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1. Full Text Characterisation of isocitrate dehydrogenase 1/isocitrate dehydrogenase 2 gene mutation and the d‐2‐hydroxyglutarate oncometabolite level in dedifferentiated chondrosarcoma
by Mohammad, Nissreen and Wong, Derek and Lum, Amy and Lin, Jonah and Ho, Julie and Lee, Cheng‐Han and Yip, Stephen
Histopathology, ISSN 0309-0167, 04/2020, Volume 76, Issue 5, pp. 722 - 730
sarcoma | 2‐hydroxyglutarate | cartilaginous neoplasms | IDH1 | IDH2 | IDH mutation | dedifferentiated chondrosarcoma | Pathology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Polymerase chain reaction | Chondrosarcoma | Dehydrogenases | Genotyping | Point mutation | IDH2 gene | Tumorigenesis | Mutation | Paraffin | Dehydrogenase | Isocitrate dehydrogenase | Tumors | Index Medicus
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2. Full Text Isocitrate dehydrogenase mutations in gliomas
by Waitkus, Matthew S and Diplas, Bill H and Yan, Hai
Neuro-oncology (Charlottesville, Va.), ISSN 1522-8517, 01/2016, Volume 18, Issue 1, pp. 16 - 26
glioma genetics | D-2-hydroxyglutarate | brain tumor metabolism | epigenetics | isocitrate dehydrogenase mutations | Oncology | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Brain Neoplasms - enzymology | Glioblastoma - enzymology | Glioma - enzymology | Humans | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Brain Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Animals | Glioblastoma - genetics | Glioblastoma - metabolism | Glutarates - metabolism | Mutation | Ketoglutaric Acids - metabolism | Index Medicus | Invited Reviews
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3. Full Text Isocitrate dehydrogenase mutations in myeloid malignancies
by Medeiros, B.C and Fathi, A.T and DiNardo, C.D and Pollyea, D.A and Chan, S.M and Swords, R
Leukemia, ISSN 0887-6924, 02/2017, Volume 31, Issue 2, pp. 272 - 281
Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Prognosis | Isoenzymes | Gene Frequency | Humans | Leukemia, Myeloid, Acute - epidemiology | Isocitrate Dehydrogenase - genetics | Myelodysplastic Syndromes - epidemiology | Biomarkers, Tumor | Myelodysplastic Syndromes - enzymology | Leukemia, Myeloid, Acute - mortality | Leukemia, Myeloid, Acute - enzymology | Animals | DNA Mutational Analysis | Isocitrate Dehydrogenase - metabolism | Myelodysplastic Syndromes - genetics | Mutation | Leukemia, Myeloid, Acute - genetics | Care and treatment | Research | Isocitrate dehydrogenase | Myelodysplastic syndromes | Krebs cycle | Mutation (Biology) | Index Medicus | Review
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4. Full Text Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery
by Merk, Alan and Bartesaghi, Alberto and Banerjee, Soojay and Falconieri, Veronica and Rao, Prashant and Davis, Mindy I and Pragani, Rajan and Boxer, Matthew B and Earl, Lesley A and Milne, Jacqueline L.S and Subramaniam, Sriram
Cell (Cambridge), ISSN 0092-8674, 06/2016, Volume 165, Issue 7, pp. 1698 - 1707
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Sulfonamides - chemistry | Humans | Models, Molecular | Crystallography, X-Ray | Glutamate Dehydrogenase - chemistry | Isocitrate Dehydrogenase - antagonists & inhibitors | Sulfonamides - pharmacology | Drug Discovery | Isocitrate Dehydrogenase - ultrastructure | Cryoelectron Microscopy | Glutamate Dehydrogenase - ultrastructure | L-Lactate Dehydrogenase - chemistry | Animals | L-Lactate Dehydrogenase - ultrastructure | Cattle | Isocitrate Dehydrogenase - chemistry | Aminoquinolines - chemistry | Chickens | Glutamate Dehydrogenase - antagonists & inhibitors | Protein Conformation | L-Lactate Dehydrogenase - antagonists & inhibitors | Aminoquinolines - pharmacology | Proteins | Analysis | Physiological aspects | Atoms | Drug discovery | Glutamate | Cells | Enzymes | Protein binding | Index Medicus
