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chemistry, organic (106) 106
isoindoline (103) 103
chemistry, multidisciplinary (71) 71
isoindolines (61) 61
derivatives (59) 59
index medicus (54) 54
chemistry, inorganic & nuclear (52) 52
chemistry (38) 38
chemistry, medicinal (33) 33
synthesis (29) 29
isoindoline nitroxides (28) 28
palladium (25) 25
catalysis (24) 24
crystal structure (24) 24
ligands (24) 24
humans (22) 22
molecular structure (22) 22
biochemistry & molecular biology (21) 21
isoindoline pincer ligand (21) 21
inhibitors (19) 19
animals (18) 18
crystallography (18) 18
structure-activity relationship (18) 18
1,3-bisisoindolines (17) 17
coordination chemistry (17) 17
oxidation (17) 17
radicals (17) 17
amines (16) 16
analysis (16) 16
asymmetric-synthesis (16) 16
crystal-structure (16) 16
cyclization (16) 16
heterocycles (15) 15
metal-complexes (15) 15
fluorescence (14) 14
pharmacology & pharmacy (14) 14
article (13) 13
zn (13) 13
free radicals (12) 12
isoindoles - chemistry (12) 12
potent (12) 12
design (11) 11
indoles - chemistry (11) 11
organic chemistry (11) 11
pd-ii complex (11) 11
spectroscopic properties (11) 11
stereoisomerism (11) 11
structural-characterization (11) 11
agents (10) 10
alkynes (10) 10
complexes (10) 10
electron-paramagnetic-resonance (10) 10
epr spectroscopy (10) 10
facile synthesis (10) 10
isoindoline derivatives (10) 10
pyrrole pigments (10) 10
1,3-bisisoindoline (9) 9
alcohols (9) 9
analogs (9) 9
chemistry, physical (9) 9
directed synthesis (9) 9
isoindoline nitroxide (9) 9
isoquinoline derivatives (9) 9
mice (9) 9
models, molecular (9) 9
mononuclear (9) 9
ruthenium complexes (9) 9
activation (8) 8
alkylation (8) 8
binding (8) 8
bisisoindole bpi ligands (8) 8
bisisoindoline complexes (8) 8
crystals (8) 8
distance measurements (8) 8
drug design (8) 8
efficient synthesis (8) 8
indoles - chemical synthesis (8) 8
iron (8) 8
isoindoline dyes (8) 8
mechanism (8) 8
nitroxide (8) 8
polymers (8) 8
rats (8) 8
redox chemistry (8) 8
spin probes (8) 8
strategy (8) 8
alkaloids (7) 7
bai ligands (7) 7
chemical sciences (7) 7
chlorin system (7) 7
copper (7) 7
cycloaddition (7) 7
discovery (7) 7
docking (7) 7
drug discovery (7) 7
electrochemistry (7) 7
electron paramagnetic resonance (7) 7
epr (7) 7
heterocyclic compounds (7) 7
inhibition (7) 7
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81. Full Text Experimental and Theoretical Studies of the Redox Potentials of Cyclic Nitroxides
by Blinco, James P and Hodgson, Jennifer L and Morrow, Benjamin J and Walker, James R and Will, Geoffrey D and Coote, Michelle L and Bottle, Steven E
The Journal of Organic Chemistry, ISSN 0022-3263, 09/2008, Volume 73, Issue 17, pp. 6763 - 6771
The redox potentials of 25 cyclic nitroxides from four different structural classes (pyrrolidine, piperidine, isoindoline, and azaphenalene) were determined... 
SUPEROXIDE | CONSTANTS | OXOAMMONIUM CATION | THERMOCHEMISTRY | KINETICS | EPR | CHEMISTRY, ORGANIC | ISOINDOLINE NITROXIDES | ACETONITRILE | GAUSSIAN-3 | FREE-RADICALS | Models, Theoretical | Isoindoles - chemistry | Cyclic N-Oxides - chemistry | Piperidines - chemistry | Algorithms | Oxidation-Reduction | Acetonitriles - chemistry | Aza Compounds - chemistry | Electrochemistry | Pyrrolidines - chemistry | Molecular dynamics | Oxidation-reduction reaction | Nitrous oxide | Chemical properties | Structure | Analysis
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82. Full Text Noncovalent and site-directed spin labeling of duplex RNA
by Kamble, Nilesh R and Gränz, Markus and Prisner, Thomas F and Sigurdsson, Snorri Th
Chemical communications (Cambridge, England), 12/2016, Volume 52, Issue 100, p. 14442
An isoindoline-nitroxide derivative of guanine (Ǵ, "G-spin") was shown to bind specifically and effectively to abasic sites in duplex RNAs. Distance... 
