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Diabetes, ISSN 0012-1797, 11/2012, Volume 61, Issue 11, pp. 2842 - 2850
In insulin-secreting cells, expression of NADPH oxidase (NOX), a potent source of ROS, has been reported, along with controversial findings regarding its... 
SIGNAL-TRANSDUCTION | NAD(P)H OXIDASE | RESPIRATORY BURST | OXIDATIVE STRESS | PROTEIN | ISLETS | SUPEROXIDE-PRODUCTION | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | DEPENDENT PATHWAY | Islets of Langerhans - drug effects | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Humans | NADPH Oxidases - metabolism | Secretory Vesicles - metabolism | Insulin-Secreting Cells - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Islets of Langerhans - metabolism | Isoenzymes - metabolism | Islets of Langerhans - cytology | NADPH Oxidases - genetics | Insulin-Secreting Cells - cytology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP - metabolism | Insulin Secretion | Cyclic AMP-Dependent Protein Kinases - metabolism | Second Messenger Systems - drug effects | Glucagon-Like Peptide 1 - metabolism | Isoenzymes - genetics | Tissue Culture Techniques | Mice, Inbred C57BL | NADPH Oxidases - antagonists & inhibitors | Cells, Cultured | Gene Silencing | NADPH Oxidase 2 | Membrane Glycoproteins - genetics | Mice, Knockout | Cyclic AMP - antagonists & inhibitors | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Secretory Vesicles - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Cyclic AMP - agonists | Isoenzymes - antagonists & inhibitors | Oxidases | Physiological aspects | Pancreatic beta cells | Research | Analysis | NADP (Coenzyme) | Index Medicus | Abridged Index Medicus | Islet Studies
Journal Article
Cell Reports, ISSN 2211-1247, 09/2015, Volume 12, Issue 12, pp. 1968 - 1977
Breast cancers (BCs) typically express estrogen receptors (ERs) but frequently exhibit de novo or acquired resistance to hormonal therapies. Here, we show that... 
NOTCH | ESTROGEN | ADJUVANT TAMOXIFEN | RECEPTOR | CELL BIOLOGY | Estradiol - analogs & derivatives | Receptors, Estrogen - metabolism | Neoplastic Stem Cells - drug effects | Receptors, Notch - metabolism | Homeodomain Proteins - metabolism | Humans | Retinal Dehydrogenase - metabolism | p-Aminoazobenzene - analogs & derivatives | Receptors, Notch - genetics | Receptors, Notch - antagonists & inhibitors | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Serrate-Jagged Proteins | p-Aminoazobenzene - pharmacology | Neoplastic Stem Cells - pathology | Estradiol - pharmacology | Jagged-1 Protein | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Isoenzymes - genetics | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | Benzazepines - pharmacology | Retinal Dehydrogenase - genetics | Breast Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Breast Neoplasms - genetics | Survival Analysis | Cell Line, Tumor | Retinal Dehydrogenase - antagonists & inhibitors | Mice | Calcium-Binding Proteins - genetics | Transcription Factor HES-1 | Gene Expression Regulation, Neoplastic | Cell Cycle Proteins - antagonists & inhibitors | Estrogen Receptor Antagonists - pharmacology | Intercellular Signaling Peptides and Proteins - metabolism | Isoenzymes - metabolism | Cell Cycle Proteins - genetics | Female | Membrane Proteins - metabolism | Calcium-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Receptors, Estrogen - genetics | Antineoplastic Agents, Hormonal - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Proto-Oncogene Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Homeodomain Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - pathology | Homeodomain Proteins - antagonists & inhibitors | Tamoxifen - pharmacology | Breast Neoplasms - mortality | Cell Proliferation - drug effects | Isoenzymes - antagonists & inhibitors | Receptor, Notch4 | Drug Resistance, Neoplasm - drug effects | Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 01/2013, Volume 365, Issue 1, pp. 11 - 16
► We study whether estradiol reverts oxLDL effects on DDAH/ADMA/NO pathway in HUAEC. ► oxLDL increased ADMA and decreased of DDAH activity. ► oxLDL reduced... 
