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Biotechnology and Bioengineering, ISSN 0006-3592, 12/2008, Volume 101, Issue 5, pp. 881 - 893
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2012, Volume 287, Issue 39, pp. 32800 - 32824
Human head and neck squamous cell carcinoma (HNSCC) is a highly malignant cancer associated with major morbidity and mortality. In this study, we determined... 
SOX2 | IN-VITRO | ISOFORMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | MARKER NANOG | NF-KAPPA-B | TRANSCRIPTIONAL REGULATION | CD44 | BREAST | MICRORNA | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Homeodomain Proteins - metabolism | Humans | Retinal Dehydrogenase - metabolism | Gene Expression Regulation, Neoplastic | Cell Survival - genetics | Drug Resistance, Neoplasm | Mouth Neoplasms - metabolism | Neoplasm Proteins - metabolism | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | Isoenzymes - metabolism | Hyaluronan Receptors - metabolism | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Epigenesis, Genetic - drug effects | Neoplasm Proteins - genetics | Mouth Neoplasms - genetics | Cell Survival - drug effects | Nanog Homeobox Protein | Isoenzymes - genetics | Hyaluronic Acid - genetics | MicroRNAs - biosynthesis | Signal Transduction - genetics | Cisplatin - pharmacology | Retinal Dehydrogenase - genetics | Hyaluronan Receptors - genetics | Homeodomain Proteins - genetics | RNA, Neoplasm - biosynthesis | Signal Transduction - drug effects | Epigenesis, Genetic - genetics | Hyaluronic Acid - metabolism | Octamer Transcription Factor-3 - metabolism | Mouth Neoplasms - pathology | RNA, Neoplasm - genetics | MicroRNAs - genetics | Index Medicus | Hyaluronan | Self-renewal | MicroRNA | Signal Transduction | Extracellular Matrix | Head and Neck Cancer | Differentiation | Cancer Stem Cells
Journal Article
PLoS Genetics, ISSN 1553-7390, 10/2010, Volume 6, Issue 10, pp. 1 - 12
Histone deacetylase Rpd3 is part of two distinct complexes: the large (Rpd3L) and small (Rpd3S) complexes. While Rpd3L targets specific promoters for gene... 
SIN3-RPD3 HISTONE DEACETYLASE | IN-VIVO | GENETICS & HEREDITY | TRANSCRIPTIONAL REPRESSION | BUR1 KINASE | PROTEIN COMPLEXES | 3'-END FORMATION | SACCHAROMYCES-CEREVISIAE | ELONGATION-FACTORS | P-TEFB | DNA-REPLICATION | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Cyclin-Dependent Kinases - metabolism | Oligonucleotide Array Sequence Analysis | Saccharomyces cerevisiae - genetics | Methyltransferases - metabolism | Methyltransferases - genetics | Gene Expression Profiling | RNA Polymerase II - metabolism | Saccharomyces cerevisiae - metabolism | Chromatin Immunoprecipitation | Isoenzymes - metabolism | Transcription, Genetic | Lysine - metabolism | Transcriptional Elongation Factors - genetics | Cyclin-Dependent Kinases - genetics | Nuclear Proteins - genetics | Gene Expression Regulation, Fungal | Chromosomal Proteins, Non-Histone - metabolism | Histone Deacetylases - genetics | Isoenzymes - genetics | Histone Deacetylases - metabolism | Nuclear Proteins - metabolism | Saccharomyces cerevisiae Proteins - genetics | Open Reading Frames - genetics | Chromosomal Proteins, Non-Histone - genetics | Transcriptional Elongation Factors - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Histones - metabolism | Mutation | Methylation | Index Medicus | Medical research | Enzymes | Genetics | Chromatin | Genes
Journal Article
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 5, pp. 492 - 497
Common multi-allelic copy number variants (CNVs) appear enriched for phenotypic associations compared to their biallelic counterparts(1-4). Here we... 
