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PLoS Biology, ISSN 1544-9173, 05/2012, Volume 10, Issue 5, pp. e1001336 - e1001336
In metazoans, the majority of mRNAs coding for secreted and membrane-bound proteins are translated on the surface of the endoplasmic reticulum (ER). Although... 
RAT-LIVER | TRANSLOCATION | DIRECT ASSOCIATION | MEMBRANE-BOUND RIBOSOMES | MITOCHONDRIAL BIOGENESIS | BUDDING YEAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | RECEPTOR | BINDING PROTEIN | POLYSOMES | MAMMALIAN-CELLS | Humans | Alkaline Phosphatase - metabolism | Cercopithecus aethiops | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Ribosomes - metabolism | RNA, Messenger - metabolism | Calreticulin - genetics | Lentivirus - metabolism | Isoenzymes - metabolism | Base Sequence | Cloning, Molecular | Escherichia coli - metabolism | HEK293 Cells | Plasmids - genetics | Calreticulin - metabolism | Lentivirus - genetics | Lysine - metabolism | Active Transport, Cell Nucleus | Insulin - genetics | Green Fluorescent Proteins - metabolism | Alkaline Phosphatase - genetics | Endoplasmic Reticulum - genetics | Isoenzymes - genetics | RNA, Messenger - genetics | Cell Size | In Situ Hybridization, Fluorescence | Receptors, Cytoplasmic and Nuclear - genetics | Plasmids - metabolism | GPI-Linked Proteins - metabolism | Protein Interaction Mapping | Protein Transport | Proteins - genetics | Insulin - metabolism | Animals | Proteins - metabolism | Escherichia coli - genetics | COS Cells | Digitonin - pharmacology | GPI-Linked Proteins - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Proteins | Medical research | Polypeptides | Yeast | Insects | Plasmids | Kinases | Gene expression | Experiments | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 37, pp. 15561 - 15576
Preferential expression of the low-activity (dimeric) M2 isoform of pyruvate kinase (PK) over its constitutively active splice variant M1 isoform is considered... 
LUNG-CANCER | METABOLISM | TUMOR SUPPRESSION | PKM2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | PREDICTING SUBCELLULAR-LOCALIZATION | HIGH-TITER LENTIVIRUS | ISOFORM | LKB1 | GENE-TRANSCRIPTION | Mitochondrial Dynamics | AMP-Activated Protein Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Pyruvate Kinase - chemistry | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Isoenzymes - chemistry | Neoplasm Proteins - metabolism | Autophagy | Recombinant Fusion Proteins - metabolism | Thyroid Hormones - chemistry | Organelle Biogenesis | RNA Interference | Isoenzymes - metabolism | Adenosine Triphosphate - metabolism | Carcinoma - enzymology | Carrier Proteins - chemistry | Membrane Proteins - metabolism | Carcinoma - pathology | Neoplasm Proteins - genetics | Dimerization | A549 Cells | Lung Neoplasms - enzymology | Pyruvate Kinase - metabolism | Isoenzymes - genetics | Membrane Proteins - genetics | AMP-Activated Protein Kinases - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Neoplasm Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Thyroid Hormones - genetics | Protein Transport | Carrier Proteins - genetics | Pyruvate Kinase - antagonists & inhibitors | Carrier Proteins - metabolism | Energy Metabolism | Membrane Proteins - antagonists & inhibitors | Membrane Proteins - chemistry | Thyroid Hormones - metabolism | Cell Line, Tumor | Carcinoma - metabolism | Mutation | Pyruvate Kinase - genetics | AMP-Activated Protein Kinases - genetics | Isoenzymes - antagonists & inhibitors | Amino Acid Substitution | Apoptosis | Index Medicus | cancer metabolism | cancer therapy | pyruvate kinase M1 | mitochondria | pyruvate kinase M2 | cancer biology | Metabolism | mitochondrial oxidative phosphorylation | energy metabolism | Warburg effect
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 10/2013, Volume 455, Issue 1, pp. 75 - 85
The resistance of mosquitoes to chemical insecticides is threatening vector control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to... 