Asymmetric dimethylarginine | Nitric oxide synthase | Estrogen | PHOSPHORYLATION | HORMONE REPLACEMENT THERAPY | CELL BIOLOGY | SYNTHASE | METABOLISM | DISEASE | ENDOCRINOLOGY & METABOLISM | DYSFUNCTION | POSTMENOPAUSAL WOMEN | PROSTACYCLIN PRODUCTION | Endothelium, Vascular - cytology | Receptors, Estrogen - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Endothelium, Vascular - drug effects | Estrogen Antagonists - pharmacology | Isoenzymes - chemistry | Receptors, G-Protein-Coupled - agonists | Estradiol - agonists | Arginine - analogs & derivatives | Nitric Oxide Synthase Type III - chemistry | Estrogen Receptor beta - metabolism | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - agonists | Arginine - antagonists & inhibitors | Isoenzymes - metabolism | Estrogen Receptor alpha - metabolism | Nitric Oxide Synthase Type III - metabolism | Protein Stability | Estrogen Receptor beta - antagonists & inhibitors | Repressor Proteins - metabolism | Amidohydrolases - metabolism | Estradiol - metabolism | Receptors, Estrogen - agonists | Lipoproteins, LDL - adverse effects | Nitric Oxide - antagonists & inhibitors | Cells, Cultured | Receptors, Estrogen - antagonists & inhibitors | Amidohydrolases - antagonists & inhibitors | Estrogen Receptor alpha - antagonists & inhibitors | Amidohydrolases - chemistry | Blotting, Western | Nitric Oxide - agonists | Nitric Oxide Synthase Type III - antagonists & inhibitors | Protein-Arginine N-Methyltransferases - metabolism | Estradiol - chemistry | Lipoproteins, LDL - antagonists & inhibitors | Endothelium, Vascular - metabolism | Umbilical Arteries - cytology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Arginine - adverse effects | Estrogens, Non-Steroidal - pharmacology | Nitric Oxide - metabolism | Arginine - metabolism | Isoenzymes - antagonists & inhibitors | Physiological aspects | Phenols | Estradiol | Nitric oxide | Endothelium | Index Medicus | Human | Proteins | Receptors | Inhibitors | Pathways | Estrogens | Exposure | Endothelial cells
Journal Article
Glycoconjugate Journal, ISSN 0282-0080, 06/2017, Volume 34, Issue 3, pp. 411 - 420
Proteoglycans and glycosaminoglycans modulate numerous cellular processes relevant to tumour progression, including cell proliferation, cell-matrix... 
EXT1 | Galactosyltransferase I | β4GalT7 | Glycosaminoglycans | Solute carriers | UDP-sugars | SYNDECAN-1 CD138 | beta 4GalT7 | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEOTIDE-SUGAR TRANSPORTER | UDP-GLUCOSE DEHYDROGENASE | GLUCURONIC ACID | SYNTHASE 2 | C-MET | ELEGANS VULVAL MORPHOGENESIS | EXPRESSION | BINDING | Heparitin Sulfate - biosynthesis | Dermatan Sulfate - genetics | RNA, Small Interfering - genetics | Cell Proliferation | Chondroitin Sulfates - genetics | Epithelial Cells - metabolism | Hyaluronan Synthases - metabolism | N-Acetyllactosamine Synthase - antagonists & inhibitors | Humans | Hyaluronan Synthases - antagonists & inhibitors | Nucleotide Transport Proteins - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Extracellular Matrix - metabolism | Heparitin Sulfate - antagonists & inhibitors | N-Acetylglucosaminyltransferases - genetics | Dermatan Sulfate - biosynthesis | Mammary Glands, Human - metabolism | Extracellular Matrix - chemistry | Dermatan Sulfate - analogs & derivatives | Chondroitin Sulfates - biosynthesis | Hyaluronan Synthases - genetics | Hyaluronic Acid - biosynthesis | Isoenzymes - metabolism | Chondroitin Sulfates - antagonists & inhibitors | Monosaccharide Transport