X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (5203) 5203
animals (4480) 4480
signal transduction (2839) 2839
mice (2579) 2579
janus kinase 2 - metabolism (2199) 2199
phosphorylation (2187) 2187
janus kinase 2 (2099) 2099
male (1780) 1780
female (1619) 1619
protein-tyrosine kinases - metabolism (1520) 1520
cell biology (1499) 1499
activation (1498) 1498
signal transduction - drug effects (1478) 1478
biochemistry & molecular biology (1470) 1470
stat3 transcription factor - metabolism (1457) 1457
expression (1334) 1334
janus kinases - metabolism (1262) 1262
janus kinase 2 - genetics (1213) 1213
oncology (1118) 1118
cell line (1079) 1079
apoptosis (1075) 1075
cell line, tumor (1066) 1066
cells, cultured (1063) 1063
mutation (1062) 1062
hematology (1010) 1010
kinases (954) 954
rats (942) 942
proto-oncogene proteins (932) 932
proteins (927) 927
janus kinase (891) 891
gene expression (883) 883
cytokines (873) 873
immunology (831) 831
dna-binding proteins - metabolism (830) 830
stat transcription factors - metabolism (827) 827
trans-activators - metabolism (823) 823
signal transduction - physiology (744) 744
research (713) 713
jak2 (711) 711
cancer (709) 709
inflammation (707) 707
janus kinase 2 - antagonists & inhibitors (688) 688
stat3 (670) 670
receptor (649) 649
cells (646) 646
middle aged (617) 617
transcription (595) 595
analysis (594) 594
gene-expression (583) 583
phosphorylation - drug effects (570) 570
adult (569) 569
cell proliferation (563) 563
janus kinase 1 (559) 559
apoptosis - drug effects (555) 555
research article (528) 528
genetic aspects (517) 517
mice, inbred c57bl (512) 512
inhibition (511) 511
pharmacology & pharmacy (505) 505
janus kinase 1 - metabolism (503) 503
polycythemia-vera (502) 502
protein kinase inhibitors - pharmacology (498) 498
cell proliferation - drug effects (487) 487
blotting, western (486) 486
multidisciplinary sciences (481) 481
transfection (480) 480
stat3 protein (479) 479
aged (477) 477
proliferation (477) 477
endocrinology & metabolism (461) 461
protein (454) 454
stat5 transcription factor - metabolism (450) 450
enzyme activation (445) 445
signal-transduction (428) 428
medicine, research & experimental (427) 427
physiological aspects (418) 418
health aspects (409) 409
enzyme inhibitors - pharmacology (406) 406
rodents (406) 406
tyrosine - metabolism (406) 406
molecular sequence data (401) 401
medicine (399) 399
pathway (399) 399
stat5 transcription factor (399) 399
signaling (397) 397
gene expression regulation (395) 395
tumors (391) 391
disease models, animal (389) 389
growth (389) 389
stat3 transcription factor (389) 389
stat3 transcription factor - genetics (387) 387
stat1 transcription factor - metabolism (384) 384
abridged index medicus (383) 383
cytokines - metabolism (383) 383
tyrosine phosphorylation (382) 382
rats, sprague-dawley (381) 381
leukemia (367) 367
protein binding (367) 367
jak (362) 362
tyrphostins - pharmacology (362) 362
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (7873) 7873
Chinese (83) 83
Japanese (39) 39
Russian (7) 7
German (3) 3
Polish (3) 3
French (2) 2
Korean (2) 2
Czech (1) 1
Danish (1) 1
Dutch (1) 1
Hungarian (1) 1
Norwegian (1) 1
Romanian (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 489, Issue 7414, pp. 155 - 159
...) in most patients with myeloproliferative neoplasm (MPN) led to the clinical development of JAK2 kinase inhibitors(6,7... 
MYELOFIBROSIS | LUNG-CANCER | POLYCYTHEMIA-VERA | GEFITINIB | MYELOPROLIFERATIVE DISORDERS | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | MUTATION | RESISTANCE | CHRONIC MYELOID-LEUKEMIA | Myeloproliferative Disorders - enzymology | Phosphorylation | Protein Biosynthesis | Humans | Protein Multimerization | STAT Transcription Factors - metabolism | TYK2 Kinase - metabolism | Janus Kinase 1 - deficiency | TYK2 Kinase - deficiency | Myeloproliferative Disorders - pathology | Janus Kinase 1 - biosynthesis | Gene Knockdown Techniques | Janus Kinase 2 - deficiency | Janus Kinase 1 - metabolism | Granulocytes - drug effects | RNA Interference | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Myeloproliferative Disorders - metabolism | Granulocytes - metabolism | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Cell Line | Janus Kinase 2 - genetics | Myeloproliferative Disorders - drug therapy | Enzyme Activation - drug effects | TYK2 Kinase - biosynthesis | Granulocytes - enzymology | Animals | Signal Transduction - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | HSP90 Heat-Shock Proteins - metabolism | Mice | TYK2 Kinase - genetics | Drug Resistance, Neoplasm - drug effects | Enzyme inhibitors | Gene mutations | Cancer cells | Dosage and administration | Genetic aspects | Cellular signal transduction | Identification and classification | Physiological aspects | Care and treatment | Research | Myeloproliferative disorders | Cancer | tyrosine kinase inhibitors | persistence | MPN | JAK2 | resistance
Journal Article
Journal Article
Journal of clinical immunology, ISSN 1573-2592, 2011, Volume 31, Issue 3, pp. 472 - 478
.... Leptin increased B cells expressing CD25 and HLA-DR. Leptin induces phosphorylation of Janus activation kinase 2 (JAK2... 
