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Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 07/2018, Volume 104, Issue 1, pp. 188 - 200
The accuracy of physiologically based pharmacokinetic (PBPK) model prediction in children, especially those younger than 2 years old, has not been... 
CLEARANCE | TISSUE DISTRIBUTION | IN-VIVO | VOLUME | ONTOGENY | PROTON PUMP INHIBITORS | PHARMACOLOGY & PHARMACY | PHARMACODYNAMICS | SIMULATION | DESLORATADINE | EXPOSURE | Humans | Anti-Asthmatic Agents - metabolism | Child, Preschool | Cytochrome P-450 Enzyme System - metabolism | Sufentanil - metabolism | Bronchodilator Agents - metabolism | Quinolines - pharmacokinetics | Theophylline - pharmacokinetics | Esomeprazole - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Ondansetron - metabolism | Child | Cytochrome P-450 CYP2C9 - metabolism | Histamine H1 Antagonists, Non-Sedating - pharmacokinetics | Infant, Newborn | Itraconazole - metabolism | Serotonin Antagonists - pharmacokinetics | Tramadol - pharmacokinetics | Theophylline - metabolism | Cytochrome P-450 CYP3A - metabolism | Models, Biological | Proton Pump Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Cytochrome P-450 CYP2D6 - metabolism | Serotonin Antagonists - metabolism | Analgesics, Opioid - metabolism | Diclofenac - metabolism | Lansoprazole - pharmacokinetics | Loratadine - pharmacokinetics | Sufentanil - pharmacokinetics | Infant | Anti-Asthmatic Agents - pharmacokinetics | Itraconazole - pharmacokinetics | Antifungal Agents - pharmacokinetics | Antifungal Agents - metabolism | Loratadine - metabolism | Cytochrome P-450 CYP2C8 - metabolism | Lansoprazole - metabolism | Acetates - metabolism | Esomeprazole - pharmacokinetics | Cytochrome P-450 CYP1A2 - metabolism | Ondansetron - pharmacokinetics | Tramadol - metabolism | Diclofenac - pharmacokinetics | Quinolines - metabolism | Pharmaceutical Preparations - metabolism | Proton Pump Inhibitors - pharmacokinetics | Bronchodilator Agents - pharmacokinetics | Analgesics, Opioid - pharmacokinetics | Cytochrome P-450 CYP2C19 - metabolism | Loratadine - analogs & derivatives | Histamine H1 Antagonists, Non-Sedating - metabolism | Pharmacokinetics | Acetates - pharmacokinetics
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 12/2006, Volume 46, Issue 12, pp. 1426 - 1438
Cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of drugs such as bupropion, efavirenz, propofol, and selegiline, among others. More than 200... 
HPLC/MS/MS | P450 2B6 | rhCYP2B6 | Drug‐drug interactions | in vitro | Drug-drug interactions | In vitro | Raloxifene Hydrochloride - pharmacology | Cytochrome P-450 Enzyme Inhibitors | Humans | Microsomes, Liver - metabolism | Sertraline - chemistry | Bupropion - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Antifungal Agents - chemistry | Xenobiotics - pharmacology | Reverse Transcriptase Inhibitors - chemistry | Xenobiotics - classification | Clotrimazole - metabolism | Platelet Aggregation Inhibitors - pharmacology | Oxazines - pharmacology | Antifungal Agents - pharmacology | Itraconazole - metabolism | Serotonin Uptake Inhibitors - metabolism | Clotrimazole - pharmacology | Serotonin Uptake Inhibitors - chemistry | Antidepressive Agents, Second-Generation - pharmacology | Clotrimazole - chemistry | Itraconazole - chemistry | Selective Estrogen Receptor Modulators - metabolism | Ticlopidine - analogs & derivatives | Raloxifene Hydrochloride - metabolism | Platelet Aggregation Inhibitors - chemistry | Oxazines - chemistry | Kinetics | Serotonin Uptake Inhibitors - pharmacology | Selective Estrogen Receptor Modulators - pharmacology | Bupropion - metabolism | Ticlopidine - pharmacology | Area Under Curve | Reverse Transcriptase Inhibitors - pharmacology | Ticlopidine - chemistry | Benzoxazines | Xenobiotics - pharmacokinetics | Itraconazole - pharmacology | Oxazines - metabolism | Microsomes, Liver - drug effects | Antifungal Agents - metabolism | Ticlopidine - metabolism | Molecular Structure | Platelet Aggregation Inhibitors - metabolism | Sertraline - metabolism | Sertraline - pharmacology | Selective Estrogen Receptor Modulators - chemistry | Algorithms | Bupropion - pharmacology | Reverse Transcriptase Inhibitors - metabolism | Antidepressive Agents, Second-Generation - metabolism | Raloxifene Hydrochloride - chemistry | Cytochrome P-450 CYP2B6 | Cytochromes | Research | Health aspects | Drug interactions
Journal Article
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 11/2012, Volume 186, Issue 10, pp. 999 - 1007
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 10, pp. 4764 - 4769
Mammalian target of rapamycin (mTOR) constitutes a nodal point of a signaling network that regulates cell growth and proliferation in response to various... 
Angiogenesis | Phosphorylation | Cell growth | Cell lines | Lysosomes | Homeostasis | Cell membranes | Physiological regulation | Cholesterols | Endothelial cells | Cholesterol homeostasis | Itraconazole | 3T3-L1 ADIPOCYTES | MAMMALIAN TARGET | RAPAMYCIN | MESSENGER-RNA TRANSLATION | cholesterol homeostasis | PHOSPHORYLATION | angiogenesis | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | itraconazole | NIEMANN-PICK-DISEASE | PATHWAY | GROWTH | PHAS-I | Membrane Glycoproteins - metabolism | Humans | Multiprotein Complexes | Androstenes - pharmacology | Intracellular Signaling Peptides and Proteins - metabolism | Itraconazole - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Proteins | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Biological Transport | RNA Interference | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Endothelial Cells - metabolism | Enzyme Inhibitors - pharmacology | Cholesterol - metabolism | Blotting, Western | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Carrier Proteins - metabolism | Endothelial Cells - cytology | Cholesterol - pharmacology | Thapsigargin - pharmacology | Cell Proliferation - drug effects | TOR Serine-Threonine Kinases | Cell Cycle - drug effects | Imipramine - pharmacology | Cyclodextrins - pharmacology | Endothelial Cells - drug effects | Cyclodextrins | Rapamycin | Dosage and administration | Research | Neovascularization | Properties | Cholesterol | Endothelium | Biological Sciences
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2010, Volume 54, Issue 10, pp. 4225 - 4234
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2004, Volume 48, Issue 9, pp. 3272 - 3278
Journal Article
Journal Article
Journal Article