Proteins - metabolism | Monosaccharide Transport Proteins - antagonists & inhibitors | Monosaccharide Transport Proteins - genetics | Signal Transduction | Cell Survival | Isoenzymes - genetics | Hyaluronic Acid - antagonists & inhibitors | Hyaluronic Acid - genetics | N-Acetyllactosamine Synthase - genetics | Epithelial Cells - pathology | Mammary Glands, Human - pathology | Cell Adhesion | N-Acetylglucosaminyltransferases - metabolism | Nucleotide Transport Proteins - metabolism | Dermatan Sulfate - antagonists & inhibitors | Heparitin Sulfate - genetics | Cell Line, Tumor | N-Acetylglucosaminyltransferases - antagonists & inhibitors | Nucleotide Transport Proteins - genetics | N-Acetyllactosamine Synthase - metabolism | Isoenzymes - antagonists & inhibitors | Cell Movement | RNA, Small Interfering - metabolism | Fibronectins | Physiological aspects | Enzymes | Breast cancer | Sulfates | Hyaluronic acid | Cell proliferation | Motility | Biosynthesis | Fibronectin | Cell adhesion & migration | Hyaluronan | Polysaccharides | Matrix | Compartments | Modulation | Sugar | Saccharides | Heparan sulfate | Proteoglycans | Invasiveness | Interference | siRNA | Adhesion | Substrates | Golgi apparatus | Diseases | Signaling | Depletion | Breast | Sulfate | Viability | Transporter | In vitro methods and tests | Syndecan | Tumors | Cancer | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2004, Volume 101, Issue 50, pp. 17468 - 17473
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2013, Volume 41, Issue 2, pp. 353 - 361
Dolutegravir (DTG; S/GSK1349572) is a potent HIV-1 integrase inhibitor with a distinct resistance profile and a once-daily dose regimen that does not require... 
SERUM CREATININE LEVELS | IMMUNODEFICIENCY-VIRUS-INFECTION | HUMAN HEPATOCYTES | HEALTHY-SUBJECTS | CYTOCHROME-P450 ENZYMES | GLOMERULAR-FILTRATION | PHARMACOLOGY & PHARMACY | GASTROINTESTINAL PH | MULTIDRUG-RESISTANCE | BOOSTED PROTEASE INHIBITORS | P-GLYCOPROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | HIV Integrase Inhibitors - pharmacology | Heterocyclic Compounds, 3-Ring - metabolism | Cricetulus | Cytochrome P-450 Enzyme Inhibitors | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cytochrome P-450 Enzyme System - metabolism | Membrane Transport Proteins - drug effects | Male | Neoplasm Proteins - antagonists & inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Organic Anion Transporters - metabolism | Glucuronosyltransferase - genetics | Drug Interactions | Transfection | Membrane Transport Proteins - genetics | Microsomes, Liver - drug effects | Madin Darby Canine Kidney Cells | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Microsomes, Liver - enzymology | Hepatocytes - drug effects | CHO Cells | Cricetinae | Organic Anion Transporters - antagonists & inhibitors | Isoenzymes | Enzyme Induction | HIV Integrase Inhibitors - metabolism | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Animals | Glucuronosyltransferase - metabolism | Dogs | Cytochrome P-450 Enzyme System - genetics | Glucuronosyltransferase - antagonists & inhibitors | ATP Binding Cassette Transporter, Sub-Family B | Multidrug Resistance-Associated Proteins - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Hepatocytes - enzymology | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2013, Volume 288, Issue 3, pp. 1883 - 1895
The JNK family of MAPKs is involved in a large variety of physiological and pathological processes in brain development, such as neural survival, migration,... 
