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Free Radical Biology and Medicine, ISSN 0891-5849, 10/2016, Volume 99, pp. 179 - 188
Reactive oxygen species (ROS) are a byproduct of normal metabolism and play important roles in cell signaling and homeostasis. Mitochondria, the main... 
Obesity | Isocitrate dehydrogenase 2 | Reactive oxygen species | ACTIVATION | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYSTEMIC OXIDATIVE STRESS | P53 | DIABETES-MELLITUS | GLUTATHIONE | ENDOCRINOLOGY & METABOLISM | FAT DEVELOPMENT | EXPRESSION | BROWN | ADIPOCYTE | Thermogenesis - genetics | Isocitrate Dehydrogenase - deficiency | Reactive Oxygen Species - metabolism | Oxidative Stress | Diabetes Mellitus, Type 2 - genetics | Adipocytes - cytology | Intra-Abdominal Fat - cytology | Diabetes Mellitus, Type 2 - metabolism | Obesity - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Energy Metabolism - genetics | Sterol Regulatory Element Binding Protein 1 - metabolism | Uncoupling Protein 1 - genetics | Oxidation-Reduction | Signal Transduction | Uncoupling Protein 1 - metabolism | Mice, Inbred C57BL | Diabetes Mellitus, Type 2 - prevention & control | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Isocitrate Dehydrogenase - genetics | Mitochondria - metabolism | Intra-Abdominal Fat - metabolism | Mice, Knockout | Obesity - metabolism | Obesity - pathology | Insulin - metabolism | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Adipocytes - metabolism | Obesity - prevention & control | Insulin Resistance - genetics | Mice | Diabetes Mellitus, Type 2 - pathology | Type 2 diabetes | Physiological aspects | Medical colleges
Journal Article
Cancer Science, ISSN 1347-9032, 10/2019, Volume 110, Issue 10, pp. 3306 - 3314
Isocitrate dehydrogenase 2 (IDH2), an important mitochondrial metabolic enzyme involved in the tricarboxylic acid cycle, is mutated in a variety of cancers.... 
Tricarboxylic acid cycle | Enzymes | Immunoglobulins | Dehydrogenases | Myeloid leukemia | Gene expression | Cell differentiation | Metabolism | Mitochondria | Enzymatic activity | Xenografts | DNA methylation | Mutation | Acute myeloid leukemia | Isocitrate dehydrogenase
Journal Article
Journal of Neuro-Oncology, ISSN 0167-594X, 2/2013, Volume 111, Issue 3, pp. 273 - 283
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 9785 - 10
Mitochondrial isocitrate dehydrogenase 2 (IDH2) converts NADP(+) to NADPH and promotes regeneration of reduced glutathione (GSH) by supplying NADPH to... 
REFINEMENT | HEARING-LOSS | LIFE-SPAN | OXIDATIVE DAMAGE | MULTIDISCIPLINARY SCIENCES | IDH2 | METABOLIC PATHWAYS | POSTTRANSLATIONAL MODIFICATIONS | MICE | CALORIE RESTRICTION | SIRT3 | Nutrient deficiency | Dehydrogenases | Thioredoxin | Antioxidants | Mitochondria | Lysine | Glutathione reductase | NADP | Acetylation | Isocitrate dehydrogenase | Reductase | Glutamine | Glutathione
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 06/2014, Volume 71, pp. 1 - 15
Oxysterol is associated with the induction of endothelial oxidative stress and impaired endothelial function. Mitochondria play a central role in oxidative... 
miRNA | Endothelial function | Oxysterol | 7-KC | IDH2 | REDOX STATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATHEROSCLEROSIS | MECHANISMS | HIGH-DENSITY-LIPOPROTEIN | PLASMA | MESSENGER-RNA | CHOLESTEROL OXIDATION-PRODUCTS | GLUTATHIONE | ENDOCRINOLOGY & METABOLISM | DYSFUNCTION | OXYSTEROLS | Glutathione - metabolism | Atherosclerosis - genetics | Humans | Argonaute Proteins - antagonists & inhibitors | Male | MicroRNAs - metabolism | Aorta - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | RNA, Messenger - metabolism | Eukaryotic Initiation Factors - antagonists & inhibitors | Cattle | RNA, Messenger - antagonists & inhibitors | NADP - metabolism | 3' Untranslated Regions | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Ketocholesterols - pharmacology | Argonaute Proteins - metabolism | Atherosclerosis - pathology | Argonaute Proteins - genetics | Oxidation-Reduction | Signal Transduction | Endothelial Cells - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Expression Regulation | Isocitrate Dehydrogenase - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Atherosclerosis - metabolism | Aorta - pathology | Animals | Isocitrate Dehydrogenase - metabolism | Mice | MicroRNAs - genetics | Endothelial Cells - pathology | Ketocholesterols - metabolism | Endothelial Cells - drug effects | Enzymes | MicroRNA | Analysis | Atherosclerosis | Physiological aspects | Development and progression | Mitochondrial DNA | Endothelium
Journal Article