Staining and Labeling - methods | Electron Spin Resonance Spectroscopy | Base Sequence | Nitrogen Oxides - chemistry | Guanine - chemistry | Molecular Structure | RNA - chemistry | Indoles - chemistry
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83. Full Text Synthesis of Nitroxide-Annulated Carbocycles and Heterocycles
by Kálai, Tamás and Bognár, Balázs and Zsolnai, Dániel and Berente, Zoltán and Hideg, Kálmán
Synthesis, ISSN 0039-7881, 12/2012, Volume 44, Issue 23, pp. 3655 - 3660
Abstract New, pyrroline nitroxide annulated lactones, polycycles, and maleimide were synthesized by classical and microwave-assisted methodology. We report the... 
paper | free radicals | lactones | quinones | metathesis | heterocycles | COUPLING REACTIONS | AMINES | ACIDS | CHEMISTRY, ORGANIC | ISOINDOLINE NITROXIDES | RADICALS | PROBES
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84. Full Text Copper-Catalyzed Benzylic C−H Oxygenation under an Oxygen Atmosphere via N-H Imines as an Intramolecular Directing Group
by Zhang, Line and Ang, Gim Yean and Chiba, Shunsuke
Organic Letters, ISSN 1523-7060, 04/2011, Volume 13, Issue 7, pp. 1622 - 1625
Copper-catalyzed benzylic C−H oxygenation under an oxygen atmosphere was developed starting from carbonitriles and Grignard reagents via N-H imine... 
OXIDATION | ORGANIC-SYNTHESIS | LEWIS-ACID | ISOINDOLINES | BIOLOGICAL EVALUATION | CHEMISTRY, ORGANIC | PHTHALAZINE PDE4 INHIBITORS | CARBON TRIPLE BOND | CLEAVAGE | RADICAL TRANSLOCATION | MOLECULAR-OXYGEN
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85. Full Text Acetyl Bromide Promoted Sequence via Allene Intermediates: Metal‐Free Construction of 2,3‐Dihydroindenes and Isoindolines
by Liu, Le and Yao, Jinzhong and Chen, Dianpeng and Zhou, Hongwei
Advanced Synthesis & Catalysis, ISSN 1615-4150, 08/2016, Volume 358, Issue 16, pp. 2671 - 2677
2,3‐Dihydroindenes and isoindolines are important skeletons present in medicinal and synthetic chemistry. In this paper, an acetyl bromide promoted metal‐free... 
acetyl bromide | isoindoline | metal-free | 2,3-dihydroindene | TANDEM | ISOMERIZATION | CHEMISTRY, ORGANIC | PYRROLES | BENZENES | 6-PI-ELECTROCYCLIZATION | HETEROCYCLES | BENZOFURANS | CHEMISTRY, APPLIED | THIOPHENES | DERIVATIVES | CYCLIZATION | Bromides | Construction | Synthesis | Catalysis | Allene
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86. Full Text Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11
by Martin, Matthew W and Lee, Jennifer Y and Lancia, David R and Ng, Pui Yee and Han, Bingsong and Thomason, Jennifer R and Lynes, Maureen S and Marshall, C. Gary and Conti, Chiara and Collis, Alan and Morales, Monica Alvarez and Doshi, Kshama and Rudnitskaya, Aleksandra and Yao, Lili and Zheng, Xiaozhang
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2018, Volume 28, Issue 12, pp. 2143 - 2147
-Hydroxy-2-arylisoindoline-4-carboxamides are potent and selective inhibitors of HDAC11. The discovery, synthesis, and structure activity relationships of this... 