NERVOUS-SYSTEM | CAENORHABDITIS-ELEGANS | GENETIC-ANALYSIS | COLORECTAL-CANCER | COMMISSURAL AXONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BRAIN-DEVELOPMENT | RECEPTOR | FOCAL ADHESION KINASE | DISTINCT ROLES | GUIDES CELL | RNA, Small Interfering - genetics | Cell Adhesion Molecules - genetics | Spinal Cord - drug effects | Spinal Cord - metabolism | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Tumor Suppressor Proteins - antagonists & inhibitors | Embryo, Mammalian | Netrin-1 | Spinal Cord - growth & development | Humans | Cell Adhesion Molecules - antagonists & inhibitors | Axons - physiology | Nerve Growth Factors - metabolism | Receptors, Cell Surface - antagonists & inhibitors | MAP Kinase Kinase 4 - metabolism | Isoenzymes - metabolism | Tumor Suppressor Proteins - genetics | HEK293 Cells | MAP Kinase Kinase 4 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - genetics | DCC Receptor | Tumor Suppressor Proteins - metabolism | Isoenzymes - genetics | Mitogen-Activated Protein Kinase 8 - metabolism | Gene Expression Regulation, Developmental - drug effects | Axons - drug effects | Receptors, Cell Surface - metabolism | Cell Adhesion Molecules - metabolism | Chick Embryo | Anthracenes - pharmacology | Animals | Signal Transduction - drug effects | Nerve Growth Factors - genetics | MAP Kinase Kinase 4 - genetics | Nerve Growth Factors - antagonists & inhibitors | Mice | Protein Kinase Inhibitors - pharmacology | Primary Cell Culture | Isoenzymes - antagonists & inhibitors | Receptors, Cell Surface - genetics | Index Medicus | Guidance | Neuroscience | Signal Transduction | DSCAM | c-Jun N-terminal Kinase (JNK) | DCC | Netrin | Neurobiology | Development | Axon | Neurite Outgrowth
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 12/2018, Volume 81, pp. 119 - 126
A series of classical and newly synthesized thymol bearing oxypropanolamine compounds were synthesized and characterized. Their antibacterial activity on and... 
α-glycosidase | Oxypropanolamine | Antibacterial effects | Carbonic anhydrase | Acetylcholinesterase | BUTYRYLCHOLINESTERASE | CARBONIC-ANHYDRASE | alpha-glycosidase | NATURAL-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESSENTIAL OIL | CHEMISTRY, ORGANIC | II INHIBITION | ALPHA-GLUCOSIDASE INHIBITORS | IN-VIVO | ANTIMICROBIAL ACTIVITY | MANNICH-BASES | Cholinergic Antagonists - chemical synthesis | Escherichia coli - drug effects | Humans | Carbonic Anhydrase II - metabolism | Structure-Activity Relationship | Carbonic Anhydrase I - metabolism | Enzyme Inhibitors - chemical synthesis | Carbonic Anhydrase II - antagonists & inhibitors | Cholinergic Antagonists - pharmacology | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Molecular Structure | Diabetes Mellitus - drug therapy | Enzyme Inhibitors - pharmacology | Diabetes Mellitus - metabolism | Hypoglycemic Agents - chemistry | Pseudomonas aeruginosa - drug effects | Hypoglycemic Agents - pharmacology | Anti-Bacterial Agents - chemical synthesis | Carbonic Anhydrase I - antagonists & inhibitors | Cholinergic Antagonists - chemistry | Hypoglycemic Agents - chemical synthesis | Anti-Bacterial Agents - pharmacology | Acetylcholine - antagonists & inhibitors | Acinetobacter baumannii - drug effects | Staphylococcus aureus - drug effects | Acetylcholinesterase - metabolism | alpha-Glucosidases - metabolism | Phenols | Enzyme inhibitors | Isoenzymes | Antibacterial agents | Escherichia coli | Index Medicus
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2015, Volume 97, Issue 1, pp. 27 - 37
Cancer microenvironment is characterized by significantly lower oxygen concentration. This hypoxic condition is known to reduce drug responsiveness to cancer... 