VARIANTS | GENETICS & HEREDITY | EARLY-ONSET | BODY-MASS INDEX | SEGMENTAL DUPLICATIONS | MICROBIOTA | POLYMORPHISM | DELETIONS | HERITABILITY | GENOME-WIDE ASSOCIATION | ACCURACY | Body Mass Index | Gene Dosage - genetics | Genetic Predisposition to Disease - genetics | Salivary alpha-Amylases - genetics | Microarray Analysis | Humans | Salivary alpha-Amylases - blood | Carbohydrate Metabolism - genetics | Genomics - methods | Odds Ratio | Obesity - genetics | Obesity | Amylases | Genetic susceptibility | Salivary glands | Genetic research | Genetic aspects | Research | Health aspects | Saliva | Risk factors | secretions | Studies | Medical research | Hospitals | Biomedical research | Genomes | Grants | Gene expression | Deoxyribonucleic acid--DNA | Index Medicus | Life Sciences | Genetics | Human genetics | body mass | major clinical study | Genomics | genetic association | gene cluster | heritability | copy number variation | enzyme activity | gene mapping | genetic risk | genetic predisposition | sugar intake | female | obesity | Genetic Predisposition to Disease | Salivary alpha-Amylases | adipose tissue | European | article | Clinical Medicine | alpha amylase saliva isoenzyme | adult | gene expression | male | carbohydrate metabolism | fat mass | gene identification | Klinisk medicin | insulin release | subcutaneous fat | priority journal | saliva level | human | gene replication | enzyme blood level | human tissue | gene linkage disequilibrium | Gene Dosage | genetic variability | nucleotide sequence | controlled study | Chinese | overlapping gene | alpha amylase pancreas isoenzyme | principal component analysis
Journal Article
Human Mutation, ISSN 1059-7794, 08/2014, Volume 35, Issue 8, pp. 983 - 989
By way of whole‐exome sequencing, we identified a homozygous missense mutation in VARS2 in one subject with microcephaly and epilepsy associated with isolated... 
aminoacyl tRNA syntethases | TARS2 | encephalomyopathy | VARS2 | OXPHOS defect | mitochondrial disease | Encephalomyopathy | Aminoacyl tRNA syntethases | Mitochondrial disease | CELLS | CARDIOMYOPATHY | INVOLVEMENT | BRAIN-STEM | TRANSFER-RNA SYNTHETASES | LEUKOENCEPHALOPATHY | GENE | DISEASE | GENETICS & HEREDITY | LACTIC-ACIDOSIS | COMPLEX-I DEFICIENCY | Mitochondria - enzymology | Saccharomyces cerevisiae - genetics | Humans | Mitochondrial Encephalomyopathies - enzymology | Infant | Male | Threonine-tRNA Ligase - genetics | HLA Antigens - genetics | RNA, Messenger - metabolism | Electron Transport Complex I - metabolism | Saccharomyces cerevisiae - metabolism | RNA, Transfer, Val - genetics | DNA, Mitochondrial - genetics | Mitochondria - genetics | Electron Transport Complex I - genetics | Isoenzymes - metabolism | Valine-tRNA Ligase - metabolism | Valine-tRNA Ligase - genetics | Child | RNA, Transfer, Thr - genetics | Fibroblasts - metabolism | Cell Line | DNA, Mitochondrial - metabolism | RNA, Transfer, Thr - metabolism | Isoenzymes - genetics | Mitochondrial Encephalomyopathies - genetics | RNA, Messenger - genetics | Mitochondria - pathology | HLA Antigens - metabolism | Polymorphism, Genetic | Mitochondrial Encephalomyopathies - pathology | RNA, Transfer, Val - metabolism | Homozygote | Heterozygote | Fibroblasts - cytology | Mutation | Threonine-tRNA Ligase - metabolism | Proteins | Care and treatment | Analysis | Epilepsy | Genetic aspects | Single nucleotide polymorphisms | Aminoacyl-tRNA synthetases | Transfer RNA | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0132977 - e0132977
Cancer stem cells are cancer cells characterized by stem cell properties and represent a small population of tumor cells that drives tumor development,... 
