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Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 17 - 30
and mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate... 
BREAST-CANCER | TRANSCRIPTIONAL ACTIVITY | IDH2 MUTATIONS | ONCOLOGY | PROLYL HYDROXYLATION | INTEGRATED GENOMIC ANALYSIS | 2-OXOGLUTARATE OXYGENASES | ACUTE MYELOID-LEUKEMIA | HIF-ALPHA | HISTONE DEMETHYLATION | FAMILY | CELL BIOLOGY | Dioxygenases - metabolism | Histone Demethylases - antagonists & inhibitors | Gene Expression - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Ketoglutaric Acids - chemistry | Glioma - genetics | F-Box Proteins | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Ketoglutaric Acids - pharmacology | Cytosine - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glutarates - chemistry | Oxidoreductases, N-Demethylating - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glioma - enzymology | Endostatins - metabolism | Models, Molecular | Isocitrate Dehydrogenase - genetics | Histone Demethylases - metabolism | Dioxygenases - antagonists & inhibitors | Amino Acid Substitution - physiology | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - pharmacology | Histones - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Caenorhabditis elegans - enzymology | Cytosine - analogs & derivatives | Gene Expression - drug effects | Caenorhabditis elegans Proteins - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Biocatalysis - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Ketoglutaric Acids - metabolism | Oxalates - pharmacology | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | 5-Methylcytosine - metabolism | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glutarates - metabolism | Index Medicus
Journal Article
Science, ISSN 0036-8075, 2/2010, Volume 327, Issue 5968, pp. 1004 - 1007
Journal Article
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7381, pp. 380 - 384
Acetyl coenzyme A (AcCoA) is the central biosynthetic precursor for fatty-acid synthesis and protein acetylation. In the conventional view of mammalian cell... 
FLUX ANALYSIS | DISTRIBUTIONS | FATTY-ACID SYNTHESIS | MULTIDISCIPLINARY SCIENCES | GROWTH | HYDROXYLATION | CELL-PROLIFERATION | SUPPRESSION | HIF-ALPHA | CANCER | DEHYDROGENASE | CD8-Positive T-Lymphocytes - cytology | Palmitic Acid - metabolism | Isocitrate Dehydrogenase - deficiency | Humans | Glutamine - metabolism | Kidney Neoplasms - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Oxygen - metabolism | Cell Hypoxia | Basic Helix-Loop-Helix Transcription Factors - metabolism | Acetyl Coenzyme A - biosynthesis | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Ketoglutaric Acids - metabolism | Lipogenesis | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Carbon - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Oxidation-Reduction | Carcinoma, Renal Cell - pathology | Cells, Cultured | Isocitrate Dehydrogenase - genetics | Acetyl Coenzyme A - metabolism | Citric Acid Cycle | Carcinoma, Renal Cell - metabolism | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Kidney Neoplasms - pathology | Physiological aspects | Hypoxia | Research | Lipid metabolism | Electron transport | Proteins | Confidence intervals | Metabolites | Lipids | Biosynthesis | Glucose | Experiments | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7598, pp. 255 - 258
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 13, pp. 7060 - 7069
Mycobacterium tuberculosis (Mtb) displays a high degree of metabolic plasticity to adapt to challenging host environments. Genetic evidence suggests that Mtb... 
BACTERIA | tricarboxylic acid cycle (TCA cycle) (Krebs cycle) | PHOSPHORYLATION | ACETYLATION | fatty acid metabolism | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | allosteric regulation | microbial pathogenesis | SACCHAROMYCES-CEREVISIAE | DEHYDROGENASE | bacterial metabolism | Mycobacterium tuberculosis | METABOLISM | pyruvate kinase | GROWTH | PHOSPHOENOLPYRUVATE | METHYLGLYOXAL | Fatty Acids, Volatile - pharmacology | Allosteric Regulation | Tuberculosis - microbiology | Isocitrate Dehydrogenase - antagonists & inhibitors | Glycolysis - drug effects | Mycobacterium tuberculosis - drug effects | Glycolysis - genetics | Pyruvaldehyde - metabolism | Gene Deletion | Aconitic Acid - metabolism | Female | Adenosine Monophosphate - pharmacology | Culture Media - chemistry | Ketoglutaric Acids - metabolism | Mycobacterium tuberculosis - metabolism | Carbon - metabolism | Gene Expression | Tuberculosis - mortality | Glutamic Acid - pharmacology | Pyruvate Kinase - metabolism | Adenosine Monophosphate - metabolism | Bacterial Proteins - genetics | Glucose-6-Phosphate - pharmacology | Isocitrate Dehydrogenase - genetics | Mice, SCID | Phosphoenolpyruvate - metabolism | Animals | Survival Analysis | Glucose - metabolism | Bacterial Proteins - metabolism | Isocitrate Dehydrogenase - metabolism | Citric Acid - metabolism | Glutamic Acid - metabolism | Mice | Enzyme Activation | Glucose-6-Phosphate - metabolism | Pyruvate Kinase - genetics | Mycobacterium tuberculosis - genetics | Index Medicus | Microbiology
Journal Article
Plant Physiology, ISSN 0032-0889, 3/2012, Volume 158, Issue 3, pp. 1451 - 1462
To analyze the copper-induced cross talk among calcium, nitric oxide (NO), and hydrogen peroxide (H₂O₂) and the calciumdependent activation of gene expression,... 
