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Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 05/2005, Volume 280, Issue 19, pp. 19078 - 19086
Mitogen-activated protein kinase phosphatase-1 (MKP-1) is a dual specificity phosphatase that is overexpressed in many human tumors and can protect cells from apoptosis caused by DNA-damaging agents or cellular stress... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Dual Specificity Phosphatase 1 | Phosphorylation | Models, Chemical | Isoquinolines | Plant Extracts - pharmacology | Humans | Electrophoresis, Gel, Two-Dimensional | JNK Mitogen-Activated Protein Kinases - metabolism | Protein Tyrosine Phosphatases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Dual Specificity Phosphatase 6 | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - chemistry | Dose-Response Relationship, Drug | Mitogen-Activated Protein Kinase Kinases - metabolism | Protein Tyrosine Phosphatases - antagonists & inhibitors | Protein Tyrosine Phosphatases - chemistry | MAP Kinase Kinase 4 | Transfection | Time Factors | Immediate-Early Proteins - chemistry | Inhibitory Concentration 50 | cdc25 Phosphatases - metabolism | Protein Phosphatase 1 | Catalytic Domain | Alkaloids - pharmacology | Gene Library | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Phosphoprotein Phosphatases - antagonists & inhibitors | Models, Statistical | Neoplasms - drug therapy | Benzophenanthridines | Protein Tyrosine Phosphatase, Non-Receptor Type 1 | Cell Line, Tumor | DNA Damage | HeLa Cells | Alkaloids - chemistry | Immediate-Early Proteins - antagonists & inhibitors | Microscopy, Fluorescence | Phosphoprotein Phosphatases - chemistry | Index Medicus
Journal Article
Molecular medicine reports, ISSN 1791-2997, 08/2015, Volume 12, Issue 2, pp. 2643 - 2649
... the expression of ECM proteins, including collagen type IV (col-IV) and interstitial collagen, including collagen type I (col-I) (2). The dysregulation of cell apoptosis... 
Oncology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Apoptosis - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | Extracellular Matrix - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Mesangial Cells - drug effects | Dose-Response Relationship, Drug | Proto-Oncogene Proteins c-bcl-2 - metabolism | Collagen Type I - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Flavonoids - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | bcl-2-Associated X Protein - genetics | Collagen Type IV - metabolism | Mevalonic Acid - pharmacology | Cell Line | Collagen Type I - metabolism | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Extracellular Matrix - drug effects | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | bcl-2-Associated X Protein - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | Mesangial Cells - cytology | Imidazoles - pharmacology | Transforming Growth Factor beta1 - genetics | Mesangial Cells - metabolism | Anthracenes - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Collagen Type IV - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Cell Cycle - drug effects | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 06/2011, Volume 300, Issue 6, pp. 1430 - 1441
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 08/2008, Volume 295, Issue 2, pp. 394 - 405
Erythropoietin (EPO) regulates the proliferation and differentiation of erythroid cells by binding to its specific transmembrane receptor EPOR. Recent studies,... 
Erythropoietin receptor | Mitogen-activated protein kinase induction | Cell signaling | Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Erythropoietin - pharmacology | RNA, Small Interfering - genetics | Pancreatic Neoplasms - metabolism | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Mitogen-Activated Protein Kinase 9 - genetics | Receptors, Erythropoietin - genetics | Receptors, Erythropoietin - immunology | Transfection | ets-Domain Protein Elk-1 - metabolism | Antibodies - immunology | Mitogen-Activated Protein Kinase 8 - genetics | JNK Mitogen-Activated Protein Kinases - genetics | Phosphorylation - drug effects | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 9 - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - metabolism | Pancreatic Neoplasms - pathology | Rats | Antibodies - pharmacology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | Cell Line, Tumor | Signal Transduction - physiology | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Kinetics | Cell Cycle - drug effects | Receptors, Erythropoietin - metabolism | Studies | Signal transduction | Rodents | Cell cycle | Cells | Binding sites | Tumors | Cancer | Index Medicus
Journal Article
Molecular and cellular biology, ISSN 0270-7306, 05/2009, Volume 29, Issue 14, pp. 3845 - 3852
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2009, Volume 8, Issue 12, pp. 3214 - 3222
Hyperactivation of c-Jun NH 2 -terminal protein kinase (JNK) has been found in various malignant lymphocytes and inhibition of JNK activity leads to cell cycle arrest and apoptosis... 