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5. Full Text Metabolome-guided genomics to identify pathogenic variants in isocitrate dehydrogenase, fumarate hydratase, and succinate dehydrogenase genes in pheochromocytoma and paraganglioma
by Richter, S and Gieldon, Laura and Pang, Ying and Peitzsch, M and Huynh, Thanh and Leton, Rocio and Timmers, H.J.L.M and Lenders, J.W and Eisenhofer, G and Klink, B
Genetics in medicine, ISSN 1098-3600, 2019, Volume 21, Issue 3, pp. 705 - 717
succinate | 2-hydroxyglutarate | next-generation sequencing | variant of unknown significance | fumarate | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Paraganglioma - genetics | Fumarate Hydratase - physiology | Humans | Isocitrate Dehydrogenase - genetics | Male | Fumarate Hydratase - genetics | Metabolome - genetics | Isocitrate Dehydrogenase - physiology | Succinate Dehydrogenase - genetics | Mass Spectrometry | Chromatography, Liquid | Female | Pheochromocytoma - genetics | Succinate Dehydrogenase - physiology | Genomics - methods | Adrenal Gland Neoplasms - genetics | Metabolites | Metabolism | Dehydrogenases | Index Medicus
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6. Full Text Isocitrate Dehydrogenase Mutation and (R)-2-Hydroxyglutarate: From Basic Discovery to Therapeutics Development
by Dang, Lenny and Su, Shin-San Michael
Annual review of biochemistry, ISSN 0066-4154, 6/2017, Volume 86, Issue 1, pp. 305 - 331
cancer therapeutics | allosteric inhibition | metabolism | oncometabolite | Allosteric inhibition | Cancer therapeutics | Metabolism | Oncometabolite | Glutarates - analysis | Antineoplastic Agents - chemical synthesis | Humans | Antineoplastic Agents - therapeutic use | Enzyme Inhibitors - chemical synthesis | Isocitrate Dehydrogenase - antagonists & inhibitors | Benzeneacetamides - chemical synthesis | Acetamides - chemical synthesis | Leukemia, Myeloid, Acute - enzymology | Benzeneacetamides - therapeutic use | Acetamides - therapeutic use | Isoenzymes - metabolism | Biomarkers, Tumor - metabolism | Leukemia, Myeloid, Acute - drug therapy | Imidazoles - chemical synthesis | Imidazoles - therapeutic use | Benzimidazoles - therapeutic use | Gene Expression | Biomarkers, Tumor - analysis | Isoenzymes - genetics | Leukemia, Myeloid, Acute - pathology | Benzimidazoles - chemical synthesis | Translational Medical Research | Small Molecule Libraries - therapeutic use | Models, Molecular | Small Molecule Libraries - chemical synthesis | Isocitrate Dehydrogenase - genetics | Drug Discovery | Enzyme Inhibitors - therapeutic use | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mutation | Isoenzymes - antagonists & inhibitors | Leukemia, Myeloid, Acute - genetics | Antimitotic agents | Gene mutations | Physiological aspects | Genetic aspects | Oxidoreductases | Research | Antineoplastic agents | Phosphates | Circuits | Leukemia | Glioblastoma | Differentiation (biology) | Clinical trials | Drug development | Dehydrogenase | Crystallography | Carcinogenesis | Carcinogens | Allosteric properties | Inhibition | Isocitrate dehydrogenase | Cholangiocarcinoma | Enzymes | Medical research | NADPH-diaphorase | Myeloid leukemia | Adenine | Isoforms | Nicotinamide adenine dinucleotide | Nicotinamide | Drug discovery | Acute myeloid leukemia | Cellular structure | Index Medicus
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