X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (696) 696
Publication (78) 78
Book Review (12) 12
Book Chapter (6) 6
Conference Proceeding (3) 3
Dissertation (2) 2
Reference (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (350) 350
animals (329) 329
jak3 (304) 304
index medicus (231) 231
mice lacking jak3 (220) 220
mice (215) 215
immunology (170) 170
janus kinase 3 (161) 161
signal transduction (137) 137
biochemistry & molecular biology (128) 128
severe combined immunodeficiency (102) 102
cell biology (100) 100
mutation (98) 98
protein-tyrosine kinases - metabolism (97) 97
activation (95) 95
phosphorylation (93) 93
male (91) 91
female (85) 85
janus kinase 3 - antagonists & inhibitors (83) 83
hematology (80) 80
protein-tyrosine kinases - genetics (77) 77
expression (72) 72
janus kinase 3 - metabolism (70) 70
lymphoid development (67) 67
t-lymphocytes - immunology (64) 64
defective lymphoid development (63) 63
janus kinase (61) 61
oncology (61) 61
protein kinase inhibitors - pharmacology (58) 58
chemistry, medicinal (57) 57
deficient mice (57) 57
cytokines (56) 56
il-2 receptor (54) 54
cells (53) 53
transplantation (52) 52
janus kinase 3 - genetics (51) 51
pharmacology & pharmacy (51) 51
gene (50) 50
mice, inbred c57bl (49) 49
cell line (48) 48
dna-binding proteins - metabolism (47) 47
mice, knockout (46) 46
analysis (45) 45
apoptosis (45) 45
research (45) 45
molecular sequence data (44) 44
trans-activators - metabolism (44) 44
severe combined immunodeficiency - genetics (43) 43
cells, cultured (41) 41
t cells (41) 41
signal-transduction (39) 39
cell differentiation (38) 38
proteins (38) 38
t-cells (38) 38
jak3 kinase (37) 37
signal transduction - physiology (37) 37
tyrosine kinase (37) 37
gene-expression (36) 36
base sequence (35) 35
immunosuppression (35) 35
protein-tyrosine kinases - antagonists & inhibitors (35) 35
protein-tyrosine kinases - physiology (35) 35
receptor-gamma-chain (35) 35
cell line, tumor (34) 34
leukemia (34) 34
protein-tyrosine kinase (34) 34
amino acid sequence (33) 33
enzyme inhibitors - pharmacology (33) 33
flow cytometry (33) 33
gamma-chain (33) 33
interleukin-2 (33) 33
lymphocytes (33) 33
signal transduction - drug effects (33) 33
signal transduction - immunology (33) 33
structure-activity relationship (33) 33
adult (32) 32
dose-response relationship, drug (32) 32
kinase (32) 32
pyrimidines - pharmacology (32) 32
receptor (32) 32
chemistry, organic (31) 31
cytokine receptors (31) 31
jak (31) 31
janus kinase 2 (31) 31
milk proteins (31) 31
stat5 transcription factor (31) 31
b-lymphocytes - immunology (30) 30
genetics & heredity (30) 30
janus kinase-3 (30) 30
lacking jak3 (30) 30
mutual fund industry (30) 30
protein kinase inhibitors - chemistry (30) 30
receptor-gamma chain (30) 30
article (29) 29
beta-chain (29) 29
cancer (29) 29
gene expression (29) 29
genetic aspects (29) 29
interleukin-7 receptor (29) 29
kinases (29) 29
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (689) 689
Chinese (4) 4
Japanese (4) 4
French (1) 1
German (1) 1
Polish (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2019, Volume 62, Issue 2, pp. 1054 - 1066
JAK family kinases are important mediators of immune cell signaling and Janus Kinase 3 (JAK3) has long been indicated as a potential target for autoimmune... 
JAK3 | POTENT | CHEMISTRY, MEDICINAL
Journal Article
Journal Article
Molecular Immunology, ISSN 0161-5890, 09/2018, Volume 101, pp. 386 - 395
Indirubin (IR) is a bisindole compound extracted from the leaves of Chinese herb . has been widely used in traditional Chinese medicine to treat inflammatory... 
Jak3/Stat3 | γδT cell | IL-17A | Indirubin | Psoriasis
Journal Article
Journal of Inflammation, ISSN 1476-9255, 2010, Volume 7, Issue 1, pp. 41 - 41
Background: The Janus kinase (JAK) family of tyrosine kinases includes JAK1, JAK2, JAK3 and TYK2, and is required for signaling through Type I and Type II... 
RHEUMATOID-ARTHRITIS | DOSE-ESCALATION | APOPTOSIS | ACTIVATION | SYNOVIAL-FLUID | IMMUNOSUPPRESSION | MONOCLONAL-ANTIBODY | KINASE INHIBITOR | IMMUNOLOGY | CP-690550 | JAK3
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 08/2015, Volume 37, Issue 1, pp. 297 - 305
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 8/2013, Volume 191, Issue 3, pp. 1164 - 1174
The role of Janus kinase (JAK)-3 in TLR-mediated innate immune responses is poorly understood, although the suppressive function of JAK3 inhibition in adaptive... 
Inflammatory cytokines | PI3K | GSK3 | JAK3 | TLR4
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 05/2018, Volume 89, pp. 21 - 29
We analyzed the transcriptome of detailed CD4 T cell subsets including them after abatacept treatment, and examined the difference among CD4 T cell subsets and... 
Zap70 | T cell receptor | Abatacept | JAK3 | Rheumatoid arthritis | RESPONSES | ACTIVATION | INHIBITION | IMMUNOLOGY | EXPRESSION
Journal Article
CLINICAL IMMUNOLOGY, ISSN 1521-6616, 02/2016, Volume 163, pp. 91 - 95
Severe combined immune deficiency (SCID) is a group of genetically heterogeneous diseases caused by an early block in T cell differentiation and present with... 
EXON | Mis-splicing mutations | IMMUNOLOGY | SCID | JAK3 | DEFICIENCY | FAMILY
Journal Article
BLOOD, ISSN 0006-4971, 10/2019, Volume 134, Issue 14, pp. 1132 - 1143
T-cell prolymphocytic leukemia (T-PLL) is a rare, mature T-cell neoplasm with a heterogeneous clinical course. With the advent of novel treatment options that... 
ALEMTUZUMAB | GENE | GUIDELINES | CHRONIC LYMPHOCYTIC-LEUKEMIA | MALIGNANCIES | MUTATIONS | HEMATOLOGY | EXPRESSION | JAK3 | CHROMOSOMAL IMBALANCES | TRANSPLANTATION | Life Sciences | Hematology | Human health and pathology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2018, Volume 115, Issue 17, pp. 4305 - 4307
Journal Article
Journal Article
The Journal of allergy and clinical immunology, ISSN 0091-6749, 7/2017, Volume 140, Issue 1, pp. 268 - 271.e6
Journal Article
Journal of Molecular Graphics and Modelling, ISSN 1093-3263, 12/2019, Volume 93, p. 107451
Analogue design forms one of the mainstays of new drug discovery. A fast-follow on approach is commonly used by modern day drug discoverers on the quest of the... 
Analogue design | MD simulations | MM/GBSA | Electron density | JAK3 | Per residue contribution
Journal Article