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Biochemical Journal, ISSN 0264-6021, 08/2014, Volume 461, Issue 3, pp. 531 - 537
IKK beta {I kappa B [inhibitor of NF-kappa B (nuclear factor kappa B)] kinase beta} is required to activate the transcription factor NF-kappa B, but how IKK... 
Inhibitor of nuclear factor κB kinase (IKK) | Linear ubiquitin chain assembly complex (LUBAC) | Nuclear factor κB(NF-κB) | Transforming growth factor β-activated kinase-1 (TAK1) | Interleukin-1 (IL-1) | nuclear factor kappa B (NF-kappa B) | linear ubiquitin chain assembly complex (LUBAC) | SIGNALING PATHWAYS | PROTEIN | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | interleukin-1 (IL-1) | KINASE COMPLEX | transforming growth factor beta-activated kinase-1 (TAK1) | UBIQUITIN CHAINS | INFLAMMATION | inhibitor of nuclear factor kappa B kinase (IKK) | POLYUBIQUITIN CHAINS | NF-KAPPA-B | NEMO | BINDING | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Ubiquitination | I-kappa B Kinase - metabolism | Protein Processing, Post-Translational - drug effects | I-kappa B Kinase - antagonists & inhibitors | HEK293 Cells | Protein Interaction Domains and Motifs | Phosphorylation - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - genetics | Mutant Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Cells, Cultured | Mutant Proteins - genetics | Recombinant Proteins - chemistry | Mice, Transgenic | Mutant Proteins - metabolism | MAP Kinase Kinase Kinases - metabolism | I-kappa B Kinase - genetics | Enzyme Activation - drug effects | Serine - metabolism | Gene Knock-In Techniques | Animals | Embryo, Mammalian - cytology | Mutant Proteins - chemistry | Mice | Protein Kinase Inhibitors - pharmacology | I-kappa B Kinase - chemistry | Amino Acid Substitution | Index Medicus | NEMO, NF-κB essential modulator | TLR, Toll-like receptor | IKK, IκB kinase | TNF, tumour necrosis factor | transforming growth factor β-activated kinase-1 (TAK1) | HEK, human embryonic kidney | IL-1, interleukin-1 | JNK, c-Jun N-terminal kinase | PP1γ, protein phosphatase 1γ | TRAF, TNF receptor-associated factor | inhibitor of nuclear factor κB kinase (IKK) | LUBAC, linear ubiquitin chain assembly complex | HOIP, HOIL1 [haem-oxidized IRP2 (iron regulatory protein 2) ubiquitin ligase 1]-interacting protein | IκB, inhibitor of NF-κB | TAB, TAK1-binding protein | TAK1, transforming growth factor β-activated kinase-1 | BMDM, bone-marrow-derived macrophage | NF-κB, nuclear factor κB | M-CSF, macrophage colony-stimulating factor | MKK, MAPK kinase | Accelerated Publication | E, embryonic day | MEF, mouse embryonic fibroblast | HA, haemaglutinnin | LPS, lipopolysaccharide | nuclear factor κB (NF-κB) | MAPK, mitogen-activated protein kinase
Journal Article
Blood, ISSN 0006-4971, 2016, Volume 127, Issue 14, pp. 1780 - 1789
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2000, Volume 275, Issue 46, pp. 36062 - 36066
Arsenite is a potent environmental toxin that causes various pathologies including cancers and skin disorders. Arsenite is believed to exert its biological... 
COMPLEX | IKK-BETA SUBUNIT | PHOSPHORYLATION | JNK | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | TRANSCRIPTION FACTOR | AP-1 | I^KB kinase | IKK protein
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2011, Volume 56, Issue 1, pp. 184 - 191
Background & Aims Mosaic G-protein alpha-subunit ( GNAS )-activating mutations are responsible for the McCune–Albright (MCA) syndrome. This oncogene that... 
