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British Journal of Haematology, ISSN 0007-1048, 10/2005, Volume 131, Issue 2, pp. 208 - 213
Summary Clinical correlates and long-term prognostic relevance of the JAK2V617F mutation was studied in 150 patients with essential thrombocythaemia (ET) from... 
JAK2 mutation | myeloproliferative disorders | prognosis | essential thrombocythaemia | Prognosis | Essential thrombocythaemia | Myeloproliferative disorders
Journal Article
Oncotarget, ISSN 1949-2553, 10/2018, Volume 9, Issue 81, pp. 35201 - 35202
Journal Article
British journal of haematology, ISSN 1365-2141, 11/2005, Volume 131, Issue 3, pp. 320 - 328
Summary An association between an activating JAK2 mutation (JAK2V617F) and BCR/ABL-negative myeloproliferative disorders was recently reported in multiple... 
mutation | Myelofibrosis | clonality | JAK2 | prognosis | polycythaemia vera | Clonality | Polycythaemia vera | Prognosis | Mutation
Journal Article
Cell death and differentiation, ISSN 1350-9047, 02/2014, Volume 21, Issue 2, pp. 234 - 246
  We previously reported that STAT1 expression is frequently abrogated in human estrogen receptor-α-positive (ERα(+)) breast cancers and mice lacking STAT1... 
breast cancer | SOCS1 | JAK2 | ERa | STAT1 | PrlR
Journal Article
Frontiers in oncology, ISSN 2234-943X, 04/2014, Volume 4, pp. 75 - 75
Chemotherapy resistance associated with recurrent disease is the major cause of poor survival of ovarian cancer patients. We have recently demonstrated... 
Recurrence | Metastasis | Ovarian carcinoma | Cancer stem cells | JAK2/STAT3 pathway | Chemoresistance
Journal Article
Oncotarget, ISSN 1949-2553, 06/2018, Volume 9, Issue 47, pp. 28745 - 28756
The role of hypothalamic growth hormone-releasing hormone (GHRH) in the release of growth hormone (GH) from the pituitary is well established. However, direct... 
Tumor | IGF-1 | Hepatocytes | JAK2/STAT5 signaling | GHRH agonists
Journal Article
Journal of cellular and molecular medicine, ISSN 1582-4934, 04/2019, Volume 23, Issue 6, pp. 4349 - 4357
Journal Article
Neural regeneration research, ISSN 1673-5374, 2017, Volume 12, Issue 1, pp. 96 - 102
Journal Article
Medicina clínica, ISSN 0025-7753, 07/2016, Volume 147, Issue 2, pp. 70 - 75
Pharmacological inhibition of the kinase activity of JAK proteins can interfere with the signaling of immunomodulatory cytokines and block the constitutive... 
Ruxolitinib | JAK2 inhibitors | Immune disorders | Myelofibrosis | Toxicity
Journal Article
Cancer biology & therapy, ISSN 1538-4047, 08/2018, Volume 19, Issue 8, pp. 676 - 686
Aberrant methylation of tumour suppressor genes is associated with the progression to a blast crisis in chronic myeloid leukaemia (CML). Methyl-CpG-binding... 
SHP1 | methyl-CpG-binding domain protein 2 | DNA methylation | therapeutic target | blast crisis | JAK2/STAT3 pathway | chronic myeloid leukaemia | Life Sciences & Biomedicine | Oncology | Science & Technology
Journal Article
Kidney research and clinical practice, ISSN 2211-9132, 12/2016, Volume 35, Issue 4, pp. 212 - 218
Abstract Background Interleukin-6 (IL6) is an important regulator of cellular hypertrophy through the gp130/Janus kinase 2 (JAK2)/signal transducer and... 
Nephrology | Podocytes | Diabetic nephropathy | JAK2/STAT3 | Hypertrophy | Interleukin-6 | Cellular signal transduction | Research | Glucose | Dextrose | STAT3 | JAK2 | Original
Journal Article
Cell cycle (Georgetown, Tex.), ISSN 1551-4005, 10/2014, Volume 6, Issue 5, pp. 550 - 566
Myeloproliferative disorders (MPDs) constitute a group of hematopoietic malignancies that feature enhanced proliferation and survival of one or more myeloid... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Thrombocythemia | Myelofibrosis | JAK2 | Polycythemia | JAK2V617F | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Animals | Humans | Myeloproliferative Disorders - metabolism | Signal Transduction - genetics | Mutation | Myeloproliferative Disorders - genetics | Oncogenes | Index Medicus
Journal Article