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jp4-039 (18) 18
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Organic Process Research & Development, ISSN 1083-6160, 01/2012, Volume 16, Issue 1, pp. 26 - 34
Journal Article
IN VIVO, ISSN 0258-851X, 03/2017, Volume 31, Issue 2, pp. 159 - 168
Background/Aim: Total-body irradiation and/or administration of chemotherapy drugs in bone marrow transplantation induce cytokines that can suppress... 
MEDICINE, RESEARCH & EXPERIMENTAL | chemotherapy drugs | mouse bone marrow | STROMAL CELL-LINES | GS-NITROXIDE JP4-039 | SMAD3(-/-) MICE | Fanconi Anemia | CANCER | TRANSPLANTATION | TGF-beta | MMS350 | HEMATOPOIESIS | JP4-039 | RADIORESISTANCE | MALIGNANCIES | total body irradiation | mitigators | molecular radiation | CULTURES | PULMONARY-FIBROSIS
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 02/2018, Volume 150, pp. 169 - 175
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 09/2019, Volume 9, Issue 1, pp. 12651 - 13
Ethylmalonic encephalopathy protein 1 (ETHE1) and molybdenum cofactor (MoCo) deficiencies are hereditary disorders that affect the catabolism of... 
OXIDATIVE STRESS | ENERGY | MOLYBDENUM COFACTOR | RADIATION MITIGATOR JP4-039 | MULTIDISCIPLINARY SCIENCES | HYDROGEN-PEROXIDE | SULFITE OXIDASE DEFICIENCY | DYSFUNCTION | MUTATIONS | ETHYLMALONIC ENCEPHALOPATHY | DISTURBANCE
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 03/2019, Volume 28, Issue 6, pp. 928 - 941
Abstract Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is the most common defect of mitochondrial long-chain fatty acid β-oxidation. Patients... 
SUPEROXIDE | FATTY-ACID OXIDATION | JP4-039 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRIHEPTANOIN TREATMENT | MTP DEFICIENCIES | STRESS-RESPONSE | GENETICS & HEREDITY | GS-NITROXIDE | ENDOPLASMIC-RETICULUM | HYDROGEN-PEROXIDE | General
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2018, Volume 819, pp. 207 - 216
Journal Article
IN VIVO, ISSN 0258-851X, 11/2019, Volume 33, Issue 6, pp. 1757 - 1766
Background/Aim: We tested JP4-039, a GS-nitroxide radiation damage mitigator in proton therapy of Fanconi anemia (FA) mice. Materials and Methods: Fanca(-/-)... 
toxicity | MARROW SUPPRESSION | MEDICINE, RESEARCH & EXPERIMENTAL | HEAD | Fanconi anemia | GS-NITROXIDE JP4-039 | RADIOPROTECTION | DAMAGE | PROTECTS | DELIVERY | mucositis | radiation protector | ORAL-CAVITY MUCOSITIS | proton | Index Medicus
Journal Article
IN VIVO, ISSN 0258-851X, 01/2020, Volume 34, Issue 1, pp. 33 - 38
Background/Aim: Radiation mitigator, GS-nitroxide, JP4-039, was evaluated for mitigation of total body irradiation (TBI) in Fanconi anemia (FA)... 
MARROW SUPPRESSION | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | JP4-039 | AMELIORATION | Fanconi Anemia | MUCOSITIS | total body irradiation | RADIOPROTECTION | MICE | RADIATION | genotype
Journal Article
Molecular pharmaceutics, ISSN 1543-8384, 1/2013, Volume 10, Issue 1, pp. 187 - 198
PEGylated lipopeptide surfactants carrying drug-interactive motifs specific for a peptide-nitroxide antioxidant, JP4-039, were designed and constructed to... 
micelle | JP4-039 | emulsion | Fmoc | nitroxide | interface | surfactant
Journal Article
Future Oncology, ISSN 1479-6694, 12/2014, Volume 10, Issue 15, pp. 2345 - 2357
Only two radioprotective compounds, amifostine and palifermin, currently have the US FDA approval for use in radiation therapy. However, several agents have... 
radioprotection | free radical scavengers | growth factors | radiation mitigators | antioxidants | radiation therapy | PROTECTS MICE | GS-NITROXIDE JP4-039 | CONVERTING ENZYME-INHIBITORS | NECK-CANCER | CELL LUNG-CANCER | CATALYTIC METALLOPORPHYRIN ANTIOXIDANT | INDUCED ORAL MUCOSITIS | ONCOLOGY | RANDOMIZED PHASE-II | SUPEROXIDE-DISMUTASE | NORMAL TISSUE-INJURY
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 08/2014, Volume 5, Issue 8, pp. 900 - 904
Low aqueous solubility is a common challenge in drug discovery and development and can lead to inconclusive biological assay results. Attaching small, polar... 
JP4-039 | Aqueous solubility | oxetane | sulfoxide | MMS-350 | DESIGN | CHEMISTRY, MEDICINAL | VIVO | ANALOGS | DRUG DISCOVERY | CLASSIFICATION | IN-VITRO | DISSOLUTION | DERIVATIVES
Journal Article
Journal Article
Journal Article
Strahlentherapie und Onkologie, ISSN 0179-7158, 8/2014, Volume 190, Issue 8, pp. 745 - 752
Journal Article