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1. Full Text Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery
by Merk, Alan and Bartesaghi, Alberto and Banerjee, Soojay and Falconieri, Veronica and Rao, Prashant and Davis, Mindy I and Pragani, Rajan and Boxer, Matthew B and Earl, Lesley A and Milne, Jacqueline L.S and Subramaniam, Sriram
Cell (Cambridge), ISSN 0092-8674, 06/2016, Volume 165, Issue 7, pp. 1698 - 1707
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Sulfonamides - chemistry | Humans | Models, Molecular | Crystallography, X-Ray | Glutamate Dehydrogenase - chemistry | Isocitrate Dehydrogenase - antagonists & inhibitors | Sulfonamides - pharmacology | Drug Discovery | Isocitrate Dehydrogenase - ultrastructure | Cryoelectron Microscopy | Glutamate Dehydrogenase - ultrastructure | L-Lactate Dehydrogenase - chemistry | Animals | L-Lactate Dehydrogenase - ultrastructure | Cattle | Isocitrate Dehydrogenase - chemistry | Aminoquinolines - chemistry | Chickens | Glutamate Dehydrogenase - antagonists & inhibitors | Protein Conformation | L-Lactate Dehydrogenase - antagonists & inhibitors | Aminoquinolines - pharmacology | Proteins | Analysis | Physiological aspects | Atoms | Drug discovery | Glutamate | Cells | Enzymes | Protein binding | Index Medicus
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2. Full Text SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status
by Yu, Wei and Dittenhafer-Reed, Kristin E and Denu, John M
The Journal of biological chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 17, pp. 14078 - 14086
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Sirtuin 3 - metabolism | Oxidation-Reduction | Oxidative Stress | Caloric Restriction | Humans | Gene Expression Regulation | Mitochondria - metabolism | NADP - chemistry | Animals | Sirtuins - chemistry | Models, Biological | HEK293 Cells | Isocitrate Dehydrogenase - metabolism | Fibroblasts - cytology | Glutathione - chemistry | Mice | Lysine - chemistry | Index Medicus | Sirtuins | Deacetylation | Metabolic Regulation | Redox Regulation | Metabolism | Isocitrate Dehydrogenase | Histone Deacetylase | Mitochondrial Metabolism
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3. Full Text A unique homodimeric NAD+‐linked isocitrate dehydrogenase from the smallest autotrophic eukaryote Ostreococcus tauri
by Tang, Wang‐Gang and Song, Ping and Cao, Zheng‐Yu and Wang, Peng and Zhu, Guo‐Ping
The FASEB journal, ISSN 0892-6638, 06/2015, Volume 29, Issue 6, pp. 2462 - 2472
adaptation | phylogenetic analysis | kinetics | coenzyme specificity determinants | Phylogenetic analysis | Kinetics | Coenzyme specificity determinants | Adaptation | Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Molecular Weight | Protein Multimerization | Molecular Sequence Data | Substrate Specificity | Phylogeny | NADP - chemistry | NAD - chemistry | Chlorophyta - genetics | Isocitrate Dehydrogenase - classification | Base Sequence | Algal Proteins - genetics | Molecular Structure | NADP - metabolism | Circular Dichroism | NAD - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Algal Proteins - chemistry | Isocitrates - metabolism | Models, Molecular | Magnesium - metabolism | Binding Sites - genetics | Blotting, Western | Sequence Homology, Amino Acid | Manganese - metabolism | Chlorophyta - enzymology | Isocitrate Dehydrogenase - chemistry | Protein Binding | Isocitrate Dehydrogenase - metabolism | Mutation | Algal Proteins - metabolism | Index Medicus
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4. Full Text Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule
by Deng, Gejing and Shen, Junqing and Yin, Ming and McManus, Jessica and Mathieu, Magali and Gee, Patricia and He, Timothy and Shi, Chaomei and Bedel, Olivier and McLean, Larry R and Le-Strat, Frank and Zhang, Ying and Marquette, Jean-Pierre and Gao, Qiang and Zhang, Bailin and Rak, Alexey and Hoffmann, Dietmar and Rooney, Eamonn and Vassort, Aurelie and Englaro, Walter and Li, Yi and Patel, Vinod and Adrian, Francisco and Gross, Stefan and Wiederschain, Dmitri and Cheng, Hong and Licht, Stuart
The Journal of biological chemistry, ISSN 0021-9258, 09/2015, Volume 290, Issue 2, pp. 762 - 774
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Isocitrate Dehydrogenase - biosynthesis | Escherichia coli | Humans | Gene Expression Regulation, Neoplastic | Mutant Proteins - genetics | Crystallography, X-Ray | Isocitrate Dehydrogenase - genetics | DNA Methylation - genetics | Enzyme Inhibitors - chemical synthesis | Isocitrate Dehydrogenase - antagonists & inhibitors | Drug Discovery | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Magnesium - chemistry | Neoplasms - genetics | Isocitrate Dehydrogenase - chemistry | Enzyme Inhibitors - chemistry | Mutant Proteins - chemistry | Allosteric Site | Protein Conformation | Neoplasms - pathology | Index Medicus | Mechanism of Inhibition | Cancer Metabolism | Drug Action | IDH1 Inhibitor | Enzymology | Metalloenzyme | Anticancer Drug | Enzyme Inhibitor
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5. Full Text Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation
by Fang Wang and Jeremy Travins and Byron DeLaBarre and Virginie Penard-Lacronique and Stefanie Schalm and Erica Hansen and Kimberly Straley and Andrew Kernytsky and Wei Liu and Camelia Gliser and Hua Yang and Stefan Gross and Erin Artin and Veronique Saada and Elena Mylonas and Cyril Quivoron and Janeta Popovici-Muller and Jeffrey O. Saunders and Francesco G. Salituro and Shunqi Yan and Stuart Murray and Wentao Wei and Yi Gao and Lenny Dang and Marion Dorsch and Sam Agresta and David P. Schenkein and Scott A. Biller and Shinsan M. Su and Stephane de Botton and Katharine E. Yen and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Science (American Association for the Advancement of Science), ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 622 - 626
