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jatrophane diterpenes (62) 62
chemistry, medicinal (54) 54
index medicus (53) 53
pharmacology & pharmacy (47) 47
euphorbiaceae (46) 46
plant sciences (43) 43
euphorbia - chemistry (42) 42
jatrophane (40) 40
diterpenes - chemistry (39) 39
humans (39) 39
multidrug-resistance (36) 36
diterpenes - pharmacology (35) 35
p-glycoprotein (34) 34
discovery (33) 33
euphorbia (32) 32
diterpenes (31) 31
chemistry, organic (30) 30
diterpenes - isolation & purification (28) 28
biochemistry & molecular biology (27) 27
molecular structure (27) 27
animals (25) 25
multidrug resistance (25) 25
cell line, tumor (23) 23
modulators (23) 23
esters (20) 20
inhibitors (19) 19
mouse lymphoma-cells (17) 17
cancer (16) 16
chemistry, multidisciplinary (16) 16
derivatives (16) 16
drug resistance in microorganisms (16) 16
plant extracts - pharmacology (16) 16
analysis (15) 15
drug resistance, multiple - drug effects (15) 15
jatrophane diterpenoids (15) 15
jatrophanes (15) 15
plant extracts - chemistry (15) 15
diterpene (14) 14
macrocyclic diterpenes (14) 14
magnetic resonance spectroscopy (14) 14
mice (13) 13
structure-activity relationship (12) 12
agents (11) 11
antineoplastic agents, phytogenic - pharmacology (11) 11
diterpenoids (11) 11
drug resistance, neoplasm - drug effects (11) 11
research (11) 11
reversal (11) 11
antineoplastic agents - pharmacology (10) 10
apoptosis (10) 10
atp-binding cassette, sub-family b, member 1 - metabolism (10) 10
biological evaluation (10) 10
cells (10) 10
organic chemistry (10) 10
antineoplastic agents, phytogenic - chemistry (9) 9
atp-binding cassette, sub-family b, member 1 - antagonists & inhibitors (9) 9
cancer-cells (9) 9
oncology (9) 9
cell proliferation - drug effects (8) 8
constituents (8) 8
latex (8) 8
lathyrane diterpenes (8) 8
molecular conformation (8) 8
roots (8) 8
chemical properties (7) 7
cytotoxic activity (7) 7
cytotoxicity (7) 7
drug resistance, neoplasm (7) 7
euphorbia esula (7) 7
macrocyclic diterpenoids (7) 7
p-glycoprotein modulators (7) 7
transporters (7) 7
care and treatment (6) 6
concise route (6) 6
euphorbia helioscopia (6) 6
health aspects (6) 6
in-vitro (6) 6
ingenane (6) 6
jatrophane polyesters (6) 6
lead (6) 6
macrocyclic diterpene (6) 6
mouse lymphoma (6) 6
natural products (6) 6
polyesters (6) 6
potent (6) 6
stereoisomerism (6) 6
terpenoids (6) 6
total synthesis (6) 6
triterpenes (6) 6
triterpenoids (6) 6
cancer cells (5) 5
chemistry, analytical (5) 5
chikungunya virus (5) 5
diterpenes - therapeutic use (5) 5
drug resistance (5) 5
euphorbia guyoniana (5) 5
euphorbia kansui (5) 5
euphorbia-pubescens (5) 5
ingenol (5) 5
integrative & complementary medicine (5) 5
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Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 09/2012, Volume 2012, Issue 27, pp. 5115 - 5130
Diterpenes occurring in plants of the Euphorbiaceae family are of considerable interest in the context of natural product drug discovery programs because of... 
Euphorbiaceae | Medicinal chemistry | Antitumor agents | Macrocycles | Natural products | Terpenoids | CANCER-CELLS | PROTEIN-KINASE-C | JATROPHANE DITERPENES | CHEMISTRY, ORGANIC | STRUCTURAL-CHARACTERIZATION | SKIN IRRITANT | MOUSE LYMPHOMA-CELLS | BASAL-CELL CARCINOMA | INGENOL MEBUTATE GEL | MULTIDRUG-RESISTANCE | EXCOECARIA-AGALLOCHA | Metabolites | Lead compounds
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2015, Volume 58, Issue 9, pp. 3720 - 3738
Five series of 37 new acylate and epoxide derivatives (3-39) of Euphorbia factor L3, a lathyrol diterpene isolated from Euphorbia lathyris, were designed by... 
BREAST-CANCER | JATROPHANE DITERPENES | PROTEIN STRUCTURES | CHEMISTRY, MEDICINAL | DRUG-BINDING | MOUSE LYMPHOMA-CELLS | DATABASE | TRANSPORTERS | MACROCYCLIC DITERPENES | GENERATION | DISCOVERY
Journal Article
Planta Medica, ISSN 0032-0943, 07/2018, Volume 84, Issue 9/10, pp. 729 - 735
Journal Article
Tetrahedron, ISSN 0040-4020, 09/2016, Volume 72, Issue 35, pp. 5394 - 5401
Three new ( ) cyclomyrsinane diterpenes and three new ( ) premyrsinane diterpenes were isolated from the aerial parts of Popov. Their chemical structures and... 
Euphorbia sogdiana | Euphorbiaceae | Diterpenoids | Cyclomyrsinane | Premyrsinane | Cytotoxic activity | POLYESTERS | CELLS | JATROPHANE DITERPENES | CHEMISTRY, ORGANIC | DISCOVERY | FALCATA | RESISTANCE | INSIGHTS | Polyols | Analysis | Leukemia
Journal Article
Organic Letters, ISSN 1523-7060, 04/2006, Volume 8, Issue 8, pp. 1573 - 1576
A scalable enantioselective synthesis of the nonnatural 17-norjatrophane diterpene 3-propionyl-15-acetyl-17-norcharaciol is described. Key C/C-connecting... 
EUPHORBIA-PUBESCENS | PEPLUANIN-A | RING-CLOSING METATHESIS | MOUSE LYMPHOMA-CELLS | MACROCYCLIC JATROPHANE DITERPENES | CHEMISTRY, ORGANIC | CONCISE ROUTE | OLEFIN METATHESIS | TUMOR INHIBITOR | MULTIDRUG-RESISTANCE | P-GLYCOPROTEIN | Alkenes - chemistry | Molecular Structure | Stereoisomerism | Diterpenes - chemical synthesis | Diterpenes - chemistry
Journal Article
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 12/2011, Volume 49, Issue 12, pp. 3165 - 3173
Journal Article
Tetrahedron, ISSN 0040-4020, 09/2016, Volume 72, Issue 37, pp. 5724 - 5728
Two new jatrophane diterpenes, guyonianin G ( ) and H ( ), were isolated from the methanol extract of Boiss. & Reut. The structures were established by means... 
GIRK channel inhibitory activity | Jatrophane diterpenes | Euphorbia guyoniana | Guyonianin G and H | FIBRILLATION | CHEMISTRY, ORGANIC | MULTIDRUG-RESISTANCE | POLYESTER DITERPENES | DISCOVERY | SALICIFOLIA | Analysis | Information management
Journal Article
Journal Article
Tetrahedron, ISSN 0040-4020, 2005, Volume 61, Issue 18, pp. 4485 - 4494
Journal Article