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Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 48, pp. 83370 - 83383
Pancreatic ductal adenocarcinoma evolves from precursor lesions, the most common of which is pancreatic intraepithelial neoplasia (PanIN). We performed... 
RNA-seq | IL2RG | JAK3 | Pancreatic cancer | PanIN | CELLS | DUCTAL ADENOCARCINOMA | PRECURSOR LESIONS | GAMMA-CHAIN | BETA | CELL BIOLOGY | REGULATOR | pancreatic cancer | THERAPY | EXPRESSION | TP53
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 02/2013, Volume 4, Issue 2, pp. 197 - 200
Organic impurities in compound libraries are known to often cause false-positive signals in screening campaigns for new leads, but organic impurities do not... 
lead identification | Pad4 | Ras | HTS | promiscuous inhibitor | assay interference | Jak3 | false positive | zinc | CHEMISTRY, MEDICINAL | ASSAY | DRUG DISCOVERY | PROMISCUOUS INHIBITORS
Journal Article
Leukemia, ISSN 0887-6924, 03/2018, Volume 32, Issue 3, pp. 774 - 787
Journal Article
Oncogene, ISSN 0950-9232, 02/2006, Volume 25, Issue 6, pp. 899 - 906
Journal Article
Journal Article
Cancer Discovery, ISSN 2159-8274, 12/2015, Volume 5, Issue 12, pp. 1328 - 1343
Journal Article
TRANSPLANTATION, ISSN 0041-1337, 01/2009, Volume 87, Issue 1, pp. 79 - 86
Introduction. CP-690,550 inhibits Janus kinase 3 (JAK3) which mediates signal transduction of receptors of the common gamma-chain cytokines. These cytokines... 
SURVIVAL | PATHWAYS | GAMMA | SURGERY | IMMUNOLOGY | TRANSPLANTATION | New immunosuppression | JANUS KINASE-3 | PROLONGS | REJECTION | Biomarkers | REGULATORY T-CELLS | JAK3 | Kidney transplant patients
Journal Article
Immunity, ISSN 1074-7613, 08/2001, Volume 15, Issue 2, pp. 313 - 321
Mast cells play a pivotal role in innate host immune response to gram-negative bacteria. We report that Janus kinase 3 plays a role in mast cell-mediated... 
JAK3 protein | Jak3 kinase
Journal Article
BMC Cancer, ISSN 1471-2407, 03/2018, Volume 18, Issue 1, pp. 287 - 9
Background: Renal cell carcinoma (RCC) account for over 80% of renal malignancies. The most common type of RCC can be classified into three subtypes including... 
Molecular classification | CcRCC | Gene expression | Pathway | ccRCC | ONCOLOGY | IDH1 | GROWTH | RECEPTOR | JAK3 | Transcription factors | Care and treatment | Analysis | Genomics | Development and progression | Genetic aspects | Research | Carcinoma, Renal cell | Epigenetic inheritance | Carcinoma | Genes | Genomes | Algorithms | Genetic research | Methylation | Cancer
Journal Article
Regulatory Toxicology and Pharmacology, ISSN 0273-2300, 04/2018, Volume 94, pp. 306 - 322
Tofacitinib, an oral Janus kinase (JAK) inhibitor for treatment of rheumatoid arthritis, targets JAK1, JAK3, and to a lesser extent JAK2 and TYK2. JAK1/3... 
Toxicology | Immunology | Immune function | Tofacitinib | Immunomodulation | Lymphoma | CELLS | NATURAL-KILLER | NONHUMAN PRIMATE | MEDICINE, LEGAL | MALIGNANT-LYMPHOMA | RECEPTOR | IL-15 | LYMPHOCYTE SUBPOPULATIONS | PHARMACOLOGY & PHARMACY | RISK-ASSESSMENT | JAK3 | EPSTEIN-BARR-VIRUS | Index Medicus
Journal Article
ANTIVIRAL RESEARCH, ISSN 0166-3542, 01/2018, Volume 149, pp. 78 - 88
Employing NOD/SCID/Jak3(-/-) mice transplanted with human PBMCs (hNOJ mice) and replication competent, red-fluorescent-protein (mCherry; mC)-labeled... 
CELLS | Post-exposure prophylaxis | In vivo imaging | HIV-1 breakthrough | POTENT ACTIVITY | PLASMA | VIROLOGY | NOD/SCID/Jak3-/- (NOJ) mice | IMMUNODEFICIENCY-VIRUS TYPE-1 | Raltegravir administration | PHARMACOLOGY & PHARMACY | INHIBITOR | mCherry-labeled HIV-1 (HIVmC)
Journal Article
Immunological Reviews, ISSN 0105-2896, 06/2008, Volume 223, Issue 1, pp. 132 - 142
Summary Cytokines play pivotal roles in immunity and inflammation, and targeting cytokines and their receptors is an effective means of treating such... 
immunoregulation | immunosuppression | kinase | cytokines | autoimmunity | transplantation | Autoimmunity | Immunosuppression | Transplantation | Cytokines | Immunoregulation | Kinase | RECEPTOR-GAMMA CHAIN | SEVERE COMBINED IMMUNODEFICIENCY | T-CELL DIFFERENTIATION | POLYCYTHEMIA-VERA | PROTEIN-TYROSINE KINASES | DEFECTIVE LYMPHOID DEVELOPMENT | IMMUNOLOGY | CHRONIC MYELOID-LEUKEMIA | TRANSDUCING ADAPTER MOLECULE | MYELOPROLIFERATIVE-DISORDERS | MICE LACKING JAK3 | Job Syndrome - immunology | Job Syndrome - drug therapy | Leukemia - pathology | Humans | Protein Kinase Inhibitors - adverse effects | Job Syndrome - enzymology | src Homology Domains - drug effects | TYK2 Kinase - immunology | Protein Kinase Inhibitors - immunology | Janus Kinases - immunology | TYK2 Kinase - antagonists & inhibitors | Autoimmune Diseases - drug therapy | Graft Rejection - enzymology | Graft Rejection - drug therapy | Janus Kinases - chemistry | Autoimmune Diseases - enzymology | Janus Kinases - genetics | Signal Transduction | Leukemia - enzymology | Autoimmune Diseases - immunology | Leukemia - drug therapy | Clinical Trials as Topic | Janus Kinases - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Animals | Mice | Graft Rejection - immunology | Mutation | TYK2 Kinase - genetics | Mutual fund industry | Phosphotransferases | Health aspects
Journal Article