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Journal of Neuroscience, ISSN 0270-6474, 11/2004, Volume 24, Issue 45, pp. 10211 - 10222
To investigate whether activation of mitogen-activated protein kinase ( MAPK) in damaged and/or undamaged primary afferents participates in neuropathic pain... 
Brain-derived neurotrophic factor | p38 mitogen-activated protein kinase | TRPV1 | Extracellular signal-regulated protein kinase | C-Jun N-terminal kinase/stress-activated protein kinase | Neuropathic pain | c-Jun N-terminal kinase/stress-activated protein kinase | NEUROTROPHIC FACTOR | WALLERIAN DEGENERATION | DRG NEURONS | NECROSIS-FACTOR-ALPHA | DORSAL-ROOT GANGLION | NEUROSCIENCES | RAT MODEL | neuropathic pain | MESSENGER-RNA | SCIATIC-NERVE | brain-derived neurotrophic factor | PRIMARY SENSORY NEURONS | extracellular signal-regulated protein kinase | Brain-Derived Neurotrophic Factor - genetics | MAP Kinase Signaling System - physiology | Nitriles - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Ion Channels - genetics | Stress, Mechanical | Male | Ganglia, Spinal - cytology | Ion Channels - physiology | Ganglia, Spinal - enzymology | Ligation | Brain-Derived Neurotrophic Factor - physiology | Brain-Derived Neurotrophic Factor - biosynthesis | Spinal Nerves - injuries | Pyrazoles - pharmacology | Butadienes - pharmacology | Ion Channels - biosynthesis | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Hot Temperature - adverse effects | Mitogen-Activated Protein Kinase 1 - physiology | p38 Mitogen-Activated Protein Kinases - physiology | TRPV Cation Channels | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation - physiology | Rats | Imidazoles - pharmacology | Neurons, Afferent - physiology | Rats, Sprague-Dawley | Anthracenes - pharmacology | Mitogen-Activated Protein Kinase 3 - physiology | Hyperalgesia - physiopathology | Animals | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - physiology | Hyperalgesia - etiology | Pyridines - pharmacology | Rhizotomy | Enzyme Activation | Lumbar Vertebrae | Physical Stimulation - adverse effects | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 2, pp. 559 - 567
ATF3 (activating transcription factor 3) gene encodes a member of the ATF/CREB (cAMP-response-element-binding protein) family of transcription factors. Its... 
Mitogen activated protein kinase (MAPK) | Activating transcription factor 3 (ATF3) | p38 | Stress response | Stress kinase | MAPK kinase (MKK) | APOPTOSIS | activating transcription factor 3 (ATF3) | stress kinase | PHOSPHORYLATION | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR-3 | mitogen activated protein kinase (MAPK) | JUN NH2-TERMINAL KINASE | INDUCTION | stress response | VASCULAR ENDOTHELIAL-CELLS | C-JUN | STRESS | INHIBITOR | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Gene Expression Regulation | Activating Transcription Factor 3 - biosynthesis | Cercopithecus aethiops | JNK Mitogen-Activated Protein Kinases - metabolism | Imidazoles - pharmacology | MAP Kinase Kinase 7 - metabolism | Transcription Factors - metabolism | Animals | Mitogen-Activated Protein Kinases - physiology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Enzyme Induction - drug effects | Anisomycin - pharmacology | Flavonoids - pharmacology | Pyridines - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Enzyme Activation | HeLa Cells | COS Cells | Activating Transcription Factor 3 - genetics | Index Medicus | IL-1β, interleukin 1β | JNK, c-Jun N-terminal kinase | DTT, dithiothreitol | shRNA, small-hairpin RNA | ERK, extracellular-signal-regulated kinase | SAPK, stress-activated protein kinase | DMEM, Dulbecco's modified Eagle's medium | ERK kinase 1 | CREB, CRE-binding protein | RT, reverse transcriptase | gadd153, growth-arrest and DNA-damage-inducible protein 153 | TNFα, tumour necrosis factor α | enhancer-binding protein | EBP-homologous protein 10 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | CRE, cAMP-response element | GST, glutathione S-transferase | HEK-293 cells, human embryonic kidney 293 cells | tetO, tet operator | NF-κB, nuclear factor κB | EBP, CCAAT | DN, dominant negative | FBS, fetal bovine serum | β-Gal, β-galactosidase | MKK, MAPK kinase | HA, haemagglutinin | CA, constitutively active | IP–kinase, immunoprecipitation coupled with kinase | MEK1, MAPK | ATF, activating transcription factor | Chop10, C | TGF-β, transforming growth factor-β | MEF, mouse embryonic fibroblast | MAPK, mitogen-activated protein kinase
Journal Article
Biology of Reproduction, ISSN 0006-3363, 04/2017, Volume 96, Issue 4, pp. 800 - 815
Journal Article
Journal Article
Science, ISSN 0036-8075, 2/2007, Volume 315, Issue 5814, pp. 1000 - 1003
Pathogenic bacteria use the type III secretion system to deliver effector proteins into host cells to modulate the host signaling pathways. In this study, the... 