Medical Microbiology | Biomedicine | Immunology | Internal Medicine | Infectious Diseases | activation markers | cytokines | B cells | PROTEIN-KINASE | TRANSDUCER | RECEPTOR | PROLIFERATION | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | DEFICIENCY | PI3K/AKT | IMMUNE-RESPONSES | T-CELLS | Autoimmunity | Interleukin-6 - analysis | Janus Kinase 2 - biosynthesis | Mitogen-Activated Protein Kinase 3 - analysis | Humans | p38 Mitogen-Activated Protein Kinases - biosynthesis | p38 Mitogen-Activated Protein Kinases - analysis | Dose-Response Relationship, Drug | Signal Transduction - immunology | Inflammation - metabolism | Mitogen-Activated Protein Kinases - analysis | Mitogen-Activated Protein Kinase 3 - biosynthesis | Mitogen-Activated Protein Kinase 6 - analysis | Leptin - pharmacology | Phosphorylation - drug effects | Interleukin-10 - analysis | B-Lymphocytes - metabolism | Janus Kinase 2 - analysis | Enzyme-Linked Immunosorbent Assay | Lymphocyte Activation | Cells, Cultured | Mitogen-Activated Protein Kinases - biosynthesis | Receptors, Leptin - immunology | STAT3 Transcription Factor - analysis | Inflammation - immunology | Tumor Necrosis Factor-alpha - analysis | STAT3 Transcription Factor - biosynthesis | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Mitogen-Activated Protein Kinase 6 - biosynthesis | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Receptors, Leptin - metabolism | Tumor Necrosis Factor-alpha - biosynthesis
Journal Article
Biochemical journal, ISSN 1470-8728, 2009, Volume 420, Issue 3, pp. 345 - 361
RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and differentiation... 
Extracellular-signal-regulated kinase (ERK) | Pleiotrophin | Anaplastic large cell lymphoma (ALCL) | Neuroblastoma | Non-small cell lung cancer (NSLCL) | Midkine | Anaplastic lymphoma kinase (ALK) | Inflammatory myofibroblastic tumour (IMT) | ALK PROTEIN EXPRESSION | inflammatory myofibroblastic tumour (IMT) | NPM-ALK | HEPARIN-BINDING | GROWTH-FACTOR PLEIOTROPHIN | non-small cell lung cancer (NSLCL) | BIOCHEMISTRY & MOLECULAR BIOLOGY | anaplastic lymphoma kinase (ALK) | EML4-ALK FUSION GENE | neuroblastoma | LARGE-CELL LYMPHOMA | extracellular-signal-regulated kinase (ERK) | pleiotrophin | NEUROTROPHIC FACTOR HBNF | INFLAMMATORY MYOFIBROBLASTIC TUMOR | NON-HODGKINS-LYMPHOMA | midkine | anaplastic large cell lymphoma (ALCL) | RECEPTOR TYROSINE KINASE | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Oncogene Proteins, Fusion - metabolism | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Neuroblastoma - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Lung Neoplasms - pathology | Nuclear Proteins - metabolism | Receptor Protein-Tyrosine Kinases | Protein-Tyrosine Kinases - genetics | Models, Biological | Oncogene Proteins, Fusion - genetics | Lymphoma, Large-Cell, Anaplastic - pathology | Neuroblastoma - metabolism | Nuclear Proteins - genetics | Lymphoma, Large-Cell, Anaplastic - metabolism | Neuroblastoma - pathology | Lymphoma, Large-Cell, Anaplastic - genetics | ALK, anaplastic lymphoma kinase | LTK, leucocyte tyrosine kinase | MUC-1, mucin-1 | IRS-1, IR substrate-1 | PTN, pleiotrophin | TGFβ, transforming growth factor β | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | Shc, Src homology and collagen homology | TPM, tropomyosin | IMP cyclohydrolase | MK, midkine | MYH9, non-muscle myosin heavy chain | MAM, meprin, A5 protein and receptor protein tyrosine phosphatase mu | NPM, nucleophosmin | mTOR, mammalian target of rapamycin | NIPA, nuclear interacting partner of ALK | RPTP, receptor protein tyrosine phosphatase | DLBCL, diffuse large B-cell lymphoma | FOXO3a, forkhead box O 3a | NF-κB, nuclear factor κB | Shp1, SH2 domain-containing phosphatase 1 | RANBP2, Ran-binding protein 2 | ALCL, anaplastic large cell lymphoma | Dpp, decapentaplegic | FRS2, fibroblast growth factor receptor substrate 2 | LDLa, low-density lipoprotein class A | EGFR, epidermal growth factor receptor | SEC31L1, SEC31 homologue A | GIST, gastrointestinal stromal tumour | RTK, receptor tyrosine kinase | SH2, Src homology 2 | TFG, TRK-fused gene | ATIC, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase | CLTC, clathrin heavy chain | MAPK, mitogen-activated protein kinase | Hen-1, hesitation-1 | MEK, MAPK | PI3K, phosphoinositide 3-kinase | HEK, human embryonic kidney | SCD-2, suppressor of constitutive dauer 2 | Review | EBPβ, CCAAT | CARS, cysteinyl-tRNA synthetase | JNK, c-Jun N-terminal kinase | ERK kinase | Grb2, growthfactor-receptor-bound protein 2 | SCC, squamous cell carcinoma | EML4, echinoderm microtubule-associated protein like 4 | SHH, sonic hedghog | BCR-Abl, breakpoint cluster region-Abl | IR, insulin receptor | ALO17, ALK lymphoma oligomerization partner on chromosome 17 | enhancer-binding protein β | PLCγ, phospholipase Cγ | NSCLC, non-small cell lung cancer | UCN-01, unco-ordinated 1 | Cdc42, cell division cycle 42 | STAT, signal transducer and activator of transcription | DRG, dorsal root ganglia | MSN, moesin | dALK, Drosophila ALK | IL-3, interleukin-3 | CNS, central nervous system | JAK, Janus kinase | CML, chronic myeloid leukaemia | Jeb, jelly belly | IMT, inflammatory myofibroblastic tumour
Journal Article
Blood, ISSN 0006-4971, 10/2012, Volume 120, Issue 17, pp. 3510 - 3518
CRLF2 rearrangements, JAK1/2 point mutations, and JAK2 fusion genes have been identified in Philadelphia chromosome (Ph... 
MAMMALIAN TARGET | RAPAMYCIN | IN-VITRO | ABERRANT STAT5 | RECEPTOR | OF-FUNCTION MUTATIONS | HEMATOLOGY | B-PROGENITOR | GENETIC ALTERATIONS | STAT5 ACTIVATION | CRLF2 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Immunoglobulins - genetics | Molecular Targeted Therapy | Immunoglobulins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Janus Kinase 1 - metabolism | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | TOR Serine-Threonine Kinases - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Receptors, Cytokine - metabolism | Drug Evaluation, Preclinical | Child | Philadelphia Chromosome | Receptors, Cytokine - genetics | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Pyrazoles - pharmacology | Acute Disease | Janus Kinase 2 - genetics | Survival Rate | Signal Transduction - genetics | Janus Kinase 1 - antagonists & inhibitors | Sirolimus - pharmacology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Lymphoid Neoplasia
Journal Article
Molecular carcinogenesis, ISSN 0899-1987, 2013, Volume 52, Issue 2, pp. 155 - 166
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is involved in immune function and cell growth... 
cigarette smoking | STAT | estrogen | JAK | colon cancer | NSAIDs | rectal cancer | SOCS | Colon cancer | Rectal cancer | Estrogen | Cigarette smoking | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | RISK | ENERGY-BALANCE | INHIBITION | ONCOLOGY | JANUS KINASES | COLORECTAL-CANCER | INFLAMMATION | PHYSICAL-ACTIVITY | Smoking - adverse effects | Colonic Neoplasms - genetics | Receptors, Estrogen - metabolism | Colorectal Neoplasms - genetics | Humans | Middle Aged | STAT Transcription Factors - metabolism | STAT4 Transcription Factor - metabolism | TYK2 Kinase - metabolism | Suppressor of Cytokine Signaling 1 Protein | Male | Janus Kinases - metabolism | Interferon-gamma - metabolism | Case-Control Studies | Colonic Neoplasms - metabolism | Janus Kinase 1 - metabolism | STAT1 Transcription Factor - metabolism | Rectal Neoplasms - genetics | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Adult | Female | Interferon-gamma - genetics | Interleukin-6 - metabolism | Colorectal Neoplasms - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Colonic Neoplasms - mortality | Genetic Predisposition to Disease | Interleukin-6 - genetics | Janus Kinases - genetics | Signal Transduction | Janus Kinase 2 - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Survival Rate | STAT1 Transcription Factor - genetics | Rectal Neoplasms - mortality | STAT Transcription Factors - genetics | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | STAT4 Transcription Factor - genetics | Aged | Polymorphism, Single Nucleotide | Rectal Neoplasms - metabolism | Suppressor of Cytokine Signaling Proteins - metabolism | TYK2 Kinase - genetics | Aspirin | Analysis | Oncology, Experimental | Research | Public health | Smoking | Cancer | Genetic diversity | Kinases | Risk factors | Colorectal cancer
Journal Article
Redox biology, ISSN 2213-2317, 2014, Volume 2, Issue 1, pp. 411 - 429
Journal Article
Journal Article