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Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 725 - 738
Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC kinase family members, including Akt, SGK1, and PKC, in response to... 
TRANSCRIPTION FACTORS | LIPID-METABOLISM | INSULIN-RESISTANCE | ELEMENT-BINDING PROTEIN-1C | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | MOTIF PHOSPHORYLATION | DIABETIC-NEPHROPATHY | GLUCOSE-UTILIZATION | CELL-GROWTH | PHOSPHOINOSITIDE 3-KINASE | CELL BIOLOGY | Glucose Intolerance - metabolism | Phosphorylation | Liver - enzymology | TOR Serine-Threonine Kinases - metabolism | Homeostasis | Glycogen Synthase Kinase 3 beta | Male | Hepatocytes - metabolism | Mechanistic Target of Rapamycin Complex 2 | Hyperglycemia - genetics | Proto-Oncogene Proteins c-akt - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Forkhead Transcription Factors - metabolism | Trans-Activators - genetics | Hyperinsulinism - genetics | Insulin - genetics | Lipogenesis | Proto-Oncogene Proteins c-akt - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Gluconeogenesis | Hyperinsulinism - metabolism | Glucose Intolerance - genetics | Signal Transduction | Liver - metabolism | Glucokinase - genetics | Glucose - genetics | Lipid Metabolism | Forkhead Transcription Factors - genetics | Glucokinase - metabolism | Glycogen Synthase Kinase 3 - metabolism | Mice, Knockout | Hyperglycemia - metabolism | Proteins - genetics | Insulin - metabolism | Animals | Proteins - metabolism | Trans-Activators - deficiency | Glycogen Synthase Kinase 3 - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Glucose - metabolism | Glycolysis | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | Transcription Factors | Glucose metabolism | Hyperglycemia | Glucose | Isoenzymes | Dextrose | Index Medicus
Journal Article
Science, ISSN 0036-8075, 9/2010, Volume 329, Issue 5998, pp. 1492 - 1499
Journal Article
Diabetes, ISSN 0012-1797, 11/2012, Volume 61, Issue 11, pp. 2842 - 2850
In insulin-secreting cells, expression of NADPH oxidase (NOX), a potent source of ROS, has been reported, along with controversial findings regarding its... 
SIGNAL-TRANSDUCTION | NAD(P)H OXIDASE | RESPIRATORY BURST | OXIDATIVE STRESS | PROTEIN | ISLETS | SUPEROXIDE-PRODUCTION | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | DEPENDENT PATHWAY | Islets of Langerhans - drug effects | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Humans | NADPH Oxidases - metabolism | Secretory Vesicles - metabolism | Insulin-Secreting Cells - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Islets of Langerhans - metabolism | Isoenzymes - metabolism | Islets of Langerhans - cytology | NADPH Oxidases - genetics | Insulin-Secreting Cells - cytology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP - metabolism | Insulin Secretion | Cyclic AMP-Dependent Protein Kinases - metabolism | Second Messenger Systems - drug effects | Glucagon-Like Peptide 1 - metabolism | Isoenzymes - genetics | Tissue Culture Techniques | Mice, Inbred C57BL | NADPH Oxidases - antagonists & inhibitors | Cells, Cultured | Gene Silencing | NADPH Oxidase 2 | Membrane Glycoproteins - genetics | Mice, Knockout | Cyclic AMP - antagonists & inhibitors | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Secretory Vesicles - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Cyclic AMP - agonists | Isoenzymes - antagonists & inhibitors | Oxidases | Physiological aspects | Pancreatic beta cells | Research | Analysis | NADP (Coenzyme) | Index Medicus | Abridged Index Medicus | Islet Studies
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 510, Issue 7504, pp. 298 - 302
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2014, Volume 111, Issue 1, pp. 279 - 284
Journal Article
Plant Cell, ISSN 1040-4651, 12/2017, Volume 29, Issue 12, pp. 3234 - 3254
Methylglyoxal (MGO) and glyoxal (GO) are toxic reactive carbonyl species generated as by-products of glycolysis. The pre-emption pathway for detoxification of... 
ARABIDOPSIS-THALIANA | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | GLYCATION | D-LACTATE DEHYDROGENASE | PLANT SCIENCES | CELL BIOLOGY | SUBSTRATE-SPECIFICITY | ENCODING GENES | GENOME-WIDE ANALYSIS | METHYLGLYOXAL | GLYOXALASE-I | Inactivation, Metabolic | Arabidopsis - enzymology | Glutathione - metabolism | Eukaryotic Cells - metabolism | RNA, Messenger - metabolism | Arabidopsis Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Protoplasts - metabolism | Pyruvaldehyde - metabolism | Isoenzymes - metabolism | Gene Expression Regulation, Plant | Free Radicals - metabolism | Plant Cells - metabolism | Lactoylglutathione Lyase - metabolism | Stress, Physiological - genetics | Alternative Splicing - genetics | Arabidopsis - cytology | RNA, Messenger - genetics | Mutation - genetics | Subcellular Fractions - metabolism | Chloroplasts - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Metals - metabolism | Plant Leaves - metabolism | Models, Biological | Cytosol - metabolism | Sugars - metabolism | Arabidopsis thaliana | Glucose metabolism | Defense industry | Germination | Glutamine | Alternative splicing | Yeast | Transcription | Splicing | Detoxification | Byproducts | Chemical reactions | Homology | Cytosol | Seedlings | Mitochondria | Developmental stages | Chloroplasts | Coding | Compartments | Isoforms | Glycolysis | Biocompatibility | Lactoylglutathione lyase | Pyruvaldehyde | Species | Sugar | Carbonyls | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0132977 - e0132977
Cancer stem cells are cancer cells characterized by stem cell properties and represent a small population of tumor cells that drives tumor development,... 
