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jagged-1 protein (309) 309
serrate-jagged proteins (308) 308
animals (266) 266
humans (234) 234
index medicus (232) 232
membrane proteins - metabolism (194) 194
mice (170) 170
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biochemistry & molecular biology (159) 159
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receptors, notch - metabolism (118) 118
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expression (110) 110
ligands (104) 104
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calcium-binding proteins - genetics (102) 102
intercellular signaling peptides and proteins - genetics (98) 98
notch (95) 95
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activation (63) 63
proteins (62) 62
jagged1 (58) 58
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stem cells (47) 47
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analysis (41) 41
molecular sequence data (41) 41
notch signaling (41) 41
ligand (40) 40
membrane proteins - chemistry (39) 39
amino acid sequence (38) 38
cancer (38) 38
mice, inbred c57bl (38) 38
phenotype (38) 38
immunohistochemistry (37) 37
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genetic aspects (36) 36
oncology (36) 36
proteins - genetics (36) 36
receptor, notch1 - genetics (36) 36
protein binding (35) 35
genes (34) 34
multidisciplinary sciences (34) 34
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cells (33) 33
notch protein (33) 33
proteins - metabolism (33) 33
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jagged-1 protein - genetics (32) 32
transcription factors (32) 32
gene expression regulation, developmental (31) 31
jagged-1 (30) 30
jagged1 protein (30) 30
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reverse transcriptase polymerase chain reaction (28) 28
rna, messenger - metabolism (28) 28
serrate (28) 28
angiogenesis (27) 27
blotting, western (26) 26
growth (26) 26
receptor, notch1 (26) 26
biophysics (25) 25
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gene-expression (25) 25
intercellular signaling peptides and proteins - chemistry (25) 25
membrane proteins (25) 25
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medicine (24) 24
mice, knockout (24) 24
protein structure, tertiary (24) 24
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Journal Article
Molecular cell, ISSN 1097-2765, 2015, Volume 57, Issue 5, pp. 912 - 924
Mind bomb (Mib) proteins are large, multi-domain E3 ligases that promote ubiquitination of the cytoplasmic tails of Notch ligands... 
SYSTEM | MORPHOGENESIS | ACTIVATION | PROTEIN | UBIQUITIN LIGASE | DELTA | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIFFERENTIATION | SERRATE | INTRACELLULAR MOTIFS | DROSOPHILA | CELL BIOLOGY | Wnt1 Protein | Epitopes - metabolism | Receptors, Notch - metabolism | Humans | Intercellular Signaling Peptides and Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Receptors, Notch - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Serrate-Jagged Proteins | HEK293 Cells | Membrane Proteins - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Drosophila Proteins - chemistry | Epitopes - genetics | Ubiquitin-Protein Ligases - chemistry | Blotting, Western | Sequence Homology, Amino Acid | Animals | Membrane Proteins - chemistry | Receptors, Notch - chemistry | Cell Line, Tumor | Protein Binding | Ligands | Epitopes - chemistry | Drosophila Proteins - genetics | Mutation | Ubiquitin-Protein Ligases - genetics | Calcium-Binding Proteins - genetics | Ubiquitin | Cellular signal transduction | Ligases | Antigenic determinants | Structure | Crystals | BASIC BIOLOGICAL SCIENCES
Journal Article
Developmental Biology, ISSN 0012-1606, 03/2012, Volume 363, Issue 2, pp. 399 - 412
Epsin is an endocytic protein that binds Clathrin, the plasma membrane, Ubiquitin, and also a variety of other endocytic proteins through well-characterized motifs... 
Endocytosis | Clathrin | Ubiquitin interaction motif | Notch signaling | Epsin | Drosophila | DEUBIQUITINATING ENZYME | CLATHRIN-INDEPENDENT ENDOCYTOSIS | FAT-FACETS | DELTA | DEVELOPMENTAL BIOLOGY | EH-DOMAIN | LIQUID-FACETS | PATHWAY | ALPHA-ADAPTIN | MELANOGASTER | PLANAR POLARITY | Receptors, Notch - metabolism | Adaptor Proteins, Vesicular Transport - genetics | Ubiquitin - metabolism | Intercellular Signaling Peptides and Proteins - chemistry | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Drosophila melanogaster - genetics | Adaptor Protein Complex 2 - chemistry | Drosophila melanogaster - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Adaptor Protein Complex 2 - metabolism | Serrate-Jagged Proteins | Gene Deletion | Female | Adaptor Proteins, Vesicular Transport - chemistry | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Jagged-1 Protein | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | Amino Acid Sequence | Signal Transduction | Animals, Genetically Modified | Ubiquitin - chemistry | Clathrin - chemistry | Clathrin - metabolism | Animals | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | Mutation | Proteins | Ubiquitin | Analysis | Chemical properties | Cells | Protein binding | endocytosis
Journal Article
The EMBO Journal, ISSN 0261-4189, 2011, Volume 30, Issue 4, pp. 770 - 782
Notch signalling is important for development and tissue homeostasis and activated in many human cancers. Nevertheless, mutations in Notch pathway components... 