Tricarboxylic acid cycle | Antioxidants | Enzymes | Calcium channels | Dehydrogenases | Calcium | Oxides | Plants | Copper | ENVIRONMENTAL STRESS AND ADAPTATION TO STRESS | Plant cells | RELEASE CHANNELS | S-NITROSYLATION | NICOTIANA-PLUMBAGINIFOLIA CELLS | ANTAGONISTS INHIBIT | SYNTHASE ACTIVITY | ISOCITRATE DEHYDROGENASE | ELICITOR CRYPTOGEIN | ENDOPLASMIC-RETICULUM | ABSCISIC-ACID | PYRUVATE-DEHYDROGENASE COMPLEX | PLANT SCIENCES | Protein Kinases - metabolism | Antimycin A - metabolism | Calmodulin - genetics | Electron Transport | Protein Kinases - genetics | Ryanodine - metabolism | Calcium Channels - metabolism | Calcium - metabolism | Transcriptional Activation | Nitric Oxide Synthase - antagonists & inhibitors | Piperazines - metabolism | Carbolines - metabolism | Antimycin A - pharmacology | Mitochondria - genetics | Time Factors | Gene Expression Regulation, Plant | Plant Proteins - metabolism | Ulva - metabolism | Calcium Channel Blockers - metabolism | Calcium Channels - genetics | Ulva - genetics | Chloroplasts - genetics | Ryanodine - pharmacology | Calmodulin - metabolism | Cell Survival | Copper - pharmacology | Mitochondria - metabolism | Calcium Channel Blockers - pharmacology | Piperazines - pharmacology | Chloroplasts - metabolism | Citric Acid Cycle | Hydrogen Peroxide - metabolism | Plant Proteins - genetics | Ulva - drug effects | Nitric Oxide Synthase - metabolism | Enzyme Activation | Nitric Oxide - metabolism | Carbolines - pharmacology | Hydrogen peroxide | Calcium, Dietary | Marine algae | Physiological aspects | Genetic aspects | Research | Gene expression | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 2166 - 2166
Isocitrate dehydrogenase (IDH) genes 1 and 2 are frequently mutated in acute myeloid leukaemia (AML), low-grade glioma, cholangiocarcinoma (CC) and... 
DNA METHYLATION | MAMMALIAN DNA | 5-METHYLCYTOSINE | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PHENOTYPE | RETINOIC ACID RECEPTORS | ACUTE MYELOID-LEUKEMIA | MUTATIONS | 5-CARBOXYLCYTOSINE | DISCOVERY | Neoplasms - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Gene Expression Regulation, Neoplastic | Cholangiocarcinoma - metabolism | Bone Neoplasms - pathology | Receptors, Retinoic Acid - genetics | Bone Neoplasms - metabolism | Glioma - metabolism | DNA-Binding Proteins - metabolism | Glioma - genetics | DNA Methylation | Neoplasms - genetics | Glioma - pathology | Trans-Activators - genetics | Chondrosarcoma - genetics | Chondrosarcoma - pathology | Bone Neoplasms - genetics | Bile Duct Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Central Nervous System Neoplasms - metabolism | Bile Duct Neoplasms - metabolism | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Central Nervous System Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Proto-Oncogene Proteins - genetics | Receptors, Retinoic Acid - metabolism | DNA-Binding Proteins - genetics | Central Nervous System Neoplasms - pathology | Cholangiocarcinoma - pathology | Chondrosarcoma - metabolism | Cholangiocarcinoma - genetics | Isocitrate Dehydrogenase - metabolism | Trans-Activators - metabolism | Glutarates - metabolism | Bile Duct Neoplasms - pathology | Mutation | Neoplasms - pathology | Leukemia, Myeloid, Acute - genetics | Index Medicus
Journal Article
BMC Plant Biology, ISSN 1471-2229, 10/2012, Volume 12, Issue 1, pp. 189 - 189
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 19, pp. 7820 - 7825
Journal Article