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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2009, Volume 106, Issue 23, pp. 9414 - 9418
Journal Article
Journal Article
Nature chemical biology, ISSN 1552-4450, 12/2014, Volume 10, Issue 12, pp. 1066 - 1072
Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these... 
DESIGN | PLACEBO | LIGANDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REACTIVITY | OPTIMIZATION | GENERATION | INHIBITORS | COORDINATE | CYSTEINES | PREDICTION | Small Molecule Libraries - pharmacology | Humans | Bacterial Proteins - chemistry | Molecular Probes - pharmacology | Janus Kinase 3 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | beta-Lactamases - genetics | Janus Kinase 3 - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Cysteine - metabolism | Bacterial Proteins - antagonists & inhibitors | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cysteine - chemistry | beta-Lactamase Inhibitors - pharmacology | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Serine - chemistry | Drug Discovery | Serine - metabolism | Gram-Negative Bacteria - enzymology | Gram-Negative Bacteria - drug effects | Small Molecule Libraries - chemistry | beta-Lactamases - chemistry | Molecular Probes - chemistry | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Gram-Negative Bacteria - growth & development | Janus Kinase 3 - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | COS Cells | beta-Lactamase Inhibitors - chemistry | Proteins | Chemical bonds | Biochemistry | Crystal structure | boronic acid | covalent virtual screening | JAK3 kinase | covalent fragments | covalent inhibition | beta-lactamase | RSK2 kinase | cyanoacrylamide | reversible covalent | covalent electrophile | MSK1 kinase
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2011, Volume 186, Issue 7, pp. 4234 - 4243
Journal Article
Nature Genetics, ISSN 1061-4036, 10/2011, Volume 43, Issue 10, pp. 932 - 941
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2017, Volume 23, Issue 3, pp. 291 - 300
Journal Article
Blood, ISSN 0006-4971, 01/2013, Volume 121, Issue 3, pp. 485 - 488
Journal Article
Leukemia, ISSN 0887-6924, 2007, Volume 21, Issue 8, pp. 1658 - 1668
JAK2V617F and MPLW515L/K represent recently identified mutations in myeloproliferative disorders (MPD) that cause dysregulated JAK-STAT signaling, which is... 
MYELOFIBROSIS | JAK2(V617F) | POLYCYTHEMIA-VERA | ESSENTIAL THROMBOCYTHEMIA | JAK2V617F | myeloproliferative disorder | mutation | kinase inhibitor | MEGAKARYOBLASTIC LEUKEMIA | ACTIVATING MUTATION | ONCOLOGY | V617F | ACUTE LYMPHOBLASTIC-LEUKEMIA | JAK2 | HEMATOLOGY | MYELOID METAPLASIA | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Apoptosis - drug effects | Humans | STAT Transcription Factors - metabolism | Polycythemia Vera - genetics | Myeloproliferative Disorders - genetics | Janus Kinase 3 - antagonists & inhibitors | Polycythemia Vera - metabolism | fms-Like Tyrosine Kinase 3 - genetics | Janus Kinase 2 - metabolism | Myeloproliferative Disorders - metabolism | Colony-Forming Units Assay | Phosphorylation - drug effects | Janus Kinase 3 - metabolism | Janus Kinase 2 - antagonists & inhibitors | Primary Myelofibrosis - metabolism | Primary Myelofibrosis - drug therapy | Thrombopoietin - metabolism | Enzyme Inhibitors - pharmacology | Janus Kinase 2 - genetics | Myeloproliferative Disorders - drug therapy | Pyrimidines - pharmacology | Mice, SCID | Mutation - genetics | Sulfonamides - pharmacology | Receptors, Thrombopoietin - metabolism | Receptors, Thrombopoietin - antagonists & inhibitors | fms-Like Tyrosine Kinase 3 - metabolism | Receptors, Thrombopoietin - genetics | Primary Myelofibrosis - genetics | Animals | Janus Kinase 3 - genetics | Stem Cells - drug effects | Polycythemia Vera - drug therapy | Cell Proliferation - drug effects | Mice | Cell Cycle - drug effects | Antibody diversity | Chemical inhibitors | Genetic aspects | Research | Health aspects | Myeloproliferative disorders
Journal Article
Neoplasia, ISSN 1476-5586, 2013, Volume 15, Issue 7, pp. 848 - IN45
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2015, Volume 290, Issue 48, pp. 29022 - 29034
Journal Article