Gastroenterology and Hepatology | CRP | interleukine 6 signal transducer | GTP | C-reactive protein | jun N-terminal kinase | serum amyloid A | JNK | macroregenerative nodule | complementary deoxyribonucleic acid | MRN | mitogen activated proteins kinase | cAMP | glycoprotein 130 | neuroendocrine secretory protein 55 | hepatocyte nuclear factor 1A | G-protein alpha stimulatory subunit | cDNA | gp130 | protein kinase A | hepatocellular carcinoma | β catenin | IHCA | McCune-Albright syndrome | HCA | PKA | HCC | MAP kinase | MCA | HNF1A | inflammatory hepatocellular adenoma | SAA | cyclic adenosine monophosphate | hepatocellular adenoma | GNAS | CTNNB1 | NESP55 | guanosine-5′-triphosphate | IL6ST | INACTIVATION | PATHWAY | HEPATOCELLULAR ADENOMA | GS-ALPHA | GROWTH | CLASSIFICATION | HUMAN CANCERS | MCCUNE-ALBRIGHT-SYNDROME | GASTROENTEROLOGY & HEPATOLOGY | G-PROTEIN | BINDING | Liver Neoplasms - classification | Humans | Middle Aged | Adenoma, Liver Cell - pathology | Male | Fibrous Dysplasia, Polyostotic - genetics | GTP-Binding Protein alpha Subunits, Gs - genetics | Chromogranins | DNA Mutational Analysis | Base Sequence | Carcinoma, Hepatocellular - genetics | Adult | Female | Liver Neoplasms - pathology | Adenoma, Liver Cell - genetics | STAT3 Transcription Factor - metabolism | Liver Neoplasms - genetics | Signal Transduction | Adenoma, Liver Cell - metabolism | Models, Biological | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Aged | DNA, Neoplasm - genetics | Mutation | Carcinoma, Hepatocellular - metabolism | Liver cancer | Genetic aspects | Nucleic acids | Adenylic acid | Mitogens | Protein kinases | Index Medicus | GTP-Binding Protein alpha Subunits, Gs | Fibrous Dysplasia, Polyostotic | Liver Neoplasms | Life Sciences | Adenoma, Liver Cell | DNA, Neoplasm | STAT3 Transcription Factor | Carcinoma, Hepatocellular | Cancer
Journal Article
Nature, ISSN 0028-0836, 11/2001, Volume 414, Issue 6861, pp. 313 - 317
The proinflammatory cytokine tumour necrosis factor-α (TNF-α) regulates immune responses, inflammation and programmed cell death (apoptosis). The ultimate fate... 
APOPTOSIS | DOMAIN | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | NECROSIS-FACTOR-ALPHA | INDUCTION | IDENTIFICATION | TNF RECEPTOR-1 | JUN KINASES | CELL-DEATH | IAP GENE | XIAP protein | JNK protein | IKK protein
Journal Article
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1130 - 16
Journal Article
Journal Article
Molecular Nutrition & Food Research, ISSN 1613-4125, 09/2015, Volume 59, Issue 9, pp. 1663 - 1673
Scope: In this study, the effects of lutein on neuroinflammation in lipopolysaccharide (LPS)-activated BV-2 microglia were investigated. Methods and results:... 
Lutein | Neuroinflammation | NF‐κB | Nrf2 | Microglia | NF-κB | PATHWAYS | CELLS | OXIDATIVE STRESS | METABOLITES | FOOD SCIENCE & TECHNOLOGY | DOWN-REGULATION | CAROTENOIDS | DIETARY LUTEIN | NF-kappa B | ZEAXANTHIN | ASTAXANTHIN | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Microglia - metabolism | Heme Oxygenase-1 - metabolism | Phosphorylation | Reactive Oxygen Species - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Neurodegenerative Diseases - drug therapy | Proto-Oncogene Proteins c-akt - genetics | Lipopolysaccharides | Heme Oxygenase-1 - genetics | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | NF-E2-Related Factor 2 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Microglia - drug effects | Mitogen-Activated Protein Kinase 3 - genetics | Cells, Cultured | p38 Mitogen-Activated Protein Kinases - genetics | Inflammation | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | NF-kappa B - genetics | Nitric Oxide Synthase Type II - genetics | NF-E2-Related Factor 2 - metabolism | Cyclooxygenase 2 - metabolism | Mice | Nitric Oxide - metabolism | Lutein - pharmacology | Nitric Oxide Synthase Type II - metabolism | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 04/2016, Volume 7, Issue 1, pp. 11292 - 11292
Journal Article