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Journal Article
Journal Article
The Journal of allergy and clinical immunology, ISSN 0091-6749, 7/2017, Volume 140, Issue 1, pp. 268 - 271.e6
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 08/2017, Volume 451, Issue C, pp. 88 - 96
Cytokines are mediating immune cells responses through the activation of the JAK/STAT signaling pathway. Being critical for immune cells, a defective JAK/STAT... 
Autoimmunity | STAT | Immunosuppression | GVHD | JAK | Myeloproliferative neoplasia | RHEUMATOID-ARTHRITIS | GRANULAR LYMPHOCYTIC-LEUKEMIA | CHRONIC MUCOCUTANEOUS CANDIDIASIS | VERSUS-HOST-DISEASE | FUNCTION IN-VITRO | CELL BIOLOGY | HYPER-IGE SYNDROME | T-REGULATORY CELLS | ENDOCRINOLOGY & METABOLISM | PLACEBO-CONTROLLED TRIAL | T(H)17 CELL-DIFFERENTIATION | MICE LACKING JAK3 | Immunologic Deficiency Syndromes - pathology | Humans | Immunosuppressive Agents - therapeutic use | Neoplasms - prevention & control | Organ Transplantation | STAT Transcription Factors - immunology | Graft vs Host Disease - immunology | Autoimmune Diseases - genetics | Graft vs Host Disease - genetics | Neoplasms - genetics | Janus Kinases - immunology | Immunologic Deficiency Syndromes - immunology | Autoimmune Diseases - pathology | Cytokines - genetics | Autoimmune Diseases - drug therapy | Cytokines - immunology | Janus Kinases - genetics | Signal Transduction | Autoimmune Diseases - immunology | Gene Expression Regulation | Graft vs Host Disease - pathology | Janus Kinases - antagonists & inhibitors | STAT Transcription Factors - genetics | Neoplasms - immunology | Protein Kinase Inhibitors - therapeutic use | Immunologic Deficiency Syndromes - genetics | Graft vs Host Disease - prevention & control | Neoplasms - pathology | Cell Movement | Drugs | Proteins | Immunotherapy
Journal Article
Human Mutation, ISSN 1059-7794, 10/2001, Volume 18, Issue 4, pp. 255 - 263
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 133, Issue 6, pp. 1660 - 1666
Journal Article
Immunity, ISSN 1074-7613, 2000, Volume 13, Issue 4, pp. 549 - 560
To assess the role of the Janus kinase (Jak) family member Tyk2, we have generated Tyk2(-/-) mice. In contrast to other Jaks, where inactivation leads to a... 
T-CELL PROLIFERATION | COMPLEMENTS DEFECTS | IFN-GAMMA PRODUCTION | ANTIVIRAL DEFENSE | INTERFERON-GAMMA | JANUS KINASES | NITRIC-OXIDE SYNTHASE | LACKING JAK3 | PROTEIN-TYROSINE KINASE | IMMUNOLOGY | SIGNAL-TRANSDUCTION PATHWAY | Spleen - immunology | Embryo, Mammalian | Humans | Interferon-gamma - metabolism | Protein-Tyrosine Kinases - deficiency | Receptors, Cytokine - physiology | Lymphokines | TYK2 Kinase | Protein-Tyrosine Kinases - physiology | Receptor, Interferon alpha-beta | Lymphocyte Activation - genetics | Interferon Type I - pharmacology | Fibroblasts | Myeloid Progenitor Cells - cytology | Colony-Forming Units Assay | Cytokines - genetics | Interleukin-12 - pharmacology | Nitric Oxide - biosynthesis | Genetic Predisposition to Disease | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | Spleen - cytology | Thrombopoietin - pharmacology | Down-Regulation - genetics | Leukemia Inhibitory Factor Receptor alpha Subunit | Membrane Proteins | Macrophages - metabolism | Trans-Activators - deficiency | Lipopolysaccharides - pharmacology | Rhabdoviridae Infections - genetics | Vaccinia - immunology | Cytokines - deficiency | Mice | Vesicular stomatitis Indiana virus - immunology | Receptors, OSM-LIF | Growth Inhibitors | Lymphocytic Choriomeningitis - immunology | Interleukin-3 - pharmacology | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Protein-Tyrosine Kinases - genetics | Spleen - enzymology | Interferon Type I - metabolism | Receptors, Interferon - antagonists & inhibitors | Leukemia Inhibitory Factor | Macrophages - immunology | Lymphocytic Choriomeningitis - genetics | Cell Line | Proteins - physiology | Cells, Cultured | Mice, Inbred Strains | Vaccinia - genetics | Proteins - genetics | Granulocyte Colony-Stimulating Factor - pharmacology | Animals | Interleukin-6 - pharmacology | Down-Regulation - immunology | Rhabdoviridae Infections - immunology | Receptors, Interferon - physiology | Trans-Activators - metabolism | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Interleukin-10 - pharmacology | Cytokines - biosynthesis
Journal Article