Hypoxia | Cancer stem-like cells | Chemosensitization | Vatalanib | Multidrug resistance transporters | SIDE POPULATION | PTK787/ZK-222584 | EFFICACY | OPEN-LABEL | SUBFAMILY-B MEMBER-1 | ADVANCED COLORECTAL-CANCER | LIVER METASTASES | LUNG-CANCER | PHARMACOLOGY & PHARMACY | TRANSPORT FUNCTION | INHIBITOR | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Apoptosis - drug effects | Colonic Neoplasms - drug therapy | Drug Resistance, Multiple - drug effects | Humans | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | Colonic Neoplasms - metabolism | Cell Hypoxia | Receptors, Vascular Endothelial Growth Factor - metabolism | ATP-Binding Cassette Transporters - genetics | Isoenzymes - metabolism | HEK293 Cells | ATP-Binding Cassette Transporters - metabolism | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Neoplasm Proteins - genetics | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Camptothecin - analogs & derivatives | Recombinant Proteins - metabolism | Antineoplastic Agents, Phytogenic - agonists | Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors | Angiogenesis Inhibitors - pharmacology | Recombinant Proteins - chemistry | Phthalazines - pharmacology | Receptors, Platelet-Derived Growth Factor - metabolism | Camptothecin - agonists | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | ATP Binding Cassette Transporter, Sub-Family B - genetics | Camptothecin - pharmacology | Isoenzymes - antagonists & inhibitors | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Chemotherapy | Colon cancer | Angiogenesis inhibitors | Drug resistance | Cancer | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2005, Volume 175, Issue 2, pp. 917 - 925
IL-4 is an important immune cytokine that regulates bone homeostasis. We investigated the molecular mechanism of IL-4 action on bone-resorbing mature... 
NECROSIS-FACTOR RECEPTOR | INTERLEUKIN-4 | CYTOSOLIC CA2 | BODY GIANT-CELLS | OSTEOPROTEGERIN LIGAND | IN-VIVO | DIFFERENTIATION FACTOR | RESISTANT ACID-PHOSPHATASE | IMMUNOLOGY | TERMINAL KINASE | T-CELLS | Intracellular Fluid - immunology | Humans | Male | NF-kappa B - metabolism | RANK Ligand | Receptors, Calcitonin - genetics | Cell Migration Inhibition | RNA, Messenger - biosynthesis | Membrane Glycoproteins - physiology | Membrane Glycoproteins - antagonists & inhibitors | Carrier Proteins - administration & dosage | Calcium Signaling - immunology | Active Transport, Cell Nucleus - genetics | Interleukin-4 - physiology | Glycoproteins - genetics | NF-kappa B - antagonists & inhibitors | Osteoclasts - pathology | Isoenzymes - genetics | Acid Phosphatase - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Hypercalcemia - metabolism | Interleukin-4 - deficiency | Receptors, Cytoplasmic and Nuclear - genetics | Bone Resorption - immunology | Mice, Knockout | Cell Differentiation - immunology | Membrane Glycoproteins - administration & dosage | Actins - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Bone Resorption - pathology | Active Transport, Cell Nucleus - immunology | Mice | Mice, Inbred BALB C | Calcium Signaling - genetics | Receptors, Calcitonin - biosynthesis | Receptor Activator of Nuclear Factor-kappa B | Actins - metabolism | Tartrate-Resistant Acid Phosphatase | Transcription Factor RelA | Hypercalcemia - immunology | Receptors, Cytoplasmic and Nuclear - biosynthesis | Osteoprotegerin | Cell Differentiation - genetics | Osteoclasts - immunology | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | Acid Phosphatase - biosynthesis | RNA, Messenger - antagonists & inhibitors | Receptors, Calcitonin - antagonists & inhibitors | Adult | Interleukin-4 - genetics | Intracellular Fluid - metabolism | Receptors, Tumor Necrosis Factor - genetics | Carrier Proteins - physiology | Hypercalcemia - pathology | Glycoproteins - antagonists & inhibitors | Osteoclasts - metabolism | Bone Resorption - prevention & control | Glycoproteins - biosynthesis | Animals | NF-kappa B - physiology | Receptors, Tumor Necrosis Factor - biosynthesis | Osteoclasts - enzymology | Isoenzymes - biosynthesis | Acid Phosphatase - genetics | Isoenzymes - antagonists & inhibitors | Index Medicus | Abridged Index Medicus
Journal Article