miR‐200 | ZEB1 | EMT | Notch | stemness | miR-200 | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | PHENOTYPE | E-CADHERIN | MIR-200 FAMILY | REPRESSORS ZEB1 | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | COLORECTAL-CANCER | Receptors, Notch - metabolism | Humans | Receptors, Notch - genetics | Gene Knockdown Techniques | Intercellular Signaling Peptides and Proteins - physiology | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Neoplasms - genetics | Membrane Proteins - physiology | Serrate-Jagged Proteins | Base Sequence | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Transcription Factors - physiology | DNA-Binding Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Models, Biological | Calcium-Binding Proteins - physiology | Homeodomain Proteins - antagonists & inhibitors | Nuclear Proteins - antagonists & inhibitors | Signal Transduction - physiology | MicroRNAs - genetics | Feedback, Physiological - physiology | MicroRNAs - physiology | Homeodomain Proteins - physiology | Calcium-Binding Proteins - genetics | Zinc Finger E-box-Binding Homeobox 1 | Proteins | Signal transduction | Cellular biology | Molecular biology | Gene expression | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0177516
Myogenic stem cells are a promising avenue for the treatment of muscular disorders. Freshly isolated muscle stem cells have a remarkable engraftment ability in... 
PROGENITOR CELLS | SATELLITE CELL NICHE | MESENCHYMAL PROGENITORS | GENE | MYOD | MULTIDISCIPLINARY SCIENCES | EXPANSION | SELF-RENEWAL | DUCHENNE MUSCULAR-DYSTROPHY | HUMAN SKELETAL-MUSCLE | TRANSPLANTATION | Immunohistochemistry | Jagged-1 Protein - metabolism | MyoD Protein - genetics | Receptors, Notch - metabolism | PAX7 Transcription Factor - genetics | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | PAX7 Transcription Factor - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Cell Differentiation - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Myoblasts - metabolism | Regeneration - genetics | Myoblasts - cytology | Membrane Proteins - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Real-Time Polymerase Chain Reaction | Membrane Proteins - genetics | Muscle Development - physiology | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | MyoD Protein - metabolism | Signal Transduction - genetics | Regeneration - physiology | Jagged-1 Protein - genetics | Muscle Cells - cytology | Animals | Muscle Development - genetics | Signal Transduction - physiology | Mice | Transplantation | Research | Health aspects | Ligands (Biochemistry) | Analysis | Stem cells | Musculoskeletal diseases | Musculoskeletal system | Cell culture | MyoD protein | Allografts | Cell number | Stem cell transplantation | Ligands | Notch protein | Gene expression | Myoblasts | Signal Transduction | Intercellular Signaling Peptides and Proteins | PAX7 Transcription Factor | Intracellular Signaling Peptides and Proteins | Cellular Biology | Stem Cells | Membrane Proteins | Life Sciences | Regeneration | Muscle Development | Receptors, Notch | Cell Differentiation | Muscle Cells | MyoD Protein | Jagged-1 Protein
Journal Article
Developmental Biology, ISSN 0012-1606, 09/2012, Volume 369, Issue 2, pp. 319 - 329
The regulation of the segment polarity gene wingless is essential for the correct patterning of the Drosophila ectoderm. We have previously shown that the... 