Hydroxamic acid | Oncology | Inflammation | HDACs | Isoindoline | HDAC11 | HISTONE DEACETYLASE 11 | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | Recombinant Proteins - metabolism | Isoindoles - chemistry | Humans | Enzyme Inhibitors - pharmacology | Histone Deacetylases - metabolism | Male | Isoindoles - chemical synthesis | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Drug Discovery | Dose-Response Relationship, Drug | Animals | Mice, Nude | Enzyme Inhibitors - chemistry | Mice | Mice, Inbred BALB C | Molecular Structure | Isoindoles - pharmacology
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87. Novel synthesis of N-(1,3-dioxoisoindol-2-yl)aminothiocarbohydrazide, and its arylidenes and glycosylidines as precursors for hybrids with thiadiazoline ring. equilibration of the glycosylidine open chain with the cyclic structures and conformation of the acyclic analogues
by El Ashry, El Sayed H and Awad, Laila F and Nasr, Mahmoud and Kassem, Ahmed A and Zakaria, Mohamed A
Current Organic Synthesis, ISSN 1570-1794, 2018, Volume 15, Issue 7, pp. 1005 - 1013
Aim and Objective: Reaction of phthalic anhydride (1) with thiocarbohydrazide (2) in methanol gave the intermediate (6) whose boiling in water or ethanol gave... 
Thiadiazoline | Hybrid heterocycles | N-(1,3-dioxoisoindol-2-yl)aminothiocarbohydrazide | Acyclo C-nucleoside | Conformation | Thiosemicarbazides | DESIGN | thiadiazoline | TRIAZOLE | THIOSEMICARBAZONES | CHEMISTRY, ORGANIC | HETEROCYCLIZATION | conformation | hybrid heterocycles | N-(1,3-dioxoisoindol-2-yl) aminothiocarbohydrazide | acyclo C-nucleoside | ISOINDOLINE DERIVATIVES
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88. Full Text Probing for improved selectivity with dipeptide-derived inhibitors of dipeptidyl peptidases 8 and 9: The impact of P1-variation
by Heirbaut, Leen and Van Goethem, Sebastiaan and Jansen, Koen and De Winter, Hans and Lamoen, Nicole and Joossens, Jurgen and Cheng, Jonathan and Chen, Xin and Lambeir, Anne-Marie and De Meester, Ingrid and Augustyns, Koen and Van Der Veken, Pieter
MedChemComm, ISSN 2040-2503, 03/2016, Volume 7, Issue 3, pp. 433 - 438
Selected pyrrolidines, 2-cyanopyrrolidines and heteroaromatic isoindoline analogues were evaluated as P1-residues in dipeptide-derived inhibitors of DPP8/9.... 
LOCALIZATION | POTENT | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISOINDOLINE
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89. Full Text Synthesis and properties of fullerene C60 and C70 spin probes containing isoindoline nitroxides
by Yan, Guo-Ping and Zhao, Biao and Bottle, Steven E and Zhang, Qiao and Li, Jia-Le
Fullerenes Nanotubes and Carbon Nanostructures, ISSN 1536-383X, 08/2015, Volume 23, Issue 8, pp. 734 - 741
spin probes | electrochemical property | electron paramagnetic resonance (EPR) | fullerene | isoindoline nitroxides
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90. Full Text Iridium Half-Sandwich Complexes with Di- and Tridentate Bis(pyridylimino)isoindolato Ligands: Stoichiometric and Catalytic Reactivity
by Müller, Astrid L and Bleith, Tim and Roth, Torsten and Wadepohl, Hubert and Gade, Lutz H
Organometallics, ISSN 0276-7333, 06/2015, Volume 34, Issue 11, pp. 2326 - 2342
A series of kappa(2)-(N,N)-coordinated bis(2-pyridylimino)-isoindolato (BPI) complexes [Cp*Ir(BPI)Cl], which possess "three-legged piano-stool" structures,... 
H BOND ACTIVATION | ASYMMETRIC TRANSFER HYDROGENATION | CP-ASTERISK | STRUCTURAL CHEMISTRY | X-RAY-STRUCTURE | HETEROCYCLIC IMINES | RUTHENIUM COMPLEXES | CHEMISTRY, ORGANIC | ISOINDOLINE PINCER LIGAND | RADICAL POLYMERIZATION | OPPENAUER-TYPE OXIDATION | CHEMISTRY, INORGANIC & NUCLEAR
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91. Full Text One-dimensional organization of free radicals via halogen bonding
by Espallargas, Guillermo Mínguez and Recuenco, Alejandro and Romero, Francisco M and Brammer, Lee and Libri, Stefano
CrystEngComm, ISSN 1466-8033, 10/2012, Volume 14, Issue 20, pp. 6381 - 6383
Halogen bonds have been applied for the supramolecular organization of organic free radicals in the solid state and their role in the propagation of the... 