TESTIS ANTIGEN BORIS | HEPATOCELLULAR-CARCINOMA | SIDE POPULATION | IN-VITRO | INDUCED APOPTOSIS | TELOMERASE | MULTIDISCIPLINARY SCIENCES | IMPRINTED SITES | CTCF | IDENTIFICATION | TUMOR-INITIATING CELLS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | RNA, Small Interfering - genetics | Cell Proliferation | Epithelial Cells - metabolism | Polycomb Repressive Complex 1 - metabolism | Homeodomain Proteins - metabolism | Humans | Retinal Dehydrogenase - metabolism | Gene Expression Regulation, Neoplastic | Spheroids, Cellular - pathology | Epithelial-Mesenchymal Transition - genetics | Neoplasm Proteins - metabolism | SOXB1 Transcription Factors - metabolism | DNA-Binding Proteins - metabolism | Octamer Transcription Factor-3 - genetics | Polycomb Repressive Complex 1 - genetics | Telomerase - genetics | ATP-Binding Cassette Transporters - genetics | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | Isoenzymes - metabolism | Hyaluronan Receptors - metabolism | ATP-Binding Cassette Transporters - metabolism | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Telomerase - metabolism | Neoplasm Proteins - genetics | DNA-Binding Proteins - antagonists & inhibitors | Nanog Homeobox Protein | Signal Transduction | Isoenzymes - genetics | Spheroids, Cellular - metabolism | Epithelial Cells - pathology | Retinal Dehydrogenase - genetics | DNA-Binding Proteins - genetics | Organ Specificity | Hyaluronan Receptors - genetics | Homeodomain Proteins - genetics | Phenotype | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Biomarkers, Tumor - genetics | Cell Movement | RNA, Small Interfering - metabolism | RNA | Genes | Colorectal cancer | Stem cells | Genetic aspects | Gene expression | Cancer | Protein binding | Neurosciences | Germ cells | Telomerase reverse transcriptase | Populations | Dyes | Mesenchyme | Oct-4 protein | Gene regulation | Oncology | Spheres | Drug resistance | Tissues | Metastases | DNA-binding protein | CD44 antigen | Cell cycle | Life sciences | Colon | Telomerase | Growth factors | Deoxyribonucleic acid--DNA | Medical research | Antigens | Cell survival | Tumor cells | Invasiveness | Cervix | Survival | Brain research | Molecular modelling | Medical prognosis | Epigenetics | Breast | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Plant Cell, ISSN 1040-4651, 8/2015, Volume 27, Issue 8, pp. 2178 - 2194
The tomato ( ) genes and encode proteins that are essential for the formation of callose, a major component of pollen mother cell walls; these enzymes also... 
Messenger RNA | RNA interference | RNA | Gels | RESEARCH ARTICLES | Viroids | Infections | Nucleotides | Plants | Symptoms | Plant cells | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | SOFTWARE | PLANT SCIENCES | CELL BIOLOGY | ARTIFICIAL MICRORNAS | PROVIDES INSIGHTS | EVOLUTION | MESSENGER-RNA | SECONDARY STRUCTURE PREDICTION | INFECTION | ARABIDOPSIS | EXPRESSION | Solanum tuberosum - virology | Molecular Sequence Data | Plant Leaves - virology | Lycopersicon esculentum - enzymology | MicroRNAs - metabolism | RNA, Messenger - metabolism | Glucosyltransferases - metabolism | RNA, Viral - genetics | RNA Interference | Virulence - genetics | Isoenzymes - metabolism | Base Sequence | Lycopersicon esculentum - genetics | Glucans - metabolism | Plant Proteins - metabolism | RNA, Viral - metabolism | Plant Leaves - enzymology | Viroids - pathogenicity | Glucosyltransferases - genetics | Isoenzymes - genetics | Lycopersicon esculentum - virology | RNA, Messenger - genetics | Glucans - genetics | Viroids - genetics | Reverse Transcriptase Polymerase Chain Reaction | Sequence Homology, Nucleic Acid | Plant Proteins - genetics | Host-Pathogen Interactions - genetics | Plant Leaves - genetics | MicroRNAs - genetics | Plant Tubers - virology | Diseases and pests | Genetic aspects | Virulence (Microbiology) | Tomatoes | Host-virus relationships | Health aspects | Infection | Enzymes | MicroRNA | Plant genetics | Genetic engineering | Index Medicus
Journal Article
The Plant Cell, ISSN 1040-4651, 6/2013, Volume 25, Issue 6, pp. 2341 - 2355
Plants differ greatly in their susceptibility to insect herbivory, suggesting both local adaptation and resistance tradeoffs. We used maize (Zea mays)... 
