X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (2599) 2599
Publication (356) 356
Book Review (21) 21
Book Chapter (14) 14
Dissertation (6) 6
Conference Proceeding (3) 3
Magazine Article (1) 1
Reference (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (1790) 1790
index medicus (1607) 1607
hematology (1377) 1377
polycythemia-vera (1190) 1190
mutation (1181) 1181
janus kinase 2 - genetics (1073) 1073
essential thrombocythemia (1046) 1046
jak2 (1016) 1016
tyrosine kinase jak2 (832) 832
female (794) 794
male (788) 788
oncology (788) 788
myeloproliferative disorders (665) 665
middle aged (652) 652
myeloproliferative neoplasms (644) 644
myelofibrosis (594) 594
aged (575) 575
adult (555) 555
myeloproliferative disorders - genetics (522) 522
jak2 v617f mutation (489) 489
genetic aspects (401) 401
polycythemia vera (401) 401
aged, 80 and over (358) 358
animals (345) 345
leukemia (340) 340
polycythemia vera - genetics (324) 324
thrombocythemia, essential - genetics (322) 322
hemic and lymphatic diseases (299) 299
janus kinase 2 (290) 290
myeloid metaplasia (286) 286
tumors (283) 283
primary myelofibrosis (279) 279
janus kinase 2 - metabolism (275) 275
disorders (267) 267
thrombosis (265) 265
primary myelofibrosis - genetics (252) 252
diagnosis (251) 251
jak2 v617f (249) 249
research (244) 244
risk factors (241) 241
jak2 mutation (231) 231
activating mutation (227) 227
chronic myeloproliferative disorders (221) 221
prognosis (214) 214
v617f mutation (214) 214
analysis (212) 212
janus kinase 2 - antagonists & inhibitors (210) 210
mice (202) 202
hematology, oncology and palliative medicine (188) 188
gene mutations (187) 187
polycythemia (187) 187
care and treatment (184) 184
adolescent (181) 181
signal transduction (180) 180
cancer (179) 179
pathology (179) 179
medicine & public health (178) 178
health aspects (172) 172
jak2v617f (170) 170
alleles (169) 169
mutation, missense (166) 166
young adult (165) 165
article (163) 163
myeloproliferative disorders - diagnosis (162) 162
expression (160) 160
myeloproliferative neoplasm (158) 158
abridged index medicus (154) 154
acute myeloid-leukemia (154) 154
amino acid substitution (154) 154
point mutation (148) 148
myeloproliferative disorders - pathology (147) 147
cell biology (144) 144
disease (143) 143
receptors, thrombopoietin - genetics (140) 140
mutation - genetics (139) 139
neoplasms (139) 139
phenotype (136) 136
calreticulin - genetics (131) 131
ruxolitinib (130) 130
polymerase chain reaction (126) 126
stem cells (126) 126
dna mutational analysis (125) 125
mutations (125) 125
allele burden (123) 123
kinases (122) 122
retrospective studies (117) 117
thrombocythemia, essential - diagnosis (117) 117
world-health-organization (115) 115
mpl (114) 114
polycythemia vera - pathology (114) 114
idiopathic myelofibrosis (113) 113
chronic myeloid-leukemia (112) 112
activation (111) 111
phosphorylation (111) 111
biochemistry & molecular biology (110) 110
bone marrow (110) 110
jak2 inhibitor (110) 110
medicine, general & internal (109) 109
risk (109) 109
myeloproliferative disorders - drug therapy (107) 107
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (2505) 2505
French (28) 28
Japanese (16) 16
Russian (13) 13
German (12) 12
Korean (11) 11
Spanish (10) 10
Polish (6) 6
Hungarian (5) 5
Chinese (3) 3
Turkish (3) 3
Czech (1) 1
Italian (1) 1
Persian (1) 1
Portuguese (1) 1
Romanian (1) 1
Slovenian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Journal Article
BLOOD, ISSN 0006-4971, 03/2006, Volume 107, Issue 5, pp. 2098 - 2100
Most patients with polycythemia vera and half with idiopathic myelofibrosis and essential thrombocythemia have an acquired V617F mutation in JAK2. Using... 
POLYCYTHEMIA-VERA | MYELOPROLIFERATIVE DISORDERS | TYROSINE KINASE JAK2 | ESSENTIAL THROMBOCYTHEMIA | HEMATOLOGY | MYELOID METAPLASIA
Journal Article
THROMBOSIS AND HAEMOSTASIS, ISSN 0340-6245, 09/2018, Volume 118, Issue 9, pp. 1586 - 1599
Journal Article
The Lancet, ISSN 0140-6736, 12/2005, Volume 366, Issue 9501, pp. 1945 - 1953
Journal Article
BRITISH JOURNAL OF HAEMATOLOGY, ISSN 0007-1048, 11/2008, Volume 143, Issue 3, pp. 307 - 320
Journal Article
BLOOD CELLS MOLECULES AND DISEASES, ISSN 1079-9796, 11/2016, Volume 62, pp. 42 - 48
The myeloproliferative neoplasms (MPNs) are characterized by hematopoietic stem/progenitor cell (HSPC) expansion and overproduction of blood cells. The... 