CUBITUS INTERRUPTUS | GENES MIDLINE | COREPRESSOR | PROTEIN | INTERACTS | TRANSCRIPTION | DEVELOPMENTAL BIOLOGY | DEPENDENT REPRESSION | EXPRESSION | H15 | DROSOPHILA | Wnt1 Protein - genetics | Drosophila melanogaster - embryology | T-Box Domain Proteins - chemistry | Molecular Sequence Data | DNA Primers - genetics | Wnt1 Protein - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Serrate-Jagged Proteins | Base Sequence | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Repressor Proteins - metabolism | Wnt1 Protein - chemistry | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Genes, Insect | Amino Acid Sequence | Repressor Proteins - chemistry | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Animals, Genetically Modified | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Repressor Proteins - genetics | Drosophila Proteins - chemistry | T-Box Domain Proteins - genetics | T-Box Domain Proteins - metabolism | Body Patterning - physiology | Sequence Homology, Amino Acid | Animals | Drosophila Proteins - genetics | Body Patterning - genetics | Basic Helix-Loop-Helix Transcription Factors - chemistry | Calcium-Binding Proteins - genetics
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2016, Volume 472, Issue 1, pp. 255 - 261
...) and a soluble Jagged1 intracellular domain (JICD). The full-length Jagged1 protein enhances prostate cancer (PCa... 
Metastasis | Jagged1 | Notch signaling | Prostate cancer | Migration | Invasion | SECRETASE | APOPTOSIS | PROTEIN | LENTIVIRUS VECTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | AKT | RELEASE | CLEAVAGE | GROWTH INHIBITION | BIOPHYSICS | LIGAND | Prostatic Neoplasms - metabolism | Receptors, Notch - metabolism | Humans | Bone Neoplasms - secondary | Intercellular Signaling Peptides and Proteins - chemistry | Male | Prostatic Neoplasms - physiopathology | Bone Neoplasms - pathology | Cell Movement - physiology | Bone Neoplasms - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Proteolysis | Serrate-Jagged Proteins | Membrane Proteins - metabolism | Peptide Fragments - genetics | Jagged-1 Protein | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | Recombinant Proteins - metabolism | Prostatic Neoplasms - pathology | Peptide Fragments - metabolism | Signal Transduction | Membrane Proteins - genetics | Neoplasm Invasiveness | Intercellular Signaling Peptides and Proteins - genetics | Mesenchymal Stromal Cells - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Peptide Fragments - chemistry | Membrane Proteins - chemistry | Cell Line, Tumor | Calcium-Binding Proteins - genetics | Analysis | PROSTATE | THERAPY | LIGANDS | NEOPLASMS | BEHAVIOR | METASTASES | BONE MARROW | CELL PROLIFERATION | PROTEOLYSIS | PROTEINS | 60 APPLIED LIFE SCIENCES | SKELETON
Journal Article
Journal Article
Stem cells (Dayton, Ohio), ISSN 1066-5099, 2017, Volume 35, Issue 7, pp. 1747 - 1759
...) to angiogenesis by endothelial cells. Exosome secretion was enhanced in HIF‐MSC. Omics analysis of miRNAs and proteins incorporated into exosomes pointed to the Notch pathway as a candidate mediator of exosome communication... 
Angiogenesis | Exosomes | Jagged 1 | Hypoxia‐inducible factor | Mesenchymal stem cells | Hypoxia-inducible factor | MIGRATION | ACTIVATION | NOTCH | MICROVESICLES | CELL & TISSUE ENGINEERING | CELL BIOLOGY | THERAPY | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HIF-1-ALPHA | STROMAL CELLS | HEMATOLOGY | GAMMA-SECRETASE | CONTRIBUTES | ENDOTHELIAL GROWTH-FACTOR | Exosomes - metabolism | Jagged-1 Protein - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Coculture Techniques | Humans | Transplantation, Heterologous | Green Fluorescent Proteins - genetics | Dental Pulp - metabolism | Cell Hypoxia | Mesenchymal Stromal Cells - cytology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Human Umbilical Vein Endothelial Cells - cytology | Jagged-1 Protein - antagonists & inhibitors | Tetraspanin 30 - genetics | Genes, Reporter | Green Fluorescent Proteins - metabolism | Transduction, Genetic | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Gene Expression Regulation | Dental Pulp - cytology | Mesenchymal Stromal Cells - metabolism | Antibodies, Neutralizing - pharmacology | Jagged-1 Protein - genetics | Animals | Mice, Nude | Luminescent Proteins - genetics | Exosomes - chemistry | Mice | Primary Cell Culture | Tetraspanin 30 - metabolism | Mesenchymal Stem Cell Transplantation | Neovascularization, Physiologic | Luminescent Proteins - metabolism | Hypoxia-inducible factor 1 | Transcription | Mesenchyme | Incubation | Secretion | Tissues | Endothelial cells | Proteins | Hypoxia-inducible factor 1a | Ischemia | Stem cells | Capillary tubes | Packaging | Hypoxia | Notch protein | Jagged1 protein | In vitro methods and tests
Journal Article
Journal Article
Journal Article