Molecules | Enzymes | Dehydrogenases | Blasts | Myeloid leukemia | REPORTS | Stem cells | Bone marrow cells | Cellular differentiation | Hematopoietic stem cells | Mesenchymal stem cells | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Proliferation | Humans | Protein Multimerization | Crystallography, X-Ray | Erythropoiesis - drug effects | Isocitrate Dehydrogenase - antagonists & inhibitors | Molecular Targeted Therapy | Hematopoiesis - drug effects | Antineoplastic Agents - metabolism | Leukemia, Myeloid, Acute - enzymology | Phenylurea Compounds - chemistry | Enzyme Inhibitors - chemistry | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Phenylurea Compounds - metabolism | Mutant Proteins - antagonists & inhibitors | Catalytic Domain | Enzyme Inhibitors - metabolism | Protein Structure, Secondary | Sulfonamides - chemistry | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Isocitrate Dehydrogenase - genetics | Mutant Proteins - metabolism | Gene Expression Regulation, Leukemic | Antineoplastic Agents - chemistry | Sulfonamides - pharmacology | Point Mutation | Isocitrate Dehydrogenase - chemistry | Small Molecule Libraries | Mutant Proteins - chemistry | Allosteric Site | Sulfonamides - metabolism | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Phenylurea Compounds - pharmacology | Leukemia, Erythroblastic, Acute | Leukemia, Myeloid, Acute - genetics | Leukemia | Cancer cells | Physiological aspects | Research | Oxidoreductases | Cell differentiation | Health aspects | Mutation | Cellular biology | Drug therapy | Cells | Index Medicus
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6. Full Text Regulation of mitochondrial dehydrogenases by calcium ions
by Denton, Richard M
Biochimica et biophysica acta. Bioenergetics, ISSN 0005-2728, 2009, Volume 1787, Issue 11, pp. 1309 - 1316
ATP supply | Mitochondria | Calcium binding | Calcium ion | Dehydrogenase | Vertebrate | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Mitochondria - enzymology | Animals | Calcium - physiology | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - physiology | Humans | Enzyme Activation | Glycerolphosphate Dehydrogenase - physiology | Ketoglutarate Dehydrogenase Complex - physiology | Isocitrate Dehydrogenase - physiology | Phosphates | Cell research | Mitochondrial DNA | Oxidoreductases | Laws, regulations and rules
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7. Full Text Structure and function of an ancestral-type β-decarboxylating dehydrogenase from Thermococcus kodakarensis
by Shimizu, Tetsu and Yin, Lulu and Yoshida, Ayako and Yokooji, Yuusuke and Hachisuka, Shin-Ichi and Sato, Takaaki and Tomita, Takeo and Nishida, Hiromi and Atomi, Haruyuki and Kuzuyama, Tomohisa and Nishiyama, Makoto
Biochemical journal, ISSN 0264-6021, 01/2017, Volume 474, Issue 1, pp. 105 - 122
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Thermococcus - genetics | Archaeal Proteins - chemistry | Substrate Specificity | Structure-Activity Relationship | Genetic Complementation Test | Oxidoreductases - chemistry | Thermus thermophilus - genetics | Isocitrates - chemistry | Thermococcus - enzymology | Malates - metabolism | Archaeal Proteins - genetics | Archaeal Proteins - metabolism | Recombinant Proteins - metabolism | Thermus thermophilus - enzymology | Catalytic Domain | Oxidoreductases - metabolism | Protein Structure, Secondary | Oxidoreductases - genetics | Isocitrates - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Tricarboxylic Acids - metabolism | Lysine - genetics | Malates - chemistry | Lysine - biosynthesis | Lysine - chemistry | Tricarboxylic Acids - chemistry | Index Medicus
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8. Full Text NADP+-dependent isocitrate dehydrogenase activity in marine plankton
by Tames-Espinosa, Mayte and Martínez, Ico and Romero-Kutzner, Vanesa and Bondyale-Juez, Daniel Rickue and Packard, Theodore T and Gómez, May
Marine chemistry, ISSN 0304-4203, 08/2018, Volume 204, pp. 86 - 94
Carbon flux | Marine ecology | Cellular respiration | NADP+-dependent isocitrate dehydrogenase | Plankton metabolism | Metabolic measurements | dependent isocitrate dehydrogenase | NADP | Physical Sciences | Chemistry | Oceanography | Chemistry, Multidisciplinary | Science & Technology
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9. Full Text Isocitrate dehydrogenase mutations in gliomas: Mechanisms, biomarkers and therapeutic target
by Guo, Changcun and Pirozzi, Christopher J and Lopez, Giselle Y and Yan, Hai
Current opinion in neurology, ISSN 1350-7540, 12/2011, Volume 24, Issue 6, pp. 648 - 652
somatic mutation | glioma | isocitrate dehydrogenase | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Biomarkers - metabolism | Brain Neoplasms - enzymology | Glioma - enzymology | Prognosis | Glioma - diagnosis | Isoenzymes - genetics | Brain Neoplasms - diagnosis | Humans | Isocitrates - metabolism | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Isoenzymes - chemistry | Glioma - genetics | Point Mutation | Isocitrate Dehydrogenase - chemistry | Isoenzymes - metabolism | Isocitrate Dehydrogenase - metabolism | Protein Conformation | Ketoglutaric Acids - metabolism | Index Medicus | Isocitrate dehydrogenase
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