TESTIS ANTIGEN BORIS | HEPATOCELLULAR-CARCINOMA | SIDE POPULATION | IN-VITRO | INDUCED APOPTOSIS | TELOMERASE | MULTIDISCIPLINARY SCIENCES | IMPRINTED SITES | CTCF | IDENTIFICATION | TUMOR-INITIATING CELLS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | RNA, Small Interfering - genetics | Cell Proliferation | Epithelial Cells - metabolism | Polycomb Repressive Complex 1 - metabolism | Homeodomain Proteins - metabolism | Humans | Retinal Dehydrogenase - metabolism | Gene Expression Regulation, Neoplastic | Spheroids, Cellular - pathology | Epithelial-Mesenchymal Transition - genetics | Neoplasm Proteins - metabolism | SOXB1 Transcription Factors - metabolism | DNA-Binding Proteins - metabolism | Octamer Transcription Factor-3 - genetics | Polycomb Repressive Complex 1 - genetics | Telomerase - genetics | ATP-Binding Cassette Transporters - genetics | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | Isoenzymes - metabolism | Hyaluronan Receptors - metabolism | ATP-Binding Cassette Transporters - metabolism | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Telomerase - metabolism | Neoplasm Proteins - genetics | DNA-Binding Proteins - antagonists & inhibitors | Nanog Homeobox Protein | Signal Transduction | Isoenzymes - genetics | Spheroids, Cellular - metabolism | Epithelial Cells - pathology | Retinal Dehydrogenase - genetics | DNA-Binding Proteins - genetics | Organ Specificity | Hyaluronan Receptors - genetics | Homeodomain Proteins - genetics | Phenotype | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Biomarkers, Tumor - genetics | Cell Movement | RNA, Small Interfering - metabolism | RNA | Genes | Colorectal cancer | Stem cells | Genetic aspects | Gene expression | Cancer | Protein binding | Neurosciences | Germ cells | Telomerase reverse transcriptase | Populations | Dyes | Mesenchyme | Oct-4 protein | Gene regulation | Oncology | Spheres | Drug resistance | Tissues | Metastases | DNA-binding protein | CD44 antigen | Cell cycle | Life sciences | Colon | Telomerase | Growth factors | Deoxyribonucleic acid--DNA | Medical research | Antigens | Cell survival | Tumor cells | Invasiveness | Cervix | Survival | Brain research | Molecular modelling | Medical prognosis | Epigenetics | Breast | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2012, Volume 109, Issue 47, pp. 19071 - 19078
Neurons within each layer in the mammalian cortex have Stereotypic projections. Four genes—Fezf2, Ctip2, Tbr1, and Satb2—regulate these projection identities.... 
Axons | Brain | Mesencephalon | Neurons | Thalamus | Genetic loci | Gene expression regulation | Pyramidal tracts | Repression | Identity | Cerebral cortex | Cell fate | Axon guidance | Transcription factor | transcription factor | CALLOSAL | cell fate | MULTIDISCIPLINARY SCIENCES | AUTISM SPECTRUM DISORDER | TBR1 | GUIDANCE | SPECIFICATION | DEVELOPING CEREBRAL-CORTEX | cerebral cortex | NEURON IDENTITY | CORTICOSPINAL TRACT | NETRIN-1 | DIFFERENTIATION | axon guidance | Axons - enzymology | Thalamus - metabolism | Alkaline Phosphatase - metabolism | Genetic Loci - genetics | Receptor, EphA4 - metabolism | Gene Regulatory Networks | Cerebral Cortex - metabolism | DNA-Binding Proteins - metabolism | Neocortex - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Isoenzymes - metabolism | Cell Adhesion Molecules, Neuronal - metabolism | Neurons - metabolism | Netrin Receptors | Repressor Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Neocortex - growth & development | Receptors, Cell Surface - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Mutation - genetics | GPI-Linked Proteins - metabolism | Nerve Tissue Proteins - metabolism | Animals | Protein Binding | Mice | Physiological aspects | Genetic aspects | Gene mutations | Neocortex | Mutation | Gene expression | Medical disorders | Genes | Index Medicus | Biological Sciences
Journal Article
Scientific Reports, ISSN 2045-2322, 03/2016, Volume 6, Issue 1, pp. 23685 - 23685
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2014, Volume 111, Issue 43, pp. 15579 - 15584
Journal Article
Journal Article