteins - genetics | Isocitrate Lyase - chemistry | Substrate Specificity | Vesicular Transport Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Proline - chemistry | Glucose - deficiency | Fructose-Bisphosphatase - metabolism | Protein Kinase C - metabolism | Proteolysis | Protein Kinase C - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - enzymology | Fructose-Bisphosphatase - chemistry | Malate Dehydrogenase - chemistry | Gluconeogenesis | Saccharomyces cerevisiae Proteins - chemistry | Biodegradation | Fructose-bisphosphatase | Residues | Enzymes | Yeast | Proteinase | Pyruvic acid | Amino acids | Malate dehydrogenase | Longevity | Glucose | Hydrophobicity | Dehydrogenase | Isocitrate lyase | Substrates | Degradation | Proteins | Genetic code | Malate | Glycolysis | Protein interaction | Ubiquitin-protein ligase | Pathways | Proline | Terminals
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 11/2015, Volume 11, Issue 11, pp. 878 - 886
Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are driver mutations in acute myeloid leukemia (AML) and other cancers. We report the development of... 
ISOCITRATE DEHYDROGENASE 1 | SELECTIVE-INHIBITION | PROGENITOR CELLS | DNA METHYLATION | SMALL-MOLECULE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLINICAL-IMPLICATIONS | KINASE INHIBITORS | CELL-DIFFERENTIATION | MYELODYSPLASTIC SYNDROMES | ACUTE PROMYELOCYTIC LEUKEMIA | Neoplastic Stem Cells - drug effects | Allosteric Regulation | Humans | Crystallography, X-Ray | Male | Isocitrate Dehydrogenase - antagonists & inhibitors | Dose-Response Relationship, Drug | Leukemia, Myeloid, Acute - enzymology | Pyrazoles - chemistry | Enzyme Inhibitors - pharmacokinetics | Granulocytes - drug effects | Cytosine - metabolism | Dihydropyridines - pharmacokinetics | Enzyme Inhibitors - chemistry | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Granulocytes - pathology | Pyrazoles - pharmacokinetics | Pyrazoles - pharmacology | Dihydropyridines - chemistry | Leukemia, Myeloid, Acute - pathology | Enzyme Inhibitors - pharmacology | Models, Molecular | Isocitrate Dehydrogenase - genetics | Cytosine - chemistry | Granulocytes - enzymology | Xenograft Model Antitumor Assays | Animals | Cell Differentiation - drug effects | Isocitrate Dehydrogenase - chemistry | Allosteric Site | Cell Line, Tumor | CpG Islands | Dihydropyridines - pharmacology | Protein Binding | Isocitrate Dehydrogenase - metabolism | Mice | Kinetics | Mutation | Primary Cell Culture | DNA Methylation - drug effects | Neoplastic Stem Cells - enzymology | Leukemia, Myeloid, Acute - genetics
Journal Article
Molecular BioSystems, ISSN 1742-206X, 6/2016, Volume 12, Issue 7, pp. 2276 - 2287
Journal Article
Nature, ISSN 0028-0836, 01/2016, Volume 529, Issue 7584, pp. 110 - 114
Gain-of-function IDH mutations are initiating events that define major clinical and prognostic classes of gliomas(1,2). Mutant IDH protein produces a new... 
MAINTENANCE | METHYLATION | LANDSCAPE | DEMETHYLATION | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | ARCHITECTURE | PHENOTYPE | EXPRESSION | 2-HYDROXYGLUTARATE | PRINCIPLES | Chromatin - metabolism | Up-Regulation | Humans | Glioma - genetics | Base Sequence | Glioma - pathology | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Binding Sites | Chromatin - drug effects | Repressor Proteins - metabolism | Oncogenes - genetics | Insulator Elements - genetics | Glioma - enzymology | Chromosomal Proteins, Non-Histone - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Isocitrate Dehydrogenase - genetics | DNA Methylation - genetics | Down-Regulation - drug effects | Mutation - genetics | CRISPR-Cas Systems - genetics | Insulator Elements - drug effects | Phenotype | Isocitrate Dehydrogenase - chemistry | Receptor, Platelet-Derived Growth Factor alpha - genetics | CCCTC-Binding Factor | CpG Islands - genetics | Protein Binding | Isocitrate Dehydrogenase - metabolism | Cell Proliferation - drug effects | Enhancer Elements, Genetic - genetics | Glutarates - metabolism | Cell Transformation, Neoplastic - drug effects | Chromatin - genetics | DNA Methylation - drug effects | Glioma - drug therapy | Complications and side effects | Care and treatment | Platelet-derived growth factor | Gliomas | Analysis | Influence | Genetic aspects | Research | Methylation | Oncogenes | DNA methylation | Epigenetics | Genomes | Mutation | Gene expression | Binding sites | Deoxyribonucleic acid--DNA | Tumors
Journal Article
FASEB Journal, ISSN 0892-6638, 06/2015, Volume 29, Issue 6, pp. 2462 - 2472
Journal Article