MOLECULAR CONDUCTORS | NITROXIDE RADICALS | COMPLEXES | CRYSTALS | M-X | FERROMAGNETIC INTERACTIONS | NETWORKS | CRYSTALLOGRAPHY | MAGNETIC-PROPERTIES | SUPRAMOLECULAR CHEMISTRY | ISOINDOLINE NITROXIDE | CHEMISTRY, MULTIDISCIPLINARY
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92. Full Text An Iron(II)(1,3-bis(2′-pyridylimino)isoindoline) Complex as a Catalyst for Substrate Oxidation with H2O2. Evidence for a Transient Peroxodiiron(III) Species
by Pap, József S and Cranswick, Matthew A and Balogh-Hergovich, É and Baráth, Gábor and Giorgi, Michel and Rohde, Gregory T and Kaizer, József and Speier, Gábor and Que, Lawrence
European journal of inorganic chemistry, ISSN 1434-1948, 8/2013, Volume 2013, Issue 22-23, pp. 3858 - 3866
The complex [Fe(indH)(solvent) 3 ](ClO 4 ) 2 ( 1 ) has been isolated from the reaction of equimolar amounts of 1,3-bis(2′-pyridylimino)isoindoline (indH) and... 
Iron-peroxo intermediate | Catalytic oxidation | Nonheme iron complex | Isoindoline | Tridentate ligand
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93. Full Text Two cadmium(II) complexes with oxazoline-based ligands as effective catalysts for C–N cross-coupling reactions
by Jia, Wei-Guo and Li, Dan-Dan and Gu, Cuiping and Dai, Yuan-Chen and Zhou, Ying-Hua and Yuan, Guozan and Sheng, En-Hong
Inorganica Chimica Acta, ISSN 0020-1693, 03/2015, Volume 427, pp. 226 - 231
Bimetallic complex [{(DMOX)CdCl} ( -Cl) ] ( ) is efficient in catalyzing C–N cross-coupling of amine with aryl halide. Binuclear [{(DMOX)CdCl} ( -Cl) ] (DMOX =... 
Cadmium | Catalysis | Oxazoline | Pincer | COORDINATION CHEMISTRY | PALLADIUM | CD(II) | BIS(OXAZOLINE) LIGANDS | CRYSTAL | POLYMERIZATION | LUMINESCENT PROPERTIES | CHEMISTRY, INORGANIC & NUCLEAR | AMINATION | ISOINDOLINE PINCER LIGAND | COBALT
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94. Full Text Correlation between the SOD-like activity of hexacoordinate iron(II) complexes and their Fe 3+/Fe 2+ redox potentials
by Kripli, Balázs and Baráth, Gábor and Balogh-Hergovich, É and Giorgi, Michel and Simaan, A. Jalila and Párkányi, László and Pap, József S and Kaizer, József and Speier, Gábor
Inorganic Chemistry Communications, ISSN 1387-7003, 2011, Volume 14, Issue 1, pp. 205 - 209
Hexacoordinate, high-spin iron(II) complexes with different isoindoline-derivative ligands have been prepared and characterized. The Fe /Fe redox transition is... 
SOD mimics | Iron | Redox chemistry | Isoindoline ligand
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95. Full Text Organic multishell isostructural host-guest crystals: Fullerenes C 60 inside a nitroxide open framework
by Bardelang, David and Giorgi, Michel and Pardanaud, Cédric and Hornebecq, Virginie and Rizzato, Egon and Tordo, Paul and Ouari, Olivier
Chemical Communications, ISSN 1359-7345, 05/2013, Volume 49, Issue 34, pp. 3519 - 3521
The dinitroxide biradical bTbk crystallizes forming hexagonal open frameworks with one-dimensional corrugated channels filled with crystallization solvent. The... 
COMPLEX | DESIGN | TECTONS | MOLECULE | NMR-SPECTROSCOPY | SOLIDS | CHEMISTRY | INCLUSION | RADICALS | ISOINDOLINE NITROXIDE | CHEMISTRY, MULTIDISCIPLINARY | Chemical Sciences
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96. Full Text Exploitation of the Menshutkin Reaction for the Controlled Assembly of Halogen Bonded Architectures Incorporating 1,2-Diiodotetrafluorobenzene and 1,3,5-Triiodotrifluorobenzene
by Pfrunder, Michael C and Micallef, Aaron S and Rintoul, Llewellyn and Arnold, Dennis P and Davy, Karl J. P and McMurtrie, John
Crystal Growth & Design, ISSN 1528-7483, 02/2012, Volume 12, Issue 2, pp. 714 - 724
1,4-Diazabicyclo[2.2.2]octane (DABCO) forms well-defined co-crystals with 1,2-diiodotetrafluorobenzene (1,2-DITFB), [(1,2-DITFB)2DABCO], and... 