DENGUE VECTOR | recombinant system | VECTOR AEDES-AEGYPTI | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | insecticide | IN-VITRO METABOLISM | ANOPHELES-GAMBIAE | resistance | mosquito | YEAST | MALARIA VECTOR | cytochrome P450 monooxygenase | metabolism | P450 | pyrethroid | Inactivation, Metabolic | Insecticides - chemistry | NADPH-Ferrihemoprotein Reductase - genetics | Saccharomyces cerevisiae - genetics | Benzoates - metabolism | Cytochrome P-450 Enzyme System - metabolism | Insecticide Resistance - genetics | NADPH-Ferrihemoprotein Reductase - chemistry | Saccharomyces cerevisiae - drug effects | Isoenzymes - chemistry | Pyrethrins - pharmacology | Insect Vectors - drug effects | Isoenzymes - metabolism | Insecticide Resistance - drug effects | Aedes - enzymology | Pyrethrins - metabolism | Insect Proteins - metabolism | Insect Vectors - enzymology | Insecticides - pharmacology | Benzaldehydes - chemistry | Escherichia coli - enzymology | NADPH-Ferrihemoprotein Reductase - metabolism | Oxidation-Reduction | Isoenzymes - genetics | Anopheles - drug effects | Insect Proteins - genetics | Benzaldehydes - pharmacology | Aedes - drug effects | Pyrethrins - chemistry | Anopheles - enzymology | Benzaldehydes - metabolism | Cytochrome P-450 Enzyme System - chemistry | Animals | Genetic Engineering | Insecticides - metabolism | Escherichia coli - genetics | Insect Proteins - chemistry | Cytochrome P-450 Enzyme System - genetics | Saccharomyces cerevisiae - enzymology | Molecular Docking Simulation | Index Medicus | AeCPR, Aedes aegypti CPR | 7-OH, 7-hydroxycoumarin | SRS, substrate recognition site | CPR, NADPH-cytochrome P450-reductase | Rt, retention time | Cyt b5, cytochrome b5 | PBAld, 3-phenoxybenzaldehyde | qPCR, quantitative real-time PCR | PBA, 3-phenoxybenzoic acid | PBAlc, 3-phenoxybenzoic alcohol | TFA, trifluoroacetic acid
Journal Article
Matrix Biology, ISSN 0945-053X, 2011, Volume 30, Issue 2, pp. 145 - 153
Aggrecan degradation in articular cartilage occurs predominantly through proteolysis and has been attributed to the action of members of the matrix... 
MMP | ADAMTS | Interglobular domain | Chondroitin-sulfate-2 region | Aggrecan catabolism | RHEUMATOID-ARTHRITIS | PROTEOLYTIC CLEAVAGE | CLEAVAGE SITE | ACTIVATION MECHANISMS | LARGE AGGREGATING PROTEOGLYCAN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | HUMAN ARTICULAR-CARTILAGE | MATRIX METALLOPROTEINASES | OSTEOARTHRITIC CARTILAGE | ONCOSTATIN-M | Matrix Metalloproteinases, Secreted - metabolism | Interleukin-1beta - pharmacology | Phenylmercuric Acetate - pharmacology | Matrix Metalloproteinase 12 - genetics | Cartilage - drug effects | Oncostatin M - pharmacology | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 7 - metabolism | Cattle | Isoenzymes - metabolism | Matrix Metalloproteinase 8 - metabolism | Gelatinases - metabolism | Matrix Metalloproteinase 1 - genetics | Recombinant Proteins - metabolism | Endopeptidases - metabolism | Matrix Metalloproteinase 8 - genetics | Peptide Fragments - metabolism | Isoenzymes - genetics | Matrix Metalloproteinase 2 - metabolism | Matrix Metalloproteinase 3 - metabolism | Aggrecans - metabolism | Matrix Metalloproteinase 12 - metabolism | Cartilage - metabolism | Aggrecans - genetics | ADAM Proteins - metabolism | Enzyme Precursors - metabolism | Matrix Metalloproteinase 7 - genetics | Animals | Endopeptidases - genetics | Matrix Metalloproteinases, Secreted - genetics | Phenylmercuric Acetate - analogs & derivatives | ADAM Proteins - genetics | Cartilage - enzymology | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 3 - genetics | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 2861 - 2871
OBJECTIVE-Class Ha histone deacetylases (HDACs) belong to a large family of enzymes involved in protein deacetylation and play a role in regulating gene... 
PLAY | PROGENITORS | RESPONSIVENESS | CONTROLS CHONDROCYTE HYPERTROPHY | SMALL-MOLECULE | GROWTH | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | MEF2 TRANSCRIPTION FACTOR | DIFFERENTIATION | INHIBITORS | Embryo, Mammalian - drug effects | Homeodomain Proteins - metabolism | Somatostatin-Secreting Cells - cytology | RNA, Messenger - metabolism | Embryo, Mammalian - metabolism | Repressor Proteins - antagonists & inhibitors | Insulin-Secreting Cells - metabolism | Isoenzymes - metabolism | Mice, Mutant Strains | Somatostatin-Secreting Cells - drug effects | Insulin-Secreting Cells - cytology | Somatostatin - metabolism | Repressor Proteins - metabolism | Animals, Newborn | Histone Deacetylases - genetics | Isoenzymes - genetics | Tissue Culture Techniques | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Developmental - drug effects | Histone Deacetylases - chemistry | Organ Size | Pancreas - drug effects | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Pancreas - metabolism | Organ Specificity | Insulin - metabolism | Algorithms | Animals | Insulin-Secreting Cells - drug effects | Cell Differentiation - drug effects | Embryo, Mammalian - cytology | Mice | Pancreas - growth & development | Somatostatin-Secreting Cells - metabolism | Isoenzymes - antagonists & inhibitors | Paired Box Transcription Factors - metabolism | Beta cells | Index Medicus | Abridged Index Medicus | Islet Studies
Journal Article
Blood, ISSN 0006-4971, 03/2010, Volume 115, Issue 10, pp. 1958 - 1968
Journal Article
Bone, ISSN 8756-3282, 2008, Volume 44, Issue 3, pp. 476 - 484
Journal Article
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 2001, Volume 15, Issue 3, pp. 553 - 555
Journal Article