Quantitative trait loci | Inbred strains | Transposons | Genetic variation | RESEARCH ARTICLES | Genes | Corn | Herbivores | Plants | Phytophagous insects | Insect genetics | RIBOSOME-INACTIVATING PROTEIN | MAPPING POPULATION | HYDROXAMIC ACIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | QUANTITATIVE TRAIT LOCUS | INSECT RESISTANCE | TRITICUM-AESTIVUM | MOLECULAR ANALYSIS | PLANT DEFENSES | PLANT SCIENCES | CELL BIOLOGY | FALL ARMYWORM | INNATE IMMUNITY | Methyltransferases - metabolism | Methyltransferases - genetics | Benzoxazines - metabolism | Molecular Sequence Data | Methyltransferases - classification | Phylogeny | Isoenzymes - classification | Plant Proteins - classification | Isoenzymes - metabolism | DNA Transposable Elements - genetics | Aphids - physiology | Plant Diseases - genetics | Plant Proteins - metabolism | Host-Parasite Interactions | Zea mays - metabolism | Disease Resistance - genetics | Amino Acid Sequence | Zea mays - genetics | Isoenzymes - genetics | Zea mays - parasitology | Chromosome Mapping | Glucosides - metabolism | Sequence Homology, Amino Acid | Plant Proteins - genetics | Animals | Mutagenesis, Insertional | Chromosomes, Plant - genetics | Plant Diseases - parasitology | Quantitative Trait Loci - genetics | Quantitative genetics | Analysis | Transferases | Genetic research | Aphididae | Genetic aspects | Instrument industry | Glucose | Dextrose | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 04/2007, Volume 115, Issue 16, pp. 2178 - 2187
Background - Recent clinical studies have suggested a major protective role for the antioxidant enzyme glutathione peroxidase-1 ( GPx1) in diabetes-associated... 
Antioxidants | Aorta | Free radicals | Cardiovascular diseases | Diabetes mellitus | Atherosclerosis | atherosclerosis | INTIMA-MEDIA THICKNESS | free radicals | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | antioxidants | CARDIOVASCULAR COMPLICATIONS | diabetes mellitus | FACTOR-KAPPA-B | cardiovascular diseases | REACTIVE OXYGEN | ENDOTHELIAL-CELLS | VASCULAR INFLAMMATION | PERIPHERAL VASCULAR DISEASE | aorta | PLATELET ACTIVATION | HEMATOLOGY | CORONARY-ARTERY-DISEASE | GLYCATION END-PRODUCTS | Superoxide Dismutase - genetics | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Membrane Glycoproteins - biosynthesis | Male | Aorta - metabolism | Vascular Endothelial Growth Factor A - genetics | Tyrosine - analogs & derivatives | NADPH Oxidases - genetics | Diabetes Mellitus, Experimental - complications | Glutathione Peroxidase - deficiency | NADPH Oxidases - biosynthesis | Receptor for Advanced Glycation End Products | Atherosclerosis - pathology | Macrophages - pathology | Oxidation-Reduction | Tyrosine - biosynthesis | Isoenzymes - genetics | Immediate-Early Proteins - biosynthesis | Glutathione Peroxidase - genetics | Mice, Knockout | Aorta - pathology | Aortic Diseases - genetics | Immediate-Early Proteins - genetics | NF-kappa B - biosynthesis | Fibrosis | Glutathione Peroxidase - physiology | Vascular Cell Adhesion Molecule-1 - biosynthesis | Mice | Receptors, Immunologic - genetics | Inflammation - enzymology | Vascular Endothelial Growth Factor A - biosynthesis | Superoxide Dismutase - biosynthesis | Glutathione - metabolism | Streptozocin | Intercellular Signaling Peptides and Proteins - biosynthesis | Atherosclerosis - etiology | Atherosclerosis - enzymology | Receptors, Immunologic - biosynthesis | Diabetic Angiopathies - complications | Diabetic Angiopathies - enzymology | Vascular Cell Adhesion Molecule-1 - genetics | Aortic Diseases - enzymology | Sinus of Valsalva - pathology | Aortic Diseases - pathology | Hyperlipoproteinemia Type II - complications | Mice, Inbred C57BL | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Glutathione Peroxidase - biosynthesis | NADPH Oxidase 2 | Membrane Glycoproteins - genetics | Animals | NF-kappa B - genetics | Apolipoproteins E - genetics | Inflammation - genetics | Isoenzymes - biosynthesis | Aortic Diseases - etiology | Connective Tissue Growth Factor | Hyperlipoproteinemia Type II - genetics | Animal models in research | Physiological aspects | Development and progression | Peroxidase | Research | Apolipoproteins | Glutathione | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 7, pp. e11428 - e11428
Journal Article