Activity | Oncogenic growth | T-ALL | JNK | Life Sciences & Biomedicine | Oncology | Science & Technology | MAP Kinase Kinase 7 - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Cell Proliferation | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Apoptosis - drug effects | Humans | Immunoblotting | JNK Mitogen-Activated Protein Kinases - metabolism | Mitogen-Activated Protein Kinase 9 - genetics | Dose-Response Relationship, Drug | MAP Kinase Kinase 7 - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry | Transfection | RNA Interference | Mitogen-Activated Protein Kinase 8 - genetics | JNK Mitogen-Activated Protein Kinases - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Cell Survival - drug effects | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Benzothiazoles - pharmacology | Jurkat Cells | Mitogen-Activated Protein Kinase 9 - metabolism | Mice, Inbred C57BL | Mitogen-Activated Protein Kinase 8 - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Anthracenes - pharmacology | Animals | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | Cell Line, Tumor | Acetonitriles - pharmacology | Mice | Cell Cycle - drug effects | Index Medicus
Journal Article
International journal of molecular medicine, 06/2016, Volume 37, Issue 6, p. 1567
.... In addition, the nuclear factor-κB (NF-κB) inhibitor, Bay 11-7082, and mitogen-activated protein kinase (MAPK) inhibitors (SB203580... 
Human Umbilical Vein Endothelial Cells | Nitriles - pharmacology | Monocytes - cytology | Coculture Techniques | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - metabolism | Monocytes - metabolism | NF-kappa B - metabolism | Sulfones - pharmacology | Artemisinins - pharmacology | Mitogen-Activated Protein Kinase 1 - genetics | Vascular Cell Adhesion Molecule-1 - genetics | JNK Mitogen-Activated Protein Kinases - genetics | Phosphorylation - drug effects | Cell Line | Butadienes - pharmacology | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | Imidazoles - pharmacology | Cell Adhesion - drug effects | Monocytes - drug effects | Tumor Necrosis Factor-alpha - pharmacology | Intercellular Adhesion Molecule-1 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | NF-kappa B - genetics | Intercellular Adhesion Molecule-1 - genetics | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Vascular Cell Adhesion Molecule-1 - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 05/2009, Volume 296, Issue 5, pp. 1425 - 1433
Journal Article
by Li, H and Xu, H and Zhou, Y and Zhang, J and Long, C and Li, S and Chen, S and Zhou, J.-M and Shao, F
Science (American Association for the Advancement of Science), ISSN 1095-9203, 02/2007, Volume 315, Issue 5814, pp. 1000 - 1003
.... In this study, the Shigella type III effector OspF was shown to inactivate mitogen-activated protein kinases (MAPKs... 
Phosphates | Phosphorylation | Phosphatases | HeLa cells | Mass spectroscopy | Immunoblotting | Bacteria | Reports | Infections | Chemical bonding | Family members | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Shigella flexneri - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Phosphoprotein Phosphatases - metabolism | Molecular Sequence Data | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Salmonella typhimurium | MAP Kinase Signaling System | p38 Mitogen-Activated Protein Kinases - metabolism | Amino Acid Sequence | Cell Line | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Bacterial Proteins - genetics | Tyrosine - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mutagenesis | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Bacterial Proteins - metabolism | HeLa Cells | Shigella flexneri - physiology | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Physiological aspects | Immune response | Gram-negative bacteria | Research | Secretion | Enzymes | Pathogens | Biochemistry | Kinases | Spectrum analysis | Index Medicus
Journal Article
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2008, Volume 121, Issue 4, pp. 893 - 902.e2
.... Objectives We sought to study the activation of the mitogen-activated protein kinase (MAPK) signaling pathway in airway cells... 
Allergy and Immunology | mitogen-activated protein kinase | chemokines | epithelial function | bronchial biopsy | Asthma | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Phosphorylation | Bronchi - enzymology | Humans | Middle Aged | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Enzyme Induction - immunology | MAP Kinase Signaling System - immunology | Enzyme Activation - immunology | Respiratory Mucosa - pathology | Chemokines - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - biosynthesis | Adult | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Bronchi - pathology | Respiratory Mucosa - secretion | Chemokines - biosynthesis | Chemokines - secretion | Mitogen-Activated Protein Kinase 1 - physiology | p38 Mitogen-Activated Protein Kinases - physiology | Asthma - enzymology | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Respiratory Mucosa - enzymology | Mitogen-Activated Protein Kinase 3 - physiology | Mitogen-Activated Protein Kinase 1 - biosynthesis | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinases - physiology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Asthma - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Protein kinases | Proteins | Studies | Signal transduction | Cell culture | Rodents | Cloning | Smooth muscle | Kinases | Index Medicus | Abridged Index Medicus
Journal Article
Biochemical journal, ISSN 1470-8728, 12/2007, Volume 408, Issue 3, pp. 297 - 315
... (mitogen-activated protein kinase) isoforms, PI-103 and wortmannin to be used in parallel to inhibit phosphatidylinositol (phosphoinositide... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | drug discovery | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | inhibitor specificity | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | anti-cancer drugs | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | protein kinase | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | kinase profiling | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article