ORGANIC IODIDES | COCRYSTALLIZATION | TERTIARY-AMINES | MATERIALS SCIENCE, MULTIDISCIPLINARY | COMPLEXES | DONORS | CRYSTALLOGRAPHY | NONCOVALENT INTERACTIONS | CHEMISTRY, MULTIDISCIPLINARY | DICHLOROMETHANE | ISOINDOLINE NITROXIDE | DERIVATIVES | CATION
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97. Full Text An Acid-Catalysed Hydroamination Approach to Isoindolines
by Henderson, Laura and Knight, David W and Williams, Andrew C
Synlett, ISSN 0936-5214, 07/2012, Volume 23, Issue 11, pp. 1667 - 1669
Abstract Acid-catalysed intramolecular hydroaminations of 2-­alkenylarylethylamine derivatives lead smoothly to isoindolines via benzylic carbenium ion... 
letter | cyclisation | isoindolines | sulfonamides | heterocycles | hydroamination | ALKENES | CHEMISTRY, ORGANIC | ALKYNES
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98. Full Text Enantioselective Synthesis of Isoindolines: An Organocatalyzed Domino Process Based On the aza‐Morita–Baylis–Hillman Reaction
by Takizawa, Shinobu and Inoue, Naohito and Hirata, Shuichi and Sasai, Hiroaki
Angewandte Chemie International Edition, ISSN 1433-7851, 12/2010, Volume 49, Issue 50, pp. 9725 - 9729
Facile, selective, and organic: Acid–base organocatalyzed aza‐Morita–Baylis–Hillman/aza‐Michael domino reactions of α,β‐unsaturated carbonyl compounds 1 with... 
organocatalysis | isoindolines | aza‐Michael addition | asymmetric catalysis | domino reactions | aza-Michael addition | BRONSTED ACID | PHOSPHINE LEWIS-BASE | N-SULFONATED IMINES | HILIMAN REACTION | METHYL VINYL KETONE | ISOQUINOLINE DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | BIFUNCTIONAL ORGANOCATALYSTS | BOND DONORS | CATALYTIC ASYMMETRIC-SYNTHESIS | ACTIVATED OLEFINS
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99. Full Text Lewis Acid‐Catalyzed CH Functionalization for Synthesis of Isoindolinones and Isoindolines
by Qian, Bo and Guo, Shengmei and Xia, Chungu and Huang, Hanmin
Advanced Synthesis & Catalysis, ISSN 1615-4150, 12/2010, Volume 352, Issue 18, pp. 3195 - 3200
The Lewis acid‐catalyzed CH functionalization of 2‐substituted azaarenes with N‐sulfonylaldimines has been developed, which provides a rapid and efficient... 
Lewis acids | isoindolines | CH functionalization | isoindolinones | tandem reactions | C-H functionalization | ACTIVATION | DIRECT ARYLATION | PYRIDINE-N-OXIDES | ALKYLATION | BOND FUNCTIONALIZATION | CHEMISTRY, ORGANIC | CROSS-COUPLING REACTIONS | AROMATIC HETEROCYCLES | SITE-SELECTIVE SP | METAL | CHEMISTRY, APPLIED | ALKENYLATION
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100. Synthesis and Properties of a Novel Colorimetric and Fluorescent Turn-On Sensor for Cyanide
by Hao, YP and Xie, ZF and Bao, WR and Wang, X and Shi, W
CHINESE JOURNAL OF ORGANIC CHEMISTRY, ISSN 0253-2786, 08/2018, Volume 38, Issue 8, pp. 2109 - 2115
A novel fluorescent "turn-on" probe 7-(dibutylamino)-2'((2-hydroxybenzylidene)amino)-3-methyl-l-phenyl-1H-spiro[chromeno[2,3-cipyrazole-4,1'-isoindolin]-3'-one... 
ANION | RECOGNITION | MECHANISM | spiro[chromene[2,3-c]pyrazole-4,1 '-isoindoline] | colorimetric | CHEMISTRY, ORGANIC | CN | AQUEOUS-SOLUTION | Schiff base | CHEMOSENSOR | fluorescence | INDUCED EMISSION ENHANCEMENT | SCHIFF-BASE | PROBE | DERIVATIVES | deprotonation | CHEMODOSIMETER
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