JAK2(V617F) | Myeloproliferative neoplasms | BONE-MARROW | MPL | DISORDERS | MICROVESSEL DENSITY | Microenvironment | JAK2V617F MUTATION | Endothelial cells | MICE LACKING | ENDOTHELIAL PROGENITOR CELLS | HEMATOPOIETIC STEM-CELLS | Hematopoietic stem/progenitor cells | C-MPL | GROWTH-FACTOR | HEMATOLOGY | THROMBOPOIETIN RECEPTOR
Journal Article
BLOOD, ISSN 0006-4971, 04/2019, Volume 133, Issue 15, pp. 1677 - 1690
Over 80% of patients with myeloproliferative neoplasms (MPNs) harbor the acquired somatic JAK2(V617F) mutation. JAK inhibition is not curative and fails to... 
PROGENITOR CELLS | JAK2V617F EXPRESSION | POLYCYTHEMIA-VERA | MYELOPROLIFERATIVE NEOPLASM | DEPENDENT KINASE 6 | JAK2 V617F MUTATION | PROLIFERATION | MYELOID MALIGNANCIES | CELL-CYCLE PROGRESSION | HEMATOLOGY | HEMATOPOIETIC STEM
Journal Article
Cytokine, ISSN 1043-4666, 11/2019, Volume 123, p. 154753
In the majority of myeloproliferative neoplasms (MPNs) patients, a point mutation, V617F has been found in Janus kinase 2 (JAK2) gene, and this JAK2 mutant... 
Myeloproliferative neoplasms (MPNs) | JAK2 V617F mutant | SOCS3 | Phosphorylation | SH2 domain | SUPPRESSOR | POLYCYTHEMIA-VERA | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | IMMUNOLOGY | CHRONIC MYELOID-LEUKEMIA | CELL BIOLOGY | BINDS | ERYTHROPOIETIN RECEPTOR | MUTATION | BOX MOTIF | EXPRESSION
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2006, Volume 103, Issue 16, pp. 6224 - 6229
Although a large proportion of patients with polycythemia vera (PV) harbor a valine-to-phenylalanine mutation at amino acid 617 (V617F) in the JAK2 signaling... 
Intermediate uveitis | Receptors | Phenotypes | Stem cells | Bone marrow | Progenitor cells | Genetic mutation | Sequencing | Hematopoietic stem cells | Blood | Mutant allele | Cell fate | JAK | Signaling progenitors | PROGENITOR CELLS | signaling | COLONY-STIMULATING FACTOR | cell fate | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOGENOUS LEUKEMIA | BCR-ABL | ACUTE MYELOID-LEUKEMIA | ESSENTIAL THROMBOCYTHEMIA | CANCER | GRANULOCYTE-MACROPHAGE | progenitors | mutant allele | CHRONIC MYELOPROLIFERATIVE DISORDERS | TYROSINE KINASE JAK2 | ADP-ribosyl Cyclase 1 - analysis | Antigens, CD34 - analysis | Humans | Polycythemia Vera - genetics | Erythroid Precursor Cells - enzymology | Janus Kinase 2 | Valine - chemistry | Protein-Tyrosine Kinases - genetics | Phenylalanine - chemistry | Hematopoietic Stem Cells - chemistry | Proto-Oncogene Proteins - antagonists & inhibitors | Erythroid Precursor Cells - cytology | Polycythemia Vera - enzymology | Hematopoiesis - genetics | Proto-Oncogene Proteins - genetics | Tyrphostins - pharmacology | Point Mutation | Phenylalanine - genetics | Hematopoietic Stem Cells - cytology | Amino Acid Substitution - genetics | Valine - genetics | Protein Kinase Inhibitors - pharmacology | Hematopoietic Stem Cells - enzymology | Thy-1 Antigens - analysis | Protein-Tyrosine Kinases - antagonists & inhibitors | Mutation (Biology) | Research | Biological Sciences
Journal Article
American Journal of Hematology, ISSN 0361-8609, 01/2012, Volume 87, Issue 1, pp. 5 - 8
The JAK2 V617F mutation is responsible for the constitutive activation of the erythropoietin receptor signaling pathway in most cases of polycythemia vera... 
POLYCYTHEMIA | HEMOGLOBIN | JAK2(V617F) | MYELOPROLIFERATIVE DISORDERS | JAK2 V617F | PERIPHERAL-BLOOD | SMOKING | MECHANISMS | JAK2V617F MUTATION | HEMATOLOGY | ERYTHROCYTOSIS | Polycythemia - genetics | Prevalence | Humans | Middle Aged | Janus Kinase 2 - genetics | Male | Mutation Rate | Smoking - genetics | Polycythemia - epidemiology | Codon | Smoking - epidemiology | Female | Aged
Journal Article