Phosphates | Phosphorylation | Phosphatases | HeLa cells | Mass spectroscopy | Immunoblotting | Bacteria | Reports | Infections | Chemical bonding | Family members | SHIGELLA-FLEXNERI | CELLS | ACTIVATION | VIRULENCE PLASMID | MULTIDISCIPLINARY SCIENCES | SECRETION SYSTEM | HOST | INFECTION | EXPRESSION | Shigella flexneri - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Phosphoprotein Phosphatases - metabolism | Molecular Sequence Data | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Salmonella typhimurium | MAP Kinase Signaling System | p38 Mitogen-Activated Protein Kinases - metabolism | Amino Acid Sequence | Cell Line | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Bacterial Proteins - genetics | Tyrosine - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mutagenesis | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Bacterial Proteins - metabolism | HeLa Cells | Shigella flexneri - physiology | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Physiological aspects | Immune response | Gram-negative bacteria | Research | Secretion | Enzymes | Pathogens | Biochemistry | Kinases | Spectrum analysis | Index Medicus
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 09/2016, Volume 78, pp. 106 - 115
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 11/2003, Volume 18, Issue 11, pp. 2060 - 2068
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 05/2009, Volume 296, Issue 5, pp. 1425 - 1433
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7674, pp. 133 - 136
Targeted BRAF inhibition (BRAFi) and combined BRAF and MEK inhibition (BRAFi and MEKi) therapies have markedly improved the clinical outcomes of patients with... 
METASTATIC MELANOMA | MEK | EPITHELIAL-CELLS | PHOSPHORYLATION | PATHWAY | RAF | P21-ACTIVATED-KINASE-1 | MULTIDISCIPLINARY SCIENCES | KINASE | MECHANISMS | THERAPIES | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | p21-Activated Kinases - antagonists & inhibitors | Melanoma - enzymology | JNK Mitogen-Activated Protein Kinases - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Melanoma - genetics | Proto-Oncogene Proteins c-raf - chemistry | Female | beta Catenin - chemistry | Phosphorylation - drug effects | p21-Activated Kinases - genetics | JNK Mitogen-Activated Protein Kinases - chemistry | Enzyme Activation - drug effects | p21-Activated Kinases - metabolism | beta Catenin - metabolism | Proto-Oncogene Proteins c-raf - metabolism | Mitogen-Activated Protein Kinase Kinases - chemistry | Drug Resistance, Neoplasm - genetics | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Mutation | Drug Resistance, Neoplasm - drug effects | Melanoma | Physiological aspects | Cellular signal transduction | Drug resistance | Observations | Health aspects | Mitogen-activated protein kinases | TOR protein | Therapy | Phosphorylation | Activation | Metastasis | Drug development | Kinases | Cancer therapies | Metastases | Proteins | β-catenin | Signal transduction | Inhibition | Extracellular signal-regulated kinase | MAP kinase | JNK protein | Patients | Signaling | Protein arrays | Molecular modelling | Biopsy | Cell lines | Apoptosis | Index Medicus
Journal Article
Aging Cell, ISSN 1474-9718, 12/2015, Volume 14, Issue 6, pp. 1067 - 1074
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2008, Volume 121, Issue 4, pp. 893 - 902.e2
Background Many airway cells manifest signs of chronic activation in asthma. The mechanism of this chronic activation is unknown. Objectives We sought to study... 
Allergy and Immunology | mitogen-activated protein kinase | chemokines | epithelial function | bronchial biopsy | Asthma | LUNG | BRONCHIAL EPITHELIAL-CELLS | MAP KINASE | asthma | PROLIFERATION | IMMUNOLOGY | ALLERGY | GM-CSF | PATHWAY | INFLAMMATION | SMOOTH-MUSCLE-CELLS | DIFFERENTIATION | EXPRESSION | Phosphorylation | Bronchi - enzymology | Humans | Middle Aged | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Enzyme Induction - immunology | MAP Kinase Signaling System - immunology | Enzyme Activation - immunology | Respiratory Mucosa - pathology | Chemokines - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - biosynthesis | Adult | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Bronchi - pathology | Respiratory Mucosa - secretion | Chemokines - biosynthesis | Chemokines - secretion | Mitogen-Activated Protein Kinase 1 - physiology | p38 Mitogen-Activated Protein Kinases - physiology | Asthma - enzymology | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Respiratory Mucosa - enzymology | Mitogen-Activated Protein Kinase 3 - physiology | Mitogen-Activated Protein Kinase 1 - biosynthesis | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinases - physiology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Asthma - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Protein kinases | Proteins | Studies | Signal transduction | Cell culture | Rodents | Cloning | Smooth muscle | Kinases | Index Medicus | Abridged Index Medicus
Journal Article